EP3801552A4 - Composition and method for inhalation - Google Patents

Composition and method for inhalation Download PDF

Info

Publication number
EP3801552A4
EP3801552A4 EP19815062.5A EP19815062A EP3801552A4 EP 3801552 A4 EP3801552 A4 EP 3801552A4 EP 19815062 A EP19815062 A EP 19815062A EP 3801552 A4 EP3801552 A4 EP 3801552A4
Authority
EP
European Patent Office
Prior art keywords
inhalation
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP19815062.5A
Other languages
German (de)
French (fr)
Other versions
EP3801552A1 (en
Inventor
Joseph J. Guarneri
Nikhil AMIN
Marshall L. Grant
John J. Freeman
Kelly S. Kraft
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mannkind Corp
Original Assignee
Mannkind Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mannkind Corp filed Critical Mannkind Corp
Publication of EP3801552A1 publication Critical patent/EP3801552A1/en
Publication of EP3801552A4 publication Critical patent/EP3801552A4/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
    • A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP19815062.5A 2018-06-07 2019-06-07 Composition and method for inhalation Pending EP3801552A4 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862682109P 2018-06-07 2018-06-07
PCT/US2019/036095 WO2019237028A1 (en) 2018-06-07 2019-06-07 Composition and method for inhalation

Publications (2)

Publication Number Publication Date
EP3801552A1 EP3801552A1 (en) 2021-04-14
EP3801552A4 true EP3801552A4 (en) 2022-02-23

Family

ID=68770678

Family Applications (1)

Application Number Title Priority Date Filing Date
EP19815062.5A Pending EP3801552A4 (en) 2018-06-07 2019-06-07 Composition and method for inhalation

Country Status (5)

Country Link
EP (1) EP3801552A4 (en)
JP (1) JP2021527058A (en)
AU (1) AU2019282808A1 (en)
CA (1) CA3102967A1 (en)
WO (1) WO2019237028A1 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3060041T (en) 2013-10-25 2021-03-12 Insmed Inc Prostacyclin compounds, compositions and methods of use thereof
EP3452170A4 (en) 2016-05-05 2020-04-01 Liquidia Technologies, Inc. Dry powder treprostinil for the treatment of pulmonary hypertension
JP7455144B2 (en) 2019-04-29 2024-03-25 インスメッド インコーポレイテッド Dry powder compositions of treprostinil prodrugs and methods of use thereof
JP2023523557A (en) 2020-04-17 2023-06-06 ユナイテッド セラピューティクス コーポレイション Treprostinil for use in the treatment of interstitial lung disease
JP2023529828A (en) 2020-06-09 2023-07-12 ユナイテッド セラピューティクス コーポレイション fumaryl diketopiperidine prodrug of treprostinil
CA3196252A1 (en) * 2020-10-28 2022-05-05 Ju Du Dry powder compositions of treprostinil prodrugs and methods of use thereof
CA3199324A1 (en) 2020-11-17 2022-05-27 Adam Marc Silverstein Inhaled imatinib for pulmonary hypertension field
CA3209987A1 (en) 2021-03-03 2022-09-09 Hitesh Batra A dry powder composition of trestinil and its prodrug thereof and further comprising comprising (e)-3,6-bis[4-(n-carbonyl-2-propenyl)amidobutyl]-2,5-diketopiperazine (fdkp)
US20230263807A1 (en) 2022-02-08 2023-08-24 United Therapeutics Corporation Treprostinil iloprost combination therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140199398A1 (en) * 2011-06-17 2014-07-17 Mannkind Corporation High capacity diektopiperazine microparticles and methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352461A (en) * 1992-03-11 1994-10-04 Pharmaceutical Discovery Corporation Self assembling diketopiperazine drug delivery system
HUE028691T2 (en) * 2005-09-14 2016-12-28 Mannkind Corp Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents
JP6523247B2 (en) * 2013-03-15 2019-05-29 マンカインド コーポレイション Method of making microcrystalline diketopiperazine particles and method of making dry powder composition
MX2018009159A (en) * 2016-01-29 2019-06-13 Mannkind Corp Dry powder inhaler.
EP3452170A4 (en) * 2016-05-05 2020-04-01 Liquidia Technologies, Inc. Dry powder treprostinil for the treatment of pulmonary hypertension

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140199398A1 (en) * 2011-06-17 2014-07-17 Mannkind Corporation High capacity diektopiperazine microparticles and methods

Also Published As

Publication number Publication date
JP2021527058A (en) 2021-10-11
CA3102967A1 (en) 2019-12-12
AU2019282808A1 (en) 2021-01-07
EP3801552A1 (en) 2021-04-14
WO2019237028A1 (en) 2019-12-12

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