MY144322A - 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions - Google Patents
8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositionsInfo
- Publication number
- MY144322A MY144322A MYPI20050575A MYPI20050575A MY144322A MY 144322 A MY144322 A MY 144322A MY PI20050575 A MYPI20050575 A MY PI20050575A MY PI20050575 A MYPI20050575 A MY PI20050575A MY 144322 A MY144322 A MY 144322A
- Authority
- MY
- Malaysia
- Prior art keywords
- xanthines
- piperidin
- amino
- preparation
- pharmaceutical compositions
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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Abstract
THE PRESENT INVENTION RELATES TO SUBSTITUTED XANTHINES OF GENERAL FORMULA WHEREIN R IS DEFINED AS IN CLAIM 1, THE TAUTOMERS, THE STEREOISOMERS, THE MIXTURES THEREOF AND THE SALTS THEREOF, WHICH HAVE VALUABLE PHARMACOLOGICAL PROPERTIES, PARTICULARLY AN INHIBITING EFFECT ON THE ACTIVITY OF THE ENZYME DIPEPTIDYLPEPTIDASE-IV (DPP-IV ).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004008112A DE102004008112A1 (en) | 2004-02-18 | 2004-02-18 | New 8-aminopiperidinyl-xanthine derivatives, useful for treating e.g. diabetes, arthritis and osteoporosis, are inhibitors of dipeptidylpeptidase-IV |
DE102004012921A DE102004012921A1 (en) | 2004-03-17 | 2004-03-17 | New 7-butynyl-8-(3-amino-1-piperidinyl)xanthine derivatives useful as dipeptidyl peptidase IV inhibitors, e.g. for treating diabetes, arthritis, obesity and osteoporosis |
DE102004032263A DE102004032263A1 (en) | 2004-07-03 | 2004-07-03 | New 7-butynyl-8-(3-amino-1-piperidinyl)xanthine derivatives useful as dipeptidyl peptidase IV inhibitors, e.g. for treating diabetes, arthritis, obesity and osteoporosis |
Publications (1)
Publication Number | Publication Date |
---|---|
MY144322A true MY144322A (en) | 2011-08-29 |
Family
ID=34922894
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MYPI20050575A MY144322A (en) | 2004-02-18 | 2005-02-16 | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
Country Status (30)
Country | Link |
---|---|
EP (2) | EP1758905B1 (en) |
JP (2) | JP4733058B2 (en) |
KR (1) | KR101207224B1 (en) |
CN (1) | CN102199151A (en) |
AR (1) | AR047614A1 (en) |
AT (1) | ATE430150T1 (en) |
AU (1) | AU2005219508B2 (en) |
BR (1) | BRPI0507873B8 (en) |
CA (1) | CA2555050C (en) |
CY (1) | CY1109284T1 (en) |
DE (1) | DE502005007196D1 (en) |
DK (1) | DK1758905T3 (en) |
EA (2) | EA200801601A1 (en) |
EC (1) | ECSP066775A (en) |
ES (1) | ES2326666T3 (en) |
HK (1) | HK1103402A1 (en) |
HR (1) | HRP20090346T1 (en) |
IL (2) | IL176920A (en) |
ME (1) | ME01108B (en) |
MY (1) | MY144322A (en) |
NO (1) | NO20062688L (en) |
NZ (1) | NZ548901A (en) |
PE (1) | PE20060210A1 (en) |
PL (1) | PL1758905T3 (en) |
PT (1) | PT1758905E (en) |
RS (1) | RS50982B (en) |
SI (1) | SI1758905T1 (en) |
TW (1) | TWI350756B (en) |
UY (1) | UY28749A1 (en) |
WO (1) | WO2005085246A1 (en) |
Families Citing this family (86)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7495005B2 (en) | 2002-08-22 | 2009-02-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, their preparation and their use in pharmaceutical compositions |
US7569574B2 (en) | 2002-08-22 | 2009-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Purine derivatives, the preparation thereof and their use as pharmaceutical compositions |
US7482337B2 (en) | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
DE10254304A1 (en) | 2002-11-21 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New xanthine derivatives, their production and their use as medicines |
US7566707B2 (en) | 2003-06-18 | 2009-07-28 | Boehringer Ingelheim International Gmbh | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions |
DE10355304A1 (en) | 2003-11-27 | 2005-06-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Novel 8- (piperazin-1-yl) and 8 - ([1,4] diazepan-1-yl) xanthines, their preparation and their use as pharmaceuticals |
PL1758905T3 (en) * | 2004-02-18 | 2009-10-30 | Boehringer Ingelheim Int | 8-[3-amino-piperidin-1-yl]-xanthine, the production thereof and the use in the form of a ddp-iv inhibitor |
US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004009039A1 (en) | 2004-02-23 | 2005-09-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8- [3-Amino-piperidin-1-yl] xanthines, their preparation and use as pharmaceuticals |
US7393847B2 (en) | 2004-03-13 | 2008-07-01 | Boehringer Ingleheim International Gmbh | Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions |
US7439370B2 (en) | 2004-05-10 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides |
DE102004030502A1 (en) | 2004-06-24 | 2006-01-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Novel imidazoles and triazoles, their preparation and use as medicines |
DE102004043944A1 (en) * | 2004-09-11 | 2006-03-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Novel 8- (3-amino-piperidin-1-yl) -7- (but-2-ynyl) -xanthines, their preparation and their use as pharmaceuticals |
DE102004044221A1 (en) | 2004-09-14 | 2006-03-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | New 3-methyl-7-butynyl xanthines, their preparation and their use as pharmaceuticals |
AU2012205240B2 (en) * | 2004-11-05 | 2015-03-26 | Boehringer Ingelheim International Gmbh | Method for producing chiral 8-(3-amino-piperidin-1-yl)-xanthines |
DE102004054054A1 (en) * | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Process for preparing chiral 8- (3-amino-piperidin-1-yl) -xanthines |
DE102005035891A1 (en) | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8- (3-amino-piperidin-1-yl) -xanthines, their preparation and their use as pharmaceuticals |
GB0526291D0 (en) | 2005-12-23 | 2006-02-01 | Prosidion Ltd | Therapeutic method |
US7728146B2 (en) | 2006-04-12 | 2010-06-01 | Probiodrug Ag | Enzyme inhibitors |
EA015687B1 (en) | 2006-05-04 | 2011-10-31 | Бёрингер Ингельхайм Интернациональ Гмбх | Polymorphs |
PE20110235A1 (en) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | PHARMACEUTICAL COMBINATIONS INCLUDING LINAGLIPTIN AND METMORPHINE |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
EP2057160A1 (en) * | 2006-08-08 | 2009-05-13 | Boehringer Ingelheim International GmbH | Pyrrolo [3, 2 -d]pyrimidines as dpp-iv inhibitors for the treatment of diabetes mellitus |
EP2089383B1 (en) | 2006-11-09 | 2015-09-16 | Probiodrug AG | 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases |
EP2091948B1 (en) | 2006-11-30 | 2012-04-18 | Probiodrug AG | Novel inhibitors of glutaminyl cyclase |
ES2533484T3 (en) | 2007-04-18 | 2015-04-10 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
BRPI0701664A2 (en) * | 2007-05-28 | 2009-01-13 | Fundacao Universidade Fed De Sco Carlos | 4-quinolinones and quinolines, preparation process, pharmaceutical formulations and their use |
CN101357922B (en) * | 2007-08-02 | 2011-05-18 | 山东轩竹医药科技有限公司 | New DPP-IV inhibitor |
UY31291A1 (en) * | 2007-08-16 | 2009-03-31 | PHARMACEUTICAL COMPOSITION THAT INCLUDES A DERIVATIVE OF PIRAZOL-0-GLUCOSIDO | |
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US20110112069A1 (en) | 2007-08-17 | 2011-05-12 | Boehringer Ingelheim International Gmbh | Purin derivatives for use in the treatment of fab-related diseases |
CN101952252A (en) | 2008-02-27 | 2011-01-19 | 住友化学株式会社 | Method for optical resolution of alkylpiperidin-3-yl carbamate and intermediate therefor |
JP2009256298A (en) | 2008-03-26 | 2009-11-05 | Sumitomo Chemical Co Ltd | Optical resolution method for piperidin-3-ylcarbamate compound, and its intermediate |
PE20091730A1 (en) | 2008-04-03 | 2009-12-10 | Boehringer Ingelheim Int | FORMULATIONS INVOLVING A DPP4 INHIBITOR |
EP2146210A1 (en) | 2008-04-07 | 2010-01-20 | Arena Pharmaceuticals, Inc. | Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditions modulated by PYY |
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KR20200118243A (en) | 2008-08-06 | 2020-10-14 | 베링거 인겔하임 인터내셔날 게엠베하 | Treatment for diabetes in patients inappropriate for metformin therapy |
MX2011001525A (en) | 2008-08-15 | 2011-03-29 | Boehringer Ingelheim Int | Purin derivatives for use in the treatment of fab-related diseases. |
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UY32177A (en) * | 2008-10-16 | 2010-05-31 | Boehringer Ingelheim Int | TREATMENT OF DIABETES IN PATIENTS WITH INSUFFICIENT GLUCEMIC CONTROL TO WEIGHT THERAPY WITH DRUG, ORAL OR NOT, ANTIDIABÉTICO |
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