UA87835C2 - 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use in the form of a dpp inhibitor - Google Patents
8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use in the form of a dpp inhibitorInfo
- Publication number
- UA87835C2 UA87835C2 UAA200609881A UAA200609881A UA87835C2 UA 87835 C2 UA87835 C2 UA 87835C2 UA A200609881 A UAA200609881 A UA A200609881A UA A200609881 A UAA200609881 A UA A200609881A UA 87835 C2 UA87835 C2 UA 87835C2
- Authority
- UA
- Ukraine
- Prior art keywords
- xanthines
- piperidin
- amino
- production
- dpp
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Abstract
The invention relates to substituted xanthines of general formula (I), wherein R is such as defined in claim 1, and to the tautomers, stereoisomers, mixtures and the salts thereof, said products exhibiting precious pharmacological properties, in particular an inhibiting effect on a dipeptidylpeptidasa-IV (DPP-IV) enzyme activity.(І)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004008112A DE102004008112A1 (en) | 2004-02-18 | 2004-02-18 | New 8-aminopiperidinyl-xanthine derivatives, useful for treating e.g. diabetes, arthritis and osteoporosis, are inhibitors of dipeptidylpeptidase-IV |
Publications (1)
Publication Number | Publication Date |
---|---|
UA87835C2 true UA87835C2 (en) | 2009-08-25 |
Family
ID=34813493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200609881A UA87835C2 (en) | 2004-02-18 | 2005-02-12 | 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use in the form of a dpp inhibitor |
Country Status (5)
Country | Link |
---|---|
CN (1) | CN1980930B (en) |
AR (1) | AR115411A2 (en) |
DE (1) | DE102004008112A1 (en) |
UA (1) | UA87835C2 (en) |
ZA (1) | ZA200604281B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20090938A1 (en) * | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | PHARMACEUTICAL COMPOSITION INCLUDING A BENZENE DERIVATIVE SUBSTITUTED WITH GLUCOPYRANOSIL |
DE102008010661A1 (en) * | 2008-02-22 | 2009-09-03 | Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG | Preparing pyridin-2-boronic acid compounds, useful e.g. to treat multiple myeloma, comprises preparing a pyridin-2-borate compound, purifying the pyridin-2-borate compound; and hydrolyzing the purified pyridin-2-borate compound |
CN102311448B (en) * | 2010-07-07 | 2014-02-19 | 中国科学院广州生物医药与健康研究院 | Thieno-pyrimidone DPP-IV (dipeptidyl peptidase) inhibitor |
KR101985384B1 (en) * | 2011-07-15 | 2019-06-03 | 베링거 인겔하임 인터내셔날 게엠베하 | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
CN103450201B (en) * | 2012-05-30 | 2017-04-12 | 博瑞生物医药(苏州)股份有限公司 | Preparation method of chiral 8-(3-aminopiperidine-1-yl)-xanthine |
CN103709163B (en) * | 2012-09-29 | 2016-12-21 | 齐鲁制药有限公司 | Xanthine derivative, Preparation Method And The Use |
CN103319483B (en) * | 2012-10-19 | 2016-08-03 | 药源药物化学(上海)有限公司 | A kind of preparation method of important intermediate of linagliptin |
CN106008507B (en) * | 2013-01-23 | 2017-11-28 | 成都苑东生物制药股份有限公司 | Xanthine derivative |
TWI682931B (en) * | 2015-05-29 | 2020-01-21 | 大陸商江蘇天士力帝益藥業有限公司 | Xanthine derivatives, their pharmaceutical compositions, their preparations and their uses |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT1953162E (en) * | 2001-02-24 | 2012-07-13 | Boehringer Ingelheim Pharma | Xanthin derivatives, their production and utilisation as medicine |
-
2004
- 2004-02-18 DE DE102004008112A patent/DE102004008112A1/en not_active Withdrawn
-
2005
- 2005-02-12 UA UAA200609881A patent/UA87835C2/en unknown
- 2005-02-12 CN CN2005800054231A patent/CN1980930B/en active Active
-
2006
- 2006-05-26 ZA ZA200604281A patent/ZA200604281B/en unknown
-
2019
- 2019-05-22 AR ARP190101358A patent/AR115411A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
CN1980930A (en) | 2007-06-13 |
AR115411A2 (en) | 2021-01-13 |
CN1980930B (en) | 2012-11-21 |
ZA200604281B (en) | 2007-10-31 |
DE102004008112A1 (en) | 2005-09-01 |
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