PL3063159T3 - Sposób oczyszczania neutralnego oligosacharydu mleka kobiecego przy użyciu chromatografii z symulowanym ruchomym złożem - Google Patents

Sposób oczyszczania neutralnego oligosacharydu mleka kobiecego przy użyciu chromatografii z symulowanym ruchomym złożem

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Publication number
PL3063159T3
PL3063159T3 PL14777665T PL14777665T PL3063159T3 PL 3063159 T3 PL3063159 T3 PL 3063159T3 PL 14777665 T PL14777665 T PL 14777665T PL 14777665 T PL14777665 T PL 14777665T PL 3063159 T3 PL3063159 T3 PL 3063159T3
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Poland
Prior art keywords
purification
moving bed
human milk
simulated moving
bed chromatography
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Application number
PL14777665T
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English (en)
Inventor
Stefan Jennewein
Markus HELFRICH
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Jennewein Biotechnologie Gmbh
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49293548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL3063159(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Jennewein Biotechnologie Gmbh filed Critical Jennewein Biotechnologie Gmbh
Publication of PL3063159T3 publication Critical patent/PL3063159T3/pl

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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/15—Vitamins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/40—Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1814—Recycling of the fraction to be distributed
    • B01D15/1821—Simulated moving beds
    • B01D15/185—Simulated moving beds characterised by the components to be separated
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/02—Reverse osmosis; Hyperfiltration ; Nanofiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/42—Electrodialysis; Electro-osmosis ; Electro-ultrafiltration; Membrane capacitive deionization
    • B01D61/422—Electrodialysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/06—Separation; Purification
    • C07H1/08—Separation; Purification from natural products
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
    • C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/16—Inorganic salts, minerals or trace elements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/04—Sulfur, selenium or tellurium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/18—Iodine; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/34—Copper; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nutrition Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Water Supply & Treatment (AREA)
  • Analytical Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Pediatric Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Nanotechnology (AREA)
  • Obesity (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
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PL14777665T 2013-10-04 2014-10-02 Sposób oczyszczania neutralnego oligosacharydu mleka kobiecego przy użyciu chromatografii z symulowanym ruchomym złożem PL3063159T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13187369.7A EP2857410A1 (en) 2013-10-04 2013-10-04 Process for purification of 2´-fucosyllactose using simulated moving bed chromatography
PCT/EP2014/071145 WO2015049331A1 (en) 2013-10-04 2014-10-02 Process for purification of a neutral human milk oligosaccharide using simulated moving bed chromatography
EP14777665.2A EP3063159B1 (en) 2013-10-04 2014-10-02 Process for purification of a neutral human milk oligosaccharide using simulated moving bed chromatography

Publications (1)

Publication Number Publication Date
PL3063159T3 true PL3063159T3 (pl) 2021-07-19

Family

ID=49293548

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14777665T PL3063159T3 (pl) 2013-10-04 2014-10-02 Sposób oczyszczania neutralnego oligosacharydu mleka kobiecego przy użyciu chromatografii z symulowanym ruchomym złożem

Country Status (13)

Country Link
US (2) US10435427B2 (pl)
EP (2) EP2857410A1 (pl)
JP (1) JP6666243B2 (pl)
KR (1) KR102298281B1 (pl)
CN (2) CN105814070A (pl)
BR (1) BR112016007342B1 (pl)
DK (1) DK3063159T3 (pl)
ES (1) ES2868249T3 (pl)
MX (2) MX373919B (pl)
PH (1) PH12016500594B1 (pl)
PL (1) PL3063159T3 (pl)
RU (1) RU2685537C2 (pl)
WO (1) WO2015049331A1 (pl)

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DK2896628T3 (en) 2014-01-20 2019-01-14 Jennewein Biotechnologie Gmbh Process for Effective Purification of Neutral Milk Oligosaccharides (HMOs) from Microbial Fermentation
WO2016063262A1 (en) 2014-10-24 2016-04-28 Glycom A/S MIXTURES OF HMOs
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EP4674526A3 (en) 2016-04-19 2026-04-01 Glycom A/S Separation of oligosaccharides from fermentation broth
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KR101979608B1 (ko) * 2017-04-17 2019-08-28 재단법인 탄소순환형 차세대 바이오매스 생산전환 기술연구단 푸코오스 분리방법 및 이를 위한 장치
US20200305488A1 (en) * 2017-07-07 2020-10-01 Societe Des Produitis Nestle S.A. Human milk fortifier
CN110914284B (zh) 2017-07-12 2025-01-07 格礼卡姆股份公司 包含中性单糖或寡糖和酸性非碳水化合物组分的无定形混合物
EP3450443A1 (en) * 2017-08-29 2019-03-06 Jennewein Biotechnologie GmbH Process for purifying sialylated oligosaccharides
WO2019050321A1 (ko) * 2017-09-07 2019-03-14 (주)프로테옴텍 다수의 검사선을 구비한 크로마토그래피용 스트립, 이를 포함하는 진단 키트 및 다수의 경쟁적 반응 측정 단계를 포함하는 정성, 반정량, 정량 분석방법
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KR20200096779A (ko) * 2017-12-08 2020-08-13 젠와인 바이오테크놀로지 게엠바하 분무건조된 인간 모유 올리고당 혼합물
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ES3040419T3 (en) 2017-12-08 2025-10-30 Chr Hansen Hmo Gmbh Spray-dried lacto-n-fucopentaose
PL3494805T3 (pl) 2017-12-08 2025-10-06 Chr. Hansen HMO GmbH Suszone rozpyłowo tetrasacharydy
PL3524067T3 (pl) 2018-02-08 2025-06-09 Chr. Hansen HMO GmbH Suszona rozpyłowo mieszanina oligosacharydów mleka ludzkiego
WO2019160922A1 (en) * 2018-02-19 2019-08-22 Dupont Nutrition Biosciences Aps Process for spray drying fucosyllactose solutions and related product compositions
EP3546060A1 (en) * 2018-03-27 2019-10-02 DuPont Nutrition Biosciences ApS Process for spray drying fucosyllactose solutions and related product compositions
JP7492458B2 (ja) * 2018-05-07 2024-05-29 クリスチャン・ハンセン・ハーエムオー・ゲーエムベーハー 微生物発酵によって得られた炭水化物からラクト－Ｎ－ネオテトラオース（ＬＮｎＴ）を精製するための簡素な方法
CN112154150A (zh) * 2018-05-23 2020-12-29 帝斯曼知识产权资产管理有限公司 寡糖的生产
CN112888317A (zh) * 2018-08-08 2021-06-01 马斯公司 含低聚糖的宠物食品及使用方法
WO2020079146A1 (en) 2018-10-18 2020-04-23 Basf Se Crystalline form ii of 2'-o-fucosyllactose, process for its preparation, nutritional, cosmetic or pharmaceutical formulation containing the same
WO2020128945A1 (en) 2018-12-19 2020-06-25 Glycom A/S Separation of oligosaccharides
EP3741770A1 (en) * 2019-05-21 2020-11-25 Jennewein Biotechnologie GmbH Purification of oligosaccharides from a fermentation broth by using filtration
EP3750902A1 (en) * 2019-06-14 2020-12-16 Jennewein Biotechnologie GmbH Process for the purification of lacto-n-neotetraose
US20220273016A1 (en) * 2019-07-18 2022-09-01 The Regents Of The University Of California Human milk oligosaccharides for control of dietary response and metabolic phenotype
TW202126317A (zh) 2019-09-24 2021-07-16 美商普拉塔生技公司 用於治療發炎和免疫疾病之組成物和方法
CN110672756B (zh) * 2019-11-07 2020-12-29 江南大学 一种奶粉中2’-岩藻糖基乳糖含量的检测方法
US20230074506A1 (en) * 2020-01-29 2023-03-09 Dsm Ip Assets B.V. Process for recovering & purifying human milk oligosaccharides
BR112022018578A2 (pt) * 2020-03-20 2022-11-08 Glycom As Métodos para fornecer um produto de hmo sólido e produtos de hmo sólido obtidos por meio deles
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CA3188645A1 (en) 2020-08-14 2022-02-17 Prolacta Bioscience, Inc. Human milk oligosaccharide compositions for use with bacteriotherapies
CN112526022A (zh) * 2020-11-27 2021-03-19 内蒙古伊利实业集团股份有限公司 一种乳中母乳低聚糖的检测方法
EP4277634A1 (en) 2021-01-12 2023-11-22 Prolacta Bioscience, Inc. Synbiotic treatment regimens
CN116940244A (zh) 2021-03-09 2023-10-24 菲仕兰坎皮纳荷兰公司 包含gos和hmo的水性组合物
CN117651602A (zh) * 2021-06-15 2024-03-05 帝斯曼知识产权资产管理有限公司 从发酵液中分离人乳寡糖
EP4418878A1 (en) * 2021-10-18 2024-08-28 DSM IP Assets B.V. A method for providing an amorphous hmo product by drying
CN117003803A (zh) 2022-05-07 2023-11-07 山东恒鲁生物科技有限公司 一种三糖的新晶型
CN115873051B (zh) 2022-05-17 2024-06-25 山东恒鲁生物科技有限公司 三糖的新晶型
CN115073539B (zh) * 2022-07-21 2023-06-16 南京工业大学 一种2’-岩藻糖基乳糖分离纯化的方法
CN115260255B (zh) * 2022-08-30 2024-06-28 南京工业大学 一种利用模拟移动床分离纯化2’-岩藻糖基乳糖的方法
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CN115856151B (zh) * 2022-12-27 2025-08-12 深圳市中科朗健生物技术有限公司 一种同时测定多种人乳低聚糖的高效液相色谱检测方法
US20240218084A1 (en) * 2022-12-28 2024-07-04 Heilongjiang Bayi Agricultural University Method for purifying fomes officinalis polysaccharide by sequential simulated moving chromatography
CN115838390A (zh) * 2022-12-30 2023-03-24 保龄宝生物股份有限公司 一种利用三组分色谱分离技术制备高含量2′-岩藻糖基乳糖的方法
WO2024165630A1 (en) * 2023-02-07 2024-08-15 N.V. Nutricia Nutritional composition with improved segregation resistance
KR20260002698A (ko) * 2023-04-19 2026-01-06 시에이치알. 한센 에이/에스 인간 모유 올리고당
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CN117089503B (zh) 2023-10-17 2024-01-02 保龄宝生物股份有限公司 一种大肠杆菌k-12 mg1655 blbyzt6及其应用
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EP3063159A1 (en) 2016-09-07
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