EA020312B1 - Композиции и способы для ингибирования экспрессии транстиретина - Google Patents

Композиции и способы для ингибирования экспрессии транстиретина Download PDF

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Publication number
EA020312B1
EA020312B1 EA201170591A EA201170591A EA020312B1 EA 020312 B1 EA020312 B1 EA 020312B1 EA 201170591 A EA201170591 A EA 201170591A EA 201170591 A EA201170591 A EA 201170591A EA 020312 B1 EA020312 B1 EA 020312B1
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EA
Eurasian Patent Office
Prior art keywords
dsrna
nucleotide
expression
acid
nucleotides
Prior art date
Application number
EA201170591A
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English (en)
Russian (ru)
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EA201170591A1 (ru
Inventor
Динах Вен-Йи Сах
Грегори Хинкл
Рене Альварес
Стюарт Милстейн
Цинминь Чэнь
Original Assignee
Элнилэм Фармасьютикалз, Инк.
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Application filed by Элнилэм Фармасьютикалз, Инк. filed Critical Элнилэм Фармасьютикалз, Инк.
Publication of EA201170591A1 publication Critical patent/EA201170591A1/ru
Publication of EA020312B1 publication Critical patent/EA020312B1/ru

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • C07F9/02—Phosphorus compounds
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EA201170591A 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина EA020312B1 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US10695608P 2008-10-20 2008-10-20
US11573808P 2008-11-18 2008-11-18
US15667009P 2009-03-02 2009-03-02
US18554509P 2009-06-09 2009-06-09
US24278309P 2009-09-15 2009-09-15
US24479409P 2009-09-22 2009-09-22
PCT/US2009/061381 WO2010048228A2 (en) 2008-10-20 2009-10-20 Compositions and methods for inhibiting expression of transthyretin

Publications (2)

Publication Number Publication Date
EA201170591A1 EA201170591A1 (ru) 2011-12-30
EA020312B1 true EA020312B1 (ru) 2014-10-30

Family

ID=42062316

Family Applications (3)

Application Number Title Priority Date Filing Date
EA201170591A EA020312B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина
EA201792626A EA036772B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина
EA201400170A EA029762B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина

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Application Number Title Priority Date Filing Date
EA201792626A EA036772B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина
EA201400170A EA029762B1 (ru) 2008-10-20 2009-10-20 Композиции и способы для ингибирования экспрессии транстиретина

Country Status (27)

Country Link
US (9) US8168775B2 (https=)
EP (4) EP3354733B1 (https=)
JP (8) JP5791505B2 (https=)
KR (6) KR101635436B1 (https=)
CN (3) CN106834291B (https=)
AU (1) AU2009307677C1 (https=)
CA (3) CA3018487A1 (https=)
CY (3) CY1116944T1 (https=)
DK (2) DK2937418T3 (https=)
EA (3) EA020312B1 (https=)
ES (2) ES2543004T3 (https=)
HR (2) HRP20150796T1 (https=)
HU (3) HUE037875T2 (https=)
IL (5) IL281434B2 (https=)
LT (2) LT2937418T (https=)
LU (1) LUC00098I2 (https=)
MX (4) MX360460B (https=)
NL (1) NL300965I2 (https=)
NO (2) NO2937418T3 (https=)
NZ (2) NZ602404A (https=)
PL (2) PL2937418T3 (https=)
PT (2) PT2937418T (https=)
SG (3) SG10201703242XA (https=)
SI (2) SI2344639T1 (https=)
SM (2) SMT201800027T1 (https=)
WO (1) WO2010048228A2 (https=)
ZA (1) ZA201102876B (https=)

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