DK3063159T3 - Fremgangsmåde til oprensning af et neutralt humant mælkeoligosaccharid ved hjælp af kromatografi med simuleret bevægeligt leje - Google Patents
Fremgangsmåde til oprensning af et neutralt humant mælkeoligosaccharid ved hjælp af kromatografi med simuleret bevægeligt leje Download PDFInfo
- Publication number
- DK3063159T3 DK3063159T3 DK14777665.2T DK14777665T DK3063159T3 DK 3063159 T3 DK3063159 T3 DK 3063159T3 DK 14777665 T DK14777665 T DK 14777665T DK 3063159 T3 DK3063159 T3 DK 3063159T3
- Authority
- DK
- Denmark
- Prior art keywords
- chimatography
- oligosaccharid
- rentals
- purification
- procedure
- Prior art date
Links
- 210000004251 human milk Anatomy 0.000 title 1
- 235000020256 human milk Nutrition 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000007935 neutral effect Effects 0.000 title 1
- 229920001542 oligosaccharide Polymers 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1814—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns recycling of the fraction to be distributed
- B01D15/1821—Simulated moving beds
- B01D15/185—Simulated moving beds characterized by the components to be separated
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
- B01D61/422—Electrodialysis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/18—Iodine; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/34—Copper; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/16—Diafiltration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nutrition Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Biochemistry (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Water Supply & Treatment (AREA)
- Analytical Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Pediatric Medicine (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Urology & Nephrology (AREA)
- Nanotechnology (AREA)
- Obesity (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP13187369.7A EP2857410A1 (en) | 2013-10-04 | 2013-10-04 | Process for purification of 2´-fucosyllactose using simulated moving bed chromatography |
PCT/EP2014/071145 WO2015049331A1 (en) | 2013-10-04 | 2014-10-02 | Process for purification of a neutral human milk oligosaccharide using simulated moving bed chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3063159T3 true DK3063159T3 (da) | 2021-05-10 |
Family
ID=49293548
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14777665.2T DK3063159T3 (da) | 2013-10-04 | 2014-10-02 | Fremgangsmåde til oprensning af et neutralt humant mælkeoligosaccharid ved hjælp af kromatografi med simuleret bevægeligt leje |
Country Status (13)
Country | Link |
---|---|
US (2) | US10435427B2 (da) |
EP (2) | EP2857410A1 (da) |
JP (1) | JP6666243B2 (da) |
KR (1) | KR102298281B1 (da) |
CN (2) | CN105814070A (da) |
BR (1) | BR112016007342B1 (da) |
DK (1) | DK3063159T3 (da) |
ES (1) | ES2868249T3 (da) |
MX (2) | MX2016004288A (da) |
PH (1) | PH12016500594A1 (da) |
PL (1) | PL3063159T3 (da) |
RU (1) | RU2685537C2 (da) |
WO (1) | WO2015049331A1 (da) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2857410A1 (en) | 2013-10-04 | 2015-04-08 | Jennewein Biotechnologie GmbH | Process for purification of 2´-fucosyllactose using simulated moving bed chromatography |
DK2896628T3 (da) | 2014-01-20 | 2019-01-14 | Jennewein Biotechnologie Gmbh | Fremgangsmåde til effektiv oprensning af neutrale modermælksoligosaccharider (HMO'er) fra mikrobiel fermentering |
CN107108677B (zh) | 2014-10-24 | 2020-08-07 | 格礼卡姆股份公司 | Hmo的混合物 |
US10829508B2 (en) | 2015-12-18 | 2020-11-10 | Glycom A/S | Fermentative production of oligosaccharides |
WO2017182965A1 (en) * | 2016-04-19 | 2017-10-26 | Glycom A/S | Separation of oligosaccharides from fermentation broth |
WO2017221208A1 (en) | 2016-06-24 | 2017-12-28 | Glycom A/S | Compositions comprising hmos, their production and use for the prevention and/or treatment of viral and/or bacterial infections |
KR101979608B1 (ko) * | 2017-04-17 | 2019-08-28 | 재단법인 탄소순환형 차세대 바이오매스 생산전환 기술연구단 | 푸코오스 분리방법 및 이를 위한 장치 |
EP3648617A1 (en) * | 2017-07-07 | 2020-05-13 | Société des Produits Nestlé S.A. | Human milk fortifier |
CN110914284A (zh) * | 2017-07-12 | 2020-03-24 | 格礼卡姆股份公司 | 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物 |
EP3450443A1 (en) | 2017-08-29 | 2019-03-06 | Jennewein Biotechnologie GmbH | Process for purifying sialylated oligosaccharides |
WO2019050321A1 (ko) * | 2017-09-07 | 2019-03-14 | (주)프로테옴텍 | 다수의 검사선을 구비한 크로마토그래피용 스트립, 이를 포함하는 진단 키트 및 다수의 경쟁적 반응 측정 단계를 포함하는 정성, 반정량, 정량 분석방법 |
AU2018343981B2 (en) * | 2017-09-29 | 2022-12-08 | Frieslandcampina Nederland B.V. | Process for the purification of a neutral human milk oligosaccharide (HMO) from microbial fermentation |
EP3494804A1 (en) | 2017-12-08 | 2019-06-12 | Jennewein Biotechnologie GmbH | Spray-dried 3-fucosyllactose |
EP3494805A1 (en) | 2017-12-08 | 2019-06-12 | Jennewein Biotechnologie GmbH | Spray-dried tetrasaccharides |
EP3494806A1 (en) | 2017-12-08 | 2019-06-12 | Jennewein Biotechnologie GmbH | Spray-dried lacto-n-fucopentaose |
EP3524067A1 (en) | 2018-02-08 | 2019-08-14 | Jennewein Biotechnologie GmbH | Spray-dried mixture of human milk oligosaccharides |
BR112020011202A2 (pt) * | 2017-12-08 | 2020-11-17 | Jennewein Biotechnologie Gmbh | tetrassacarídeos secos por pulverização |
EP3494807A1 (en) | 2017-12-11 | 2019-06-12 | Jennewein Biotechnologie GmbH | Spray-dried sialyllactose |
WO2019160922A1 (en) * | 2018-02-19 | 2019-08-22 | Dupont Nutrition Biosciences Aps | Process for spray drying fucosyllactose solutions and related product compositions |
EP3546060A1 (en) * | 2018-03-27 | 2019-10-02 | DuPont Nutrition Biosciences ApS | Process for spray drying fucosyllactose solutions and related product compositions |
KR20210006916A (ko) * | 2018-05-07 | 2021-01-19 | 젠와인 바이오테크놀로지 게엠바하 | 미생물 발효에 의해 수득된 탄수화물로부터 락토-N-네오테트라오스 (LNnT)를 정제하기 위한 간단한 방법 |
KR20210013138A (ko) * | 2018-05-23 | 2021-02-03 | 디에스엠 아이피 어셋츠 비.브이. | 올리고당의 제조 |
CN112888317A (zh) * | 2018-08-08 | 2021-06-01 | 马斯公司 | 含低聚糖的宠物食品及使用方法 |
AU2019362595A1 (en) | 2018-10-18 | 2021-04-29 | Basf Se | Crystalline form II of 2'-O-fucosyllactose, process for its preparation, nutritional, cosmetic or pharmaceutical formulation containing the same |
EP3741770A1 (en) * | 2019-05-21 | 2020-11-25 | Jennewein Biotechnologie GmbH | Purification of oligosaccharides from a fermentation broth by using filtration |
EP3750902A1 (en) * | 2019-06-14 | 2020-12-16 | Jennewein Biotechnologie GmbH | Process for the purification of lacto-n-neotetraose |
US20220273016A1 (en) * | 2019-07-18 | 2022-09-01 | The Regents Of The University Of California | Human milk oligosaccharides for control of dietary response and metabolic phenotype |
EP4034143A1 (en) | 2019-09-24 | 2022-08-03 | Prolacta Bioscience, Inc. | Compositions and methods for treatment of inflammatory and immune diseases |
CN110672756B (zh) * | 2019-11-07 | 2020-12-29 | 江南大学 | 一种奶粉中2’-岩藻糖基乳糖含量的检测方法 |
BR112022014823A2 (pt) * | 2020-01-29 | 2022-10-04 | Dsm Ip Assets Bv | Processo para recuperação e purificação de oligosacarídeos do leite humano |
KR20220155595A (ko) * | 2020-03-20 | 2022-11-23 | 글리콤 에이/에스 | 고체 hmo 생성물을 제공하는 방법, 및 이에 의해 수득된 고체 hmo 생성물 |
MX2023001743A (es) | 2020-08-14 | 2023-04-21 | Prolacta Bioscience Inc | Composiciones de oligosacáridos de la leche humana para usarse con bacterioterapias. |
CN112526022A (zh) * | 2020-11-27 | 2021-03-19 | 内蒙古伊利实业集团股份有限公司 | 一种乳中母乳低聚糖的检测方法 |
WO2022155201A1 (en) | 2021-01-12 | 2022-07-21 | Prolacta Bioscience, Inc. | Synbiotic treatment regimens |
WO2023066907A1 (en) * | 2021-10-18 | 2023-04-27 | Dsm Ip Assets B.V. | A method for providing an amorphous hmo product by drying |
CN117003803A (zh) | 2022-05-07 | 2023-11-07 | 山东恒鲁生物科技有限公司 | 一种三糖的新晶型 |
CN115873051B (zh) | 2022-05-17 | 2024-06-25 | 山东恒鲁生物科技有限公司 | 三糖的新晶型 |
CN115073539B (zh) * | 2022-07-21 | 2023-06-16 | 南京工业大学 | 一种2’-岩藻糖基乳糖分离纯化的方法 |
CN115260255B (zh) * | 2022-08-30 | 2024-06-28 | 南京工业大学 | 一种利用模拟移动床分离纯化2’-岩藻糖基乳糖的方法 |
WO2024130119A2 (en) | 2022-12-16 | 2024-06-20 | Prolacta Bioscience, Inc. | Synbiotic compositions for short chain fatty acid production |
CN115838390A (zh) * | 2022-12-30 | 2023-03-24 | 保龄宝生物股份有限公司 | 一种利用三组分色谱分离技术制备高含量2′-岩藻糖基乳糖的方法 |
WO2024165630A1 (en) * | 2023-02-07 | 2024-08-15 | N.V. Nutricia | Nutritional composition with improved segregation resistance |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02286695A (ja) * | 1989-04-28 | 1990-11-26 | Sumitomo Heavy Ind Ltd | オリゴ糖の分離方法 |
JPH0779927B2 (ja) * | 1992-05-22 | 1995-08-30 | 川崎重工業株式会社 | 擬似移動床式液体クロマトオリゴ糖分離装置 |
JPH06253879A (ja) * | 1993-03-01 | 1994-09-13 | Snow Brand Milk Prod Co Ltd | グルクロン酸結合オリゴ糖の分離方法 |
DE4326665C2 (de) * | 1993-08-09 | 1995-07-13 | Biotest Pharma Gmbh | Verfahren zur Sterilfiltration von Milch |
JP3368389B2 (ja) | 1993-09-14 | 2003-01-20 | 雪印乳業株式会社 | シアル酸含有オリゴ糖の分離方法 |
FI962204A0 (fi) * | 1996-05-24 | 1996-05-24 | Cultor Oy | Foerfarande foer fraktionering av en loesning |
CN1242776A (zh) * | 1996-10-10 | 2000-01-26 | 尼澳斯技术股份有限公司 | 用超滤、反渗透和纳滤纯化糖类 |
CA2268168C (en) | 1996-10-10 | 2008-04-29 | Cytel Corporation | Carbohydrate purification using ultrafiltration, reverse osmosis and nanofiltration |
JP5219329B2 (ja) * | 2002-06-28 | 2013-06-26 | ネステク、リミテッド | 下痢の予防又は治療用の医薬組成物 |
EP1634599A1 (en) * | 2004-08-20 | 2006-03-15 | N.V. Nutricia | Iimmune stimulatory infant nutrition |
JP5184768B2 (ja) * | 2006-09-05 | 2013-04-17 | 株式会社林原 | トレハロース高含有糖液の回収方法並びに結晶トレハロースの製造方法 |
EP2293677B1 (en) * | 2008-06-13 | 2017-11-15 | N.V. Nutricia | Nutritional composition for infants delivered via caesarean section |
CN101367844A (zh) * | 2008-09-17 | 2009-02-18 | 无锡绿色分离应用技术研究所有限公司 | 一种从阿拉伯胶水解液中提取阿拉伯糖的方法 |
CN102459294A (zh) | 2009-04-07 | 2012-05-16 | 格礼卡姆股份公司 | 2’-o-岩藻糖基乳糖的合成 |
AU2009347610B2 (en) * | 2009-06-08 | 2013-02-21 | Chr. Hansen HMO GmbH | HMO synthesis |
CN101831475A (zh) * | 2010-03-24 | 2010-09-15 | 方煜宇 | 一种生产高纯度低聚半乳糖的方法 |
CA2798675A1 (en) * | 2010-06-01 | 2011-12-08 | Glycom A/S | Polymorphs of 2'-o-fucosyllactose and producing thereof |
EP2465507A1 (en) * | 2010-11-23 | 2012-06-20 | Nestec S.A. | Oligosaccharide composition for treating skin diseases |
JP6047505B2 (ja) | 2011-02-16 | 2016-12-21 | グリコシン リミテッド ライアビリティー カンパニー | 操作された細菌におけるヒト乳オリゴ糖の生合成 |
CN102676604A (zh) * | 2011-03-08 | 2012-09-19 | 保龄宝生物股份有限公司 | 一种连续模拟移动床色谱分离制备高纯度低聚半乳糖的方法 |
US9567361B2 (en) * | 2011-05-13 | 2017-02-14 | Glycosyn LLC | Use of purified 2′-fucosyllactose, 3-fucosyllactose and lactodifucotetraose as prebiotics |
CN103562214B9 (zh) * | 2011-05-13 | 2016-12-14 | 格力康公司 | 人乳寡糖(hmo)或其前体的多样化 |
WO2012156897A1 (en) * | 2011-05-13 | 2012-11-22 | Glycom A/S | METHOD FOR GENERATING HUMAN MILK OLIGOSACCHARIDES (HMOs) OR PRECURSORS THEREOF |
EP2526784A1 (en) * | 2011-05-24 | 2012-11-28 | Nestec S.A. | Milk oligosaccharide-galactooligosaccharide composition for infant formula containing the soluble oligosaccharide fraction present in milk, and having a low level of monosaccharides, and a process to produce the composition |
EP2861609A4 (en) | 2012-06-14 | 2015-11-04 | Glycom As | IMPROVING STABILITY AND PURITY AND INCREASING THE BIOAVAILABILITY OF HUMAN MILK OLIGOSACCHARIDES OR PRECURSORS OR MIXTURES THEREOF |
CN103113422B (zh) * | 2013-02-06 | 2015-06-10 | 广西轻工业科学技术研究院 | 一种用模拟流动床分离精制高纯度l-阿拉伯糖、d-木糖的方法 |
EP2857410A1 (en) | 2013-10-04 | 2015-04-08 | Jennewein Biotechnologie GmbH | Process for purification of 2´-fucosyllactose using simulated moving bed chromatography |
-
2013
- 2013-10-04 EP EP13187369.7A patent/EP2857410A1/en active Pending
-
2014
- 2014-10-02 US US15/027,047 patent/US10435427B2/en active Active
- 2014-10-02 CN CN201480054230.4A patent/CN105814070A/zh not_active Withdrawn
- 2014-10-02 CN CN201811603666.0A patent/CN109705175B/zh active Active
- 2014-10-02 BR BR112016007342-8A patent/BR112016007342B1/pt active IP Right Grant
- 2014-10-02 DK DK14777665.2T patent/DK3063159T3/da active
- 2014-10-02 RU RU2016109548A patent/RU2685537C2/ru active
- 2014-10-02 ES ES14777665T patent/ES2868249T3/es active Active
- 2014-10-02 MX MX2016004288A patent/MX2016004288A/es active IP Right Grant
- 2014-10-02 KR KR1020167008862A patent/KR102298281B1/ko active IP Right Grant
- 2014-10-02 JP JP2016520025A patent/JP6666243B2/ja active Active
- 2014-10-02 WO PCT/EP2014/071145 patent/WO2015049331A1/en active Application Filing
- 2014-10-02 PL PL14777665T patent/PL3063159T3/pl unknown
- 2014-10-02 EP EP14777665.2A patent/EP3063159B1/en active Active
-
2016
- 2016-04-01 PH PH12016500594A patent/PH12016500594A1/en unknown
- 2016-04-01 MX MX2020004844A patent/MX2020004844A/es unknown
-
2019
- 2019-06-13 US US16/440,100 patent/US11168105B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
KR102298281B1 (ko) | 2021-09-07 |
MX2020004844A (es) | 2020-10-20 |
RU2016109548A3 (da) | 2018-06-25 |
ES2868249T3 (es) | 2021-10-21 |
RU2016109548A (ru) | 2017-11-09 |
CN105814070A (zh) | 2016-07-27 |
US11168105B2 (en) | 2021-11-09 |
JP6666243B2 (ja) | 2020-03-13 |
BR112016007342A2 (pt) | 2017-08-01 |
MX2016004288A (es) | 2017-01-18 |
EP2857410A1 (en) | 2015-04-08 |
US20190292211A1 (en) | 2019-09-26 |
BR112016007342B1 (pt) | 2020-11-17 |
KR20160090791A (ko) | 2016-08-01 |
PL3063159T3 (pl) | 2021-07-19 |
WO2015049331A1 (en) | 2015-04-09 |
US20160237104A1 (en) | 2016-08-18 |
RU2685537C2 (ru) | 2019-04-22 |
JP2016535724A (ja) | 2016-11-17 |
EP3063159A1 (en) | 2016-09-07 |
CN109705175B (zh) | 2022-07-05 |
CN109705175A (zh) | 2019-05-03 |
EP3063159B1 (en) | 2021-04-07 |
PH12016500594A1 (en) | 2016-06-13 |
US10435427B2 (en) | 2019-10-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK3063159T3 (da) | Fremgangsmåde til oprensning af et neutralt humant mælkeoligosaccharid ved hjælp af kromatografi med simuleret bevægeligt leje | |
DK3824991T3 (da) | Fremgangsmåde til forberedelse af lithiumsulfat | |
DK3301115T3 (da) | Kontinuerlig flertrinsfremgangsmåde til oprensning af antistoffer | |
DK2900675T3 (da) | Fremgangsmåde til fremstilling af et thienopyrimidinderivat | |
DK3257546T3 (da) | Fremgangsmåde til fremstilling af et brugsklart kateter | |
DK3076967T3 (da) | Fremgangsmåder til behandling af residuelle symptomer på skizofreni | |
DK3611262T3 (da) | Fremgangsmåder til sekvensering af immunrepertoire | |
DK3454346T3 (da) | Anordning til cylotronfremstilling af technetium-99m | |
DK2895156T3 (da) | Fremgangsmåde til fremstilling af terapeutiske nanopartikler | |
DK2953904T3 (da) | Fremgangsmåde til kontrolleret fremstilling af et biocid | |
BR112013019150A2 (pt) | engenharia do âmbito da imunoglobulina | |
DK2708147T3 (da) | Fremgangsmåder til forøgelse af hjernefunktionalitet under anvendelse af 2-fucosyl-lactose | |
DK2854769T3 (da) | Fremgangsmåder til behandling af artritis | |
DK3010895T3 (da) | Fremgangsmåde til fremstilling af 4-propargyleret aminobenzoxazinoner | |
DK3007726T3 (da) | Fremgangsmåder til behandling af en tauopati | |
DK3680000T3 (da) | Fremgangsmåder til oprensning af antistoffer | |
DK3696824T3 (da) | Styring af et system til eluering af rubidium | |
DK2897611T3 (da) | Fremgangsmåder til behandling af hepatitis c | |
DK2822965T3 (da) | FREMGANGSMÅDE TIL BERIGELSE AF IgA | |
DK2728009T3 (da) | Fremgangsmåde til fremstilling af monosaccharider | |
DK2838907T3 (da) | Aminosteroider til behandlingen af en ptp1b-associeret sygdom | |
DK2985275T3 (da) | Fremgangsmåde til oprensning af beta-hydroxy-beta-methylsmørsyre | |
DK2906219T3 (da) | Orvepitant til behandling af kronisk pruritus | |
DK2908724T3 (da) | Fremgangsmåde til at følge udviklingen af en hjernelæsion | |
DK2897714T3 (da) | Fremgangsmåde til undervandstest af et filtreringssystem |