DK3193901T3 - Pirinpolypeptid og immunmodulation - Google Patents
Pirinpolypeptid og immunmodulation Download PDFInfo
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- DK3193901T3 DK3193901T3 DK15819853.1T DK15819853T DK3193901T3 DK 3193901 T3 DK3193901 T3 DK 3193901T3 DK 15819853 T DK15819853 T DK 15819853T DK 3193901 T3 DK3193901 T3 DK 3193901T3
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Claims (12)
1. Polypeptid HP eller en polynukleotidsekvens der koder for polypeptid HP til anvendelse i behandlingen og/eller forebyggelse afen sygdom hos et individ; hvor sygdommen er en inflammatorisk sygdom og/eller en autoimmun sygdom; hvor polypeptidet har mindst 75% identitet med SEQ ID NO 2, SEQ ID NO 4 eller SEQ ID NO 6 og hvor polynukleotidsekvensen koder for et polypeptid der har mindst 75% identitet med SEQ ID NO 2, SEQ ID NO 4 eller SEQ ID NO 6 og/eller hvor polynukleotidsekvensen har mindst 75% identitet med SEQ ID NO 1, SEQ ID NO 3 eller SEQ ID NO 5.
2. Polypeptidet eller polynukleotidsekvensen ifølge krav 1 til anvendelsen ifølge krav 1, hvor sygdommen rammer gastrointestinalkanalen, et afsnit af gastrointestinalkanalen, leveren, leverceller, epitelceller, epidermalceller, neuronale nyreceller, milt, lunger, hjerte, bugspytkirtel, og/eller bugspytkirtelceller, eller hvor sygdommen er valgt fra gruppen bestående af inflammatoriske tarmsygdomme (IBD), colitis, rheumatoid arthritis, psoriasis, multipel sclerose, type I diabetes, cøliakisygdom, atopisk dermatitis, rhinitis, irritabelt tarmsyndrom (IBS), ulcerativ colitis, pouchitis, Crohn's sygdom, funktionel dyspepsi, atopiske sygdomme, nekrotiserende enterocolitis, ikke-alkoholisk fedtleversygdom, gastrointestinal-infektion Lupus, nephritis/glomerulonephritis, astma, COPD, mycocarditis og kombinationer deraf.
3. Polypeptidet eller polynukleotidsekvensen ifølge krav 1 til anvendelsen ifølge krav 1, hvor sygdommen er en inflammatorisk tarmsygdom (IBD).
4. Polypeptidet eller polynukleotidsekvensen ifølge et hvilket som helst af de foregående krav til anvendelsen ifølge et hvilket som helst af de foregående krav hvor polypeptidet eller polypeptidsekvensen er til anvendelse i reduktion af inflammationen af en celle, et væv eller et organ hos et individ.
5. Polypeptidet eller polynukleotidsekvensen ifølge krav 4 til anvendelsen ifølge krav 4, hvor cellen, væv eller organ er gastrointestinalkanalen, et afsnit af gastrointestinalkanalen, leveren, leverceller, epitelceller, epidermalceller, neuronalceller, nyrer, milt, lunger, hjerte, bugspytkirtel, og/eller bugspytkirtelceller.
6. Polypeptidet eller polynukleotidsekvensen ifølge et hvilket som helst af kravene 4 til 5 til anvendelsen ifølge et hvilket som helst af kravene 4 til 5, hvor polypeptidet eller polypeptidsekvensen er til anvendelse i at reducere inflammationen af epitelceller fra vævet eller organet.
7. Polypeptidet eller polynukleotidet ifølge et hvilket som helst af kravene 1 til 3 til anvendelsen ifølge et hvilket som helst af kravene 1 til 3, hvor polypeptidet eller polypeptidsekvensen er til anvendelse i at: a) forbedre tarmbarriereintegriteten hos et individ, b) modificere den bakterielle sammensætning i et væv eller organ til at tilvejebringe en gavnlig mikroflora, fortrinsvis hvor polypeptidet eller polypeptidsekvensen er til anvendelse i reduktion af niveauet af én eller flere typer af laktose fermenterende bakterier i et væv eller et organ hos et individ og/eller reducere niveauet af én eller flere typer af ikke-lactose fermenterende bakterier i et væv eller et organ hos et individ, eventuelt hvor vævet eller organet er valgt fra gruppen bestående af mesenteriallymfeknuder, lever, bugspytkirtel, milt, nyre, hjerte, lunge og kombinationer deraf, c) opretholde længden af tyktarmen og/eller tyndtarmen hos et individ, såsom forbygge en reduktion i længden af tyktarmen og/eller forebygge en stigning i længden af tyndtarmen, d) reducere afbrydelsen til et individs tarm, såsom reducere eller modvirke afbrydelse til integriteten af slimhindeepitelet og/eller reducere eller modvirke en reduktion i antallet af goblet-celler i epitelet og/eller reducere eller modvirke infiltrationen af immunceller i lamina propria, e) regulere ekspressionen af ét eller flere pro-inflammatoriske gener og/eller ét eller flere barriereintegritetsgener i en celle eller celler hos et individ, f) regulere ekspressionen i en celle eller celler hos et individ af ét eller flere gener valgt fra gruppen bestående af regenererende islet-afledte 3 beta gen (Reg3b), resistin-lignende gamma resistin-lignende beta gen (Retnlg|Retnlb) sucrase-isomaltase (alfa-glucosidase) gen (Si), defensin alfa 24 gen (Defa24), hydroxysteroid 11-beta dehydrogenase 2 gen (Hsdllb2), hydroxysteroid (17-beta) dehydrogenase 2 gen (Hsdl7b2), resistin-lignende molekyle-beta (RELMb), og nuklear receptor 1D1 thyroid hormonreceptor alfa gen (Nrl dl|Thra), såsom reduktion af ekspressionen af ét eller flere gener valgt fra gruppen bestående af regenererende ø-afledte 3 beta gen (Reg3b); resistin-lignende gamma resistin lignende betagen (Retnlg|Retnlb); resistin-lignende molekyle beta (RELMb), sucrase-isomaltase (alfa-glucosidase) gen (Si); og defensin alfa 24-gen (Defa24), eller øge ekspressionen af ét eller flere gener valgt fra gruppen bestående af hydroxysteroid 11-beta-dehydrogenase 2-gen (Hsdllb2); hydroxysteroid (17-beta) dehydrogenase 2-gen (Hsdl7b2); og nuklear receptor lDl-thyroidhormonreceptor alfa gen (Nrldl|Thra), g) reducere aktiveringen af pro-inflammatoriske spredningsveje i en celle eller celler hos et individ, h) reducere aktiviteten og/eller ekspressionen af NF-κβ i en celle eller celler hos et individ, eller i) forbedre gastrointestinal-sundheden hos et individ.
8. Farmaceutisk sammensætning omfattende polypeptid HP eller en polynukleotidsekvens der koder for polypeptid HP og en farmaceutisk acceptabel excipiens, bærer eller fortyndingsmiddel; hvor polypeptidet har mindst 75% identitet med SEQ ID NO 2, SEQ ID NO 4 eller SEQ ID NO 6 og hvor polynukleotidsekvensen koder for et polypeptid der har mindst 75% identitet med SEQ ID NO 2, SEQ ID NO 4 eller SEQ ID NO 6 og/eller hvor polynukleotidsekvensen har mindst 75% identitet med SEQ ID NO i, SEQ ID NO 3 eller SEQ ID NO 5.
9. Polypeptidet eller polynukleotidsekvensen ifølge et hvilket som helst af kravene 1 til 7 til anvendelsen ifølge et hvilket som helst af kravene 1 til 7, eller den farmaceutiske sammensætning ifølge krav 8, hvor polypeptidet eller polypeptidsekvensen er indkapslet.
10. Polypeptidet eller polynukleotidsekvensen ifølge et hvilket som helst af kravene 1 til 7 og 9 til anvendelsen ifølge et hvilket som helst af kravene 1 til 7 and 9, eller den farmaceutiske sammensætning ifølge krav 8 eller 9, hvor polypeptidet er et rekombinant polypeptid.
11. Polypeptidet eller polynukleotidsekvensen ifølge et hvilket som helst af kravene 1 til 7 og 9 til anvendelsen ifølge et hvilket som helst af kravene 1 til 7 og 9, eller den farmaceutiske sammensætning ifølge krav 8 eller 9, hvor en ekspressionsvektor indeholder polynukleotidsekvensen.
12. Fremgangsmåde til fremstilling af en farmaceutisk sammensætning ifølge et hvilket som helst af kravene 8 til 11, hvilken fremgangsmåde omfatter blanding af polypeptidet eller polynukleotidsekvensen med en farmaceutisk acceptabel excipiens, bærer eller fortyndingsmiddel; eventuelt er polypeptidet eller polynukleotidsekvensen indkapslet i denne fremgangsmåde; hvor polypeptidet har mindst 75% identitet med SEQ ID NO 2, SEQ ID NO 4 eller SEQ ID NO 6 og hvor polynukleotidsekvensen koder for et polypeptid der har mindst 75% identitet med SEQ ID NO 2, SEQ ID NO 4 eller SEQ ID NO 6 og/eller hvor polynukleotidsekvensen har mindst 75% identitet med SEQ ID NO 1, SEQ ID NO 3 eller SEQ ID NO 5.
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GB201306536D0 (en) | 2013-04-10 | 2013-05-22 | Gt Biolog Ltd | Polypeptide and immune modulation |
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MA41010B1 (fr) | 2015-06-15 | 2020-01-31 | 4D Pharma Res Ltd | Compositions comprenant des souches bactériennes |
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PT3630136T (pt) | 2017-05-22 | 2021-06-11 | 4D Pharma Res Ltd | Composições que compreendem estirpes bacterianas |
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