CN116940244A - 包含gos和hmo的水性组合物 - Google Patents
包含gos和hmo的水性组合物 Download PDFInfo
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- CN116940244A CN116940244A CN202280017753.6A CN202280017753A CN116940244A CN 116940244 A CN116940244 A CN 116940244A CN 202280017753 A CN202280017753 A CN 202280017753A CN 116940244 A CN116940244 A CN 116940244A
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- Prior art keywords
- oligosaccharides
- gos
- group
- fos
- combinations
- Prior art date
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- Pending
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Abstract
一种水性低聚糖组合物,其具有的固体含量为50‑80wt%,所述固体的45‑100wt%由以下项组成:(i)一种或多种低聚糖,其选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合,和(ii)一种或多种人乳低聚糖(HMO),其中(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)人乳低聚糖的重量比的范围为0.25‑600。
Description
本发明涉及包含至少一种人乳低聚糖(HMO)的微生物安全且储存稳定的水性组合物、其制备和用途。
人乳中含有多种不易消化的低聚糖。这些低聚糖是人乳提供的先天免疫系统中的主要成分。它们通过促进有益微生物群(如双歧杆菌和乳酸杆菌)的生长在健康肠道微生物群的发展中发挥着重要作用,并且在预防病原体和毒素的粘附中发挥着重要作用。
人乳中存在的低聚糖与家畜(例如奶牛)的乳中存在的低聚糖不同。人乳中存在超过100种不同的低聚糖,其中存在最丰富的低聚糖是岩藻糖基化乳糖如2’-岩藻糖基乳糖(2’-FL)和3-岩藻糖基乳糖(3-FL)、唾液酸化乳糖如3’-唾液乳糖(3’-SL)和6’-唾液乳糖(6’-SL)、以及四糖像乳糖-N-四糖(LNT)和乳糖-N-新四糖(LNnT)。存在最丰富的人乳低聚糖(HMO)是2’-FL。
为了将HMO添加到营养组合物中,特别是婴儿配方乳中,HMO的合成越来越受欢迎。合成涉及使用微生物转化乳糖,然后通过常规方法如色谱法、纳滤和/或电渗析进行分离和纯化。所得产物是含有HMO的糖浆,通常含有25wt%或更多,优选25-50wt%的HMO。为了减少微生物污染,特别是真菌生长,重要的是将糖浆浓缩至高于约70wt%的浓度,将其冷却,或将其转化为干燥(无定形或结晶)材料。然而,这样的浓缩或冷却可能导致部分HMO从糖浆中结晶出来,这意味着这样的糖浆是储存不稳定的。因此,将所得纯化的HMO糖浆进行结晶步骤或进行干燥(例如通过喷雾干燥、冷冻干燥或喷雾冷却)以形成粉末。
与人乳低聚糖一样,已知低聚半乳糖(GOS)和低聚果糖(FOS;其包括菊粉)也对成人和儿童的人体微生物群具有积极影响。
已经报告了GOS和FOS的各种生理功能,包括刺激肠道中双歧杆菌生长、支持正常肠道转运、促进自然防御、增强矿物质吸收以及刺激免疫功能和降低炎症的能力。
在本文件中,术语“GOS”或“低聚半乳糖”包括β-GOS、α-GOS及其组合,但是β-GOS是优选的GOS类型。
GOS,特别是β-GOS,因其促进双歧杆菌、乳酸杆菌和其他肠道细菌生长的益生元效应而受到了特别关注。因此,GOS通常用于婴儿配方乳、乳酸杆菌发酵饮料、酸奶、果汁和饮品中。
常规的β-GOS包含半乳糖单元和末端葡萄糖单元链,其通过半乳糖苷酶(β-半乳糖苷酶)催化的连续转半乳糖基化反应产生。这产生具有不同聚合度(DP)的低聚半乳糖的混合物,包含乳糖。典型的β-GOS制剂主要包含二糖至六糖。某些GOS组分在人母乳和牛初乳中天然存在。
用于生产常规的β-GOS的β-半乳糖苷酶是在许多微生物如环状芽孢杆菌(Bacillus circulans)、米曲霉(Aspergillus oryzae)、马克斯克鲁维酵母(Kluyveromyces marxianus)、脆壁克鲁维酵母(Kluyveromyces fragilis)、独特掷孢酵母(Sporobolomyces singularis)、发酵乳酸杆菌(Lactobacillus fermentum)和土生蝶孢银耳(Papiliotrema terrestris,也称为土生隐球菌(Cryptococcus Papiliotrematerrestris))中生产的那些酶。β-半乳糖苷酶在其三维结构上不同,导致糖苷键的立体选择性和区域选择性的形成。
酶促反应后,使用常规方法(例如使用纳滤或顺序模拟移动床(SSMB))分离和纯化β-GOS。所得产物是含GOS的糖浆,如果需要,可以对其进行干燥(例如通过喷雾干燥、冷冻干燥或喷雾冷却)以形成粉末。
α-低聚半乳糖(α-GOS)天然存在于各种植物中,如豌豆。
聚葡萄糖(PDX)是合成产生的葡萄糖单元的支化聚合物。聚葡萄糖是可溶性纤维的形式,并且已显示出健康益处。
低聚果糖(FOS)包含(β-连接的)果糖单元链,其DP或平均DP为2-250,优选2-100,甚至更优选10-60,并且最优选20-60。
低聚果糖(FOS)属于果聚糖类,是自然界中广泛存在的果糖的直链和支化聚合物。果聚糖是继淀粉之后最丰富的非结构天然多糖。在本文件中,术语“FOS”或“低聚果糖”包括菊粉、左聚糖、它们的低聚糖水解产物以及通过蔗糖(sucrose或saccharose)的酶促反式果糖基化获得的低聚果糖。
菊粉天然大量存在于常见蔬菜和谷物中,如菊苣、菊芋(topinambour)、洋葱和朝鲜蓟。菊粉的化学结构是(果糖)n或葡萄糖(果糖)n;表示由β(2-1)-键连接的n个果糖单元。平均聚合度(DP)可以为2-250,优选2-100,甚至更优选10-60,并且最优选20-60。
左聚糖型FOS与菊粉型FOS的不同之处在于果糖单元是β(2-6)连接的。
许多营养组合物,包括许多配方乳,是通过湿法共混成分,然后(喷雾)干燥来制备的。在湿法共混中固体(粉末状或结晶)HMO的计量需要通常不安装在湿法共混生产设备中的计量单元,或者需要将HMO溶解在水中的额外处理步骤。因此,使用湿法共混的制造商希望获得呈液体制剂的低聚糖和HMO而不是固体材料。
因此,本发明的一个问题是提供一种微生物安全且储存稳定的包含HMO的水性组合物。
现在已经令人惊讶地发现可以通过将含有HMO的糖浆与含有GOS、FOS和/或PDX的糖浆共混来解决该问题。已发现所得水性组合物是储存稳定的。所得液体组合物可以容易地在湿法共混工艺中计量。此外,这种水性组合物的使用不太复杂并且更可持续,因为它省去了结晶步骤和能量密集型干燥步骤。
因此,本发明涉及一种水性低聚糖组合物,其具有的固体含量为50-80wt%,优选70-75wt%。该固体含量中,45-100wt%、优选57-95wt%由以下项组成:
(i)一种或多种低聚糖,其选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合,和
(ii)一种或多种人乳低聚糖(HMO),
其中,(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)人乳低聚糖的重量比的范围为0.25-600,优选0.25-200,甚至更优选0.5-150,更优选1-100,甚至更优选2-50,并且最优选2-20。
在优选的实施例中,一种或多种低聚糖选自低聚半乳糖(GOS),和低聚半乳糖(GOS)与低聚果糖(FOS)和/或PDX(聚葡萄糖)的组合,甚至更优选地选自低聚半乳糖(GOS),并且最优选地选自β-低聚半乳糖(β-GOS)。
在一个实施例中,水性组合物包含GOS,优选β-GOS,与FOS和/或PDX组合,优选与FOS组合。在水性组合物中,GOS与FOS和/或PDX的重量比的范围优选为0.05-25,更优选1-20,甚至更优选2-20,更优选7-12,并且最优选约9。
GOS是具有不同链长、键类型和支化程度的碳水化合物的复杂混合物。GOS优选包含基于干重40-100wt%、更优选50-90wt%、并且最优选60-80wt%的低聚糖(DP≥3)。GOS可以进一步含有单糖像葡萄糖和半乳糖,以及二糖如乳糖、乳果糖和异乳糖。乳糖含量的范围通常为0-60wt%,优选0-40wt%,并且最优选0-30wt%;单糖含量的范围通常为0-10wt%;基于干重。
本文件中提及的任何重量百分比GOS是指存在于所述GOS中的二糖和低聚糖(即DP≥2),包括乳糖的重量。但是并不包括单糖,例如葡萄糖和半乳糖。
文件中提到的重量比也是如此:对于重量比的计算,不包括单糖,但考虑了GOS中存在的所有较长糖(即DP≥2),包括乳糖。
例如,取决于HMO的类型及其在人母乳中的浓度,(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的至少一种低聚糖与(ii)人乳低聚糖的重量比的范围优选为0.25-600,优选0.25-200,甚至更优选0.5-150,更优选1-100,甚至更优选2-50,并且最优选2-20。
人乳低聚糖优选选自由以下组成的组:岩藻糖基化乳糖、唾液酸化乳糖、四糖及其组合,优选选自由以下组成的组:2’-岩藻糖基乳糖(2’-FL)、3-岩藻糖基乳糖(3-FL)、3’-唾液乳糖(3’-SL)、6’-唾液乳糖(6’-SL)、乳糖-N-四糖(LNT)、乳糖-N-新四糖(LNnT)及其组合,更优选为2’-岩藻糖基乳糖(2’-FL)或2’-FL与一种或多种额外的HMO的组合,最优选为2’-FL。
如果水性组合物包含2’-FL,则(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)2’-FL的重量比的范围优选为1-20,优选1-7,甚至更优选1-4,最优选2-4。
如果水性组合物包含3-FL,则(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)3-FL的重量比的范围优选为1-60,优选1-20,甚至更优选1-4,最优选2-4。
如果水性组合物包含3’-SL,则(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)3’-SL的重量比的范围优选为4-400,优选7-300。
如果水性组合物包含6’-SL,则(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)6’-SL的重量比的范围优选为10-600,优选20-160。
如果水性组合物包含LNT,则(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)LNT的重量比的范围优选为1-20,优选1-7,甚至更优选1-4,最优选2-4。
如果水性组合物包含LNnT,则(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)LNnT的重量比的范围优选为1-100,优选1-50,甚至更优选1-8,最优选2-8。
根据本发明的水性组合物优选具有糖浆的形式,更优选具有在2500-3000mPa·s、2600-2900mPa·s、更优选2650-2850mPa·s、并且最优选2700-2800mPa·s范围内的粘度,如在20℃下以受控的剪切速率模式通过使用旋转流变仪测定的。在此温度下,组合物的粘度通常与剪切速率无关。
水性组合物优选具有3.0-4.0、优选3.2-3.8范围内的pH,这有助于获得微生物稳定性,这可以通过添加酸如柠檬酸来获得。
根据本发明的水性组合物可以通过将含有GOS的糖浆与至少一种含有HMO的糖浆在20℃-70℃、更优选40℃-60℃的优选共混温度下共混来制备,以防止HMO结晶。
根据本发明的水性组合物可适合用于制备包含HMO与GOS、FOS和/或PDX的组合的营养组合物。该水性组合物特别适合于通过湿法共混制备营养组合物。
在用于生产配方乳的湿法共混工艺中,将各种成分共混在一起、均质化、巴氏灭菌和喷雾干燥以生产粉末状产品。巴氏灭菌步骤可以破坏成分中可能存在的有害细菌。与干法共混工艺相比,湿法共混工艺对成分微生物质量的依赖要小得多。该方法还具有确保整个批次中营养物质均匀分布的优点。
在一个实施例中,将根据本发明的水性组合物干燥,优选喷雾干燥,以形成包含HMO以及GOS、FOS和/或PDX两者的粉末。首先提供包含两种类型组分的水性组合物的优点是允许(i)均质混合物和(ii)仅一个喷雾干燥步骤而不是两个--对于GOS/FOS/PDX至少一个,以及对于HMO至少一个--从而节省能源并降低碳足迹。
营养组合物的实例是配方乳。配方乳选自下组:婴儿配方乳、较大婴儿配方乳(follow-up formula)和成长型配方乳(growing-up formula)(也称为幼儿配方乳)。营养组合物的其他实例是用于成人(如患者或虚弱的老年人或希望增强其免疫系统或肠道健康的任何其他人)的组合物。
婴儿配方乳、新生儿配方乳或纯配方乳(just formula)(美式英语)或新生儿乳、婴儿乳或初乳(first milk)(英式英语)是为喂养12个月以下的新生儿和婴儿而设计和销售的加工食品,通常由粉末(与水混合)或液体(有或没有另外的水)制备用于奶瓶喂养或奶杯喂养。美国联邦食品、药品和化妆品法案(FFDCA)将婴儿配方乳定义为“由于其模拟人乳或其适合作为人乳的完全或部分替代品而声称或代表仅作为婴儿食品的特殊饮食用途的食品”。类似地,国际食品法典(Codex Alimentarius international food standards)(WHO和FAO)将婴儿配方乳定义为专门制造的母乳替代品,其本身满足婴儿在出生后前几个月直至引入适当的辅食喂养期间的营养需求。食品法典描述了婴儿配方乳的基本成分,包括脂质源、蛋白源、碳水化合物源、维生素和矿物质的量和规格的。
为了构成营养组合物,特别是配方乳,将根据本发明的水性组合物或由其获得的(喷雾)干燥的粉末与营养组合物的其他成分共混。就配方乳而言,这些成分包括至少一种蛋白质源、至少一种脂质源、维生素和矿物质。优选地,将水性组合物添加到所述成分的液体共混物中。
用于配方乳的脂质源可以是适合在配方乳中使用的任何脂质或脂肪。优选的脂肪源包括乳脂肪、红花籽油、蛋黄脂质、菜籽油、橄榄油、椰子油、棕榈仁油、大豆油、鱼油、棕榈油酸、高油酸葵花籽油和高油酸红花籽油、以及含有长链多不饱和脂肪酸的微生物发酵油。在一个实施例中,使用无水乳脂肪。脂质源也可以是源自这些油如棕榈油精、中链甘油三酯,和脂肪酸如花生四烯酸、亚油酸、棕榈酸、硬脂酸、二十二碳六烯酸、亚麻酸、油酸、月桂酸、癸酸、辛酸、己酸等的酯的级分形式。可以添加少量的含有大量预先形成的花生四烯酸和二十二碳六烯酸的油,如鱼油或微生物油。脂肪源优选地具有约5:1至约15:1;例如约8:1至约10:1的n-6与n-3脂肪酸比率。在特定方面,婴儿配方乳包含油混合物,该油混合物包含被酯化为三酰基甘油的棕榈酸,例如其中在三酰基甘油的sn-2位置被酯化的棕榈酸的量为按重量计10%至60%的总棕榈酸,并且在三酰基甘油的sn-1/sn-3位置被酯化的棕榈酸的量为按重量计30%至80%的总棕榈酸。
蛋白质源的实例包括乳,优选牛乳,和选自乳清蛋白浓缩物和血清蛋白浓缩物的乳清蛋白源。
优选地存在于配方乳中的维生素和矿物质的实例为维生素A、维生素B1、维生素B2、维生素B6、维生素B12、维生素E、维生素K、维生素C、维生素D、叶酸、肌醇、烟酸、生物素、泛酸、胆碱、钙、磷、碘、铁、镁、铜、锌、锰、氯化物、钾、钠、硒、铬、钼、牛磺酸和L-肉碱。矿物质通常以盐的形式添加。
如有必要,营养组合物可含有乳化剂和稳定剂,如大豆卵磷脂、单甘油和二甘油的柠檬酸酯等。营养组合物也可含有可能具有有益效果的其他物质,如乳铁蛋白、核苷酸、核苷、益生菌等。合适的益生菌包括乳酸菌(Lactobacteria)、乳酸双歧杆菌(Bifidobacterium lactis)如乳酸双歧杆菌Bb12、嗜热链球菌(Streptococcusthermophilus)、约氏乳酸杆菌(Lactobacillus johnsonii)La1、长双歧杆菌(Bifidobacterium longum)BL999、鼠李糖乳酸杆菌(Lactobacillus rhamnosus)LPR、鼠李糖乳酸杆菌(L.rhamnosus)GG、罗伊氏乳酸杆菌(Lactobacillus reuteri)、唾液乳酸杆菌(Lactobacillus salivarius)。这样的益生元是可商购的。
实例
使用两种GOS糖浆。第一糖浆的干物质(DM)含量为50wt%;第二糖浆的干物质含量为55wt%。
使用干物质含量为30wt%的2’-FL糖浆。
糖浆为澄清溶液。基于干物质,2’-FL糖浆含有96.7%(以白利糖度计)2’-FL,50%DM GOS糖浆包含71.1%(以白利糖度计)GOS,并且55% DM GOS糖浆包含71.6%(以白利糖度计)GOS(通过HPLC测定;见下文)。
糖浆按表1中列出的量共混。通过血清移液管将2’-FL糖浆添加到GOS糖浆中,同时在50℃下搅拌来进行共混。
在所有浓度线消失后(T0)、共混1小时后(T1)和共混2小时后(T2),取出30g样品。
混合过程中,pH和白利糖度保持不变,如表2所示。
使用旋转蒸发器在50℃、20rpm下通过蒸发将一些共混物浓缩至75%白利糖度的目标浓度。
作为对照,也使用相同的设置将50%和55% GOS糖浆以及2'-FL糖浆蒸发至75%白利糖度的目标浓度。
在20℃下储存至少8周后,所有这些浓缩样品均保持澄清溶液,但2’-FL糖浆除外,它显示出结晶。在4℃储存时进行了相同的观察。
通过HPLC分析样品。GOS通过指纹色谱中的5个特定GOS峰进行定量。作为参考标准,以至少5种不同的浓度使用GOS。制作GOS浓度相对于5个峰的总面积的校准曲线,并使用该校准曲线从峰的总面积计算样品中的GOS浓度。
表1
表2
表3
Claims (16)
1.一种水性低聚糖组合物,其具有的固体含量为50-80wt%,所述固体的45-100wt%由以下项组成:
(i)一种或多种低聚糖,其选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合,和
(ii)一种或多种人乳低聚糖(HMO),
其中,(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)人乳低聚糖的重量比的范围为0.25-600。
2.根据权利要求1所述的水性组合物,其中,该固体含量为70-75wt%。
3.根据权利要求1或2所述的水性组合物,其中,这些固体的57-95wt%由以下项组成:(i)一种或多种低聚糖,其选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合,和(ii)一种或多种人乳低聚糖(HMO)。
4.根据前述权利要求中任一项所述的水性组合物,其中,(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)人乳低聚糖的重量比的范围为0.25-200,优选0.5-150,最优选1-100。
5.根据前述权利要求中任一项所述的水性组合物,其中,该人乳低聚糖选自由以下组成的组:岩藻糖基化乳糖、唾液酸化乳糖、四糖及其组合,优选选自由以下组成的组:2’-岩藻糖基乳糖(2’-FL)、3-岩藻糖基乳糖(3-FL)、3’-唾液乳糖(3’-SL)、6’-唾液乳糖(6’-SL)、乳糖-N-四糖(LNT)、乳糖-N-新四糖(LNnT)及其组合,最优选为2’-岩藻糖基乳糖(2’-FL)。
6.根据前述权利要求中任一项所述的水性组合物,其中,该一种或多种低聚糖选自低聚半乳糖(GOS),和低聚半乳糖(GOS)与低聚果糖(FOS)和/或PDX(聚葡萄糖)的组合,甚至更优选地选自低聚半乳糖(GOS),并且最优选地选自β-低聚半乳糖(β-GOS)。
7.根据前述权利要求中任一项所述的水性组合物,其中,这些HMO中的至少一种为2’-FL,且(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)2’-FL的重量比为1-20,优选1-7,甚至更优选为1-4,最优选2-4。
8.根据前述权利要求中任一项所述的水性组合物,其中,这些HMO中的至少一种为3-FL,且(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)3-FL的重量比的范围为1-60,优选1-20,甚至更优选为1-4,最优选2-4。
9.根据前述权利要求中任一项所述的水性组合物,其中,这些HMO中的至少一种为3’-SL,且(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)3’-SL的重量比的范围为4-400,优选7-300。
10.根据前述权利要求中任一项所述的水性组合物,其中,这些HMO中的至少一种为6’-SL,且(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)6’-SL的重量比的范围为10-600,优选20-100。
11.根据前述权利要求中任一项所述的水性组合物,其中,这些HMO中的至少一种为LNT,且(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)LNT的重量比的范围为1-20,优选1-7,甚至更优选为1-4,最优选2-4。
12.根据前述权利要求中任一项所述的水性组合物,其中,这些HMO中的至少一种为LNnT,且(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)LNnT的重量比的范围为1-100,优选1-50,甚至更优选1-8,最优选2-8。
13.一种用于制备如前述权利要求中任一项所述的水性组合物的方法,其中将第一糖浆与至少一种另外的糖浆共混,该第一糖浆包含基于该糖浆的重量4.5-80wt%、优选20-79wt%、最优选30-50wt%的至少一种选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖,该至少一种另外的糖浆包含基于该糖浆的重量至少0.05-70wt%、优选25-70wt%的人乳低聚糖。
14.一种用于制备营养组合物的方法,该营养组合物包含(i)至少一种低聚糖,其选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合,和(ii)至少一种人乳低聚糖(HMO),该方法包括将根据权利要求1-12中任一项所述的水性组合物与液体组合物共混的步骤,该液体组合物包含该营养组合物的其他成分,所述营养组合物优选选自配方乳,如婴儿配方乳、较大婴儿配方乳或成长型配方乳。
15.一种粉末组合物,其包含45-100wt%的:
(i)一种或多种低聚糖,其选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合,和
(ii)一种或多种人乳低聚糖(HMO),
其中,(i)选自低聚半乳糖(GOS)、低聚果糖(FOS)、聚葡萄糖(PDX)及其组合的低聚糖与(ii)人乳低聚糖的重量比的范围为0.25-600。
16.一种用于制备根据权利要求15所述的粉末组合物的方法,该方法是通过干燥、优选喷雾干燥如权利要求1-12中任一项所述的水性组合物。
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