PL2970376T3 - Sposób oczyszczania białek zależnych od witaminy k za pomocą chromatografii anionowymiennej - Google Patents

Sposób oczyszczania białek zależnych od witaminy k za pomocą chromatografii anionowymiennej

Info

Publication number
PL2970376T3
PL2970376T3 PL14709972T PL14709972T PL2970376T3 PL 2970376 T3 PL2970376 T3 PL 2970376T3 PL 14709972 T PL14709972 T PL 14709972T PL 14709972 T PL14709972 T PL 14709972T PL 2970376 T3 PL2970376 T3 PL 2970376T3
Authority
PL
Poland
Prior art keywords
vitamin
anion exchange
exchange chromatography
purification method
dependent proteins
Prior art date
Application number
PL14709972T
Other languages
English (en)
Inventor
Artur Mitterer
Meinhard Hasslacher
Christian Fiedler
Dominik MITTERGRADNEGGER
Original Assignee
Baxalta Incorporated
Baxalta GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta Incorporated, Baxalta GmbH filed Critical Baxalta Incorporated
Publication of PL2970376T3 publication Critical patent/PL2970376T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/644—Coagulation factor IXa (3.4.21.22)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21022—Coagulation factor IXa (3.4.21.22)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
PL14709972T 2013-03-15 2014-03-14 Sposób oczyszczania białek zależnych od witaminy k za pomocą chromatografii anionowymiennej PL2970376T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792772P 2013-03-15 2013-03-15
PCT/EP2014/055120 WO2014140289A1 (en) 2013-03-15 2014-03-14 Purification method for vitamin k dependent proteins by anion exchange chromatography
EP14709972.5A EP2970376B1 (en) 2013-03-15 2014-03-14 Purification method for vitamin k dependent proteins by anion exchange chromatography

Publications (1)

Publication Number Publication Date
PL2970376T3 true PL2970376T3 (pl) 2018-10-31

Family

ID=50277247

Family Applications (1)

Application Number Title Priority Date Filing Date
PL14709972T PL2970376T3 (pl) 2013-03-15 2014-03-14 Sposób oczyszczania białek zależnych od witaminy k za pomocą chromatografii anionowymiennej

Country Status (12)

Country Link
US (1) US10202417B2 (pl)
EP (1) EP2970376B1 (pl)
JP (1) JP6571011B2 (pl)
AU (1) AU2014230101B2 (pl)
DK (1) DK2970376T3 (pl)
ES (1) ES2682928T3 (pl)
HU (1) HUE037677T2 (pl)
NZ (1) NZ629845A (pl)
PL (1) PL2970376T3 (pl)
SI (1) SI2970376T1 (pl)
TR (1) TR201808584T4 (pl)
WO (1) WO2014140289A1 (pl)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI684599B (zh) * 2014-08-12 2020-02-11 美商巴克斯歐塔公司 因子ｘ活化

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4981952A (en) 1988-10-04 1991-01-01 Eli Lilly And Company Method for the purification of vitamin K-dependent proteins
CA2143125C (en) 1992-08-27 2008-09-23 Koenraad Mertens Antibodies specific for a haemostatic protein, their use for isolating intact protein, haemostatic compositions devoid of proteolytic cleavage products of the protein
DE4406515C1 (de) * 1994-02-28 1995-10-19 Immuno Ag Verfahren zur Isolierung und Reinigung Vitamin K-abhängiger Proteine
US5714583A (en) 1995-06-07 1998-02-03 Genetics Institute, Inc. Factor IX purification methods
ES2340008T3 (es) 1997-02-14 2010-05-27 American Red Cross Expresion de factor ix humano activo en tejido mamario de animales transgenicos.
CN1250567C (zh) 2000-07-21 2006-04-12 财团法人化学及血清疗法研究所 钙离子结合蛋白的提纯方法
EP1797180A2 (en) * 2004-09-29 2007-06-20 Novo Nordisk Health Care AG Purification of a bulk of a factor vii polypeptide by fractionated elution from an anion-exchange material
ES2395544T3 (es) 2004-12-23 2013-02-13 Novo Nordisk Health Care Ag Reducción del contenido de contaminantes proteínicos en composiciones que comprenden una proteína dependiente de la vitamina K de interés
US20080268521A1 (en) 2005-09-01 2008-10-30 Novo Nordisk Healthcare A/G Purification of Coagulation Factor VII Polypeptides
FR2901796A1 (fr) 2006-05-31 2007-12-07 Lab Francais Du Fractionnement Procede d'extraction d'une ou de plusieurs proteines presentes dans du lait
FR2901707B1 (fr) 2006-05-31 2017-09-29 Lab Francais Du Fractionnement Composition de facteur vii recombinant ou transgenique, chaque molecule de facteur vii possedant deux sites de n-glycosylation a motifs glycanniques definis
WO2008104372A1 (en) * 2007-02-28 2008-09-04 Baxter International Inc. Method for the purification of recombinant blood coagulation factor ix enriched in sulfated and/or phosphorylated molecules
CN104193798A (zh) 2009-12-18 2014-12-10 Csl有限公司 纯化多肽的方法
MX336728B (es) * 2010-04-29 2016-01-27 Baxter Int Metodo de purificacion para proteinas de union de cation divalente en resina de intercambio anionico.
AU2012322948B2 (en) * 2011-10-14 2014-11-06 Takeda Pharmaceutical Company Limited Protein purification by anion exchange chromatography
JP6117219B2 (ja) 2011-10-14 2017-04-19 バクスアルタ ゲーエムベーハー 陰イオン交換クロマトグラフィによるタンパク質の精製方法

Also Published As

Publication number Publication date
JP6571011B2 (ja) 2019-09-04
EP2970376B1 (en) 2018-05-23
AU2014230101A1 (en) 2015-10-08
SI2970376T1 (sl) 2018-09-28
US20160039869A1 (en) 2016-02-11
HUE037677T2 (hu) 2018-09-28
WO2014140289A1 (en) 2014-09-18
AU2014230101B2 (en) 2018-04-19
EP2970376A1 (en) 2016-01-20
US10202417B2 (en) 2019-02-12
JP2016512215A (ja) 2016-04-25
HK1219285A1 (en) 2017-03-31
DK2970376T3 (en) 2018-07-02
TR201808584T4 (tr) 2018-07-23
NZ629845A (en) 2016-10-28
ES2682928T3 (es) 2018-09-24

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PL2970376T3 (pl) Sposób oczyszczania białek zależnych od witaminy k za pomocą chromatografii anionowymiennej