UA105362C2 - 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators - Google Patents
1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators Download PDFInfo
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- UA105362C2 UA105362C2 UAA201012717A UAA201012717A UA105362C2 UA 105362 C2 UA105362 C2 UA 105362C2 UA A201012717 A UAA201012717 A UA A201012717A UA A201012717 A UAA201012717 A UA A201012717A UA 105362 C2 UA105362 C2 UA 105362C2
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Classifications
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract
В заявке описаны новые 1,6-дизамещенные пиразолопиримидиноны, в которых i) атом азота пиразольной группы, следующий за пиримидиновой группой, присоединенный к неароматическому, органическому гетероциклу, который содержит, по меньшей мере, один кольцевой гетероатом, выбранный из группы, включающей О, N и S, и ii) с атомом С, расположенным между двумя атомами азота пиримидинонового кольца, через необязательно замещенный метиленовый мостик связанный второй заместитель.Согласно одному аспекту данного изобретения эти новые соединения применимы для приготовления лекарственных средств, в частности лекарственных средств, предназначенных для лечения патологических состояний, связанных с недостаточностью восприятия, сосредоточенности, способности к обучению или памяти.Эти новые соединения также применимы для приготовл
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US (2) | US8623879B2 (ru) |
EP (1) | EP2300478B1 (ru) |
JP (1) | JP5391264B2 (ru) |
KR (1) | KR101623762B1 (ru) |
CN (1) | CN101983199B (ru) |
AR (1) | AR071577A1 (ru) |
AU (1) | AU2009232017B2 (ru) |
BR (1) | BRPI0910690B8 (ru) |
CA (1) | CA2716410C (ru) |
CL (1) | CL2009000800A1 (ru) |
CO (1) | CO6321264A2 (ru) |
CY (1) | CY1117626T1 (ru) |
DK (1) | DK2300478T3 (ru) |
EA (1) | EA021504B1 (ru) |
EC (1) | ECSP10010506A (ru) |
ES (1) | ES2573330T3 (ru) |
HK (1) | HK1149549A1 (ru) |
HR (1) | HRP20160683T2 (ru) |
HU (1) | HUE027771T2 (ru) |
IL (1) | IL207710A (ru) |
MA (1) | MA32201B1 (ru) |
ME (1) | ME02427B (ru) |
MX (1) | MX2010010821A (ru) |
MY (2) | MY182670A (ru) |
NZ (1) | NZ588245A (ru) |
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UA (1) | UA105362C2 (ru) |
UY (1) | UY31748A (ru) |
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DE10238722A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
DE102004001873A1 (de) | 2004-01-14 | 2005-09-29 | Bayer Healthcare Ag | Cyanopyrimidinone |
JP5498392B2 (ja) | 2007-11-30 | 2014-05-21 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 1,5−ジヒドロ−ピラゾロ[3,4−d]ピリミジン−4−オン誘導体及びcns障害の治療のためのpde9aモジュレーターとしてのそれらの使用 |
UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
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