AR115411A2 - 8- [3-AMINO-PIPERIDIN-1-IL] -XANTHINES AS INHIBITORS OF DPP-IV - Google Patents
8- [3-AMINO-PIPERIDIN-1-IL] -XANTHINES AS INHIBITORS OF DPP-IVInfo
- Publication number
- AR115411A2 AR115411A2 ARP190101358A ARP190101358A AR115411A2 AR 115411 A2 AR115411 A2 AR 115411A2 AR P190101358 A ARP190101358 A AR P190101358A AR P190101358 A ARP190101358 A AR P190101358A AR 115411 A2 AR115411 A2 AR 115411A2
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- dpp
- piperidin
- amino
- xanthines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
Abstract
8-[3-amino-piperidin-1-il]-xantinas sustituidas como inhibidoras de DPP-IV utilizadas en el tratamiento de la diabetes mellitus de tipo I o tipo II. Reivindicación 1: Un compuesto caracterizado por la fórmula general (1), en donde R se selecciona del grupo que consiste en (3-ciano-piridin-2-il)metilo, (3-ciano-quinolin-2-il)metilo, (4,6-dimetil-pirimidin-2-il)metilo y (4-metil-pirimidin-2-il)metilo, 2-cianobencilo.8- [3-amino-piperidin-1-yl] -xanthines substituted as DPP-IV inhibitors used in the treatment of type I or type II diabetes mellitus. Claim 1: A compound characterized by the general formula (1), wherein R is selected from the group consisting of (3-cyano-pyridin-2-yl) methyl, (3-cyano-quinolin-2-yl) methyl, (4,6-dimethyl-pyrimidin-2-yl) methyl and (4-methyl-pyrimidin-2-yl) methyl, 2-cyanobenzyl.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004008112A DE102004008112A1 (en) | 2004-02-18 | 2004-02-18 | New 8-aminopiperidinyl-xanthine derivatives, useful for treating e.g. diabetes, arthritis and osteoporosis, are inhibitors of dipeptidylpeptidase-IV |
Publications (1)
Publication Number | Publication Date |
---|---|
AR115411A2 true AR115411A2 (en) | 2021-01-13 |
Family
ID=34813493
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP190101358A AR115411A2 (en) | 2004-02-18 | 2019-05-22 | 8- [3-AMINO-PIPERIDIN-1-IL] -XANTHINES AS INHIBITORS OF DPP-IV |
Country Status (5)
Country | Link |
---|---|
CN (1) | CN1980930B (en) |
AR (1) | AR115411A2 (en) |
DE (1) | DE102004008112A1 (en) |
UA (1) | UA87835C2 (en) |
ZA (1) | ZA200604281B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20090938A1 (en) * | 2007-08-16 | 2009-08-08 | Boehringer Ingelheim Int | PHARMACEUTICAL COMPOSITION INCLUDING A BENZENE DERIVATIVE SUBSTITUTED WITH GLUCOPYRANOSIL |
DE102008010661A1 (en) * | 2008-02-22 | 2009-09-03 | Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG | Preparing pyridin-2-boronic acid compounds, useful e.g. to treat multiple myeloma, comprises preparing a pyridin-2-borate compound, purifying the pyridin-2-borate compound; and hydrolyzing the purified pyridin-2-borate compound |
CN102311448B (en) * | 2010-07-07 | 2014-02-19 | 中国科学院广州生物医药与健康研究院 | Thieno-pyrimidone DPP-IV (dipeptidyl peptidase) inhibitor |
EP2731947B1 (en) * | 2011-07-15 | 2019-01-16 | Boehringer Ingelheim International GmbH | Substituted dimeric quinazoline derivative, its preparation and its use in pharmaceutical compositions for the treatment of type i and ii diabetes |
CN103450201B (en) * | 2012-05-30 | 2017-04-12 | 博瑞生物医药(苏州)股份有限公司 | Preparation method of chiral 8-(3-aminopiperidine-1-yl)-xanthine |
CN103709163B (en) * | 2012-09-29 | 2016-12-21 | 齐鲁制药有限公司 | Xanthine derivative, Preparation Method And The Use |
CN103319483B (en) * | 2012-10-19 | 2016-08-03 | 药源药物化学(上海)有限公司 | A kind of preparation method of important intermediate of linagliptin |
CN106008507B (en) * | 2013-01-23 | 2017-11-28 | 成都苑东生物制药股份有限公司 | Xanthine derivative |
CN106188058B (en) * | 2015-05-29 | 2020-11-06 | 江苏天士力帝益药业有限公司 | Xanthine derivatives |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100883277B1 (en) * | 2001-02-24 | 2009-02-12 | 베링거 잉겔하임 파르마 게엠베하 운트 코 카게 | Pharmaceutical composition comprising xanthine derivative and process for the preparation thereof |
-
2004
- 2004-02-18 DE DE102004008112A patent/DE102004008112A1/en not_active Withdrawn
-
2005
- 2005-02-12 CN CN2005800054231A patent/CN1980930B/en active Active
- 2005-02-12 UA UAA200609881A patent/UA87835C2/en unknown
-
2006
- 2006-05-26 ZA ZA200604281A patent/ZA200604281B/en unknown
-
2019
- 2019-05-22 AR ARP190101358A patent/AR115411A2/en unknown
Also Published As
Publication number | Publication date |
---|---|
UA87835C2 (en) | 2009-08-25 |
DE102004008112A1 (en) | 2005-09-01 |
CN1980930B (en) | 2012-11-21 |
CN1980930A (en) | 2007-06-13 |
ZA200604281B (en) | 2007-10-31 |
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