AR115411A2 - 8-[3-amino-piperidin-1-il]-xantinas como inhibidores de dpp-iv - Google Patents

8-[3-amino-piperidin-1-il]-xantinas como inhibidores de dpp-iv

Info

Publication number
AR115411A2
AR115411A2 ARP190101358A ARP190101358A AR115411A2 AR 115411 A2 AR115411 A2 AR 115411A2 AR P190101358 A ARP190101358 A AR P190101358A AR P190101358 A ARP190101358 A AR P190101358A AR 115411 A2 AR115411 A2 AR 115411A2
Authority
AR
Argentina
Prior art keywords
methyl
dpp
piperidin
amino
xanthines
Prior art date
Application number
ARP190101358A
Other languages
English (en)
Inventor
Leo Thomas
Mohammad Tadayyon
Matthias Eckhardt
Elke Langkopf
Frank Himmelsbach
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of AR115411A2 publication Critical patent/AR115411A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

8-[3-amino-piperidin-1-il]-xantinas sustituidas como inhibidoras de DPP-IV utilizadas en el tratamiento de la diabetes mellitus de tipo I o tipo II. Reivindicación 1: Un compuesto caracterizado por la fórmula general (1), en donde R se selecciona del grupo que consiste en (3-ciano-piridin-2-il)metilo, (3-ciano-quinolin-2-il)metilo, (4,6-dimetil-pirimidin-2-il)metilo y (4-metil-pirimidin-2-il)metilo, 2-cianobencilo.
ARP190101358A 2004-02-18 2019-05-22 8-[3-amino-piperidin-1-il]-xantinas como inhibidores de dpp-iv AR115411A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004008112A DE102004008112A1 (de) 2004-02-18 2004-02-18 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel

Publications (1)

Publication Number Publication Date
AR115411A2 true AR115411A2 (es) 2021-01-13

Family

ID=34813493

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP190101358A AR115411A2 (es) 2004-02-18 2019-05-22 8-[3-amino-piperidin-1-il]-xantinas como inhibidores de dpp-iv

Country Status (5)

Country Link
CN (1) CN1980930B (es)
AR (1) AR115411A2 (es)
DE (1) DE102004008112A1 (es)
UA (1) UA87835C2 (es)
ZA (1) ZA200604281B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20090938A1 (es) * 2007-08-16 2009-08-08 Boehringer Ingelheim Int Composicion farmaceutica que comprende un derivado de benceno sustituido con glucopiranosilo
DE102008010661A1 (de) * 2008-02-22 2009-09-03 Dr. Felix Jäger und Dr. Stefan Drinkuth Laborgemeinschaft OHG Verfahren zur Herstellung von Pyridin-2-Boronsäure und Derivaten davon
CN102311448B (zh) * 2010-07-07 2014-02-19 中国科学院广州生物医药与健康研究院 噻吩并嘧啶酮类dpp-iv抑制剂
WO2013010964A1 (en) * 2011-07-15 2013-01-24 Boehringer Ingelheim International Gmbh Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions
CN103450201B (zh) * 2012-05-30 2017-04-12 博瑞生物医药（苏州）股份有限公司 手性8‑（3‑氨基哌啶‑1‑基）‑黄嘌呤的制备方法
CN103709163B (zh) * 2012-09-29 2016-12-21 齐鲁制药有限公司 黄嘌呤衍生物、其制备方法及用途
CN103319483B (zh) * 2012-10-19 2016-08-03 药源药物化学（上海）有限公司 一种利拉列汀重要中间体的制备方法
CN103936740B (zh) * 2013-01-23 2016-06-29 成都苑东生物制药股份有限公司 黄嘌呤衍生物
CN106188058B (zh) * 2015-05-29 2020-11-06 江苏天士力帝益药业有限公司 黄嘌呤衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1953162B9 (de) * 2001-02-24 2012-10-31 Boehringer Ingelheim Pharma GmbH & Co. KG Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel

Also Published As

Publication number Publication date
CN1980930A (zh) 2007-06-13
ZA200604281B (en) 2007-10-31
CN1980930B (zh) 2012-11-21
DE102004008112A1 (de) 2005-09-01
UA87835C2 (en) 2009-08-25

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