EA201001518A1 - Производные 1-гетероциклил-1,5-дигидропиразоло[3,4-d]пиримидин-4-она и их применение в качестве модуляторов pde9a - Google Patents

Производные 1-гетероциклил-1,5-дигидропиразоло[3,4-d]пиримидин-4-она и их применение в качестве модуляторов pde9a

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Publication number
EA201001518A1
EA201001518A1 EA201001518A EA201001518A EA201001518A1 EA 201001518 A1 EA201001518 A1 EA 201001518A1 EA 201001518 A EA201001518 A EA 201001518A EA 201001518 A EA201001518 A EA 201001518A EA 201001518 A1 EA201001518 A1 EA 201001518A1
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EA
Eurasian Patent Office
Prior art keywords
drugs
pyrimidine
heterocyclil
dihydropyrazolo
group
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EA201001518A
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English (en)
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EA021504B1 (ru
Inventor
Риккардо Джованнини
Корнелиа Дорнер-Циоссек
Кристиан Айкмайер
Деннис Фиген
Томас Фокс
Клаус Фукс
Никлас Хайне
Хольгер Розенброк
Герхард Шэнцле
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Бёрингер Ингельхайм Интернациональ Гмбх
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Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201001518A1 publication Critical patent/EA201001518A1/ru
Publication of EA021504B1 publication Critical patent/EA021504B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Abstract

В заявке описаны новые 1,6-дизамещенные пиразолопиримидиноны, в которых i) атом азота пиразольной группы, следующий за пиримидиновой группой, присоединен к неароматическому, органическому гетероциклу, содержащему по меньшей мере один кольцевой гетероатом, выбранный из группы, включающей О, N и S, и ii) с атомом С, расположенным между двумя атомами азота пиримидинонового кольца, через необязательно замещенный метиленовый мостик связан второй заместитель. В соответствии с одним объектом настоящего изобретения эти новые соединения применимы для приготовления лекарственных средств, в частности, лекарственных средств, предназначенных для лечения патологических состояний, связанных с недостаточностью восприятия, сосредоточенности, способности к обучению или памяти. Эти новые соединения также применимы для приготовления лекарственных средств, предназначенных для лечения болезни Альцгеймера.
EA201001518A 2008-04-02 2009-04-01 Производные 1-гетероциклил-1,5-дигидропиразоло[3,4-d]пиримидин-4-она и их применение в качестве модуляторов pde9a EA021504B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08153987 2008-04-02
PCT/EP2009/053907 WO2009121919A1 (en) 2008-04-02 2009-04-01 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-d] pyrimidin-4-one derivatives and their use as pde9a modulators

Publications (2)

Publication Number Publication Date
EA201001518A1 true EA201001518A1 (ru) 2011-06-30
EA021504B1 EA021504B1 (ru) 2015-07-30

Family

ID=39790395

Family Applications (1)

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EA201001518A EA021504B1 (ru) 2008-04-02 2009-04-01 Производные 1-гетероциклил-1,5-дигидропиразоло[3,4-d]пиримидин-4-она и их применение в качестве модуляторов pde9a

Country Status (34)

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US (2) US8623879B2 (ru)
EP (1) EP2300478B1 (ru)
JP (1) JP5391264B2 (ru)
KR (1) KR101623762B1 (ru)
CN (1) CN101983199B (ru)
AR (1) AR071577A1 (ru)
AU (1) AU2009232017B2 (ru)
BR (1) BRPI0910690B8 (ru)
CA (1) CA2716410C (ru)
CL (1) CL2009000800A1 (ru)
CO (1) CO6321264A2 (ru)
CY (1) CY1117626T1 (ru)
DK (1) DK2300478T3 (ru)
EA (1) EA021504B1 (ru)
EC (1) ECSP10010506A (ru)
ES (1) ES2573330T3 (ru)
HK (1) HK1149549A1 (ru)
HR (1) HRP20160683T2 (ru)
HU (1) HUE027771T2 (ru)
IL (1) IL207710A (ru)
MA (1) MA32201B1 (ru)
ME (1) ME02427B (ru)
MX (1) MX2010010821A (ru)
MY (2) MY169766A (ru)
NZ (1) NZ588245A (ru)
PE (1) PE20091756A1 (ru)
PL (1) PL2300478T3 (ru)
RS (1) RS54724B1 (ru)
SG (1) SG189706A1 (ru)
SI (1) SI2300478T1 (ru)
TW (1) TWI433850B (ru)
UA (1) UA105362C2 (ru)
UY (1) UY31748A (ru)
WO (1) WO2009121919A1 (ru)

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AR071577A1 (es) 2010-06-30
CA2716410C (en) 2017-03-28
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BRPI0910690B8 (pt) 2021-05-25
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KR20100138991A (ko) 2010-12-31
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AU2009232017A1 (en) 2009-10-08
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SI2300478T1 (sl) 2016-07-29
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