CN102652136B - 3,4,4A,10B-四氢-1H-噻喃并[4,3-c]异喹啉衍生物 - Google Patents

3,4,4A,10B-四氢-1H-噻喃并[4,3-c]异喹啉衍生物 Download PDF

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Publication number
CN102652136B
CN102652136B CN201080057293.7A CN201080057293A CN102652136B CN 102652136 B CN102652136 B CN 102652136B CN 201080057293 A CN201080057293 A CN 201080057293A CN 102652136 B CN102652136 B CN 102652136B
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Prior art keywords
methyl
ethyl
compound
phenyl
methoxy
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Expired - Fee Related
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CN201080057293.7A
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English (en)
Chinese (zh)
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CN102652136A (zh
Inventor
D.弗洛克齐
T.施滕格尔
A.曼
H.奥默
U.考茨
S.魏因布伦纳
S.菲舍尔
C.齐特
A.哈策尔曼
T.邓克恩
C.黑斯林格
T.迈尔
H.特诺尔
C.布劳恩
R.屈尔策
D.马克思
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AstraZeneca AB
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Nycomed GmbH
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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CN201080057293.7A 2009-12-18 2010-12-15 3,4,4A,10B-四氢-1H-噻喃并[4,3-c]异喹啉衍生物 Expired - Fee Related CN102652136B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09179982.5 2009-12-18
EP09179982 2009-12-18
US31555210P 2010-03-19 2010-03-19
US61/315552 2010-03-19
PCT/EP2010/069704 WO2011073231A1 (en) 2009-12-18 2010-12-15 3,4,4A,10B-TETRAHYDRO-1H-THIOPYRANO-[4, 3-c] ISOQUINOLINE DERIVATIVES

Publications (2)

Publication Number Publication Date
CN102652136A CN102652136A (zh) 2012-08-29
CN102652136B true CN102652136B (zh) 2014-11-26

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CN201080057293.7A Expired - Fee Related CN102652136B (zh) 2009-12-18 2010-12-15 3,4,4A,10B-四氢-1H-噻喃并[4,3-c]异喹啉衍生物

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US (1) US9018175B2 (enExample)
EP (2) EP2513119B1 (enExample)
JP (1) JP5645961B2 (enExample)
KR (1) KR20120123313A (enExample)
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RU2013142268A (ru) * 2011-02-17 2015-03-27 Сипла Лимитед Фармацевтическая композиция
EP2721036B1 (en) * 2011-06-15 2015-07-22 Takeda GmbH Novel 3,4,4a,10b-tetrahydro-1h-thiopyrano[4,3-c]isoquinoline compounds
WO2014016548A2 (en) * 2012-07-27 2014-01-30 Cipla Limited Pharmaceutical composition
WO2014090990A1 (en) * 2012-12-13 2014-06-19 Ludwig Aigner Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease
WO2014117947A1 (en) 2013-02-04 2014-08-07 Grünenthal GmbH 4-amino substituted condensed pyrimidine compounds as pde4 inhibitors
KR20150119370A (ko) 2013-02-19 2015-10-23 화이자 인코포레이티드 Cns 장애 및 다른 장애의 치료를 위한 pde4 동종효소의 억제제로서의 아자벤즈이미다졸 화합물
EP3172210B1 (en) 2014-07-24 2020-01-15 Pfizer Inc Pyrazolopyrimidine compounds
WO2016020786A1 (en) 2014-08-06 2016-02-11 Pfizer Inc. Imidazopyridazine compounds
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
WO2022006470A1 (en) 2020-07-01 2022-01-06 Vanderbilt University Methods of treatment for a kidney disease

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