EA023212B1 - ПРОИЗВОДНЫЕ 3,4,4a,10b-ТЕТРАГИДРО-1H-ТИОПИРАНО[4,3-c]ИЗОХИНОЛИНА - Google Patents
ПРОИЗВОДНЫЕ 3,4,4a,10b-ТЕТРАГИДРО-1H-ТИОПИРАНО[4,3-c]ИЗОХИНОЛИНА Download PDFInfo
- Publication number
- EA023212B1 EA023212B1 EA201200891A EA201200891A EA023212B1 EA 023212 B1 EA023212 B1 EA 023212B1 EA 201200891 A EA201200891 A EA 201200891A EA 201200891 A EA201200891 A EA 201200891A EA 023212 B1 EA023212 B1 EA 023212B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methyl
- ethyl
- compound
- phenyl
- ethoxy
- Prior art date
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- ZQCSTHXMOLTGJA-UHFFFAOYSA-N 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline Chemical class N1=CC2=CC=CC=C2C2C1CCSC2 ZQCSTHXMOLTGJA-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 855
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- -1 1-methyl-1H-imidazol-2-yl Chemical group 0.000 claims description 626
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 322
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 173
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 151
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims description 83
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- 238000011282 treatment Methods 0.000 claims description 40
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims description 37
- 238000002360 preparation method Methods 0.000 claims description 35
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| US20110300432A1 (en) | 2010-06-07 | 2011-12-08 | Snyder Shawn W | Rechargeable, High-Density Electrochemical Device |
| WO2012110770A2 (en) * | 2011-02-17 | 2012-08-23 | Cipla Limited | Pharmaceutical composition |
| JP2014519519A (ja) * | 2011-06-15 | 2014-08-14 | タケダ ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規３，４，４ａ，１０ｂ−テトラヒドロ−１Ｈ−チオピラノ［４，３−ｃ］イソキノリン化合物 |
| WO2014016548A2 (en) * | 2012-07-27 | 2014-01-30 | Cipla Limited | Pharmaceutical composition |
| US20150322049A1 (en) * | 2012-12-13 | 2015-11-12 | Ludwig Aigner | Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease |
| MX2015009678A (es) | 2013-02-04 | 2015-11-25 | Gruenenthal Gmbh | Compuestos de pirimidina condensada sustituida con amino en la posicion 4 como inhibidores de fosfodiesterasa 4 (pde4). |
| MD20150071A2 (ro) | 2013-02-19 | 2016-02-29 | Pfizer Inc. | Compuşi azabenzimidazolici ca inhibitori ai PDE4 izoenzimelor pentru tratamentul tulburărilor SNC şi altor afecţiuni |
| WO2016012896A1 (en) | 2014-07-24 | 2016-01-28 | Pfizer Inc. | Pyrazolopyrimidine compounds |
| EA031201B1 (ru) | 2014-08-06 | 2018-11-30 | Пфайзер Инк. | Соединения имидазопиридазина |
| WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
| US12383547B2 (en) | 2020-07-01 | 2025-08-12 | Vanderbilt University | Methods of treatment for a kidney disease |
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| DE2047465A1 (de) | 1970-09-26 | 1972-03-30 | Farbwerke Hoechst AG, vorm Meister Lucius & Bruning, 6000 Frankfurt | Neue Oxdiazole und Verfahren zu lh rer Herstellung |
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| DE4003272A1 (de) | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
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| WO2006027345A2 (en) * | 2004-09-08 | 2006-03-16 | Altana Pharma Ag | Novel 3-thia-10-aza-phenanthrene derivatives |
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