BR112015014687A2 - compostos de piridazina bicíclicos fundidos substituídos por arila - Google Patents
compostos de piridazina bicíclicos fundidos substituídos por arilaInfo
- Publication number
- BR112015014687A2 BR112015014687A2 BR112015014687A BR112015014687A BR112015014687A2 BR 112015014687 A2 BR112015014687 A2 BR 112015014687A2 BR 112015014687 A BR112015014687 A BR 112015014687A BR 112015014687 A BR112015014687 A BR 112015014687A BR 112015014687 A2 BR112015014687 A2 BR 112015014687A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- aryl substituted
- fused bicyclic
- substituted fused
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
abstract the present invention provides a compound of formula (i): (i) as described herein, and pharmaceutically acceptable salts, enantiomers, rotamers, tautomers, or racemates thereof. also provided are methods of treating a disease or condition mediated by pim kinase using the compounds of formula i, and pharmaceutical compositions comprising such compounds. tradução do resumo resumo patente de invenção para "compostos de piridazina bicíclicos fundidos substituídos por arila". a presente invenção fornece um composto de fórmula (i): (i) como descrito aqui, e sais farmaceuticamente aceitáveis, enantiômeros, rotâmeros, tautômeros, ou racematos dos mesmos. da mesma fornecidos são os métodos de tratar uma doença ou condição mediada por pim cinase usando os compostos de fórmula (i), e composição farmacêuticas compreendendo tais compostos.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261739522P | 2012-12-19 | 2012-12-19 | |
| PCT/US2013/075613 WO2014099880A1 (en) | 2012-12-19 | 2013-12-17 | Aryl-substituted fused bicyclic pyridazine compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112015014687A2 true BR112015014687A2 (pt) | 2017-07-11 |
Family
ID=49918880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015014687A BR112015014687A2 (pt) | 2012-12-19 | 2013-12-17 | compostos de piridazina bicíclicos fundidos substituídos por arila |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20150336960A1 (pt) |
| EP (1) | EP2935270A1 (pt) |
| KR (1) | KR20150095928A (pt) |
| AU (1) | AU2013363047A1 (pt) |
| BR (1) | BR112015014687A2 (pt) |
| CA (1) | CA2895338A1 (pt) |
| WO (1) | WO2014099880A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
| KR102403306B1 (ko) | 2013-01-15 | 2022-06-02 | 인사이트 홀딩스 코포레이션 | Pim 키나제 저해제로서 유용한 티아졸카복스아마이드 및 피리딘카복스아마이드 화합물 |
| JP2016528298A (ja) | 2013-08-23 | 2016-09-15 | インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉｍキナーゼ阻害剤として有用なフロピリジン及びチエノピリジンカルボキシアミド化合物 |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016010897A1 (en) * | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
| JO3589B1 (ar) | 2014-08-06 | 2020-07-05 | Novartis Ag | مثبطات كيناز البروتين c وطرق استخداماتها |
| WO2016196244A1 (en) * | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| TWI734699B (zh) | 2015-09-09 | 2021-08-01 | 美商英塞特公司 | Ｐｉｍ激酶抑制劑之鹽 |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| CN112739345A (zh) | 2017-11-06 | 2021-04-30 | 斯奈普生物公司 | Pim激酶抑制剂组合物，方法和其用途 |
| AR113922A1 (es) | 2017-12-08 | 2020-07-01 | Incyte Corp | Terapia de combinación de dosis baja para el tratamiento de neoplasias mieloproliferativas |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2514733A1 (en) | 2003-02-28 | 2004-09-16 | Transform Pharmaceuticals, Inc. | Pharmaceutical co-crystal compositions of drugs such as carbamazepine, celecoxib, olanzapine, itraconazole, topiramate, modafinil, 5-fluorouracil, hydrochlorothiazide, acetaminophen, aspirin, flurbiprofen, phenytoin and ibuprofen |
| US8318723B2 (en) | 2006-08-16 | 2012-11-27 | Boehringer Ingelheim International Gmbh | Pyrazine compounds, their use and methods of preparation |
| MX2009009304A (es) | 2007-03-01 | 2009-11-18 | Novartis Ag | Inhibidores de cinasa pim y metodos para su uso. |
| NZ591449A (en) | 2008-09-02 | 2012-12-21 | Novartis Ag | Picolinamide derivatives as kinase inhibitors |
| KR101464060B1 (ko) | 2010-04-07 | 2014-11-20 | 에프. 호프만-라 로슈 아게 | 피라졸-4-일-헤테로사이클릴-카복사마이드 화합물 및 사용 방법 |
| CN103080106A (zh) | 2010-07-06 | 2013-05-01 | 诺瓦提斯公司 | 用作激酶抑制剂的环醚化合物 |
| UY33930A (es) | 2011-03-04 | 2012-10-31 | Novartis Ag | Inhibidores novedosos de quinasas |
| US20120225061A1 (en) | 2011-03-04 | 2012-09-06 | Matthew Burger | Tetrasubstituted cyclohexyl compounds as kinase inhibitors |
| US9187486B2 (en) | 2011-04-29 | 2015-11-17 | Amgen Inc. | Bicyclic pyridazine compounds as Pim inhibitors |
-
2013
- 2013-12-07 US US14/651,996 patent/US20150336960A1/en not_active Abandoned
- 2013-12-17 EP EP13818112.8A patent/EP2935270A1/en not_active Ceased
- 2013-12-17 CA CA2895338A patent/CA2895338A1/en not_active Abandoned
- 2013-12-17 AU AU2013363047A patent/AU2013363047A1/en not_active Abandoned
- 2013-12-17 KR KR1020157019414A patent/KR20150095928A/ko not_active Application Discontinuation
- 2013-12-17 WO PCT/US2013/075613 patent/WO2014099880A1/en active Application Filing
- 2013-12-17 BR BR112015014687A patent/BR112015014687A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2014099880A1 (en) | 2014-06-26 |
| KR20150095928A (ko) | 2015-08-21 |
| US20150336960A1 (en) | 2015-11-26 |
| EP2935270A1 (en) | 2015-10-28 |
| CA2895338A1 (en) | 2014-06-26 |
| AU2013363047A1 (en) | 2015-07-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112015014687A2 (pt) | compostos de piridazina bicíclicos fundidos substituídos por arila | |
| BR112014028954A2 (pt) | amidas de n-piridinila substituídas no anel como inibidores da quinase | |
| CY1122046T1 (el) | Δικυκλικα ετεροκυκλικα παραγωγα ως αναστολεις βρομοτομεων | |
| BR112016016844A2 (pt) | Compostos heterocíclicos | |
| PH12017500276A1 (en) | Aminopyrimidinyl compounds as jak inhibitors | |
| EA201992128A1 (ru) | Конденсированные имидазопиперидиновые ингибиторы jak | |
| BR112013017316A2 (pt) | compostos de indol ou análogos dos mesmos para o tratamento de degeneração macular relacionada à idade (amd) | |
| EA201500298A1 (ru) | Алкоксипиразолы в качестве активаторов растворимой гуанилатциклазы | |
| BR112014018990A8 (pt) | Derivados de ácido benzotiazol-6-il acético e seu uso para tratamento de uma infecção | |
| EA201691803A1 (ru) | Ингибиторы калликреина плазмы человека | |
| ECSP13013024A (es) | 1,3-oxazinas como inhibidores de bace1 y/o bace2 | |
| EA201591727A1 (ru) | Соединения биариламида в качестве ингибиторов киназы | |
| BR112013028430A2 (pt) | composto, composição farmacêutica, método para tratar uma doença ou condição mediada por tirosina quinase do baço (syk), e, uso de uma quantidade terapeuticamente eficiente do composto | |
| EA201590975A1 (ru) | Ингибиторы prmt5 и их применение | |
| BR112015003188A2 (pt) | Composto, composição farmacêutica, uso do composto e método para tratar uma doença ou condição mediada por rorgammat em um paciente | |
| BR112015003859A2 (pt) | compostos de pirazolopirimidina como inibidores de quinase | |
| EA201290237A1 (ru) | Киназные ингибиторы | |
| EA201370166A1 (ru) | Содержащие диарилацетиленгидразид ингибиторы тирозинкиназы | |
| WO2014031438A3 (en) | SUBSTITUTED PHENYL SPLEEN TYROSINE KINASE (Syk) INHIBITORS | |
| CR20130588A (es) | Halogenoalquil-1,3-oxazinas como inhibidores de la bace1 y/o bace 2 | |
| TR201802944T4 (tr) | İlaç olarak azai̇ndazol veya di̇azai̇ndazol türünün türevleri̇ | |
| EA201492285A1 (ru) | Соединения n-алкилтриазола в качестве антагонистов лизофосфатидной кислоты (lpar) | |
| EA201000341A1 (ru) | 2-анилинопурин-8-оны в качестве ингибиторов ttk/mps1 для лечения пролиферативных нарушений | |
| BR112013017362A2 (pt) | composto de fórmula (i), processo para preparar um composto de fórmula (i), composição farmacêutica e compostos, métodos e usos inovadores | |
| BR112017000584A2 (pt) | inibidores da aldosterona sintase |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application fees: dismissal - article 86 of industrial property law | ||
| B08K | Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87) |