PT679657E - Nucleosidos e oligonucleotidos com grupos 2'-eter - Google Patents
Nucleosidos e oligonucleotidos com grupos 2'-eterInfo
- Publication number
- PT679657E PT679657E PT95810259T PT95810259T PT679657E PT 679657 E PT679657 E PT 679657E PT 95810259 T PT95810259 T PT 95810259T PT 95810259 T PT95810259 T PT 95810259T PT 679657 E PT679657 E PT 679657E
- Authority
- PT
- Portugal
- Prior art keywords
- formula
- nucleosid
- eter
- oligonucleotides
- groups
- Prior art date
Links
- 108091034117 Oligonucleotide Proteins 0.000 title abstract 2
- VZQXUWKZDSEQRR-UHFFFAOYSA-N Nucleosid Natural products C12=NC(SC)=NC(NCC=C(C)C)=C2N=CN1C1OC(CO)C(O)C1O VZQXUWKZDSEQRR-UHFFFAOYSA-N 0.000 title 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
- 239000002773 nucleotide Substances 0.000 abstract 2
- 125000003729 nucleotide group Chemical group 0.000 abstract 2
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 1
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 150000003833 nucleoside derivatives Chemical class 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
- IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH130794 | 1994-04-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT679657E true PT679657E (pt) | 2003-11-28 |
Family
ID=4207379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT95810259T PT679657E (pt) | 1994-04-27 | 1995-04-19 | Nucleosidos e oligonucleotidos com grupos 2'-eter |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US5750673A (pt) |
| EP (1) | EP0679657B1 (pt) |
| JP (1) | JPH07300493A (pt) |
| KR (1) | KR950032263A (pt) |
| CN (1) | CN1066456C (pt) |
| AT (1) | ATE244723T1 (pt) |
| AU (1) | AU682576B2 (pt) |
| CA (1) | CA2147798A1 (pt) |
| CY (1) | CY2498B1 (pt) |
| DE (1) | DE59510742D1 (pt) |
| DK (1) | DK0679657T3 (pt) |
| ES (1) | ES2203635T3 (pt) |
| IL (1) | IL113482A0 (pt) |
| PT (1) | PT679657E (pt) |
| ZA (1) | ZA953383B (pt) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0497875B1 (en) * | 1989-10-24 | 2000-03-22 | Isis Pharmaceuticals, Inc. | 2' modified oligonucleotides |
| EP0679657B1 (de) * | 1994-04-27 | 2003-07-09 | Novartis AG | Nukleoside und Oligonukleotide mit 2'-Ethergruppen |
| US6166197A (en) * | 1995-03-06 | 2000-12-26 | Isis Pharmaceuticals, Inc. | Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions |
| ATE327244T1 (de) * | 1995-03-06 | 2006-06-15 | Isis Pharmaceuticals Inc | Verfahren zur synthese von 2'-0-substituierten pyrimidinen und oligomere davon |
| US5962271A (en) * | 1996-01-03 | 1999-10-05 | Cloutech Laboratories, Inc. | Methods and compositions for generating full-length cDNA having arbitrary nucleotide sequence at the 3'-end |
| WO1997037993A1 (en) * | 1996-04-09 | 1997-10-16 | Yamasa Corporation | 9-(2-DEOXY-2-FLUORO-4-THIO-β-D-ARABINOFURANOSYL)PURINE DERIVATIVES |
| JP2000512630A (ja) * | 1996-06-06 | 2000-09-26 | ノバルティス アクチエンゲゼルシャフト | ２’―置換ヌクレオシドおよびオリゴヌクレオチド誘導体 |
| CN1268137A (zh) * | 1997-07-03 | 2000-09-27 | 杜邦药品公司 | 治疗神经失调的咪唑并嘧啶和咪唑并吡啶 |
| US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
| US6124463A (en) * | 1998-07-02 | 2000-09-26 | Dupont Pharmaceuticals | Benzimidazoles as corticotropin release factor antagonists |
| FR2788524B1 (fr) * | 1999-01-18 | 2002-04-26 | Merial Sas | Procede utile pour transformer la fonction 4"(s)-oh du motif cladinose d'un aza macrolide en 4"(r)-nh2 |
| AR025996A1 (es) | 1999-10-07 | 2002-12-26 | Valigen Us Inc | Plantas no transgenicas resistentes a los herbicidas. |
| DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
| DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
| DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
| US7094768B2 (en) * | 2002-09-30 | 2006-08-22 | Genelabs Technologies, Inc. | Nucleoside derivatives for treating hepatitis C virus infection |
| TW200418498A (en) * | 2002-09-30 | 2004-10-01 | Genelabs Tech Inc | Nucleoside derivatives for treating hepatitis C virus infection |
| KR100481356B1 (ko) * | 2002-10-17 | 2005-04-07 | 이수화학 주식회사 | 2'-ｏ-치환된 뉴클레오시드의 제조 방법 |
| US8044060B2 (en) | 2003-05-09 | 2011-10-25 | Boehringer Ingelheim International Gmbh | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory |
| DE10320785A1 (de) | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Arylmethyl-substituierte Pyrazolopyrimidine |
| US7947817B2 (en) * | 2003-06-30 | 2011-05-24 | Roche Molecular Systems, Inc. | Synthesis and compositions of 2'-terminator nucleotides |
| WO2005044835A1 (en) * | 2003-10-27 | 2005-05-19 | Genelabs Technologies, Inc. | METHODS FOR PREPARING 7-(2'-SUBSTITUTED-ß-D-RIBOFURANOSYL)-4-(NR2R3)-5-(SUBSTITUTED ETHYN-1-YL)-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVES |
| DE102004001873A1 (de) | 2004-01-14 | 2005-09-29 | Bayer Healthcare Ag | Cyanopyrimidinone |
| US7745125B2 (en) * | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| EP2923563B1 (en) | 2006-01-12 | 2024-09-18 | Cibus Europe B.V. | EPSPS mutants |
| CA2893168C (en) | 2006-06-28 | 2017-11-07 | Nucelis Inc. | Fatty acid blends and uses therefor |
| US7820810B2 (en) * | 2007-03-19 | 2010-10-26 | Isis Pharmaceuticals, Inc. | Process for the synthesis of 2′-O-substituted purine nulceosides |
| CN108342376A (zh) | 2007-10-05 | 2018-07-31 | 赛布斯欧洲公司 | 芸苔属中突变的乙酰羟酸合酶基因 |
| EP2217602B1 (en) | 2007-11-30 | 2018-08-29 | Boehringer Ingelheim International GmbH | 1,5-dihydro-pyrazolo[3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators for the treatment of cns disorders |
| UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| AU2009248852B9 (en) | 2008-05-23 | 2015-08-13 | Cibus Europe B.V. | Production of squalene using yeast |
| JP5438922B2 (ja) * | 2008-06-25 | 2014-03-12 | 日東電工株式会社 | 核酸の製造方法 |
| PE20110383A1 (es) | 2008-09-08 | 2011-07-15 | Boehringer Ingelheim Int | Pirazolopirimidinonas como inhibidores de la fosfodiesterasa 9a (pde9a) |
| AU2009308217B2 (en) * | 2008-10-24 | 2016-01-21 | Ionis Pharmaceuticals, Inc. | 5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom |
| CA2757231A1 (en) | 2009-03-31 | 2010-10-07 | Boehringer Ingelheim International Gmbh | 1-heterocyclyl-1,5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
| AR077859A1 (es) * | 2009-08-12 | 2011-09-28 | Boehringer Ingelheim Int | Compuestos para el tratamiento de trastornos del snc |
| CN107058145A (zh) | 2009-11-23 | 2017-08-18 | 纽塞利斯公司 | 使用酵母产生角鲨烯的方法和组合物 |
| UA112969C2 (uk) | 2010-08-03 | 2016-11-25 | Сібас Юс Ллс | Рослина, стійка до одного або більше ррх-інгібуючих гербіцидів, яка містить мутантний ген протопорфіриноген ix оксидази (ррх) |
| US20120122223A1 (en) | 2010-08-03 | 2012-05-17 | Cibus Us Llc | Mutated protoporphyrinogen ix oxidase (ppx) genes |
| CA2807687C (en) | 2010-08-12 | 2019-01-08 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-1, 5-dihydro-pyrazolo [3,4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors |
| US20130040971A1 (en) | 2011-02-14 | 2013-02-14 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of cns disorders |
| US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
| US9790515B2 (en) | 2013-03-14 | 2017-10-17 | Cibus Us Llc | Mutated allene oxide synthase 2 (AOS2) genes |
| US12331303B2 (en) | 2013-03-15 | 2025-06-17 | Cibus Us Llc | Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair |
| EA201591447A1 (ru) | 2013-03-15 | 2016-05-31 | Сибас Юс Ллс | Способы и композиции для повышения эффективности направленной модификации генов с применением опосредованной олигонуклеотидами репарации генов |
| UA120033C2 (uk) | 2013-03-15 | 2019-09-25 | Сібас Юс Ллс | Спосіб підвищення ефективності спрямованої модифікації генів із застосуванням опосередкованої олігонуклеотидами репарації генів |
| US9957515B2 (en) | 2013-03-15 | 2018-05-01 | Cibus Us Llc | Methods and compositions for targeted gene modification |
| AU2015229095B2 (en) | 2014-03-14 | 2022-01-27 | Cibus Europe B.V. | Methods and compositions for increasing efficiency of targeted gene modification using oligonucleotide-mediated gene repair |
| BR112018016278A2 (pt) | 2016-02-09 | 2019-01-02 | Cibus Europe Bv | métodos e composições para aumentar a eficiência da modificação do gene direcionada usando reparação de gene mediada por oligonucleotídeo |
| CN116178468A (zh) * | 2016-07-27 | 2023-05-30 | 罗氏创新中心哥本哈根有限公司 | 5’s-lna核苷酸和寡核苷酸 |
| US11180756B2 (en) | 2017-03-09 | 2021-11-23 | Ionis Pharmaceuticals | Morpholino modified oligomeric compounds |
| WO2019140009A1 (en) | 2018-01-09 | 2019-07-18 | Cibus Us Llc | Shatterproof genes and mutations |
| AU2019247403B2 (en) | 2018-04-04 | 2025-04-10 | Cibus Europe, B.V. | FAD2 genes and mutations |
| WO2021030778A1 (en) | 2019-08-15 | 2021-02-18 | Ionis Pharmaceuticals, Inc. | Linkage modified oligomeric compounds and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4806463A (en) * | 1986-05-23 | 1989-02-21 | Worcester Foundation For Experimental Biology | Inhibition of HTLV-III by exogenous oligonucleotides |
| EP0266099A3 (en) * | 1986-10-28 | 1990-09-19 | The Johns Hopkins University | Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids |
| AU636573B2 (en) * | 1988-02-26 | 1993-05-06 | Worcester Foundation For Biomedical Research, Inc. | Inhibition of htlv-iii by exogenous oligonucleotides |
| JPH0372493A (ja) * | 1989-08-10 | 1991-03-27 | Kikkoman Corp | ２´―ｏ―置換―アデノシン―３´，５´―環状リン酸又はその塩の製法 |
| EP0497875B1 (en) * | 1989-10-24 | 2000-03-22 | Isis Pharmaceuticals, Inc. | 2' modified oligonucleotides |
| US5506351A (en) * | 1992-07-23 | 1996-04-09 | Isis Pharmaceuticals | Process for the preparation of 2'-O-alkyl guanosine and related compounds |
| DE4037363A1 (de) * | 1990-04-09 | 1991-10-10 | Europ Lab Molekularbiolog | 2-0-alkylnukleotide sowie polymere, die solche nukleotide enthalten |
| JPH06256380A (ja) * | 1993-03-09 | 1994-09-13 | Toagosei Chem Ind Co Ltd | ヌクレオシド誘導体ならびにリンカーを有するヌクレオシド誘導体の合成方法 |
| ATE177430T1 (de) * | 1993-05-12 | 1999-03-15 | Novartis Erfind Verwalt Gmbh | Nukleoside und oligonukleotide mit 2'- ethergruppen |
| DE4317323A1 (de) * | 1993-05-25 | 1994-12-01 | Bayer Ag | N-(4-Fluor-phenyl)-heteroaryloxyacetamide |
| EP0679657B1 (de) * | 1994-04-27 | 2003-07-09 | Novartis AG | Nukleoside und Oligonukleotide mit 2'-Ethergruppen |
-
1995
- 1995-04-19 EP EP95810259A patent/EP0679657B1/de not_active Expired - Lifetime
- 1995-04-19 AT AT95810259T patent/ATE244723T1/de active
- 1995-04-19 PT PT95810259T patent/PT679657E/pt unknown
- 1995-04-19 DE DE59510742T patent/DE59510742D1/de not_active Expired - Lifetime
- 1995-04-19 DK DK95810259T patent/DK0679657T3/da active
- 1995-04-19 ES ES95810259T patent/ES2203635T3/es not_active Expired - Lifetime
- 1995-04-20 US US08/426,807 patent/US5750673A/en not_active Expired - Lifetime
- 1995-04-25 CA CA002147798A patent/CA2147798A1/en not_active Abandoned
- 1995-04-25 IL IL11348295A patent/IL113482A0/xx unknown
- 1995-04-26 CN CN95104242A patent/CN1066456C/zh not_active Expired - Fee Related
- 1995-04-26 JP JP7102074A patent/JPH07300493A/ja active Pending
- 1995-04-26 AU AU17653/95A patent/AU682576B2/en not_active Ceased
- 1995-04-26 ZA ZA953383A patent/ZA953383B/xx unknown
- 1995-04-27 KR KR1019950010012A patent/KR950032263A/ko not_active Ceased
-
1998
- 1998-02-20 US US09/026,713 patent/US5977332A/en not_active Expired - Lifetime
-
2004
- 2004-12-27 CY CY0400093A patent/CY2498B1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL113482A0 (en) | 1995-07-31 |
| AU1765395A (en) | 1995-11-02 |
| CY2498B1 (en) | 2005-09-02 |
| EP0679657B1 (de) | 2003-07-09 |
| US5750673A (en) | 1998-05-12 |
| CA2147798A1 (en) | 1995-10-28 |
| ZA953383B (en) | 1995-10-27 |
| AU682576B2 (en) | 1997-10-09 |
| ES2203635T3 (es) | 2004-04-16 |
| CN1066456C (zh) | 2001-05-30 |
| DE59510742D1 (de) | 2003-08-14 |
| KR950032263A (ko) | 1995-12-20 |
| US5977332A (en) | 1999-11-02 |
| EP0679657A3 (de) | 1996-04-10 |
| DK0679657T3 (da) | 2003-10-27 |
| ATE244723T1 (de) | 2003-07-15 |
| CN1115320A (zh) | 1996-01-24 |
| JPH07300493A (ja) | 1995-11-14 |
| EP0679657A2 (de) | 1995-11-02 |
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