TWI468411B - 新穎３，４，４ａ，１０ｂ－四氫－１Ｈ－噻喃并［４，３－ｃ］異喹啉化合物 - Google Patents

新穎３，４，４ａ，１０ｂ－四氫－１Ｈ－噻喃并［４，３－ｃ］異喹啉化合物 Download PDF

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Publication number
TWI468411B
TWI468411B TW99144591A TW99144591A TWI468411B TW I468411 B TWI468411 B TW I468411B TW 99144591 A TW99144591 A TW 99144591A TW 99144591 A TW99144591 A TW 99144591A TW I468411 B TWI468411 B TW I468411B
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Taiwan
Prior art keywords
methyl
ethyl
compound
oxadiazol
phenyl
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TW99144591A
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English (en)
Chinese (zh)
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TW201130851A (en
Inventor
Dieter Flockerzi
Thomas Stengel
Alexander Mann
Harald Ohmer
Ulrich Kautz
Steffen Weinbrenner
Stefan Fischer
Christof Zitt
Armin Hatzelmann
Torsten Dunkern
Christian Hesslinger
Thomas Maier
Hermann Tenor
Clemens Braun
Degenhard Marx
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Takeda Gmbh
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Publication of TW201130851A publication Critical patent/TW201130851A/zh
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    • C07—ORGANIC CHEMISTRY
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    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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TW99144591A 2009-12-18 2010-12-17 新穎３，４，４ａ，１０ｂ－四氫－１Ｈ－噻喃并［４，３－ｃ］異喹啉化合物 TWI468411B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09179982 2009-12-18
US31555210P 2010-03-19 2010-03-19

Publications (2)

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TW201130851A TW201130851A (en) 2011-09-16
TWI468411B true TWI468411B (zh) 2015-01-11

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US (1) US9018175B2 (enExample)
EP (2) EP2813509B1 (enExample)
JP (1) JP5645961B2 (enExample)
KR (1) KR20120123313A (enExample)
CN (1) CN102652136B (enExample)
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US20150322049A1 (en) * 2012-12-13 2015-11-12 Ludwig Aigner Leukotriene pathway antagonists for the treatment of dementia, cognitive deficits in parkinson's disease and/or learning and memory deficiencies in parkinson's disease
EP2951161A1 (en) 2013-02-04 2015-12-09 Grünenthal GmbH 4-amino substituted condensed pyrimidine compounds as pde4 inhibitors
BR112015019276A2 (pt) 2013-02-19 2017-07-18 Pfizer compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios
US10131669B2 (en) 2014-07-24 2018-11-20 Pfizer Inc. Pyrazolopyrimidine compounds
EA031201B1 (ru) 2014-08-06 2018-11-30 Пфайзер Инк. Соединения имидазопиридазина
WO2017089347A1 (en) 2015-11-25 2017-06-01 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas
WO2022006470A1 (en) 2020-07-01 2022-01-06 Vanderbilt University Methods of treatment for a kidney disease

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