DK3284754T3 - Anti-cd38-antistoffer - Google Patents

Anti-cd38-antistoffer Download PDF

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Publication number
DK3284754T3
DK3284754T3 DK17189925.5T DK17189925T DK3284754T3 DK 3284754 T3 DK3284754 T3 DK 3284754T3 DK 17189925 T DK17189925 T DK 17189925T DK 3284754 T3 DK3284754 T3 DK 3284754T3
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antibodies
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DK17189925.5T
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Danish (da)
English (en)
Inventor
Kathleen Ann Elias
Gregory Landes
Shweta Singh
Wouter Korver
Andrew Walling Drake
Mary Haak-Frendscho
Gyorgy Pal Snell
Vinay Bhaskar
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Takeda Pharmaceuticals Co
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Publication of DK3284754T3 publication Critical patent/DK3284754T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6871—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting an enzyme
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/99—Enzyme inactivation by chemical treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK17189925.5T 2010-12-30 2011-12-30 Anti-cd38-antistoffer DK3284754T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201061428699P 2010-12-30 2010-12-30
US201161470406P 2011-03-31 2011-03-31
US201161470382P 2011-03-31 2011-03-31
US201161485104P 2011-05-11 2011-05-11
EP11811633.4A EP2658871B1 (en) 2010-12-30 2011-12-30 Anti-cd38 antibodies

Publications (1)

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DK3284754T3 true DK3284754T3 (da) 2020-12-21

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Application Number Title Priority Date Filing Date
DK17189925.5T DK3284754T3 (da) 2010-12-30 2011-12-30 Anti-cd38-antistoffer
DK11811633.4T DK2658871T3 (en) 2010-12-30 2011-12-30 ANTI-CD38 ANTIBODIES
DK11810777.0T DK2658870T3 (en) 2010-12-30 2011-12-30 CONJUGED ANTI-CD38 ANTIBODIES

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DK11811633.4T DK2658871T3 (en) 2010-12-30 2011-12-30 ANTI-CD38 ANTIBODIES
DK11810777.0T DK2658870T3 (en) 2010-12-30 2011-12-30 CONJUGED ANTI-CD38 ANTIBODIES

Country Status (38)

Country Link
US (11) US9102744B2 (cg-RX-API-DMAC7.html)
EP (6) EP2658870B1 (cg-RX-API-DMAC7.html)
JP (10) JP5843884B2 (cg-RX-API-DMAC7.html)
KR (5) KR102070326B1 (cg-RX-API-DMAC7.html)
CN (4) CN113480649B (cg-RX-API-DMAC7.html)
AR (1) AR084747A1 (cg-RX-API-DMAC7.html)
AU (3) AU2011351921B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013017009B1 (cg-RX-API-DMAC7.html)
CA (1) CA2822061C (cg-RX-API-DMAC7.html)
CO (1) CO6761368A2 (cg-RX-API-DMAC7.html)
CR (1) CR20130313A (cg-RX-API-DMAC7.html)
CY (3) CY1122161T1 (cg-RX-API-DMAC7.html)
DK (3) DK3284754T3 (cg-RX-API-DMAC7.html)
EA (2) EA201791186A1 (cg-RX-API-DMAC7.html)
EC (1) ECSP13012794A (cg-RX-API-DMAC7.html)
ES (3) ES2674175T3 (cg-RX-API-DMAC7.html)
GE (1) GEP20166493B (cg-RX-API-DMAC7.html)
HR (3) HRP20181245T1 (cg-RX-API-DMAC7.html)
HU (3) HUE052906T2 (cg-RX-API-DMAC7.html)
IL (1) IL226973A (cg-RX-API-DMAC7.html)
JO (2) JOP20210044A1 (cg-RX-API-DMAC7.html)
LT (3) LT2658871T (cg-RX-API-DMAC7.html)
MA (1) MA34763B1 (cg-RX-API-DMAC7.html)
MX (2) MX350903B (cg-RX-API-DMAC7.html)
MY (1) MY160499A (cg-RX-API-DMAC7.html)
NZ (2) NZ705848A (cg-RX-API-DMAC7.html)
PE (1) PE20140247A1 (cg-RX-API-DMAC7.html)
PL (3) PL2658870T3 (cg-RX-API-DMAC7.html)
PT (3) PT3284754T (cg-RX-API-DMAC7.html)
RS (3) RS61280B1 (cg-RX-API-DMAC7.html)
SG (1) SG191211A1 (cg-RX-API-DMAC7.html)
SI (3) SI3284754T1 (cg-RX-API-DMAC7.html)
SM (2) SMT201800388T1 (cg-RX-API-DMAC7.html)
TR (1) TR201808709T4 (cg-RX-API-DMAC7.html)
TW (1) TWI564304B (cg-RX-API-DMAC7.html)
UY (1) UY33850A (cg-RX-API-DMAC7.html)
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ZA (1) ZA201304696B (cg-RX-API-DMAC7.html)

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AU2019264573A1 (en) 2019-12-05
JP2021087437A (ja) 2021-06-10
SI3284754T1 (sl) 2021-03-31
KR20140032963A (ko) 2014-03-17
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KR102070326B1 (ko) 2020-01-29
EP3789404A1 (en) 2021-03-10
JP6148984B2 (ja) 2017-06-14
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HRP20181245T1 (hr) 2018-10-05
WO2012092612A1 (en) 2012-07-05
JP6563446B2 (ja) 2019-08-21
SMT201800388T1 (it) 2018-09-13
US20130171154A1 (en) 2013-07-04
KR101945002B1 (ko) 2019-02-07
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JP6840813B2 (ja) 2021-03-10
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AU2017204571B2 (en) 2019-09-19
PT3284754T (pt) 2020-12-21
SI2658871T1 (sl) 2018-11-30
WO2012092616A1 (en) 2012-07-05
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PL2658870T3 (pl) 2018-11-30
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ZA201304696B (en) 2014-09-25
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US10494444B2 (en) 2019-12-03
PT2658871T (pt) 2018-08-07
CN119775422A (zh) 2025-04-08
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US8926969B2 (en) 2015-01-06
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CA2822061C (en) 2022-10-18
US20200031951A1 (en) 2020-01-30
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JP2021019588A (ja) 2021-02-18
LT2658871T (lt) 2018-09-10
KR102602640B1 (ko) 2023-11-16
HK1250735A1 (en) 2019-01-11
KR102451597B1 (ko) 2022-10-06
US9102744B2 (en) 2015-08-11
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IL226973A (en) 2016-08-31
US20180066069A1 (en) 2018-03-08
JP7096301B2 (ja) 2022-07-05
EP3284755B1 (en) 2020-10-07
JP2019205454A (ja) 2019-12-05
JP2014509837A (ja) 2014-04-24
ES2690095T3 (es) 2018-11-19
RS57494B1 (sr) 2018-10-31
GEP20166493B (en) 2016-06-27
JP2018029581A (ja) 2018-03-01
EA201390993A1 (ru) 2013-12-30
SI2658870T1 (sl) 2018-10-30
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JP2020022464A (ja) 2020-02-13
KR20190015764A (ko) 2019-02-14

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