EA201101395A1 - Производные 1-гетероциклил-1,5-дигидропиразоло[3,4d]пиримидин-4-oha и их применение в качестве модуляторов pde9a - Google Patents

Производные 1-гетероциклил-1,5-дигидропиразоло[3,4d]пиримидин-4-oha и их применение в качестве модуляторов pde9a

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Publication number
EA201101395A1
EA201101395A1 EA201101395A EA201101395A EA201101395A1 EA 201101395 A1 EA201101395 A1 EA 201101395A1 EA 201101395 A EA201101395 A EA 201101395A EA 201101395 A EA201101395 A EA 201101395A EA 201101395 A1 EA201101395 A1 EA 201101395A1
Authority
EA
Eurasian Patent Office
Prior art keywords
treatment
medicaments
group
heterocyclil
pde9a
Prior art date
Application number
EA201101395A
Other languages
English (en)
Inventor
Риккардо Джованнини
Корнелиа Дорнер-Циоссек
Кристиан Айкмайер
Деннис Фиген
Томас Фокс
Клаус Фукс
Никлас Хайне
Хольгер Розенброк
Герхард Шэнцле
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/EP2009/053907 external-priority patent/WO2009121919A1/en
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA201101395A1 publication Critical patent/EA201101395A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

В заявке описаны новые 1,6-дизамещенные пиразолопиримидиноны формулы (I),в которойобозначает тетрагидропиранильную группу и Rобозначает группу V-W-, где V и W независимо друг от друга могут обозначать арильную группу иди гетероарильную группу, которые независимо друг от друга могут быть необязательно замещены. В соответствии с одним объектом настоящего изобретения эти новые соединения пригодны для применения в качестве лекарственных средств или для приготовления лекарственных средств, в частности лекарственных средств, предназначенных для лечения патологических состояний, связанных с недостаточностью восприятия, сосредоточенности, способности к обучению или памяти. Эти новые соединения также применимы для приготовления лекарственных средств и/или предназначены для лечения, например, болезни Альцгеймера, в частности для лечения нарушения познавательной способности, связанного с болезнью Альцгеймера.
EA201101395A 2009-03-31 2010-03-26 Производные 1-гетероциклил-1,5-дигидропиразоло[3,4d]пиримидин-4-oha и их применение в качестве модуляторов pde9a EA201101395A1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
VE57409 2009-03-31
PCT/EP2009/053907 WO2009121919A1 (en) 2008-04-02 2009-04-01 1-heterocyclyl-1,5-dihydro-pyrazolo[3,4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
EP09171906 2009-09-30
PCT/EP2010/054050 WO2010112437A1 (en) 2009-03-31 2010-03-26 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators

Publications (1)

Publication Number Publication Date
EA201101395A1 true EA201101395A1 (ru) 2012-06-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
EA201101395A EA201101395A1 (ru) 2009-03-31 2010-03-26 Производные 1-гетероциклил-1,5-дигидропиразоло[3,4d]пиримидин-4-oha и их применение в качестве модуляторов pde9a

Country Status (34)

Country Link
US (2) US8623901B2 (ru)
EP (1) EP2414363B1 (ru)
JP (1) JP5542196B2 (ru)
KR (1) KR20120003868A (ru)
CN (1) CN102365285B (ru)
AP (1) AP2011005819A0 (ru)
AR (1) AR076171A1 (ru)
AU (1) AU2010230290B2 (ru)
BR (1) BRPI1011533A2 (ru)
CA (1) CA2757231A1 (ru)
CL (1) CL2011002454A1 (ru)
CO (1) CO6501182A2 (ru)
DK (1) DK2414363T3 (ru)
EA (1) EA201101395A1 (ru)
EC (1) ECSP11011386A (ru)
ES (1) ES2460019T3 (ru)
GE (1) GEP20146098B (ru)
HK (1) HK1163105A1 (ru)
HR (1) HRP20140312T1 (ru)
IL (1) IL214436A0 (ru)
MA (1) MA33152B1 (ru)
MX (1) MX2011010184A (ru)
MY (1) MY156377A (ru)
NZ (1) NZ594567A (ru)
PE (1) PE20120505A1 (ru)
PL (1) PL2414363T3 (ru)
PT (1) PT2414363E (ru)
RS (1) RS53167B (ru)
SG (1) SG174964A1 (ru)
SI (1) SI2414363T1 (ru)
TN (1) TN2011000493A1 (ru)
TW (1) TW201100426A (ru)
UY (1) UY32531A (ru)
WO (1) WO2010112437A1 (ru)

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