EA201290237A1 - Киназные ингибиторы - Google Patents

Киназные ингибиторы

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Publication number
EA201290237A1
EA201290237A1 EA201290237A EA201290237A EA201290237A1 EA 201290237 A1 EA201290237 A1 EA 201290237A1 EA 201290237 A EA201290237 A EA 201290237A EA 201290237 A EA201290237 A EA 201290237A EA 201290237 A1 EA201290237 A1 EA 201290237A1
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EA
Eurasian Patent Office
Prior art keywords
protein kinase
diseases
pyrido
pyrimidin
disorders
Prior art date
Application number
EA201290237A
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English (en)
Other versions
EA029273B1 (ru
Inventor
Хонг Ву Ким
Джонг Сунг Кох
Джаекиоо Ли
Хо-Джун Сонг
Янгсам Ким
Хее Киу Ли
Джэнг-Сик Чой
Сун-Хее Лим
Сунва Чэнг
Original Assignee
Джиноско
Оскотек Инк.
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43922599&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201290237(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Джиноско, Оскотек Инк. filed Critical Джиноско
Publication of EA201290237A1 publication Critical patent/EA201290237A1/ru
Publication of EA029273B1 publication Critical patent/EA029273B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

Заявляется новая группа протеинкиназных ингибиторов, производных пиридо[4,3-d]пиримидин-5-она, и их фармацевтически приемлемые соли и пролекарства, которые применяют для лечения клеточных пролиферативных заболеваний и расстройств, таких как рак, аутоиммунные заболевания, инфекции, сердечно-сосудистые заболевания и нейродегенеративные заболевания и расстройства. В данном изобретении представлены способы синтеза и введения соединений ингибитора протеинкиназы. В данном изобретении также представлены фармацевтические композиции, содержащие по меньшей мере одно соединение ингибитора протеинкиназы вместе с фармацевтически приемлемым носителем, разбавителем или наполнителем. В изобретении также представлены промежуточные соединения, полученные во время синтеза производных пиридо[4,3-d]пиримидин-5-она.
EA201290237A 2009-10-29 2010-10-29 Киназные ингибиторы EA029273B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25622209P 2009-10-29 2009-10-29
PCT/US2010/054853 WO2011053861A1 (en) 2009-10-29 2010-10-29 Kinase inhibitors

Publications (2)

Publication Number Publication Date
EA201290237A1 true EA201290237A1 (ru) 2013-04-30
EA029273B1 EA029273B1 (ru) 2018-03-30

Family

ID=43922599

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201290237A EA029273B1 (ru) 2009-10-29 2010-10-29 Киназные ингибиторы

Country Status (18)

Country Link
US (1) US8404677B2 (ru)
EP (1) EP2493313B1 (ru)
JP (1) JP5993742B2 (ru)
KR (1) KR101690358B1 (ru)
CN (1) CN102695416B (ru)
BR (1) BR112012010085B1 (ru)
CA (1) CA2779105C (ru)
CL (1) CL2012001073A1 (ru)
EA (1) EA029273B1 (ru)
ES (1) ES2658290T3 (ru)
IL (1) IL219447A (ru)
MX (1) MX2012004846A (ru)
MY (1) MY173494A (ru)
NZ (2) NZ599040A (ru)
SG (1) SG10201407012XA (ru)
TR (1) TR201802464T4 (ru)
WO (1) WO2011053861A1 (ru)
ZA (1) ZA201203842B (ru)

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