EA200801601A1 - 8-[3-аминопиперидин-1-ил]ксантины, их получение и их применение в качестве ингибиторов dpp-iy - Google Patents

8-[3-аминопиперидин-1-ил]ксантины, их получение и их применение в качестве ингибиторов dpp-iy

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Publication number
EA200801601A1
EA200801601A1 EA200801601A EA200801601A EA200801601A1 EA 200801601 A1 EA200801601 A1 EA 200801601A1 EA 200801601 A EA200801601 A EA 200801601A EA 200801601 A EA200801601 A EA 200801601A EA 200801601 A1 EA200801601 A1 EA 200801601A1
Authority
EA
Eurasian Patent Office
Prior art keywords
dpp
xanthines
aminopiperidin
inhibitors
application
Prior art date
Application number
EA200801601A
Other languages
English (en)
Inventor
Франк Химмельсбах
Эльке Лангкопф
Маттиас Эккхардт
Мохаммад Тадайон
Лео Томас
Original Assignee
Бёрингер Ингельхайм Интернациональ Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34922894&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200801601(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE102004008112A external-priority patent/DE102004008112A1/de
Priority claimed from DE102004012921A external-priority patent/DE102004012921A1/de
Priority claimed from DE102004032263A external-priority patent/DE102004032263A1/de
Application filed by Бёрингер Ингельхайм Интернациональ Гмбх filed Critical Бёрингер Ингельхайм Интернациональ Гмбх
Publication of EA200801601A1 publication Critical patent/EA200801601A1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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Abstract

В заявке описаны замещенные ксантины общей формулы (I)в которой R имеет указанные в п.1 формулы изобретения значения, их таутомеры, их стереоизомеры, их смеси и их соли, которые обладают ценными фармакологическими свойствами, прежде всего ингибирующим действием на активность дипептидилпептидазы-IV (DPP-IV).
EA200801601A 2004-02-18 2005-02-12 8-[3-аминопиперидин-1-ил]ксантины, их получение и их применение в качестве ингибиторов dpp-iy EA200801601A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004008112A DE102004008112A1 (de) 2004-02-18 2004-02-18 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel
DE102004012921A DE102004012921A1 (de) 2004-03-17 2004-03-17 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
DE102004032263A DE102004032263A1 (de) 2004-07-03 2004-07-03 8-[3-Amino-piperidin-1yl]-xanthine, deren Herstellung und deren Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
EA200801601A1 true EA200801601A1 (ru) 2009-08-28

Family

ID=34922894

Family Applications (2)

Application Number Title Priority Date Filing Date
EA200601496A EA010854B1 (ru) 2004-02-18 2005-02-12 8-[3-аминопиперидин-1-ил]ксантины, их получение и их применение в качестве ингибиторов dpp-iv
EA200801601A EA200801601A1 (ru) 2004-02-18 2005-02-12 8-[3-аминопиперидин-1-ил]ксантины, их получение и их применение в качестве ингибиторов dpp-iy

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EA200601496A EA010854B1 (ru) 2004-02-18 2005-02-12 8-[3-аминопиперидин-1-ил]ксантины, их получение и их применение в качестве ингибиторов dpp-iv

Country Status (30)

Country Link
EP (2) EP2119717B1 (ru)
JP (2) JP4733058B2 (ru)
KR (1) KR101207224B1 (ru)
CN (1) CN102199151A (ru)
AR (1) AR047614A1 (ru)
AT (1) ATE430150T1 (ru)
AU (1) AU2005219508B2 (ru)
BR (1) BRPI0507873B8 (ru)
CA (1) CA2555050C (ru)
CY (1) CY1109284T1 (ru)
DE (1) DE502005007196D1 (ru)
DK (1) DK1758905T3 (ru)
EA (2) EA010854B1 (ru)
EC (1) ECSP066775A (ru)
ES (1) ES2326666T3 (ru)
HK (1) HK1103402A1 (ru)
HR (1) HRP20090346T1 (ru)
IL (2) IL176920A (ru)
ME (1) ME01108B (ru)
MY (1) MY144322A (ru)
NO (1) NO20062688L (ru)
NZ (1) NZ548901A (ru)
PE (1) PE20060210A1 (ru)
PL (1) PL1758905T3 (ru)
PT (1) PT1758905E (ru)
RS (1) RS50982B (ru)
SI (1) SI1758905T1 (ru)
TW (1) TWI350756B (ru)
UY (1) UY28749A1 (ru)
WO (1) WO2005085246A1 (ru)

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