DK2491038T3 - Disubstituerede octahydropyrrolo [3,4-c]pyrroler som orexin receptormodulatorer - Google Patents

Disubstituerede octahydropyrrolo [3,4-c]pyrroler som orexin receptormodulatorer Download PDF

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Publication number
DK2491038T3
DK2491038T3 DK10773477.4T DK10773477T DK2491038T3 DK 2491038 T3 DK2491038 T3 DK 2491038T3 DK 10773477 T DK10773477 T DK 10773477T DK 2491038 T3 DK2491038 T3 DK 2491038T3
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Prior art keywords
phenyl
triazol
carbonyl
hexahydropyrrolo
pyrrol
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DK10773477.4T
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Danish (da)
English (en)
Inventor
Wenying Chai
Michael A Letavic
Kiev S Ly
Daniel J Pippel
Dale A Rudolph
Brad M Savall
Chandravadan R Shah
Brock T Shireman
Akinola Soyode-Johnson
Emily M Stocking
Devin M Swanson
Kathleen C Strother
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Janssen Pharmaceutica Nv
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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DK10773477.4T 2009-10-23 2010-10-21 Disubstituerede octahydropyrrolo [3,4-c]pyrroler som orexin receptormodulatorer DK2491038T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25450909P 2009-10-23 2009-10-23
PCT/US2010/053606 WO2011050198A1 (en) 2009-10-23 2010-10-21 Disubstituted octahy - dropyrrolo [3,4-c] pyrroles as orexin receptor modulators

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DK2491038T3 true DK2491038T3 (da) 2016-07-18

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DK16163733.5T DK3093291T3 (da) 2009-10-23 2010-10-21 Disubstituerede octahy-dropyrrolo [3,4-c]pyrroler som orexinreceptormodulatorer
DK10773477.4T DK2491038T3 (da) 2009-10-23 2010-10-21 Disubstituerede octahydropyrrolo [3,4-c]pyrroler som orexin receptormodulatorer

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US (8) US8653263B2 (OSRAM)
EP (3) EP2491038B1 (OSRAM)
JP (1) JP5759470B2 (OSRAM)
KR (3) KR101859400B1 (OSRAM)
CN (1) CN102781942B (OSRAM)
AR (2) AR078731A1 (OSRAM)
AU (2) AU2010310595B2 (OSRAM)
BR (1) BR112012010820B1 (OSRAM)
CA (1) CA2778484C (OSRAM)
CL (1) CL2010001162A1 (OSRAM)
CO (1) CO6541572A2 (OSRAM)
CR (1) CR20120273A (OSRAM)
CY (2) CY1117743T1 (OSRAM)
DK (2) DK3093291T3 (OSRAM)
EA (1) EA022766B1 (OSRAM)
EC (1) ECSP12011908A (OSRAM)
ES (2) ES2735411T3 (OSRAM)
HR (2) HRP20160781T1 (OSRAM)
HU (2) HUE043962T2 (OSRAM)
IL (1) IL219234A (OSRAM)
JO (2) JO3267B1 (OSRAM)
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NI (1) NI201200062A (OSRAM)
NZ (1) NZ599629A (OSRAM)
PE (1) PE20110404A1 (OSRAM)
PH (1) PH12012500796A1 (OSRAM)
PL (2) PL3093291T3 (OSRAM)
PT (2) PT3093291T (OSRAM)
RS (2) RS59004B1 (OSRAM)
SI (2) SI3093291T1 (OSRAM)
SM (2) SMT201900392T1 (OSRAM)
TR (1) TR201910327T4 (OSRAM)
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UA (1) UA107812C2 (OSRAM)
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WO2012145581A1 (en) 2011-04-20 2012-10-26 Janssen Pharmaceutica Nv Disubstituted octahy-dropyrrolo [3,4-c] pyrroles as orexin receptor modulators
US8501768B2 (en) * 2011-05-17 2013-08-06 Hoffmann-La Roche Inc. Hexahydrocyclopentapyrrolone, hexahydropyrrolopyrrolone, octahydropyrrolopyridinone and octahydropyridinone compounds
KR101676930B1 (ko) 2011-11-08 2016-11-16 액테리온 파마슈티칼 리미티드 오렉신 수용체 길항제로서의 ２-(１,２,３-트리아졸-２-일)벤즈아미드 및 ３-(１,２,３-트리아졸-２-일)피콜린아미드 유도체
US9440982B2 (en) 2012-02-07 2016-09-13 Eolas Therapeutics, Inc. Substituted prolines/piperidines as orexin receptor antagonists
ES2672732T3 (es) 2012-02-07 2018-06-15 Eolas Therapeutics Inc. Prolinas/piperidinas sustituidas como antagonistas del receptor de orexina
MY169986A (en) 2012-06-04 2019-06-19 Idorsia Pharmaceuticals Ltd Benzimidazole-proline derivatives
CA2882132C (en) * 2012-08-16 2021-07-06 The Scripps Research Institute Kappa opioid ligands
AR092955A1 (es) 2012-10-10 2015-05-06 Actelion Pharmaceuticals Ltd Antagonistas de receptores de orexina los cuales son derivados de [orto bi-(hetero-)aril]-[2-(meta bi-(hetero-)aril)-pirrolidin-1-il]-metanona
CN103012293A (zh) * 2012-12-13 2013-04-03 同济大学 一种抗失眠药物mk-4305中间体的合成方法
WO2014141065A1 (en) 2013-03-12 2014-09-18 Actelion Pharmaceuticals Ltd Azetidine amide derivatives as orexin receptor antagonists
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