DK2383295T3 - Ip-10-antistoffer og anvendelser heraf - Google Patents
Ip-10-antistoffer og anvendelser heraf Download PDFInfo
- Publication number
- DK2383295T3 DK2383295T3 DK11166104.7T DK11166104T DK2383295T3 DK 2383295 T3 DK2383295 T3 DK 2383295T3 DK 11166104 T DK11166104 T DK 11166104T DK 2383295 T3 DK2383295 T3 DK 2383295T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibody
- seq
- ser
- variable region
- chain variable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/521—Chemokines
- C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Psychology (AREA)
Claims (15)
- IP-10-ANTISTOFFER OG ANVENDEFSER HERAF1. Isoleret humant monoklonalt antistof, eller en antigenbindende del deraf, hvor antistoffet specifikt binder til human IP-10 og ikke krydsreagerer med human MIG og ikke krydsreagerer med human ITAC.
- 2. Antistof ifølge krav 1, der er et fuldlængdeantistof af en IgGl- eller IgG4-isotype eller er et antistoffragment.
- 3. Antistof eller antigen-bindende del ifølge krav 1, omfattende en tungkæde variabel region, der omfatter CDR1-, CDR2- og CDR3-sekvenser og en letkædevariabel region, der omfatter CDR1-, CDR2- og CDR3-sekvenser, hvor: (a) tungkædevariabel region CDR3-sekvensen omfatter aminosyresekvensen af SEQ ID NO: 32, og tungkædevariabel region CDR3-sekvensen omfatter aminosyresekvensen af SEQ ID NO: 81; (b) tungkædevariabel region CDR3-sekvensen omfatter aminosyresekvenserne af SEQ ID NO: 24 og tungkædevariabel region CDR3-sekvensen omfatter aminosyresekvensen af SEQ ID NO: 73 eller (c) tungkædevariabel region CDR3-sekvensen omfatter aminosyresekvenserne af SEQ ID NO: 28 og tungkædevariabel region CDR3-sekvensen omfatter aminosyresekvensen af SEQ ID NO: 77.
- 4. Antistof eller antigenbindende del ifølge et hvilket som helst af kravene 1 til 3, omfattende: (a) en tungkædevariabel region CDR1 omfattende SEQ ID NO: 9, en tungkædevariabel region CDR2 omfattende SEQ ID NO: 21, en tungkædevariabel region CDR3 omfattende SEQ ID NO: 32, en letkædevariabel region CDR1 omfattende SEQ ID NO: 59, en letkædevariabel region CDR2 omfattende SEQ ID NO: 70 og en letkædevariabel region CDR3 omfattende SEQ ID NO: 81; (b) en tungkædevariabel region CDR1 omfattende SEQ ID NO: 1, en tungkædevariabel region CDR2 omfattende SEQ ID NO: 13, en tungkædevariabel region CDR3 omfattende SEQ ID NO: 24, en letkædevariabel region CDR1 omfattende SEQ ID NO: 51, en letkædevariabel region CDR2 omfattende SEQ ID NO: 62 og en letkædevariabel region CDR3 omfattende SEQ ID NO: 73; eller (c) en tungkædevariabel region CDR1 omfattende SEQ ID NO: 5, en tungkædevariabel region CDR2 omfattende SEQ ID NO: 17, en tungkædevariabel region CDR3 omfattende SEQ ID NO: 28, en letkædevariabel region CDR1 omfattende SEQ ID NO: 55, en letkædevariabel region CDR2 omfattende SEQ ID NO: 66 og en letkædevariabel region CDR3 omfattende SEQ ID NO: 77.
- 5. Antistof eller antigen-bindende del ifølge krav 1 eller 2, der konkurrerer om binding til IP-10 med antistoffet ifølge krav 4 eller der binder til samme epitop på IP-10 som antistof ifølge krav 4.
- 6. Immunokonjugat omfattende antistoffet eller den antigenbindende del ifølge et hvilket som helst af kravene 1 til 4 bundet til et terapeutisk middel såsom et cytotoxin eller en radioaktiv isotop.
- 7. Bispecifikt molekyle omfattende antistoffet eller den antigen-bindende del ifølge et hvilket som helst af kravene 1 til 4, bundet til en anden funktionsdel med en anden bindingsspecificitet end antistoffet eller den antigenbindende del.
- 8. Sammensætning omfattende antistoffet eller den antigenbindende del ifølge et hvilket som helst af kravene 1 til 4, immunokonjugat ifølge krav 6 eller bispecifikt molekyle ifølge krav 7 og et farmaceutisk acceptabelt bærestof.
- 9. Isoleret nukleinsyremolekyle, der koder for antistoffet eller den antigenbindende del ifølge et hvilket som helst af kravene 1 til 4, eller en ekspressionsvektor omfattende nukleinsyren, eller en værtscelle omfattende ekspressionsvektoren.
- 10. Transgen mus omfattende humane immunoglobulin tung- og letkædetransgener, hvor musen udtrykker antistoffet ifølge et hvilket som helst af kravene 1 til 4, eller et hybridom fremstillet ud fra musen, hvor hybridomet producerer antistoffet.
- 11. Antistof eller antigenbindende del ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til behandling af en inflammatorisk eller autoimmun sygdom.
- 12. Antistof eller antigenbindende del ifølge krav 11 til anvendelse i en fremgangsmåde til behandling ifølge krav 11, hvor sygdommen er udvalgt fra multipel sklerose, rheumatoid arthritis, inflammatorisk tarmsygdom (f.eks. ulcerativ colitis, Crohns sygdom), systemic lupus erythematosus, Type I diabetes, inflammatorisk hudsygdomme (f.eks. psoriasis, lichen pianus), autoimmun thyroidea-sygdom (f.eks. Graves' sygdom, Hashimotos thyroiditis), Sjogrens syndrom, lungeinflammation (f.eks. astma, kronisk obstruktiv lungesygdom, lungesarcoidose, lymfocytisk alveolitis), transplantatafstødning, rygmarvsskade, hjerneskade f.eks. apopleksi), neurodegenerative sygdomme f.eks. Alzheimers sygdom, Parkinsons sygdom), gingivitis, genterapiinduceret inflammation, angiogenesesygdomme, inflammatorisk nyresygdom f.eks. IgA-nephropati, membranoproliferativ glomerulonephritis, hurtigt progredierende glomerulonephritis) og atherosklerose.
- 13. Antistof eller antigenbindende del ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til behandling af en virus- eller bakterieinfektion, der involverer uønsket IP-10-aktivitet.
- 14. Antistof eller antigenbindende del ifølge krav 13 til anvendelse i en fremgangsmåde til behandling ifølge krav 13, hvor virusinfektionen er medieret ved humant immundefekt virus (HIV), hepatitis C virus (HCV), herpes simplex virus type I (HSV-1) eller SARS- (Severe Acute Respiratory Syndrome) virus.
- 15. Fremgangsmåde til fremstilling af antistoffet eller den antigenbindende del som defineret i krav 1 omfattende: (a) tilvejebringelse af: (i) en tungkædevariabel region-antistofsekvens omfattende en CDRl-sekvens, der er udvalgt fra SEQ ID NO: 5, 9 og 1, en CDR2-sekvens, der er udvalgt fra SEQ ID NO: 17, 21 og 13; og en CDR3-sekvens, der er udvalgt fra SEQ ID NO: 28, 32 og 24; eller (ii) en letkædevariabel region-antistofsekvens omfattende en CDRl-sekvens, der er udvalgt fra SEQ ID NO: 55, 59 og 51, en CDR2-sekvens, der er udvalgt fra SEQ ID NO: 66, 70 og 62 og en CDR3-sekvens der er udvalgt fra SEQ ID NO: 77, 81 og 73; (b) ændring af mindst én aminosyrerest i mindst én variabel region-antistofsekvens, hvilken sekvens er udvalgt fra tungkædevariabel region-antistofsekvensen og letkædevariabel region-antistofsekvensen, for at frembringe mindst én ændret antistof sekvens; og (c) ekspression af den ændrede antistofsekvens som et protein.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52918003P | 2003-12-10 | 2003-12-10 | |
EP04813771A EP1691837B1 (en) | 2003-12-10 | 2004-12-10 | Ip-10 antibodies and their uses |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2383295T3 true DK2383295T3 (da) | 2015-06-15 |
Family
ID=34699950
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11166104.7T DK2383295T3 (da) | 2003-12-10 | 2004-12-10 | Ip-10-antistoffer og anvendelser heraf |
DK04813771.5T DK1691837T3 (da) | 2003-12-10 | 2004-12-10 | IP-10-antistoffer og anvendelse heraf |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04813771.5T DK1691837T3 (da) | 2003-12-10 | 2004-12-10 | IP-10-antistoffer og anvendelse heraf |
Country Status (25)
Country | Link |
---|---|
US (4) | US20050191293A1 (da) |
EP (3) | EP1691837B1 (da) |
JP (2) | JP4942487B2 (da) |
KR (4) | KR101333449B1 (da) |
CN (2) | CN1889979B (da) |
AU (1) | AU2004298492B2 (da) |
BR (1) | BRPI0417429A (da) |
CA (1) | CA2548338C (da) |
CY (2) | CY1113096T1 (da) |
DK (2) | DK2383295T3 (da) |
ES (2) | ES2388435T3 (da) |
HK (3) | HK1163707A1 (da) |
HR (2) | HRP20120702T1 (da) |
HU (1) | HUE025328T2 (da) |
IL (1) | IL175855A (da) |
MX (1) | MXPA06005941A (da) |
NO (1) | NO342278B1 (da) |
NZ (1) | NZ547499A (da) |
PL (2) | PL1691837T3 (da) |
PT (2) | PT1691837E (da) |
RS (1) | RS53984B1 (da) |
RU (1) | RU2486199C2 (da) |
SI (2) | SI2383295T1 (da) |
WO (1) | WO2005058815A2 (da) |
ZA (1) | ZA200604620B (da) |
Families Citing this family (117)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10303974A1 (de) | 2003-01-31 | 2004-08-05 | Abbott Gmbh & Co. Kg | Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung |
US8597911B2 (en) * | 2003-06-11 | 2013-12-03 | Chugai Seiyaku Kabushiki Kaisha | Process for producing antibodies |
AR045563A1 (es) | 2003-09-10 | 2005-11-02 | Warner Lambert Co | Anticuerpos dirigidos a m-csf |
PL1691837T3 (pl) | 2003-12-10 | 2012-11-30 | Squibb & Sons Llc | IP-10 przeciwciała i ich zastosowanie |
RS51908B (en) * | 2004-02-06 | 2012-02-29 | University Of Massachusetts | CLOSTRIDIUM DIFFICILE TOXIN ANTIBODIES AND THEIR USES |
TW200714610A (en) | 2005-02-16 | 2007-04-16 | Univ Maryland | CXCR3 is a gliadin receptor |
WO2006106905A1 (ja) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | 会合制御によるポリペプチド製造方法 |
AU2006294663B2 (en) | 2005-09-26 | 2012-03-22 | Medarex, Inc. | Human monoclonal antibodies to CD70 |
CA2631195C (en) | 2005-11-30 | 2016-04-05 | Abbott Laboratories | Monoclonal antibodies against amyloid beta protein and uses thereof |
CN101432302A (zh) | 2005-11-30 | 2009-05-13 | 艾博特公司 | 抗-Aβ球聚体抗体,其抗原结合部分,相应的杂交瘤、核酸、载体、宿主细胞,生产所述抗体的方法,包含所述抗体的组合物,所述抗体的应用以及使用所述抗体的方法 |
AU2013200177B2 (en) * | 2005-11-30 | 2014-10-02 | Abbvie Deutschland Gmbh & Co Kg | Monoclonal antibodies against amyloid beta protein and uses thereof |
EP4218801A3 (en) | 2006-03-31 | 2023-08-23 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
US11046784B2 (en) * | 2006-03-31 | 2021-06-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
JP2010502220A (ja) | 2006-09-05 | 2010-01-28 | メダレックス インコーポレーティッド | 骨形態形成タンパク質およびその受容体に対する抗体ならびにその使用方法 |
WO2008044824A1 (en) * | 2006-10-13 | 2008-04-17 | Seoul National University Industry Foundation | Antibodies to ip-10 for treating bone diseases with bone destruction |
US8455626B2 (en) | 2006-11-30 | 2013-06-04 | Abbott Laboratories | Aβ conformer selective anti-aβ globulomer monoclonal antibodies |
AU2007333098A1 (en) * | 2006-12-14 | 2008-06-19 | Medarex, Inc. | Human antibodies that bind CD70 and uses thereof |
WO2008096359A2 (en) * | 2007-02-08 | 2008-08-14 | Rappaport Family Institute For Research In The Medical Sciences | Agents for the treatment of multiple sclerosis and methods of using same |
EP2124952A2 (en) | 2007-02-27 | 2009-12-02 | Abbott GmbH & Co. KG | Method for the treatment of amyloidoses |
AU2008219570B2 (en) * | 2007-02-28 | 2013-08-22 | Novimmune Sa | Human anti-IP-10 antibodies and uses thereof |
US8263064B2 (en) | 2007-06-04 | 2012-09-11 | Rappaport Family Institute For Research In The Medical Sciences | Method of suppressing disease severity of multiple sclerosis using chemokine CXC11 |
US9693539B2 (en) | 2007-08-10 | 2017-07-04 | E. R. Squibb & Sons, L.L.C. | HCO32 and HCO27 and related examples |
CN101970491A (zh) * | 2007-08-30 | 2011-02-09 | 沃尔特及伊莱萨霍尔医学研究院 | 树突状细胞标记物及其用途 |
ES2687808T3 (es) | 2007-09-26 | 2018-10-29 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
SI2202245T1 (sl) | 2007-09-26 | 2016-10-28 | Chugai Seiyaku Kabushiki Kaisha | Postopek modificiranja izoelektrične točke protitelesa preko aminokislinske substitucije v CDR |
PL2195017T3 (pl) * | 2007-10-01 | 2015-03-31 | Bristol Myers Squibb Co | Ludzkie antyciała, które wiążą mezotelinę i ich zastosowania |
SI2851374T1 (sl) * | 2007-12-14 | 2017-08-31 | Bristol-Myers Squibb Company | Vezavne molekule k humanemu ox40 receptorju |
US8802089B2 (en) | 2008-01-03 | 2014-08-12 | Genmab A/S | Monoclonal antibodies against CD32B |
PL2275443T3 (pl) * | 2008-04-11 | 2016-05-31 | Chugai Pharmaceutical Co Ltd | Cząsteczka wiążąca antygen zdolna do wiązania dwóch lub więcej cząsteczek antygenu w sposób powtarzalny |
PL2346994T3 (pl) * | 2008-09-30 | 2022-04-19 | Ablexis, Llc | Myszy knock-in do wytwarzania chimerycznych przeciwciał |
UA109633C2 (uk) | 2008-12-09 | 2015-09-25 | Антитіло людини проти тканинного фактора | |
WO2010103517A1 (en) | 2009-03-12 | 2010-09-16 | Rappaport Family Institute For Research In The Medical Sciences | Soluble compositions for the treatment of cxcr3-ligand associated diseases |
TWI544077B (zh) | 2009-03-19 | 2016-08-01 | Chugai Pharmaceutical Co Ltd | Antibody constant region change body |
JP5717624B2 (ja) | 2009-03-19 | 2015-05-13 | 中外製薬株式会社 | 抗体定常領域改変体 |
WO2010129351A1 (en) | 2009-04-28 | 2010-11-11 | Schepens Eye Research Institute | Method to identify and treat age-related macular degeneration |
PL2248825T3 (pl) * | 2009-05-04 | 2013-04-30 | Ribovax Biotechnologies Sa | Fragmenty przeciwciała wiążące antygen do zastosowania w leczeniu i diagnozowaniu chorób oczu |
US9445581B2 (en) | 2012-03-28 | 2016-09-20 | Kymab Limited | Animal models and therapeutic molecules |
HUE055817T2 (hu) | 2009-07-08 | 2021-12-28 | Kymab Ltd | Állatmodellek és terápiás molekulák |
EP2481752B1 (en) | 2009-09-24 | 2016-11-09 | Chugai Seiyaku Kabushiki Kaisha | Modified antibody constant regions |
WO2011108714A1 (ja) | 2010-03-04 | 2011-09-09 | 中外製薬株式会社 | 抗体定常領域改変体 |
JP6055312B2 (ja) | 2010-03-10 | 2017-01-11 | ゲンマブ エー/エス | C−metに対するモノクローナル抗体 |
CA3006800C (en) | 2010-03-31 | 2022-10-04 | Ablexis, Llc | Genetic engineering of non-human animals for the production of chimeric antibodies |
US8987419B2 (en) | 2010-04-15 | 2015-03-24 | AbbVie Deutschland GmbH & Co. KG | Amyloid-beta binding proteins |
CN106084053B (zh) | 2010-06-15 | 2020-01-17 | 根马布股份公司 | 针对组织因子的人抗体药物缀合物 |
MX358739B (es) | 2010-08-14 | 2018-09-03 | Abbvie Inc Star | Proteinas de union a amiloide beta. |
KR101398363B1 (ko) | 2010-11-17 | 2014-05-22 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
MX365235B (es) | 2010-11-30 | 2019-05-28 | Chugai Pharmaceutical Co Ltd | Molécula de unión a antígeno capaz de unir repetidamente a la pluralidad de moléculas de antígeno. |
PL2647707T3 (pl) | 2010-11-30 | 2019-02-28 | Chugai Seiyaku Kabushiki Kaisha | Środek terapeutyczny wywołujący cytotoksyczność |
CN102161982B (zh) * | 2011-03-09 | 2012-12-26 | 苏州大学 | 抗人cxcr3分子单抗及其应用 |
WO2012149320A1 (en) | 2011-04-29 | 2012-11-01 | Bristol-Myers Squibb Company | Ip-10 antibody dosage escalation regimens |
CN103945689B (zh) | 2011-09-19 | 2016-10-19 | 科马布有限公司 | 免疫球蛋白基因多样性的操纵及多抗体治疗剂 |
WO2013045916A1 (en) | 2011-09-26 | 2013-04-04 | Kymab Limited | Chimaeric surrogate light chains (slc) comprising human vpreb |
US9253965B2 (en) | 2012-03-28 | 2016-02-09 | Kymab Limited | Animal models and therapeutic molecules |
JP5963233B2 (ja) * | 2011-12-07 | 2016-08-03 | 学校法人 聖マリアンナ医科大学 | Htlv−1関連脊髄症を治療または予防するための医薬および前記医薬を用いた抗体療法の治療効果の確認方法 |
US10251377B2 (en) | 2012-03-28 | 2019-04-09 | Kymab Limited | Transgenic non-human vertebrate for the expression of class-switched, fully human, antibodies |
GB2502127A (en) | 2012-05-17 | 2013-11-20 | Kymab Ltd | Multivalent antibodies and in vivo methods for their production |
CN103417967B (zh) * | 2012-05-15 | 2017-05-10 | 中国医学科学院基础医学研究所 | Cxcl‑10抑制剂在制备治疗和/或预防肺损伤的药物中的用途 |
US9758591B2 (en) | 2012-08-24 | 2017-09-12 | The Regents Of The University Of California | Antibodies and vaccines for use in treating ROR1 cancers and inhibiting metastasis |
KR101452865B1 (ko) * | 2012-09-17 | 2014-10-21 | 서울대학교산학협력단 | 신규한 ip-10 에피토프 및 이에 대한 항체 |
US9788534B2 (en) | 2013-03-18 | 2017-10-17 | Kymab Limited | Animal models and therapeutic molecules |
US9783618B2 (en) | 2013-05-01 | 2017-10-10 | Kymab Limited | Manipulation of immunoglobulin gene diversity and multi-antibody therapeutics |
US9783593B2 (en) | 2013-05-02 | 2017-10-10 | Kymab Limited | Antibodies, variable domains and chains tailored for human use |
US11707056B2 (en) | 2013-05-02 | 2023-07-25 | Kymab Limited | Animals, repertoires and methods |
EP3050896B1 (en) | 2013-09-27 | 2021-07-07 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide heteromultimer |
SG10201802295XA (en) | 2013-10-01 | 2018-04-27 | Kymab Ltd | Animal Models and Therapeutic Molecules |
ES2899779T3 (es) * | 2014-12-05 | 2022-03-14 | Memorial Sloan Kettering Cancer Center | Receptores antigénicos quiméricos dirigidos a receptor acoplado a proteína G y usos de los mismos |
JP6676058B2 (ja) | 2015-01-14 | 2020-04-08 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | ヘテロアリーレン架橋したベンゾジアゼピン二量体、そのコンジュゲート、ならびに製造および使用方法 |
US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
JP2018536404A (ja) | 2015-11-09 | 2018-12-13 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Cho細胞において産生したポリペプチドの品質特性を操作する方法 |
WO2017095875A1 (en) | 2015-11-30 | 2017-06-08 | Bristol-Myers Squibb Company | Anti human ip-10 antibodies and their uses |
MX2018007479A (es) | 2015-12-21 | 2018-08-01 | Squibb Bristol Myers Co | Anticuerpos variantes para conjugacion especifica de sitio. |
MX2018007781A (es) | 2015-12-28 | 2018-09-05 | Chugai Pharmaceutical Co Ltd | Metodo para promover la eficiencia de purificacion del polipeptido que contiene la region de fragmento cristalizable (fc). |
CN109069665A (zh) | 2016-05-10 | 2018-12-21 | 百时美施贵宝公司 | 具有增强的稳定性的微管溶素类似物的抗体-药物缀合物 |
KR102531889B1 (ko) | 2016-06-20 | 2023-05-17 | 키맵 리미티드 | 항-pd-l1 및 il-2 사이토카인 |
MY196869A (en) | 2016-06-27 | 2023-05-05 | Univ California | Cancer treatment combinations |
CN109641911B (zh) | 2016-08-19 | 2023-02-21 | 百时美施贵宝公司 | seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法 |
RS65595B1 (sr) * | 2016-09-14 | 2024-06-28 | Teneoone Inc | Antitela koja vezuju cd3 |
US10398783B2 (en) | 2016-10-20 | 2019-09-03 | Bristol-Myers Squibb Company | Antiproliferative compounds and conjugates made therefrom |
BR112019008265A2 (pt) | 2016-11-28 | 2019-07-09 | Chugai Pharmaceutical Co Ltd | molécula de ligação ao ligante cuja atividade de li-gação ao ligante é ajustável |
US20180206726A1 (en) | 2016-12-07 | 2018-07-26 | Progenity Inc. | Gastrointestinal tract detection methods, devices and systems |
WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
EP3635097A1 (en) | 2017-06-05 | 2020-04-15 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
US10487084B2 (en) | 2017-08-16 | 2019-11-26 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor |
US10494370B2 (en) | 2017-08-16 | 2019-12-03 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor |
US10457681B2 (en) | 2017-08-16 | 2019-10-29 | Bristol_Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor |
US10508115B2 (en) | 2017-08-16 | 2019-12-17 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor |
US10472361B2 (en) | 2017-08-16 | 2019-11-12 | Bristol-Myers Squibb Company | Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor |
EP3679364A1 (en) | 2017-09-07 | 2020-07-15 | Bristol-Myers Squibb Company | Method of purity determination by capillary electrophoresis |
CN107656067B (zh) * | 2017-09-18 | 2019-11-15 | 上海交通大学医学院附属上海儿童医学中心 | 一种评估sle患儿总体疾病活动度和肾脏疾病活动度的检测方法及其应用 |
BR112020010450A2 (pt) | 2017-11-28 | 2020-11-24 | Chugai Seiyaku Kabushiki Kaisha | polipeptídeo que inclui domínio de ligação a antígeno e seção transportadora |
GB201803892D0 (en) * | 2018-03-12 | 2018-04-25 | Ultrahuman Six Ltd | C-met binding agents |
CN108531460B (zh) * | 2018-03-30 | 2020-07-14 | 四川迈克生物新材料技术有限公司 | 抗人IgM单克隆抗体、其杂交瘤细胞株及应用 |
WO2019209811A1 (en) | 2018-04-24 | 2019-10-31 | Bristol-Myers Squibb Company | Macrocyclic toll-like receptor 7 (tlr7) agonists |
TW202010755A (zh) | 2018-05-07 | 2020-03-16 | 丹麥商珍美寶股份有限公司 | 使用抗pd-1抗體與抗組織因子抗體-藥物共軛體之組合以治療癌症之方法 |
CN112368020B (zh) | 2018-05-07 | 2024-05-31 | 展马博联合股份有限公司 | 抗pd-1抗体和抗组织因子抗体-药物偶联物组合治疗癌症的方法 |
EA202092747A1 (ru) | 2018-05-29 | 2021-03-16 | Бристол-Маерс Сквибб Компани | Модифицированные саморазрушающиеся фрагменты для применения в пролекарствах и конъюгатах и способы применения и изготовления |
US11554120B2 (en) | 2018-08-03 | 2023-01-17 | Bristol-Myers Squibb Company | 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor |
TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子(vegf)抗體與抗組織因子(tf)抗體-藥物共軛體之組合以治療癌症之方法 |
EP3883635A1 (en) | 2018-11-19 | 2021-09-29 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
CN111228491B (zh) * | 2018-11-29 | 2022-07-01 | 中国人民解放军军事科学院军事医学研究院 | Ip-10抑制剂在预防和/或治疗寨卡病毒感染中的应用 |
ES2943474T3 (es) | 2018-11-30 | 2023-06-13 | Bristol Myers Squibb Co | Anticuerpo que comprende una extensión carboxiterminal de una cadena ligera que contiene glutamina, conjugados del mismo, y métodos y usos |
WO2020123425A2 (en) | 2018-12-12 | 2020-06-18 | Bristol-Myers Squibb Company | Antibodies modified for transglutaminase conjugation, conjugates thereof, and methods and uses |
GB201820554D0 (en) * | 2018-12-17 | 2019-01-30 | Univ Oxford Innovation Ltd | BTLA antibodies |
KR20220020810A (ko) | 2019-06-14 | 2022-02-21 | 테네오바이오, 인코포레이티드 | Cd22와 cd3에 결합하는 다중특이적 중쇄 항체 |
WO2021055306A1 (en) | 2019-09-16 | 2021-03-25 | Bristol-Myers Squibb Company | Dual capture method for analysis of antibody-drug conjugates |
BR112022004776A2 (pt) * | 2019-09-16 | 2022-06-21 | Opsidio Llc | Anticorpos anti-fator de células-tronco e métodos para uso dos mesmos |
IL292685A (en) | 2019-11-04 | 2022-07-01 | Seagen Inc | Anti-cd30 drug-antibody conjugates and their use in the treatment of HIV infection |
TW202131954A (zh) | 2019-11-07 | 2021-09-01 | 丹麥商珍美寶股份有限公司 | 利用鉑類劑與抗組織因子抗體-藥物共軛體之組合來治療癌症之方法 |
AU2020380732A1 (en) | 2019-11-07 | 2022-06-02 | Genmab A/S | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
CN115666704A (zh) | 2019-12-13 | 2023-01-31 | 比奥拉治疗股份有限公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
WO2022002940A1 (en) | 2020-06-29 | 2022-01-06 | Genmab A/S | Anti-tissue factor antibody-drug conjugates and their use in the treatment of cancer |
EP4247849A2 (en) | 2020-11-17 | 2023-09-27 | Seagen Inc. | Methods of treating cancer with a combination of tucatinib and an anti-pd-1/anti-pd-l1 antibody |
CN113603773B (zh) * | 2021-08-17 | 2023-05-09 | 中国医科大学附属第一医院 | 靶向淀粉样蛋白的单克隆抗体7b8、分泌该抗体的杂交瘤细胞株及应用 |
KR20240099363A (ko) | 2021-10-29 | 2024-06-28 | 씨젠 인크. | 항-pd-1 항체와 항-cd30 항체-약물 접합체의 조합을 사용하여 암을 치료하는 방법 |
CN114656561B (zh) * | 2022-03-05 | 2023-06-09 | 南京鼓楼医院 | 一种抗ip-10单克隆抗体 |
WO2023213960A1 (en) | 2022-05-06 | 2023-11-09 | Genmab A/S | Methods of treating cancer with anti-tissue factor antibody-drug conjugates |
JP7535164B1 (ja) | 2023-08-22 | 2024-08-15 | 星和電機株式会社 | バスバー保持具とそれを用いたバスバー組立体 |
Family Cites Families (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
US4475196A (en) | 1981-03-06 | 1984-10-02 | Zor Clair G | Instrument for locating faults in aircraft passenger reading light and attendant call control system |
US4447233A (en) | 1981-04-10 | 1984-05-08 | Parker-Hannifin Corporation | Medication infusion pump |
US4439196A (en) | 1982-03-18 | 1984-03-27 | Merck & Co., Inc. | Osmotic drug delivery system |
US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
US4447224A (en) | 1982-09-20 | 1984-05-08 | Infusaid Corporation | Variable flow implantable infusion apparatus |
US4487603A (en) | 1982-11-26 | 1984-12-11 | Cordis Corporation | Implantable microinfusion pump system |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4486194A (en) | 1983-06-08 | 1984-12-04 | James Ferrara | Therapeutic device for administering medicaments through the skin |
EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
US4954617A (en) | 1986-07-07 | 1990-09-04 | Trustees Of Dartmouth College | Monoclonal antibodies to FC receptors for immunoglobulin G on human mononuclear phagocytes |
US4881175A (en) | 1986-09-02 | 1989-11-14 | Genex Corporation | Computer based system and method for determining and displaying possible chemical structures for converting double- or multiple-chain polypeptides to single-chain polypeptides |
US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
DE3883899T3 (de) | 1987-03-18 | 1999-04-22 | Sb2, Inc., Danville, Calif. | Geänderte antikörper. |
US5013653A (en) | 1987-03-20 | 1991-05-07 | Creative Biomolecules, Inc. | Product and process for introduction of a hinge region into a fusion protein to facilitate cleavage |
DE3856559T2 (de) | 1987-05-21 | 2004-04-29 | Micromet Ag | Multifunktionelle Proteine mit vorbestimmter Zielsetzung |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5258498A (en) | 1987-05-21 | 1993-11-02 | Creative Biomolecules, Inc. | Polypeptide linkers for production of biosynthetic proteins |
US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
GB8809129D0 (en) | 1988-04-18 | 1988-05-18 | Celltech Ltd | Recombinant dna methods vectors and host cells |
US5476996A (en) | 1988-06-14 | 1995-12-19 | Lidak Pharmaceuticals | Human immune system in non-human animal |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
ATE135370T1 (de) | 1988-12-22 | 1996-03-15 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
JP3443119B2 (ja) * | 1989-08-07 | 2003-09-02 | ペプテック リミテッド | 腫瘍壊死因子結合リガンド |
US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6673986B1 (en) | 1990-01-12 | 2004-01-06 | Abgenix, Inc. | Generation of xenogeneic antibodies |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
US5877397A (en) | 1990-08-29 | 1999-03-02 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1994025585A1 (en) | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US6255458B1 (en) | 1990-08-29 | 2001-07-03 | Genpharm International | High affinity human antibodies and human antibodies against digoxin |
US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5874299A (en) | 1990-08-29 | 1999-02-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5789650A (en) | 1990-08-29 | 1998-08-04 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
EP0814159B1 (en) | 1990-08-29 | 2005-07-27 | GenPharm International, Inc. | Transgenic mice capable of producing heterologous antibodies |
US7084260B1 (en) * | 1996-10-10 | 2006-08-01 | Genpharm International, Inc. | High affinity human antibodies and human antibodies against human antigens |
US6300129B1 (en) | 1990-08-29 | 2001-10-09 | Genpharm International | Transgenic non-human animals for producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
CA2124967C (en) | 1991-12-17 | 2008-04-08 | Nils Lonberg | Transgenic non-human animals capable of producing heterologous antibodies |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
WO1993022332A2 (en) | 1992-04-24 | 1993-11-11 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
GB9223377D0 (en) | 1992-11-04 | 1992-12-23 | Medarex Inc | Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes |
WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
US5625825A (en) | 1993-10-21 | 1997-04-29 | Lsi Logic Corporation | Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
GB9621295D0 (en) * | 1995-12-07 | 1996-11-27 | Cambridge Antibody Tech | Specific binding members,materials and methods |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
DE69833755T2 (de) | 1997-05-21 | 2006-12-28 | Biovation Ltd. | Verfahren zur herstellung von nicht-immunogenen proteinen |
US6177545B1 (en) * | 1997-09-02 | 2001-01-23 | Insight Strategy & Marketing Ltd. | Heparanase specific molecular probes and their use in research and medical applications |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
ES2340112T3 (es) | 1998-04-20 | 2010-05-28 | Glycart Biotechnology Ag | Ingenieria de glicosilacion de anticuerpos para la mejora de la citotoxicidad celular dependiente de anticuerpos. |
PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
EP1151011A1 (en) * | 1999-01-29 | 2001-11-07 | Millennium Pharmaceuticals, Inc. | Anti-ccr1 antibodies and methods of use therefor |
CA2704600C (en) | 1999-04-09 | 2016-10-25 | Kyowa Hakko Kirin Co., Ltd. | A method for producing antibodies with increased adcc activity |
DE60037896D1 (de) | 1999-07-29 | 2008-03-13 | Medarex Inc | Menschliche antikörper gegen her2/neu |
JP3585399B2 (ja) * | 1999-07-30 | 2004-11-04 | 独立行政法人 科学技術振興機構 | 抗マウスtrailモノクローナル抗体 |
KR100942863B1 (ko) | 1999-08-24 | 2010-02-17 | 메다렉스, 인코포레이티드 | 인간 씨티엘에이-4 항체 및 그의 용도 |
US6652854B2 (en) * | 2000-08-08 | 2003-11-25 | Immunex Corporation | Methods for treating autoimmune and chronic inflammatory conditions using antagonists of CD30 or CD30L |
JP4864278B2 (ja) | 2000-08-18 | 2012-02-01 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 脱髄疾患を処置する方法 |
JP3523245B1 (ja) | 2000-11-30 | 2004-04-26 | メダレックス,インコーポレーテッド | ヒト抗体作製用トランスジェニック染色体導入齧歯動物 |
WO2002092780A2 (en) | 2001-05-17 | 2002-11-21 | Diversa Corporation | Novel antigen binding molecules for therapeutic, diagnostic, prophylactic, enzymatic, industrial, and agricultural applications, and methods for generating and screening thereof |
US20030166589A1 (en) * | 2001-06-05 | 2003-09-04 | Nathan Karin | Method and pharmaceutical composition for the treatment of multiple sclerosis |
AU2002316674B2 (en) | 2001-07-12 | 2007-09-13 | The Regents Of The University Of California | CXCL10 treatment of secondary tissue degeneration |
US20040096446A1 (en) | 2001-08-17 | 2004-05-20 | Lane Thomas E. | Methods for treating demyelinating diseases |
MXPA04003798A (es) | 2001-10-25 | 2004-07-30 | Genentech Inc | Composiciones de glicoproteina. |
US7442512B2 (en) * | 2001-11-30 | 2008-10-28 | Chemocentryx, Inc. | Compositions and methods for detecting and treating diseases and conditions related to chemokine receptors |
AU2003224604B2 (en) * | 2002-01-28 | 2007-06-14 | Medarex, Inc. | Human monoclonal antibodies to prostate specific membrane antigen (PSMA) |
US20040110226A1 (en) | 2002-03-01 | 2004-06-10 | Xencor | Antibody optimization |
US7498414B2 (en) * | 2002-03-04 | 2009-03-03 | Imclone Systems Incorporated | Human antibodies specific to KDR and uses thereof |
AU2003294290A1 (en) * | 2002-11-15 | 2004-06-15 | Morehouse School Of Medicine | Anti-chemokine and associated receptor antibodies and uses for inhibition of inflammation. |
WO2004101511A2 (en) * | 2003-05-09 | 2004-11-25 | Protein Design Labs, Inc | Anti-ip-10 antibodies and methods of using thereof for the treatment of inflamatory bowel diseases |
ATE501173T1 (de) * | 2003-12-04 | 2011-03-15 | Abbott Biotherapeutics Corp | Anti-ip-10-antikörper |
PL1691837T3 (pl) * | 2003-12-10 | 2012-11-30 | Squibb & Sons Llc | IP-10 przeciwciała i ich zastosowanie |
AU2008219570B2 (en) * | 2007-02-28 | 2013-08-22 | Novimmune Sa | Human anti-IP-10 antibodies and uses thereof |
WO2012149320A1 (en) | 2011-04-29 | 2012-11-01 | Bristol-Myers Squibb Company | Ip-10 antibody dosage escalation regimens |
-
2004
- 2004-12-10 PL PL04813771T patent/PL1691837T3/pl unknown
- 2004-12-10 DK DK11166104.7T patent/DK2383295T3/da active
- 2004-12-10 RU RU2006124611/10A patent/RU2486199C2/ru not_active IP Right Cessation
- 2004-12-10 SI SI200432240T patent/SI2383295T1/sl unknown
- 2004-12-10 PL PL11166104T patent/PL2383295T3/pl unknown
- 2004-12-10 DK DK04813771.5T patent/DK1691837T3/da active
- 2004-12-10 BR BRPI0417429-1A patent/BRPI0417429A/pt not_active IP Right Cessation
- 2004-12-10 SI SI200431929T patent/SI1691837T1/sl unknown
- 2004-12-10 KR KR1020127005738A patent/KR101333449B1/ko active IP Right Grant
- 2004-12-10 JP JP2006544041A patent/JP4942487B2/ja not_active Expired - Fee Related
- 2004-12-10 CN CN2004800368431A patent/CN1889979B/zh not_active Expired - Fee Related
- 2004-12-10 MX MXPA06005941A patent/MXPA06005941A/es active IP Right Grant
- 2004-12-10 ES ES04813771T patent/ES2388435T3/es active Active
- 2004-12-10 ZA ZA200604620A patent/ZA200604620B/en unknown
- 2004-12-10 KR KR1020067013685A patent/KR20060135690A/ko not_active Application Discontinuation
- 2004-12-10 US US11/009,731 patent/US20050191293A1/en not_active Abandoned
- 2004-12-10 WO PCT/US2004/041506 patent/WO2005058815A2/en active Application Filing
- 2004-12-10 KR KR1020127033449A patent/KR101374514B1/ko active IP Right Grant
- 2004-12-10 EP EP04813771A patent/EP1691837B1/en active Active
- 2004-12-10 RS RS20150285A patent/RS53984B1/en unknown
- 2004-12-10 HU HUE11166104A patent/HUE025328T2/en unknown
- 2004-12-10 NZ NZ547499A patent/NZ547499A/en unknown
- 2004-12-10 CA CA2548338A patent/CA2548338C/en not_active Expired - Fee Related
- 2004-12-10 EP EP20140191352 patent/EP2865687A1/en not_active Withdrawn
- 2004-12-10 AU AU2004298492A patent/AU2004298492B2/en not_active Ceased
- 2004-12-10 PT PT04813771T patent/PT1691837E/pt unknown
- 2004-12-10 ES ES11166104.7T patent/ES2537163T3/es active Active
- 2004-12-10 EP EP20110166104 patent/EP2383295B1/en active Active
- 2004-12-10 CN CN201210260781.9A patent/CN102838675B/zh not_active Expired - Fee Related
- 2004-12-10 PT PT111661047T patent/PT2383295E/pt unknown
- 2004-12-10 KR KR1020137029040A patent/KR20130133302A/ko not_active Application Discontinuation
-
2006
- 2006-05-23 IL IL175855A patent/IL175855A/en not_active IP Right Cessation
- 2006-06-08 NO NO20062630A patent/NO342278B1/no not_active IP Right Cessation
- 2006-08-31 HK HK12104279.0A patent/HK1163707A1/xx not_active IP Right Cessation
- 2006-08-31 HK HK06109717.7A patent/HK1087644A1/xx not_active IP Right Cessation
-
2009
- 2009-05-27 US US12/472,877 patent/US8258266B2/en active Active
-
2011
- 2011-12-15 JP JP2011274263A patent/JP5466691B2/ja not_active Expired - Fee Related
-
2012
- 2012-05-23 US US13/478,786 patent/US8945546B2/en active Active
- 2012-09-04 HR HRP20120702TT patent/HRP20120702T1/hr unknown
- 2012-09-05 CY CY20121100802T patent/CY1113096T1/el unknown
-
2014
- 2014-12-22 US US14/579,156 patent/US9994633B2/en active Active
-
2015
- 2015-04-20 HR HRP20150429TT patent/HRP20150429T1/hr unknown
- 2015-06-05 CY CY20151100500T patent/CY1116364T1/el unknown
- 2015-10-20 HK HK15110321.2A patent/HK1209759A1/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2383295T3 (da) | Ip-10-antistoffer og anvendelser heraf | |
DK1781705T3 (da) | Interferon-alpha-receptor-1-antistoffer og anvendelser heraf | |
WO2017095875A1 (en) | Anti human ip-10 antibodies and their uses | |
AU2011250741B2 (en) | IP-10 antibodies and their uses | |
AU2011236019B2 (en) | Interferon alpha receptor 1 antibodies and their uses | |
KR20070073790A (ko) | 아이아르티에이-4 항체 및 이의 용도 |