ES8400444A1 - Procedimiento para la preparacion de nuevos derivados de carbapenem. - Google Patents

Procedimiento para la preparacion de nuevos derivados de carbapenem.

Info

Publication number
ES8400444A1
ES8400444A1 ES515098A ES515098A ES8400444A1 ES 8400444 A1 ES8400444 A1 ES 8400444A1 ES 515098 A ES515098 A ES 515098A ES 515098 A ES515098 A ES 515098A ES 8400444 A1 ES8400444 A1 ES 8400444A1
Authority
ES
Spain
Prior art keywords
group
alkyl
yes
hydroxy
carboxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515098A
Other languages
English (en)
Other versions
ES515098A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Original Assignee
Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56129648A external-priority patent/JPS5832879A/ja
Priority claimed from JP57081067A external-priority patent/JPS58198486A/ja
Application filed by Sankyo Co Ltd filed Critical Sankyo Co Ltd
Publication of ES515098A0 publication Critical patent/ES515098A0/es
Publication of ES8400444A1 publication Critical patent/ES8400444A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
    • C07D477/20—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE CARBAPENEM Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R3 ES CARBOXI O CARBOXI PROTEGIDO; Y R1 Y R2 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE SUSTITUCION ENTRE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO MERCAPTO DE FORMULA HSR11, EN LAS QUE R7, ES UNO DE LOS GRUPOS R1 PROTEGIDO, R8 ES CARBOXI PROTEGIDO, Y R10 Y R11 PUEDEN SER VARIOS TIPOS DE RADICALES; SEGUIDA DE LA SEPARACION DE CUALQUIER GRUPO PROTECTOR. LA REACCION DE SUSTITUCION SE LLEVA A CABO EN PRESENCIA DE UNA BASE,A UNA TEMPERATURA ENTRE -20JC Y LA AMBIENTE.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS.
ES515098A 1981-08-19 1982-08-18 Procedimiento para la preparacion de nuevos derivados de carbapenem. Expired ES8400444A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56129648A JPS5832879A (ja) 1981-08-19 1981-08-19 カルバペネム−３−カルボン酸誘導体およびその製法
JP57081067A JPS58198486A (ja) 1982-05-14 1982-05-14 ペネムまたはカルバペネム−３−カルボン酸誘導体およびその製法

Publications (2)

Publication Number Publication Date
ES515098A0 ES515098A0 (es) 1983-10-16
ES8400444A1 true ES8400444A1 (es) 1983-10-16

Family

ID=26422100

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515098A Expired ES8400444A1 (es) 1981-08-19 1982-08-18 Procedimiento para la preparacion de nuevos derivados de carbapenem.

Country Status (19)

Country Link
US (2) US4552873A (es)
EP (2) EP0165384B1 (es)
KR (1) KR890001426B1 (es)
AT (2) ATE42952T1 (es)
AU (2) AU563447B2 (es)
CA (1) CA1214462A (es)
CH (1) CH657853A5 (es)
DE (2) DE3279683D1 (es)
DK (2) DK169820B1 (es)
ES (1) ES8400444A1 (es)
FI (2) FI76339C (es)
FR (1) FR2511678B1 (es)
GB (2) GB2104075B (es)
HU (1) HU189171B (es)
IE (2) IE53736B1 (es)
IT (1) IT1156491B (es)
NO (2) NO159656C (es)
NZ (1) NZ201633A (es)
PH (1) PH20772A (es)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
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US4997936A (en) * 1977-10-19 1991-03-05 Merck & Co., Inc. 2-carbamimidoyl-6-substituted-1-carbadethiapen-2-em-3-carboxylic acids
US5071843A (en) * 1978-07-24 1991-12-10 Merck & Co., Inc. Combination of 2-substituted carbapenems with dipeptidase inhibitors
US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them
US4710568A (en) * 1982-04-09 1987-12-01 Bristol-Myers Company Carbapenem antibiotics
US4642341A (en) * 1982-04-09 1987-02-10 Bristol-Myers Company Carbapenem antibiotics
US4640799A (en) * 1982-06-18 1987-02-03 Bristol-Myers Company Carbapenem antibiotics
US4536335A (en) * 1982-06-18 1985-08-20 Bristol-Myers Company Carbapenem antibiotics
US4665170A (en) * 1982-06-18 1987-05-12 Bristol-Myers Company Carbapenem antibiotics
US4644061A (en) * 1982-09-28 1987-02-17 Bristol-Myers Company Carbapenem antibiotics
NZ205626A (en) * 1982-09-28 1986-12-05 Bristol Myers Co Carbapenem antibiotics
US4746736A (en) * 1982-09-28 1988-05-24 Bristol-Myers Company Carbapenem antibiotics
US4732977A (en) * 1982-09-28 1988-03-22 Bristol Myers Company Carbapenem antibiotics
DK140584A (da) * 1983-03-08 1984-09-09 Bristol Myers Co Fremgangsmaade til fremstilling af carbapenemderivater
CA1283906C (en) * 1983-05-09 1991-05-07 Makoto Sunagawa .beta.-LACTAM COMPOUNDS AND PRODUCTION THEREOF
US4772597A (en) * 1983-10-14 1988-09-20 Pfizer Inc. 2-azacycloalkylthiopenem derivatives
US4717728A (en) * 1983-11-21 1988-01-05 Merck & Co., Inc. Cyclic amidinyl and cyclic guanidinyl thio carbapenems
US4992542A (en) * 1984-01-24 1991-02-12 Merck & Co., Inc. 2-substituted-6-carbadethiapen-2-em-3-carboxylic acids
JPS60202886A (ja) * 1984-03-27 1985-10-14 Sankyo Co Ltd １―置換カルバペネム―３―カルボン酸誘導体
US4696923A (en) * 1984-04-23 1987-09-29 Merck & Co., Inc. 6-[1-hydroxyethyl]-2-SR8 -1-methyl-1-carbadethiapen-2-em-3-carboxylic acids
DK270685A (da) * 1984-06-29 1985-12-30 Hoffmann La Roche Carbapenemderivater
US4820817A (en) * 1984-09-10 1989-04-11 Merck & Co., Inc. Process for preparing 3-substituted-6-substituted-7-oxo-1-azabicycl(3.2.0)-hept-2-ene-2-carboxylic acid
US4757066A (en) * 1984-10-15 1988-07-12 Sankyo Company Limited Composition containing a penem or carbapenem antibiotic and the use of the same
DE3579888D1 (de) * 1984-11-08 1990-10-31 Sumitomo Pharma Carbapenemverbindungen und deren herstellung.
FI81576C (fi) * 1984-12-25 1990-11-12 Sankyo Co Foerfarande foer framstaellning av derivat av 6-(1-hydroxietyl)-2-(1,2-disubstituerade-4-pyrrolidinyltio)-2- karbapenem-3-karboxylsyra, vilka aer anvaendbara som laekemedel.
PH24782A (en) * 1985-10-24 1990-10-30 Sankyo Co Composition containing a penem or carbapenem antibiotic and the use of the same
DE3780344T2 (de) * 1986-03-27 1993-01-28 Sumitomo Pharma Beta-lactam-verbindungen und deren herstellung.
KR880006244A (ko) * 1986-11-24 1988-07-22 후지사와 도모 기찌 로 3-피롤리디닐티오-1-아자바이스클로[3.2.0]햅트2-엔-2-카르복실산 화합물 및 이의 제조방법
EP0272455B1 (en) * 1986-11-24 1993-02-10 Fujisawa Pharmaceutical Co., Ltd. 3-Pyrrolidinylthio-1-azabicyclo [3.2.0] hept-2-ene-2-carboxylic acid compounds
US4866171A (en) * 1987-04-11 1989-09-12 Lederle (Japan), Ltd. (1R,5S,6S)-2-[(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazolium-6-yl)]thio-6-[R-1-hydroxyethyl]-1-methyl-carbapenum-3-carboxylate
JPS6425779A (en) * 1987-04-11 1989-01-27 Lederle Japan Ltd (1r,5s,6s)-2-substituted-thio-6-((r)-1-hydroxyethyl)-1-methyl -carbapenem-3-carboxylic acid derivative
GB8804058D0 (en) * 1988-02-22 1988-03-23 Fujisawa Pharmaceutical Co 3-alkenyl-1-azabicyclo(3 2 0)hept-2-ene-2-carboxylic acid compounds
US4925838A (en) * 1988-03-18 1990-05-15 Fujisawa Pharmaceutical Company, Ltd. 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds
US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
IE950607L (en) * 1988-04-01 1989-10-01 Sankyo Co 2-(heterocyclylthio) carbapenem derivatives, their¹preparation and their use as antibiotics
GB8811237D0 (en) * 1988-05-12 1988-06-15 Fujisawa Pharmaceutical Co 3-pyrrolidinylthio-1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives
US4963544A (en) * 1988-05-23 1990-10-16 Fujisawa Pharmaceutical Company, Ltd. 3-pyrrolidinylthio-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid compounds
US5102877A (en) * 1989-04-28 1992-04-07 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
GB8923844D0 (en) * 1989-10-23 1989-12-13 Fujisawa Pharmaceutical Co Carbapenem compounds
FI96863C (fi) * 1990-02-23 1996-09-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten /2-(1-homopiperatsiinikarbonyyli)pyrrolidin-4-yylitio/-6-(1-hydroksietyyli)-1-karbapen-2-eemi-3-karboksylaattisuolojen valmistamiseksi
CA2036960A1 (en) * 1990-02-26 1991-08-27 Thomas A. Rano Novel synthesis of carbapenem intermediates
AU644008B2 (en) * 1990-08-10 1993-12-02 Sumitomo Pharmaceuticals Company, Limited Beta-lactam compounds, and their production and use
US5286721A (en) * 1990-10-15 1994-02-15 Fujisawa Pharmaceutical Co., Ltd. 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds
US5116833A (en) * 1990-10-19 1992-05-26 Bristol-Myers Squibb Company Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof
US5712267A (en) * 1991-06-04 1998-01-27 Sankyo Company,. Limited Carbapenem derivatives, their preparation and their use as antibiotics
JPH05236980A (ja) * 1991-12-17 1993-09-17 Sankyo Co Ltd トランス−４−ヒドロキシ−ｌ−プロリンの製造法
GB9210096D0 (en) * 1992-05-11 1992-06-24 Fujisawa Pharmaceutical Co 1-azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid derivatives and their preparation
JP2783683B2 (ja) * 1992-12-21 1998-08-06 ジョン グン ダン コーポレーション ２−（２−置換されたピロリジン−４−イル）チオ−カバペネム誘導体
US5602118A (en) * 1993-03-16 1997-02-11 American Cyanamid Company 2-thiosubstituted carbapenems
AU4844896A (en) * 1995-03-02 1996-09-18 Takeda Chemical Industries Ltd. Carbapenem compounds, their production and use
KR100599876B1 (ko) * 2004-08-31 2006-07-13 한국화학연구원 2-아릴메틸아제티딘 카바페넴 유도체 및 그의 제조방법
KR100975907B1 (ko) * 2008-03-12 2010-08-13 (주)하이텍팜 입체선택적 3-아세틸티오-1-(아세트이미도일)피롤리딘유도체의 제조방법
KR101028689B1 (ko) * 2008-03-12 2011-04-14 (주)하이텍팜 신규한 결정성 3-머캅토-1-(아세트이미도일)피롤리딘유도체 및 그의 제조방법
AU2009277936B2 (en) 2008-07-30 2014-11-27 Sun Pharmaceutical Industries Limited Process for the preparation of carbapenem compounds
WO2011048583A1 (en) 2009-10-23 2011-04-28 Ranbaxy Laboratories Limited Process for the preparation of carbapenem compounds
KR100948403B1 (ko) * 2010-01-11 2010-03-19 (주) 대진유압기계 파이프 피팅 및 이에 이용되는 피팅용링 제조방법
CN101885727A (zh) * 2010-07-02 2010-11-17 深圳市海滨制药有限公司 一种制备帕尼培南的方法
WO2023235456A1 (en) * 2022-06-01 2023-12-07 The Johns Hopkins University Penem antibacterials against mycobacterial pathogens and d,d- and l,d transpeptidases

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AU4061378A (en) * 1977-10-19 1980-04-17 Merck & Co., Inc. 1-azabicyclo (3.2.0) hept-2-enes
US4189493A (en) * 1977-12-28 1980-02-19 Merck & Co., Inc. N-heterocyclic derivatives of thienamycin
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JPS56122379A (en) * 1980-03-03 1981-09-25 Sankyo Co Ltd 1-carba-2-penem-3-carboxylic acid derivative
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JPS56156281A (en) * 1980-05-06 1981-12-02 Sanraku Inc Production of beta-lactam compound
JPS56161393A (en) * 1980-05-16 1981-12-11 Sanraku Inc Beta-lactam compound
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US4552873A (en) * 1981-08-19 1985-11-12 Sankyo Company Limited Carbapenem compounds, and compositions containing them

Also Published As

Publication number Publication date
KR890001426B1 (ko) 1989-05-03
DE3269183D1 (en) 1986-03-27
IE862673L (en) 1983-02-19
AU6513286A (en) 1987-02-19
IE53736B1 (en) 1989-02-01
DK170073B1 (da) 1995-05-15
ES515098A0 (es) 1983-10-16
HU189171B (en) 1986-06-30
AU563447B2 (en) 1987-07-09
NO167918B (no) 1991-09-16
IT8268024A0 (it) 1982-08-19
DK370682A (da) 1983-02-20
GB2163156B (en) 1986-07-16
FR2511678B1 (fr) 1986-04-25
DK40094A (da) 1994-04-07
CH657853A5 (de) 1986-09-30
FI822864A0 (fi) 1982-08-18
AU8720782A (en) 1983-02-24
FR2511678A1 (fr) 1983-02-25
AU582480B2 (en) 1989-03-23
EP0072710B1 (en) 1986-02-19
GB8518818D0 (en) 1985-08-29
USRE34960E (en) 1995-05-30
EP0072710A1 (en) 1983-02-23
ATE42952T1 (de) 1989-05-15
NZ201633A (en) 1985-11-08
FI873303A (fi) 1987-07-29
GB2104075A (en) 1983-03-02
CA1214462A (en) 1986-11-25
IE821990L (en) 1983-02-19
EP0165384A1 (en) 1985-12-27
NO167918C (no) 1991-12-27
KR840001174A (ko) 1984-03-28
NO159656B (no) 1988-10-17
NO875188L (no) 1983-02-21
FI822864L (fi) 1983-02-20
FI84826B (fi) 1991-10-15
NO822793L (no) 1983-02-21
FI76339B (fi) 1988-06-30
GB2104075B (en) 1986-05-29
PH20772A (en) 1987-04-10
NO159656C (no) 1989-01-25
IT1156491B (it) 1987-02-04
DK169820B1 (da) 1995-03-06
NO875188D0 (no) 1987-12-14
DE3279683D1 (en) 1989-06-15
GB2163156A (en) 1986-02-19
ATE18048T1 (de) 1986-03-15
IE53737B1 (en) 1989-02-01
FI76339C (fi) 1988-10-10
EP0165384B1 (en) 1989-05-10
FI84826C (fi) 1992-01-27
FI873303A0 (fi) 1987-07-29
US4552873A (en) 1985-11-12

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