EA021838B1 - Производные 2,5-пиперазиндиона в качестве ингибиторов apaf-1 - Google Patents
Производные 2,5-пиперазиндиона в качестве ингибиторов apaf-1 Download PDFInfo
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- EA021838B1 EA021838B1 EA201270215A EA201270215A EA021838B1 EA 021838 B1 EA021838 B1 EA 021838B1 EA 201270215 A EA201270215 A EA 201270215A EA 201270215 A EA201270215 A EA 201270215A EA 021838 B1 EA021838 B1 EA 021838B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- ethyl
- compound
- pharmaceutically acceptable
- aryl
- pathologies
- Prior art date
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- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200901757 | 2009-07-30 | ||
| PCT/ES2010/000349 WO2011012746A2 (es) | 2009-07-30 | 2010-07-29 | Compuestos inhibidores de apaf-1 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201270215A1 EA201270215A1 (ru) | 2012-11-30 |
| EA021838B1 true EA021838B1 (ru) | 2015-09-30 |
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| RS58405B1 (sr) | 2009-12-01 | 2019-04-30 | Translate Bio Inc | Stereoidni derivati za isporuku irnk u humanim genetskim oboljenjima |
| US9193827B2 (en) | 2010-08-26 | 2015-11-24 | Massachusetts Institute Of Technology | Poly(beta-amino alcohols), their preparation, and uses thereof |
| CA2831392C (en) | 2011-03-28 | 2020-04-28 | Massachusetts Institute Of Technology | Conjugated lipomers and uses thereof |
| JP6184945B2 (ja) | 2011-06-08 | 2017-08-23 | シャイアー ヒューマン ジェネティック セラピーズ インコーポレイテッド | ｍＲＮＡ送達のための脂質ナノ粒子組成物および方法 |
| PE20181541A1 (es) | 2011-10-27 | 2018-09-26 | Massachusetts Inst Technology | Derivados de aminoacidos funcionalizados en la terminal n capaces de formar microesferas encapsuladoras de farmaco |
| WO2013078413A1 (en) * | 2011-11-22 | 2013-05-30 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Modulators of lipid storage |
| US20150267192A1 (en) | 2012-06-08 | 2015-09-24 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
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| WO2014028487A1 (en) | 2012-08-13 | 2014-02-20 | Massachusetts Institute Of Technology | Amine-containing lipidoids and uses thereof |
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| WO2016004202A1 (en) | 2014-07-02 | 2016-01-07 | Massachusetts Institute Of Technology | Polyamine-fatty acid derived lipidoids and uses thereof |
| LT3310764T (lt) | 2015-06-19 | 2023-06-12 | Massachusetts Institute Of Technology | Alkenilu pakeisti 2,5-piperazindionai ir jų panaudojimas kompozicijose, skirtose agento pristatymui į subjektą ar ląstelę |
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| US10561736B1 (en) | 2019-01-09 | 2020-02-18 | Spiral Therapeutics, Inc. | Apoptosis inhibitor formulations for prevention of hearing loss |
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| EP4137131A1 (en) * | 2021-08-17 | 2023-02-22 | Centre National de la Recherche Scientifique (CNRS) | Novel serotonin analogues and their uses for treating iron-associated disorders |
| CN115124449B (zh) * | 2022-05-24 | 2024-02-02 | 上海英诺富成生物科技有限公司 | 一种吲哚化合物及制备方法与应用 |
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Also Published As
| Publication number | Publication date |
|---|---|
| KR20120052354A (ko) | 2012-05-23 |
| NZ598125A (en) | 2014-05-30 |
| MX2012001339A (es) | 2012-03-07 |
| CN102574818A (zh) | 2012-07-11 |
| CA2769408A1 (en) | 2011-02-03 |
| BR112012002134A2 (pt) | 2016-05-31 |
| CN102574818B (zh) | 2015-02-25 |
| EP2460798A4 (en) | 2013-02-27 |
| ES2727711T3 (es) | 2019-10-18 |
| TR201907804T4 (tr) | 2019-06-21 |
| BR112012002134B1 (pt) | 2021-03-02 |
| BR112012002134B8 (pt) | 2021-05-25 |
| US20120122868A1 (en) | 2012-05-17 |
| US9040701B2 (en) | 2015-05-26 |
| KR101786761B1 (ko) | 2017-10-18 |
| IN2012DN01378A (OSRAM) | 2015-06-05 |
| AU2010277505A1 (en) | 2012-03-08 |
| CA2769408C (en) | 2017-09-05 |
| AU2010277505B2 (en) | 2016-01-14 |
| EA201270215A1 (ru) | 2012-11-30 |
| WO2011012746A3 (es) | 2011-07-14 |
| EP2460798A2 (en) | 2012-06-06 |
| EP2460798B1 (en) | 2019-02-27 |
| JP2013500314A (ja) | 2013-01-07 |
| WO2011012746A2 (es) | 2011-02-03 |
| JP5694320B2 (ja) | 2015-04-01 |
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