DK2855509T3 - NON-NATURAL CONSENSUS ALBUMIN BINDING DOMAINS - Google Patents

Info

Publication number

DK2855509T3

DK2855509T3 DK13793564.9T DK13793564T DK2855509T3 DK 2855509 T3 DK2855509 T3 DK 2855509T3 DK 13793564 T DK13793564 T DK 13793564T DK 2855509 T3 DK2855509 T3 DK 2855509T3

Authority

DK

Denmark

Prior art keywords

ala

lys

glu

leu

albumin

Prior art date

2012-05-25

Links

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• 102000009027 Albumins Human genes 0.000 title claims abstract description 149
• 108010088751 Albumins Proteins 0.000 title claims abstract description 149
• 230000027455 binding Effects 0.000 title claims abstract description 124
• 108091033319 polynucleotide Proteins 0.000 claims abstract description 37
• 102000040430 polynucleotide Human genes 0.000 claims abstract description 37
• 239000002157 polynucleotide Substances 0.000 claims abstract description 37
• 238000000034 method Methods 0.000 claims abstract description 31
• 108090000623 proteins and genes Proteins 0.000 claims description 73
• 102000004169 proteins and genes Human genes 0.000 claims description 67
• 150000001413 amino acids Chemical class 0.000 claims description 33
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• 125000003275 alpha amino acid group Chemical group 0.000 claims description 29
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• 238000006467 substitution reaction Methods 0.000 claims description 19
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• 230000005593 dissociations Effects 0.000 claims description 5
• 238000000338 in vitro Methods 0.000 claims description 5
• 239000008194 pharmaceutical composition Substances 0.000 claims description 5
• 229920001213 Polysorbate 20 Polymers 0.000 claims description 4
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims description 4
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• 108091008324 binding proteins Proteins 0.000 claims description 3
• UQLDLKMNUJERMK-UHFFFAOYSA-L di(octadecanoyloxy)lead Chemical compound [Pb+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O UQLDLKMNUJERMK-UHFFFAOYSA-L 0.000 claims description 3
• 239000003085 diluting agent Substances 0.000 claims description 3
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• 125000000539 amino acid group Chemical group 0.000 claims description 2
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• HILMIYALTUQTRC-XVKPBYJWSA-N Glu-Gly-Val Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](C(C)C)C(O)=O HILMIYALTUQTRC-XVKPBYJWSA-N 0.000 description 23
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