DK40094A - Fremgangsmåde til fremstilling af carbapenemderivater og præparater indeholdende disse - Google Patents

Fremgangsmåde til fremstilling af carbapenemderivater og præparater indeholdende disse Download PDF

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Publication number
DK40094A
DK40094A DK040094A DK40094A DK40094A DK 40094 A DK40094 A DK 40094A DK 040094 A DK040094 A DK 040094A DK 40094 A DK40094 A DK 40094A DK 40094 A DK40094 A DK 40094A
Authority
DK
Denmark
Prior art keywords
group
alkyl
chem
hydroxy
carboxy
Prior art date
Application number
DK040094A
Other languages
English (en)
Other versions
DK170073B1 (da
Inventor
Tetsuo Miyadera
Yukio Sugimura
Toshiko Hashimoto
Teruo Tanaka
Kimio Iino
Tomoyuki Shibata
Shinichi Sagawara
Original Assignee
Sankyo Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56129648A external-priority patent/JPS5832879A/ja
Priority claimed from JP57081067A external-priority patent/JPS58198486A/ja
Application filed by Sankyo Co filed Critical Sankyo Co
Publication of DK40094A publication Critical patent/DK40094A/da
Application granted granted Critical
Publication of DK170073B1 publication Critical patent/DK170073B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of El Displays (AREA)
DK040094A 1981-08-19 1994-04-07 Analogifremgangsmåde til fremstilling af carbapenemderivater DK170073B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP12964881 1981-08-19
JP56129648A JPS5832879A (ja) 1981-08-19 1981-08-19 カルバペネム−３−カルボン酸誘導体およびその製法
JP8106782 1982-05-14
JP57081067A JPS58198486A (ja) 1982-05-14 1982-05-14 ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法

Publications (2)

Publication Number Publication Date
DK40094A true DK40094A (da) 1994-04-07
DK170073B1 DK170073B1 (da) 1995-05-15

Family

ID=26422100

Family Applications (2)

Application Number Title Priority Date Filing Date
DK370682A DK169820B1 (da) 1981-08-19 1982-08-18 Analogifremgangsmåde til fremstilling af carbapenemderivater
DK040094A DK170073B1 (da) 1981-08-19 1994-04-07 Analogifremgangsmåde til fremstilling af carbapenemderivater

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK370682A DK169820B1 (da) 1981-08-19 1982-08-18 Analogifremgangsmåde til fremstilling af carbapenemderivater

Country Status (19)

Country Link
US (2) US4552873A (da)
EP (2) EP0072710B1 (da)
KR (1) KR890001426B1 (da)
AT (2) ATE42952T1 (da)
AU (2) AU563447B2 (da)
CA (1) CA1214462A (da)
CH (1) CH657853A5 (da)
DE (2) DE3279683D1 (da)
DK (2) DK169820B1 (da)
ES (1) ES515098A0 (da)
FI (2) FI76339C (da)
FR (1) FR2511678B1 (da)
GB (2) GB2104075B (da)
HU (1) HU189171B (da)
IE (2) IE53737B1 (da)
IT (1) IT1156491B (da)
NO (2) NO159656C (da)
NZ (1) NZ201633A (da)
PH (1) PH20772A (da)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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US5071843A (en) * 1978-07-24 1991-12-10 Merck & Co., Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4642341A (en) * 1982-04-09 1987-02-10 Bristol-Myers Company Carbapenem antibiotics
US4710568A (en) * 1982-04-09 1987-12-01 Bristol-Myers Company Carbapenem antibiotics
US4665170A (en) * 1982-06-18 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
US4644061A (en) * 1982-09-28 1987-02-17 Bristol-Myers Company Carbapenem antibiotics
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US4732977A (en) * 1982-09-28 1988-03-22 Bristol Myers Company Carbapenem antibiotics
US4746736A (en) * 1982-09-28 1988-05-24 Bristol-Myers Company Carbapenem antibiotics
DK140584A (da) * 1983-03-08 1984-09-09 Bristol Myers Co Fremgangsmaade til fremstilling af carbapenemderivater
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US4772597A (en) * 1983-10-14 1988-09-20 Pfizer Inc. 2-azacycloalkylthiopenem derivatives
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JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
US4866171A (en) * 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
GB8804058D0 (en) * 1988-02-22 1988-03-23 Fujisawa Pharmaceutical Co 3-alkenyl-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds
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US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
IE950607L (en) * 1988-04-01 1989-10-01 Sankyo Co 2-(heterocyclylthio) carbapenem derivatives, their¹preparation and their use as antibiotics
GB8811237D0 (en) * 1988-05-12 1988-06-15 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
US4963544A (en) * 1988-05-23 1990-10-16 Fujisawa Pharmaceutical Company, Ltd. 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
GB8923844D0 (en) * 1989-10-23 1989-12-13 Fujisawa Pharmaceutical Co Carbapenem compounds
FI96863C (fi) * 1990-02-23 1996-09-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
CA2036960A1 (en) * 1990-02-26 1991-08-27 Thomas A. Rano Novel synthesis of carbapenem intermediates
AU644008B2 (en) * 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
US5286721A (en) * 1990-10-15 1994-02-15 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
US5116833A (en) * 1990-10-19 1992-05-26 Bristol-Myers Squibb Company Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
JPH05236980A (ja) * 1991-12-17 1993-09-17 Sankyo Co Ltd トランス−４−ヒドロキシ−ｌ−プロリンの製造法
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AU5717894A (en) * 1992-12-21 1994-07-19 Chong Kun Dang Corporation 2-(2-substituted pyrrolidin-4-yl)thio-carbapenem derivatives
US5602118A (en) * 1993-03-16 1997-02-11 American Cyanamid Company 2-thiosubstituted carbapenems
WO1996026939A1 (en) * 1995-03-02 1996-09-06 Takeda Chemical Industries, Ltd. Carbapenem compounds, their production and use
KR100599876B1 (ko) * 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
KR100975907B1 (ko) * 2008-03-12 2010-08-13 (주)하이텍팜 입체선택적 3-아세틸티오-1-(아세트이미도일)피롤리딘유도체의 제조방법
KR101028689B1 (ko) * 2008-03-12 2011-04-14 (주)하이텍팜 신규한 결정성 3-머캅토-1-(아세트이미도일)피롤리딘유도체 및 그의 제조방법
EP2326648B1 (en) 2008-07-30 2012-09-19 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
KR100948403B1 (ko) * 2010-01-11 2010-03-19 (주) 대진유압기계 파이프 피팅 및 이에 이용되는 피팅용링 제조방법
CN101885727A (zh) * 2010-07-02 2010-11-17 深圳市海滨制药有限公司 一种制备帕尼培南的方法
WO2023235456A1 (en) * 2022-06-01 2023-12-07 The Johns Hopkins University Penem antibacterials against mycobacterial pathogens and d,d- and l,d transpeptidases

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AU4061378A (en) * 1977-10-19 1980-04-17 Merck & Co., Inc. 1-azabicyclo (3.2.0) hept-2-enes
US4189493A (en) * 1977-12-28 1980-02-19 Merck & Co., Inc. N-heterocyclic derivatives of thienamycin
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JPS56156281A (en) * 1980-05-06 1981-12-02 Sanraku Inc Production of beta-lactam compound
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US4347183A (en) * 1981-02-02 1982-08-31 Schering Corporation Process for the synthesis of penems and carbapenems
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them

Also Published As

Publication number Publication date
GB2163156B (en) 1986-07-16
CA1214462A (en) 1986-11-25
ATE42952T1 (de) 1989-05-15
FI76339B (fi) 1988-06-30
IE53736B1 (en) 1989-02-01
IE53737B1 (en) 1989-02-01
DK169820B1 (da) 1995-03-06
GB2104075B (en) 1986-05-29
GB2163156A (en) 1986-02-19
EP0165384A1 (en) 1985-12-27
FI84826C (fi) 1992-01-27
DE3279683D1 (en) 1989-06-15
EP0165384B1 (en) 1989-05-10
GB8518818D0 (en) 1985-08-29
EP0072710B1 (en) 1986-02-19
NO167918C (no) 1991-12-27
FI822864L (fi) 1983-02-20
NO875188L (no) 1983-02-21
NO159656C (no) 1989-01-25
KR890001426B1 (ko) 1989-05-03
DK170073B1 (da) 1995-05-15
IE862673L (en) 1983-02-19
NZ201633A (en) 1985-11-08
EP0072710A1 (en) 1983-02-23
FI873303A (fi) 1987-07-29
NO822793L (no) 1983-02-21
AU6513286A (en) 1987-02-19
FI76339C (fi) 1988-10-10
AU8720782A (en) 1983-02-24
US4552873A (en) 1985-11-12
ES8400444A1 (es) 1983-10-16
NO875188D0 (no) 1987-12-14
FI84826B (fi) 1991-10-15
IT8268024A0 (it) 1982-08-19
IE821990L (en) 1983-02-19
PH20772A (en) 1987-04-10
CH657853A5 (de) 1986-09-30
AU582480B2 (en) 1989-03-23
IT1156491B (it) 1987-02-04
FI822864A0 (fi) 1982-08-18
DK370682A (da) 1983-02-20
GB2104075A (en) 1983-03-02
USRE34960E (en) 1995-05-30
DE3269183D1 (en) 1986-03-27
AU563447B2 (en) 1987-07-09
FR2511678B1 (fr) 1986-04-25
HU189171B (en) 1986-06-30
ES515098A0 (es) 1983-10-16
NO167918B (no) 1991-09-16
FR2511678A1 (fr) 1983-02-25
KR840001174A (ko) 1984-03-28
NO159656B (no) 1988-10-17
FI873303A0 (fi) 1987-07-29
ATE18048T1 (de) 1986-03-15

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B1 Patent granted (law 1993)
PUP Patent expired