DK2120875T3 - Fremgangsmåde til terapeutisk administration af dhe med henblik på at muliggøre hurtig lindring af migræne samtidig med minimering af bivirkningsprofilen - Google Patents
Fremgangsmåde til terapeutisk administration af dhe med henblik på at muliggøre hurtig lindring af migræne samtidig med minimering af bivirkningsprofilen Download PDFInfo
- Publication number
- DK2120875T3 DK2120875T3 DK08725456.1T DK08725456T DK2120875T3 DK 2120875 T3 DK2120875 T3 DK 2120875T3 DK 08725456 T DK08725456 T DK 08725456T DK 2120875 T3 DK2120875 T3 DK 2120875T3
- Authority
- DK
- Denmark
- Prior art keywords
- dhe
- dihydroergotamine
- administration
- migraine
- cmax
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
- A61K31/10—Sulfides; Sulfoxides; Sulfones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Dispersion Chemistry (AREA)
Claims (11)
1. Forbindelse, der er dihydroergotamin eller et salt, et hydrat, en polymorf eller et ionpar deraf til anvendelse ved en fremgangsmåde til behandling af migræne hos et menneskeindivid; hvor behandlingen omfatter afgivelse via lungeinhalation ved hjælp af en indretning, som omfatter en tørpulverinhalator, forstøver, fordamper, tryksat inhalator til afmålte doser eller åndedrætsaktiveret tryksat inhalator til afmålte doser, af en samlet dosis af dihydroergotamin eller et salt, et hydrat, en polymorf eller et ionpar deraf på fra 0,1 til 10 mg pr. migræneanfald; og hvor dosen er i en fast eller flydende formulering eller aerosolformulering, der er tilpasset til administration ved hjælp af indretningen med henblik på at administrere dihydroergotaminet eller et salt, et hydrat, en polymorf eller et ionpar deraf ved en sådan hastighed, at topplasmakoncentrationen (Cmax) af dihydroergotamin er mindre end 15.000 pg/ml, og tiden til Cmax (T max) af dihydroergotamin er mindre end 20 minutter efter administration.
2. Forbindelse ifølge krav 1 til anvendelse ifølge krav 1, hvorTmax af dihydroergotamin er inden for 15 minutter efter administration.
3. Forbindelse ifølge krav 1 til anvendelse ifølge krav 1, hvor den samlede dosis ligger i intervallet fra 0,5 mg til 5,0 mg.
4. Forbindelse ifølge krav 1 til anvendelse ifølge krav 1, hvor dihydroergotaminet, saltet, hydratet, polymorfen eller ionparret deraf administreres i en enhedsdosis på mindre end 3,0 mg.
5. Forbindelse ifølge krav 1 til anvendelse ifølge krav 1, hvor den samlede dosis ligger i intervallet fra 1,0 mg til 2,0 mg.
6. Forbindelse ifølge krav 1 til anvendelse ifølge krav 1, hvor indretningen er en inhalatorindretning, som omfatter én eller flere enhedsdoser af en formulering af dihydroergotamin eller et salt, et hydrat, en polymorf eller et ionpar deraf, hvor hver enhedsdosis administreres ved en sådan hastighed, at Cmax er mindre end 10.000 pg/ml, og Tmax er mindre end 20 minutter efter administration.
7. Forbindelse ifølge krav 1 til anvendelse ifølge krav 1, hvilken forbindelse omfatter dihydroergotaminmesylat.
8. Forbindelse ifølge krav 1 til anvendelse ifølge krav 1, hvor fremgangsmåden omfatter administration af forbindelsen ved hjælp af en indretning, som omfatter en åndedrætsaktiveret tryksat inhalator til afmålte doser.
9. Forbindelse ifølge krav 1 til anvendelse ifølge krav 1, hvor fremgangsmåden omfatter administration af forbindelsen ved hjælp afen indretning, som omfatter en tørpulverinhalator.
10. Forbindelse ifølge krav 1 til anvendelse ifølge krav 1, hvor formuleringen administreres til individet ved hjælp afen åndedrætsaktiveret inhalator til afmålte doser, hvor dihydroergotaminet eller et salt, et hydrat, en polymorf eller et ionpar deraf administreres ved en sådan hastighed, at topplasmakoncentrationen af dihydroergotamin (Cmax) er mindre end 10.000 pg/ml koncentration, og tiden (T max ) efter administration, når topplasmakoncentrationen opnås, er mindre end 20 minutter efter administration, og hvor formuleringen administreres uden administration af et antiemetikum.
11. Anvendelse af en forbindelse, der er dihydroergotamin eller et salt, et hydrat, en polymorf eller et ionpar deraf ved fremstilling af et medikament til behandling af migræne hos et menneskeindivid; hvor behandlingen omfatter afgivelse via lungeinhalation ved hjælp afen indretning, som omfatter en tørpulverinhalator, forstøver, fordamper, tryksat inhalator til afmålte doser eller åndedrætsaktiveret tryksat inhalator til afmålte doser, af en samlet dosis af dihydroergotamin eller et salt, hydrat, polymorf eller ionpar deraf på fra 0,1 til 10 mg pr. migræneanfald; og hvor dosen er i en fast eller flydende formulering eller aerosolformulering, der er tilpasset til administration ved hjælp af indretningen med henblik på at afgive dihydroergotamin eller et salt, hydrat, polymorf eller ionpar deraf ved en sådan hastighed, at topplasmakoncentrationen (Cmax) af dihydroergotamin er mindre end 15.000 pg/ml, og tiden til Cmax (Tmax) af dihydroergotamin er mindre end 20 minutter efter administration.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90085007P | 2007-02-11 | 2007-02-11 | |
| PCT/US2008/001829 WO2008097664A1 (en) | 2007-02-11 | 2008-02-11 | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2120875T3 true DK2120875T3 (da) | 2018-10-22 |
Family
ID=39400937
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08725456.1T DK2120875T3 (da) | 2007-02-11 | 2008-02-11 | Fremgangsmåde til terapeutisk administration af dhe med henblik på at muliggøre hurtig lindring af migræne samtidig med minimering af bivirkningsprofilen |
| DK11191794.4T DK2425820T3 (da) | 2007-02-11 | 2008-02-11 | Fremgangsmåde til terapeutisk administration af dhe for at muliggøre hurtig lindring af migræne, mens bivirkningsprofilen minimeres |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11191794.4T DK2425820T3 (da) | 2007-02-11 | 2008-02-11 | Fremgangsmåde til terapeutisk administration af dhe for at muliggøre hurtig lindring af migræne, mens bivirkningsprofilen minimeres |
Country Status (19)
| Country | Link |
|---|---|
| US (10) | US8148377B2 (da) |
| EP (3) | EP2425820B1 (da) |
| JP (4) | JP5825757B2 (da) |
| KR (3) | KR20150041804A (da) |
| CN (2) | CN101677954A (da) |
| AU (3) | AU2008214205B2 (da) |
| CA (1) | CA2677838C (da) |
| CY (1) | CY1116546T1 (da) |
| DK (2) | DK2120875T3 (da) |
| ES (2) | ES2538082T3 (da) |
| HK (1) | HK1204918A1 (da) |
| HU (1) | HUE026884T2 (da) |
| IL (1) | IL200333A (da) |
| MX (1) | MX2009008582A (da) |
| PL (1) | PL2425820T3 (da) |
| PT (1) | PT2425820E (da) |
| SI (1) | SI2425820T1 (da) |
| WO (1) | WO2008097664A1 (da) |
| ZA (1) | ZA200905628B (da) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8022095B2 (en) * | 1996-08-16 | 2011-09-20 | Pozen, Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| CA2538237A1 (en) * | 2003-09-10 | 2005-03-24 | Map Pharmaceuticals, Inc. | Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation |
| EP2425820B1 (en) | 2007-02-11 | 2015-04-08 | MAP Pharmaceuticals Inc | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
| CN101980738A (zh) | 2008-02-07 | 2011-02-23 | 华盛顿大学 | 圆周气雾设备 |
| US20110082150A1 (en) * | 2008-02-11 | 2011-04-07 | Robert Owen Cook | Headache pre-emption by dihydroergotamine treatment during headache Precursor events |
| US20110171141A1 (en) * | 2009-06-26 | 2011-07-14 | Kellerman Donald J | Administration of dihydroergotamine mesylate particles using a metered dose inhaler |
| WO2011079313A1 (en) * | 2009-12-23 | 2011-06-30 | Map Pharmaceuticals, Inc. | Novel ergoline analogs |
| BR122021002471B8 (pt) | 2011-03-03 | 2022-10-25 | Impel Neuropharma Inc | Dispositivo de distribuição de droga nasal |
| RU2741249C2 (ru) | 2011-05-09 | 2021-01-22 | Импел Ньюрофарма Инк. | Наконечники для назальной доставки лекарственных средств |
| CN103827113A (zh) | 2011-06-23 | 2014-05-28 | Map药物公司 | 新型氟麦角碱类似物 |
| CA2859173A1 (en) | 2011-12-19 | 2013-06-27 | Map Pharmaceuticals, Inc. | Novel iso-ergoline derivatives |
| AU2012355983A1 (en) | 2011-12-21 | 2015-01-22 | Map Pharmaceuticals, Inc. | Novel neuromodulatory compounds |
| US9012640B2 (en) | 2012-06-22 | 2015-04-21 | Map Pharmaceuticals, Inc. | Cabergoline derivatives |
| US20140179707A1 (en) * | 2012-12-21 | 2014-06-26 | Map Pharmaceuticals, Inc. | Novel ergoline derivatives and uses thereof |
| WO2014100351A2 (en) | 2012-12-21 | 2014-06-26 | Map Pharmaceuticals, Inc. | 8'-hydroxy-dihydroergotamine compounds and compositions |
| WO2014100353A1 (en) * | 2012-12-21 | 2014-06-26 | Map Pharmaceuticals, Inc. | 8'-hydroxy-dihydroergotamine compounds and compositions |
| CA2909954C (en) | 2013-04-28 | 2021-03-23 | Impel Neuropharma, Inc. | Medical unit dose container |
| CA2998182A1 (en) | 2015-09-10 | 2017-03-16 | Impel Neuropharma, Inc. | In-line nasal delivery device |
| EP3713628A4 (en) | 2017-11-21 | 2021-08-18 | Impel Neuropharma Inc. | INTRA-NASAL DEVICE WITH DIVER TUBE |
| JP2021503988A (ja) | 2017-11-21 | 2021-02-15 | インペル ニューロファーマ インコーポレイテッド | インレットインターフェースを用いた鼻腔内装置 |
| CA3088942C (en) * | 2018-01-05 | 2023-01-03 | Impel Neuropharma, Inc. | Intranasal delivery of dihydroergotamine by precision olfactory device |
| KR20200118034A (ko) | 2018-01-05 | 2020-10-14 | 임펠 뉴로파마 인코포레이티드 | 정밀 후각기관 장치에 의한 올란자핀의 비강내 전달 |
| US11083712B1 (en) * | 2018-03-20 | 2021-08-10 | Relevale, Inc. | Low concentration delivery of an ergoline derivative for treatment of a headache |
| JP2021532098A (ja) | 2018-07-19 | 2021-11-25 | インペル ニューロファーマ インコーポレイテッド | パーキンソン病の治療のためのレボドパおよびドーパデカルボキシラーゼ阻害剤の呼吸管路送達 |
| CN113423400A (zh) * | 2018-12-11 | 2021-09-21 | 小蜜橘制药公司 | 用于治疗或预防头痛的组合物、装置和方法 |
| CN113473967B (zh) | 2019-01-03 | 2022-09-09 | 英倍尔制药公司 | 经鼻药物递送装置 |
| BR112021023049A8 (pt) | 2019-05-17 | 2022-10-18 | Impel Neuropharma Inc | Dispositivo de dispensação nasal de uso único |
| US11786512B2 (en) | 2019-09-23 | 2023-10-17 | Slayback Pharma Llc | Stable pharmaceutical compositions of dihydroergotamine mesylate |
| US20230043204A1 (en) * | 2019-12-23 | 2023-02-09 | Scienture, Inc. | Dihydroergotamine mesylate formulations and pre-filled injectors for therapeutic delivery of the same |
| CN115279371A (zh) * | 2020-01-14 | 2022-11-01 | 英倍尔制药公司 | 重复施用双氢麦角胺治疗频繁偏头痛 |
| CA3210442A1 (en) * | 2021-03-03 | 2022-09-09 | Jason M. Perry | Dihydroergotamine dry powder formulations and methods of use |
Family Cites Families (360)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US147389A (en) * | 1874-02-10 | Improvement in sawing-machines | ||
| US605674A (en) | 1898-06-14 | Combined pencil-case and comb-case | ||
| BE555319A (da) * | 1956-03-21 | 1900-01-01 | ||
| US2885427A (en) * | 1956-11-15 | 1959-05-05 | Dow Chemical Co | Fluorination of trichloroethylene |
| BE556587A (da) | 1957-01-31 | 1957-04-11 | ||
| US2865427A (en) | 1957-05-10 | 1958-12-23 | Robert E Garfield | Sliding automobile seat attachment |
| BE629985A (da) * | 1962-11-29 | |||
| US3320125A (en) * | 1964-04-28 | 1967-05-16 | Merck & Co Inc | Inhalation aerosol composition |
| US3261748A (en) * | 1964-07-17 | 1966-07-19 | Dow Chemical Co | 1,1,1,2-tetrafluoroethane anesthetic |
| GB1200886A (en) * | 1966-09-23 | 1970-08-05 | Allen & Hanburys Ltd | Phenylaminoethanol derivatives |
| GB1429184A (en) | 1972-04-20 | 1976-03-24 | Allen & Hanburys Ltd | Physically anti-inflammatory steroids for use in aerosols |
| US4044126A (en) * | 1972-04-20 | 1977-08-23 | Allen & Hanburys Limited | Steroidal aerosol compositions and process for the preparation thereof |
| US3897779A (en) * | 1973-06-27 | 1975-08-05 | American Cyanamid Co | Triamcinolone acetonide inhalation therapy |
| US3809294A (en) * | 1973-06-27 | 1974-05-07 | American Cyanamid Co | Dispensing lung contacting powdered medicaments |
| US3994421A (en) * | 1975-09-29 | 1976-11-30 | American Cyanamid Company | Unitary therapeutic aerosol dispenser |
| FI770215A (da) | 1976-01-30 | 1977-07-31 | Fisons Ltd | |
| US4405598A (en) | 1976-01-30 | 1983-09-20 | Fisons, Limited | Composition for treating asthma |
| NL7708731A (nl) | 1976-08-13 | 1978-02-15 | Montedison Spa | Werkwijze voor de bereiding van nieuwe drijf- middelsamenstellingen voor aerosolen. |
| JPS5325284A (en) | 1976-08-19 | 1978-03-08 | Daikin Ind Ltd | Aerosol composition |
| DE2750090A1 (de) * | 1976-11-19 | 1978-06-01 | Sandoz Ag | Neue verabreichungsformen fuer organische verbindungen |
| GB2001334B (en) | 1977-07-19 | 1982-03-03 | Fisons Ltd | Pressurised aerosol formulation |
| US4129603A (en) * | 1978-02-07 | 1978-12-12 | Imperial Chemical Industries Limited | Manufacture of halogenated compounds |
| US4241048A (en) | 1979-05-01 | 1980-12-23 | Bristol-Myers Company | Suspension composition of benzocaine |
| IT1121513B (it) | 1979-05-28 | 1986-04-02 | Chiesi Farma Spa | Processo per la conversione di umo steroide antiinfiammatorio in una forma suscettibile di essere somministarta come aerosol |
| JPS6034925B2 (ja) | 1979-07-31 | 1985-08-12 | 帝人株式会社 | 持続性鼻腔用製剤およびその製造法 |
| ZA81976B (en) | 1980-02-15 | 1982-07-28 | Glaxo Group Ltd | Androstane carbothioates |
| US4352789A (en) | 1980-03-17 | 1982-10-05 | Minnesota Mining And Manufacturing Company | Aerosol compositions containing finely divided solid materials |
| EP0050650A1 (en) | 1980-04-21 | 1982-05-05 | University Of Southern California | Prolonged action drug formulation |
| EP0039369B1 (en) | 1980-05-02 | 1983-06-15 | Schering Corporation | Beclomethasone ester solvates, process for their preparation, and preparation of a formulation |
| DE3017101C2 (de) | 1980-05-03 | 1983-07-21 | PS Pharma Maschinen und Geräte GmbH, 6800 Mannheim | Dragierwand |
| FI63672C (fi) | 1980-05-19 | 1983-08-10 | Orion Yhtymae Oy | Foerfarande foer framstaellning av en blandning av beklometasondipropionat och triklorfluormetan eller diklordifluormetan |
| US4311863A (en) | 1980-06-11 | 1982-01-19 | E. I. Du Pont De Nemours & Company | Process for the manufacture of 1,1,1,2-tetrafluoroethane |
| GB2078422B (en) | 1980-06-19 | 1983-12-21 | Standard Telephones Cables Ltd | Matrix addressing of display devices |
| US4710495A (en) | 1980-07-10 | 1987-12-01 | Otsuka Pharmaceutical Co., Ltd. | Soft steroids having anti-inflammatory activity |
| US4423099A (en) | 1980-07-28 | 1983-12-27 | Ciba-Geigy Corporation | Membrane modified hydrogels |
| AU548467B2 (en) | 1980-08-12 | 1985-12-12 | Glaxo Group Limited | Tryptamines and their isoindolylethyl derivatives |
| DE3274065D1 (de) | 1981-07-08 | 1986-12-11 | Draco Ab | Powder inhalator |
| DE3268533D1 (en) | 1981-07-24 | 1986-02-27 | Fisons Plc | Inhalation drugs, methods for their production and pharmaceutical formulations containing them |
| GB2105189B (en) | 1981-07-24 | 1985-03-20 | Fisons Plc | Inhalation drugs |
| KR890000664B1 (ko) | 1981-10-19 | 1989-03-22 | 바리 안소니 뉴우샘 | 미분된 베클로메타손 디프로피오네이트 일수화물의 제조방법 |
| JPS5921613A (ja) | 1982-07-28 | 1984-02-03 | Takeda Chem Ind Ltd | 直腸投与製剤 |
| US4659696A (en) | 1982-04-30 | 1987-04-21 | Takeda Chemical Industries, Ltd. | Pharmaceutical composition and its nasal or vaginal use |
| US4582731A (en) | 1983-09-01 | 1986-04-15 | Battelle Memorial Institute | Supercritical fluid molecular spray film deposition and powder formation |
| HU196752B (en) | 1983-12-06 | 1989-01-30 | Glaxo Group Ltd | Process for production of medical compositions containing indole-derivatives and these compounds |
| US4514574A (en) | 1984-01-09 | 1985-04-30 | The Dow Chemical Company | Process for separating isomeric mixtures |
| JPS60224638A (ja) | 1984-04-23 | 1985-11-09 | Kao Corp | 経皮吸収促進剤およびこれを含有する外用剤 |
| JPS60227805A (ja) | 1984-04-26 | 1985-11-13 | Mitsubishi Plastics Ind Ltd | 複合ダイヤフラム |
| US4629478A (en) | 1984-06-22 | 1986-12-16 | Georgia Tech Research Corporation | Monodisperse aerosol generator |
| IE59086B1 (en) | 1984-07-25 | 1994-01-12 | Hovione Int Ltd | Preparation and use of new solvates of beclomthasone 17,21-dipropionate |
| GB8432063D0 (en) | 1984-12-19 | 1985-01-30 | Riker Laboratories Inc | Physically modified steroids |
| GB8501015D0 (en) | 1985-01-16 | 1985-02-20 | Riker Laboratories Inc | Drug |
| US5069911A (en) | 1985-02-05 | 1991-12-03 | Sandoz Ltd. | Pharmaceutical 9,10-dihydrogenated ergot alkaloid containing compositions |
| US5192528A (en) * | 1985-05-22 | 1993-03-09 | Liposome Technology, Inc. | Corticosteroid inhalation treatment method |
| US5021428A (en) | 1985-07-02 | 1991-06-04 | Merrell Dow Pharmaceuticals Inc. | Novel chemical compounds for the prophylactic treatment of migraine |
| US4737384A (en) | 1985-11-01 | 1988-04-12 | Allied Corporation | Deposition of thin films using supercritical fluids |
| NZ221411A (en) | 1986-08-11 | 1989-10-27 | Innovata Biomed Ltd | Pharmaceutical compositions containing microcapsules and a surfactant |
| US5200413A (en) | 1987-01-05 | 1993-04-06 | Beecham Group P.L.C. | Indolyl carboxamides useful treating migraine, cluster headache, trigeminal neuralgia or emesis |
| US4767612A (en) | 1987-01-23 | 1988-08-30 | Rorer Pharmaceutical Corporation | Triamcinolone acetonide for the treatment of allergic rhinitis |
| US4851595A (en) | 1987-07-07 | 1989-07-25 | E. I. Du Pont De Nemours And Company | Liquid phase halogen exchange process for the manufacture of 1,1,1,2-tetrafluoroethane |
| IT1222509B (it) | 1987-08-17 | 1990-09-05 | Miat Spa | Insufflatore per la somministrazione di farmaci sotto forma di polvere predosata in opercoli |
| US5364863A (en) | 1987-09-08 | 1994-11-15 | Eli Lilly And Company | Specific 5-HT3 antagonists |
| US4963557A (en) | 1987-09-28 | 1990-10-16 | Smithkline Beecham Corporation | Immunomodulatory azaspiranes |
| EP0321607B1 (en) | 1987-12-21 | 1993-09-22 | Union Carbide Corporation | Supercritical fluids as diluents in liquid spray application of coatings |
| DE3744329A1 (de) | 1987-12-28 | 1989-07-06 | Schwarz Pharma Gmbh | Verfahren zur herstellung einer mindestens einen wirkstoff und einen traeger umfassenden zubereitung |
| JPH01176437A (ja) | 1987-12-29 | 1989-07-12 | Ono Pharmaceut Co Ltd | 有機物質の微粒化方法 |
| DE3823378A1 (de) | 1988-07-09 | 1990-01-11 | Knoll Ag | (s)-emopamil zur anwendung bei der behandlung von migraene |
| US5066522A (en) | 1988-07-14 | 1991-11-19 | Union Carbide Chemicals And Plastics Technology Corporation | Supercritical fluids as diluents in liquid spray applications of adhesives |
| US5206268A (en) | 1988-08-16 | 1993-04-27 | Burroughs Wellcome Co. | Medicaments |
| GB8820398D0 (en) | 1988-08-27 | 1988-09-28 | Fisons Plc | Pharmaceutical formulation |
| WO1990003782A2 (en) | 1988-10-05 | 1990-04-19 | The Upjohn Company | Finely divided solid crystalline powders via precipitation into an anti-solvent |
| US5707634A (en) | 1988-10-05 | 1998-01-13 | Pharmacia & Upjohn Company | Finely divided solid crystalline powders via precipitation into an anti-solvent |
| US5766573A (en) | 1988-12-06 | 1998-06-16 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| GB8828477D0 (en) | 1988-12-06 | 1989-01-05 | Riker Laboratories Inc | Medical aerosol formulations |
| US5225183A (en) | 1988-12-06 | 1993-07-06 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| GB8828544D0 (en) | 1988-12-07 | 1989-01-11 | Ici Plc | Chemical process |
| GB8900267D0 (en) | 1989-01-06 | 1989-03-08 | Riker Laboratories Inc | Narcotic analgesic formulations and apparatus containing same |
| US5011678A (en) | 1989-02-01 | 1991-04-30 | California Biotechnology Inc. | Composition and method for administration of pharmaceutically active substances |
| DE3905726A1 (de) | 1989-02-24 | 1990-08-30 | Hoechst Ag | Druckgaspackung und treibmittel fuer aerosole |
| GB8904370D0 (en) | 1989-02-25 | 1989-04-12 | Cosmas Damian Ltd | Liquid delivery compositions |
| SE466684B (sv) | 1989-03-07 | 1992-03-23 | Draco Ab | Anordning vid en inhalator samt foerfarande foer att med anordningen registrera medicinering med inhalator |
| GB8908250D0 (en) | 1989-04-12 | 1989-05-24 | Fisons Plc | Formulations |
| GB8909891D0 (en) | 1989-04-28 | 1989-06-14 | Riker Laboratories Inc | Device |
| ES2087911T3 (es) | 1989-04-28 | 1996-08-01 | Riker Laboratories Inc | Dispositivo de inhalacion de polvo seco. |
| US4945119A (en) | 1989-05-10 | 1990-07-31 | The Dow Chemical Company | Foaming system for rigid urethane and isocyanurate foams |
| US4940171A (en) | 1989-05-18 | 1990-07-10 | Gilroy Gordon C | Aerosol package having compressed gas propellant and vapor tap of minute size |
| US5176878A (en) | 1989-05-23 | 1993-01-05 | Teledyne Industries, Inc. | Zirconium-hafnium separation process |
| AU633584B2 (en) | 1989-06-15 | 1993-02-04 | Tokyo Tanabe Company Limited | Aerosols of pyrido(1,2-a)pyrimidine compounds |
| US5232707A (en) | 1989-07-10 | 1993-08-03 | Syntex (U.S.A.) Inc. | Solvent extraction process |
| US4916125A (en) | 1989-07-11 | 1990-04-10 | Sandoz Ltd. | Method of treating migraine |
| US5130137A (en) | 1989-08-09 | 1992-07-14 | The General Hospital Corporation | Continuous delivery of luteinizing hormone releasing hormone compositions in combination with sex steroid delivery for use in treating benign ovarian secretory disorders |
| DE69033389T2 (de) | 1989-08-18 | 2000-07-06 | Foster Miller Inc | Behälterbau |
| GB8918879D0 (en) | 1989-08-18 | 1989-09-27 | Danbiosyst Uk | Pharmaceutical compositions |
| US5225163A (en) | 1989-08-18 | 1993-07-06 | Angenics, Inc. | Reaction apparatus employing gravitational flow |
| US5238920A (en) | 1989-08-22 | 1993-08-24 | Abbott Laboratories | Pulmonary surfactant protein fragments |
| GB2235627B (en) | 1989-09-08 | 1993-09-01 | Glaxo Group Ltd | Inhalation medicaments for treating respiratory disorders |
| US5270305A (en) | 1989-09-08 | 1993-12-14 | Glaxo Group Limited | Medicaments |
| GB8921222D0 (en) | 1989-09-20 | 1989-11-08 | Riker Laboratories Inc | Medicinal aerosol formulations |
| US5178878A (en) | 1989-10-02 | 1993-01-12 | Cima Labs, Inc. | Effervescent dosage form with microparticles |
| US5223264A (en) | 1989-10-02 | 1993-06-29 | Cima Labs, Inc. | Pediatric effervescent dosage form |
| US5106659A (en) | 1989-10-04 | 1992-04-21 | Nordson Corporation | Method and apparatus for spraying a liquid coating containing supercritical fluid or liquified gas |
| US5439670A (en) | 1989-11-28 | 1995-08-08 | Riker Laboratories, Inc. | Medicinal aerosol formulations |
| GB9001635D0 (en) | 1990-01-24 | 1990-03-21 | Ganderton David | Aerosol carriers |
| US5376386A (en) | 1990-01-24 | 1994-12-27 | British Technology Group Limited | Aerosol carriers |
| DE4003270A1 (de) | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgase und ihre verwendung in arzneimittelzubereitungen |
| IL97065A (en) | 1990-02-02 | 1994-01-25 | Fisons Plc | Repellent preparations for aerosol |
| DE4003272A1 (de) | 1990-02-03 | 1991-08-08 | Boehringer Ingelheim Kg | Neue treibgasmischungen und ihre verwendung in arzneimittelzubereitungen |
| DE4004904A1 (de) | 1990-02-16 | 1990-09-13 | Gerhard Brendel | Trommel-applikator |
| US5118494A (en) | 1990-03-23 | 1992-06-02 | Minnesota Mining And Manufacturing Company | Use of soluble fluorosurfactants for the preparation of metered-dose aerosol formulations |
| DE69109284T2 (de) | 1990-03-23 | 1995-08-24 | Minnesota Mining & Mfg | Verwendung von fluorierten löslichen tensiden zur herstellung von aerosolarzneimitteln mit dosierter abgabe. |
| US4970093A (en) | 1990-04-12 | 1990-11-13 | University Of Colorado Foundation | Chemical deposition methods using supercritical fluid solutions |
| US5123924A (en) * | 1990-04-25 | 1992-06-23 | Spire Corporation | Surgical implants and method |
| JP3122671B2 (ja) | 1990-05-23 | 2001-01-09 | 協和醗酵工業株式会社 | 複素環式化合物 |
| YU48855B (sh) | 1990-06-07 | 2002-06-19 | The Wellcome Foundation Limited | Heterociklična jedinjenja i njihovi derivati koji su modifikatori dejstva 5-hidroksi-triptamina i postupak njihovog dobijanja |
| DE69112917T2 (de) | 1990-06-15 | 1996-05-15 | Merck & Co Inc | Kristallisationsverfahren zur Verbesserung der Kristallstruktur und -grösse. |
| US5273579A (en) | 1990-06-19 | 1993-12-28 | Mitsubishi Mining And Cement Co., Ltd. | Quick setting compositions |
| CA2020018A1 (en) | 1990-06-27 | 1991-12-28 | Don L. Simmons | Method and composition for treating the migraine complex |
| DE69101639T2 (de) | 1990-06-27 | 1994-10-06 | Minnesota Mining & Mfg | Anwendung von löslichen fluorhaltigen tensiden zur herstellung von aerosol-präparaten mit dosierter abgabe. |
| US5126123A (en) | 1990-06-28 | 1992-06-30 | Glaxo, Inc. | Aerosol drug formulations |
| PT98105B (pt) | 1990-06-28 | 1998-11-30 | Glaxo Inc | Processo para a preparacao de formulacoes em aerossol contendo como propulsor 1,1,1,2-tetrafluoroetano |
| EP0756275B1 (en) | 1990-06-29 | 1999-12-15 | Sony Corporation | Magneto-optical disc recording/reproducing system |
| HUT63554A (en) | 1990-06-29 | 1993-09-28 | Fisons Plc | Aerosol preparations under pressure |
| GB9017155D0 (en) | 1990-08-03 | 1990-09-19 | Ici Plc | Spray drying |
| US5292499A (en) | 1990-09-11 | 1994-03-08 | University Of Wales College Of Cardiff | Method of preparing medical aerosol formulations including drug dissolved in reverse micelles |
| US5230884A (en) | 1990-09-11 | 1993-07-27 | University Of Wales College Of Cardiff | Aerosol formulations including proteins and peptides solubilized in reverse micelles and process for making the aerosol formulations |
| MX9203481A (es) | 1990-10-18 | 1992-07-01 | Minnesota Mining & Mfg | Formulaciones. |
| ES2064160T3 (es) | 1990-10-18 | 1995-01-16 | Minnesota Mining & Mfg | Formulacion de aerosol que comprende 17,21-dipropionato de beclometasona. |
| GB9024365D0 (en) | 1990-11-09 | 1991-01-02 | Glaxo Group Ltd | Medicaments |
| GB9024366D0 (en) | 1990-11-09 | 1991-01-02 | Glaxo Group Ltd | Medicaments |
| US5919435A (en) | 1990-11-09 | 1999-07-06 | Glaxo Group Limited | Aerosol formulation containing a particulate medicament |
| US5254755A (en) | 1990-12-04 | 1993-10-19 | Allied-Signal Inc. | Partially fluorinated alkanols having a tertiary structure |
| DE4118230A1 (de) | 1990-12-20 | 1992-06-25 | Bayer Ag | Verfahren zur isolierung von polymeren aus ihren loesungsmitteln mit kohlendioxid-haltigen fluessigkeiten |
| US6006745A (en) | 1990-12-21 | 1999-12-28 | Minnesota Mining And Manufacturing Company | Device for delivering an aerosol |
| US5290539A (en) | 1990-12-21 | 1994-03-01 | Minnesota Mining And Manufacturing Company | Device for delivering an aerosol |
| DE4041563A1 (de) | 1990-12-22 | 1992-06-25 | Sanol Arznei Schwarz Gmbh | Verfahren zur herstellung wirkstoffhaltiger mikropartikel aus hydrolytisch abbaubaren polymeren |
| US5317103A (en) | 1991-01-15 | 1994-05-31 | Merck Sharp & Dohme Limited | Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists |
| US5145684A (en) | 1991-01-25 | 1992-09-08 | Sterling Drug Inc. | Surface modified drug nanoparticles |
| US5182097A (en) | 1991-02-14 | 1993-01-26 | Virginia Commonwealth University | Formulations for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content |
| US5190029A (en) | 1991-02-14 | 1993-03-02 | Virginia Commonwealth University | Formulation for delivery of drugs by metered dose inhalers with reduced or no chlorofluorocarbon content |
| EP0504112A3 (en) | 1991-03-14 | 1993-04-21 | Ciba-Geigy Ag | Pharmaceutical aerosol formulations |
| US5186164A (en) | 1991-03-15 | 1993-02-16 | Puthalath Raghuprasad | Mist inhaler |
| US5182040A (en) | 1991-03-28 | 1993-01-26 | E. I. Du Pont De Nemours And Company | Azeotropic and azeotrope-like compositions of 1,1,2,2-tetrafluoroethane |
| GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
| US5491148A (en) | 1991-04-26 | 1996-02-13 | Syntex (U.S.A.) Inc. | Isoquinolinone and dihydroisoquinolinone 5-HT3 receptor antagonists |
| DE4117751A1 (de) | 1991-05-30 | 1992-12-03 | Bayer Ag | Verfahren zur isolierung von polycarbonaten |
| CA2111002C (en) | 1991-06-10 | 2000-08-22 | Julianne Fassberg | Non-chlorofluorocarbon aerosol formulations |
| NZ243062A (en) | 1991-06-10 | 1993-09-27 | Schering Corp | Aerosol containing medicament and 1,1,1,2-tetrafluoroethane |
| AU2178392A (en) | 1991-06-12 | 1993-01-12 | Minnesota Mining And Manufacturing Company | Albuterol sulfate suspension aerosol formulations |
| GB9113802D0 (en) | 1991-06-26 | 1991-08-14 | Smithkline Beecham Plc | Medicaments |
| EP0592540B1 (en) | 1991-07-02 | 2000-01-26 | Inhale, Inc. | Method and device for delivering aerosolized medicaments |
| US5464632C1 (en) | 1991-07-22 | 2001-02-20 | Prographarm Lab | Rapidly disintegratable multiparticular tablet |
| NZ244439A (en) | 1991-09-25 | 1994-01-26 | Fisons Plc | Pressurised aerosol compositions comprising hydrofluoroalkane, dispersed |
| US6123924A (en) | 1991-09-25 | 2000-09-26 | Fisons Plc | Pressurized aerosol inhalation compositions |
| US6063910A (en) | 1991-11-14 | 2000-05-16 | The Trustees Of Princeton University | Preparation of protein microparticles by supercritical fluid precipitation |
| IL104068A (en) | 1991-12-12 | 1998-10-30 | Glaxo Group Ltd | Pharmaceutical preparations in a spray without surfactant containing 1, 1, 1, 2 tetrafluoroethane or 1,1,2,3,3 petafluor N propane as propellant |
| US5658549A (en) | 1991-12-12 | 1997-08-19 | Glaxo Group Limited | Aerosol formulations containing propellant 134a and fluticasone propionate |
| US5744123A (en) | 1991-12-12 | 1998-04-28 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| US5674471A (en) | 1991-12-12 | 1997-10-07 | Glaxo Group Limited | Aerosol formulations containing P134a and salbutamol |
| JP3026841B2 (ja) * | 1991-12-12 | 2000-03-27 | グラクソ、グループ、リミテッド | 医 薬 |
| US5916540A (en) | 1994-10-24 | 1999-06-29 | Glaxo Group Limited | Aerosol formulations containing P134A and/or P227 and particulate medicament |
| US5653962A (en) | 1991-12-12 | 1997-08-05 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicaments |
| ATE128350T1 (de) | 1991-12-12 | 1995-10-15 | Glaxo Group Ltd | Pharmazeutische aerosolformulierung. |
| US5736124A (en) | 1991-12-12 | 1998-04-07 | Glaxo Group Limited | Aerosol formulations containing P134a and particulate medicament |
| WO1993011747A1 (en) | 1991-12-18 | 1993-06-24 | Minnesota Mining And Manufacturing Company | Suspension aerosol formulations |
| CA2084531A1 (en) | 1991-12-19 | 1993-06-20 | David W. Smith | Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkyl piperazines |
| GB9200148D0 (en) | 1992-01-06 | 1992-02-26 | Minnesota Mining & Mfg | Aerosol valves |
| US5320094A (en) | 1992-01-10 | 1994-06-14 | The Johns Hopkins University | Method of administering insulin |
| US5202110A (en) | 1992-01-22 | 1993-04-13 | Virginia Commonwealth University | Formulations for delivery of beclomethasone diproprionate by metered dose inhalers containing no chlorofluorocarbon propellants |
| GB9202519D0 (en) | 1992-02-06 | 1992-03-25 | Glaxo Group Ltd | Medicaments |
| US5196575A (en) | 1992-02-19 | 1993-03-23 | Hoechst Celanese Corp. | Supercritical separation of isomers of functional organic compounds at moderate conditions |
| US5639441A (en) | 1992-03-06 | 1997-06-17 | Board Of Regents Of University Of Colorado | Methods for fine particle formation |
| US5242949A (en) | 1992-03-13 | 1993-09-07 | Rugby-Darby Group Companies, Inc. | Treating classic migraine |
| JPH05280282A (ja) | 1992-03-31 | 1993-10-26 | Kubota Corp | 埋設管の地中引き込み装置 |
| WO1993025198A1 (en) * | 1992-06-12 | 1993-12-23 | Teijin Limited | Ultrafine powder for inhalation and production thereof |
| US5376359A (en) | 1992-07-07 | 1994-12-27 | Glaxo, Inc. | Method of stabilizing aerosol formulations |
| US5833950A (en) | 1992-07-31 | 1998-11-10 | Glaxo Group Limited | Aerosol formulations containing beclomethasone dipropionate-1, 1, 1, 2-tetrafluoroethane solvate |
| MX9304585A (es) | 1992-07-31 | 1994-03-31 | Glaxo Group Ltd | Formulacion farmaceutica en aerosol, lata adecuada para liberar la formulacion e inhalador de dosis dosificada que comprende la lata. |
| US5314682A (en) | 1992-09-21 | 1994-05-24 | Great Lakes Chemical Corp. | Ozone friendly sterilant mixture |
| NZ257212A (en) | 1992-09-29 | 1996-11-26 | Inhale Therapeutic Syst | Parathyroid hormone formulations comprising a biologically active n-terminal fragment of the hormone |
| WO1994008599A1 (en) | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
| BR9307346A (pt) | 1992-11-02 | 1999-06-01 | Ferro Corp | Processo para preparação de materiais de revestimento |
| GB9226474D0 (en) | 1992-12-18 | 1993-02-10 | Ici Plc | Production of particulate materials |
| DK154092D0 (da) | 1992-12-23 | 1992-12-23 | Neurosearch As | Imidazolforbindelser, deres fremstilling og anvendelse |
| US5364838A (en) | 1993-01-29 | 1994-11-15 | Miris Medical Corporation | Method of administration of insulin |
| EP0612697B1 (de) | 1993-02-24 | 1998-01-21 | Sulzer Chemtech AG | Reinigung von salzbeladenem Abwasser durch Nassoxidation bei superkritischen Bedingungen |
| US5354934A (en) | 1993-02-04 | 1994-10-11 | Amgen Inc. | Pulmonary administration of erythropoietin |
| US6162234A (en) | 1993-03-23 | 2000-12-19 | Freedland; Yosef | Adjustable button cinch anchor orthopedic fastener |
| ES2194867T3 (es) | 1993-03-26 | 2003-12-01 | Franciscus Wilhelmus He Merkus | Composiciones farmaceuticas para la administracion intranasal de apomorfina. |
| BE1006872A6 (nl) | 1993-03-26 | 1995-01-10 | Merkus Franciscus W H M | Nasale farmaceutische preparaten met dihydroergotamine (dhe). |
| US5492688A (en) | 1993-04-28 | 1996-02-20 | The Center For Innovative Technology | Metered dose inhaler fomulations which include the ozone-friendly propellant HFC 134a and a pharmaceutically acceptable suspending, solubilizing, wetting, emulsifying or lubricating agent |
| IL105658A (en) | 1993-05-11 | 1995-10-31 | Ultrasonic Dryer Ltd | Spray drying system |
| TW402506B (en) | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
| DE4322181A1 (de) | 1993-06-29 | 1995-01-12 | Hottinger Adolf Masch | Vorrichtung und Verfahren zum Greifen eines Gießereikerns, insbesondere eines Sohlenkerns |
| GB9313642D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| GB9313650D0 (en) | 1993-07-01 | 1993-08-18 | Glaxo Group Ltd | Method and apparatus for the formation of particles |
| JP3750872B2 (ja) * | 1993-07-14 | 2006-03-01 | 株式会社小松製作所 | 車両用エンジンの過給装置およびその制御方法 |
| DE69415998T2 (de) | 1993-11-08 | 1999-08-12 | Gillette Co | Verfahren zur formung von partikeln unter verwendung einer überkritischen flüssigkeit so hergestellte aerogelpartikel und aerogelpartikel enthaltenden antiperspirantien |
| EP0655237A1 (de) | 1993-11-27 | 1995-05-31 | Hoechst Aktiengesellschaft | Medizinische Aerosolformulierung |
| IT1265473B1 (it) | 1993-12-30 | 1996-11-22 | Otefal Srl | Procedimento per la produzione di polveri a granulometria controllata e prodotto in polvere cosi' ottenuto |
| US5468768A (en) | 1994-01-06 | 1995-11-21 | Bristol-Myers Squibb Company | Antimigraine derivatives of indolylcycloalkanylamines |
| US5595761A (en) | 1994-01-27 | 1997-01-21 | The Board Of Regents Of The University Of Oklahoma | Particulate support matrix for making a rapidly dissolving tablet |
| US5635210A (en) | 1994-02-03 | 1997-06-03 | The Board Of Regents Of The University Of Oklahoma | Method of making a rapidly dissolving tablet |
| SI9400079B (sl) | 1994-02-15 | 2003-02-28 | Dr. Weidner Eckhard, Dipl. Ing. | Postopek in naprava za pridobivanje in frakcioniranje majhnih delcev iz raztopin nasičenih s plinom |
| PT748213E (pt) | 1994-03-07 | 2004-08-31 | Nektar Therapeutics | Metodos e composicoes para administracao pulmonar de insulina |
| GB9404945D0 (en) | 1994-03-15 | 1994-04-27 | Glaxo Group Ltd | Pharmaceutical composition |
| US5508023A (en) | 1994-04-11 | 1996-04-16 | The Center For Innovative Technology | Pharmaceutically acceptable agents for solubilizing, wetting, emulsifying, or lubricating in metered dose inhaler formulations which use HFC-227 propellant |
| NZ285664A (en) | 1994-05-18 | 1998-07-28 | Inhale Therapeutic Syst | Dry powder interferon composition adapted for pulmonary delivery |
| JPH0817132A (ja) | 1994-06-30 | 1996-01-19 | Rohm Co Ltd | 円盤状情報記録担体の再生装置 |
| GB9413202D0 (en) | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
| DE4425255A1 (de) * | 1994-07-16 | 1996-01-18 | Asta Medica Ag | Formulierung zur inhalativen Applikation |
| US6290991B1 (en) | 1994-12-02 | 2001-09-18 | Quandrant Holdings Cambridge Limited | Solid dose delivery vehicle and methods of making same |
| US5560543A (en) | 1994-09-19 | 1996-10-01 | Board Of Regents, The University Of Texas System | Heat-resistant broad-bandwidth liquid droplet generators |
| GB9419536D0 (en) | 1994-09-28 | 1994-11-16 | Glaxo Inc | Medicaments |
| US6117455A (en) | 1994-09-30 | 2000-09-12 | Takeda Chemical Industries, Ltd. | Sustained-release microcapsule of amorphous water-soluble pharmaceutical active agent |
| DE4438978A1 (de) | 1994-10-31 | 1996-05-02 | Helmut Wurzer | Elektrochirurgiegerät und Verfahren zu dessen Betrieb |
| DE59509057D1 (de) | 1994-11-07 | 2001-04-05 | Eupec Gmbh & Co Kg | Brücken-Modul |
| US5693609A (en) | 1994-11-17 | 1997-12-02 | Eli Lilly And Company | Acylated insulin analogs |
| GB9425160D0 (en) | 1994-12-10 | 1995-02-08 | Glaxo Group Ltd | Medicaments |
| MX9504934A (es) | 1994-12-12 | 1997-01-31 | Morton Int Inc | Revestimientos en polvo de pelicula delgada lisa. |
| GB9426252D0 (en) | 1994-12-24 | 1995-02-22 | Glaxo Group Ltd | Pharmaceutical composition |
| US6013245A (en) | 1995-01-26 | 2000-01-11 | Glaxo Group Limited | Aerosol formulation containing beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant |
| US5639475A (en) | 1995-02-03 | 1997-06-17 | Eurand America, Incorporated | Effervescent microcapsules |
| JPH11509433A (ja) | 1995-04-14 | 1999-08-24 | グラクソ、ウェルカム、インコーポレーテッド | アルブテロール用計量投与用吸入器 |
| EA000889B1 (ru) * | 1995-04-14 | 2000-06-26 | Глаксо Веллкам Инк. | Дозирующий ингалятор дипропионата беклометазона |
| RO119116B1 (ro) | 1995-04-14 | 2004-04-30 | Glaxo Wellcome Inc. | Inhalator pentru dozarea salmeterolului |
| HU219899B (hu) | 1995-04-14 | 2001-09-28 | Glaxo Wellcome Inc. | Inhalálóberendezés flutikaszon-propionát adagolására mért dózisban |
| US5607697A (en) | 1995-06-07 | 1997-03-04 | Cima Labs, Incorporated | Taste masking microparticles for oral dosage forms |
| AU709262B2 (en) | 1995-10-17 | 1999-08-26 | Board Of Regents, The University Of Texas System | Insoluble drug delivery |
| US5807578A (en) | 1995-11-22 | 1998-09-15 | Lab Pharmaceutical Research International Inc. | Fast-melt tablet and method of making same |
| GB9526392D0 (en) | 1995-12-22 | 1996-02-21 | Glaxo Group Ltd | Medicaments |
| WO1997031691A1 (en) | 1996-03-01 | 1997-09-04 | The University Of Kansas | Methods and apparatus for particle precipitation and coating using near-critical and supercritical antisolvents |
| US5874029A (en) | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
| GB9606677D0 (en) | 1996-03-29 | 1996-06-05 | Glaxo Wellcome Inc | Process and device |
| US5875776A (en) | 1996-04-09 | 1999-03-02 | Vivorx Pharmaceuticals, Inc. | Dry powder inhaler |
| US5776573A (en) | 1996-04-16 | 1998-07-07 | Cd Magic, Inc. | Compact disc revitalizer formulations and revitalizer |
| US5648004A (en) | 1996-04-19 | 1997-07-15 | Simpson; Claudie | Kit and method to retrofit heating elements for curling iron holder |
| DE19617487A1 (de) | 1996-05-02 | 1997-11-06 | Merck Patent Gmbh | Geschmacksverbesserung von Arzneimittelwirkstoffen |
| US5874064A (en) | 1996-05-24 | 1999-02-23 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6503480B1 (en) | 1997-05-23 | 2003-01-07 | Massachusetts Institute Of Technology | Aerodynamically light particles for pulmonary drug delivery |
| US6054488A (en) | 1996-06-11 | 2000-04-25 | 3M Innovative Properties Company | Medicinal aerosol formulations of formoterol |
| US6284267B1 (en) | 1996-08-14 | 2001-09-04 | Nutrimed Biotech | Amphiphilic materials and liposome formulations thereof |
| CZ299790B6 (cs) | 1996-08-22 | 2008-11-26 | Skyepharma Canada Inc. | Kompozice mikrocástic ve vode nerozpustné látky, farmaceutická kompozice, zpusob prípravy stabilních cástic, mikrocástice ve vode nerozpustné nebo slabe rozpustné slouceniny, kompozice obsahující tyto mikrocástice a zpusob prípravy mikrocástic |
| US6068832A (en) | 1996-08-29 | 2000-05-30 | Schering Corporation | Chlorofluorocarbon-free mometasone furoate aerosol formulations |
| FR2753639B1 (fr) | 1996-09-25 | 1998-12-11 | Procede de preparation de microcapsules de matieres actives enrobees par un polymere et nouvelles microcapsules notamment obtenues selon le procede | |
| CN1233954A (zh) | 1996-10-01 | 1999-11-03 | 西马实验室股份有限公司 | 掩盖味道的微胶囊组合物及其制备方法 |
| US5891885A (en) * | 1996-10-09 | 1999-04-06 | Algos Pharmaceutical Corporation | Method for treating migraine |
| US5813597A (en) | 1996-10-15 | 1998-09-29 | Ethicon Endo-Surgery, Inc. | Dual orientation dispenser carton |
| GB9622173D0 (en) | 1996-10-24 | 1996-12-18 | Glaxo Group Ltd | Particulate Products |
| US6077539A (en) * | 1996-11-12 | 2000-06-20 | Pozen, Inc. | Treatment of migraine headache |
| GB9702799D0 (en) | 1997-02-12 | 1997-04-02 | Scherer Corp R P | Process for preparing solid pharmaceutical dosage forms |
| IT1291779B1 (it) | 1997-02-17 | 1999-01-21 | Magnetek Spa | Procedimento per la realizzazione di circuiti stampati e circuiti stampati cosi'ottenuti |
| GB9703673D0 (en) | 1997-02-21 | 1997-04-09 | Bradford Particle Design Ltd | Method and apparatus for the formation of particles |
| US6236747B1 (en) | 1997-02-26 | 2001-05-22 | Acuity Imaging, Llc | System and method for image subtraction for ball and bumped grid array inspection |
| US6024981A (en) | 1997-04-16 | 2000-02-15 | Cima Labs Inc. | Rapidly dissolving robust dosage form |
| US6129905A (en) * | 1997-04-21 | 2000-10-10 | Aeropharm Technology, Inc. | Aerosol formulations containing a sugar as a dispersant |
| US5916125A (en) | 1997-05-16 | 1999-06-29 | Allison Engine Company, Inc. | Forced purge wave rotor |
| US6120752A (en) | 1997-05-21 | 2000-09-19 | 3M Innovative Properties Company | Medicinal aerosol products containing formulations of ciclesonide and related steroids |
| SE9701956D0 (sv) | 1997-05-23 | 1997-05-23 | Astra Ab | New composition of matter |
| US6315122B1 (en) | 1997-05-29 | 2001-11-13 | Mitsubishi Polyester Film, Llc | Palletless packaging system |
| US6236647B1 (en) | 1998-02-24 | 2001-05-22 | Tantivy Communications, Inc. | Dynamic frame size adjustment and selective reject on a multi-link channel to improve effective throughput and bit error rate |
| US6200293B1 (en) | 1997-08-27 | 2001-03-13 | Science Incorporated | Fluid delivery device with temperature controlled energy source |
| US6309623B1 (en) | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| EP1027036A2 (en) | 1997-10-03 | 2000-08-16 | ELAN CORPORATION, Plc | Taste masked formulations |
| US5954047A (en) * | 1997-10-17 | 1999-09-21 | Systemic Pulmonary Development, Ltd. | Methods and apparatus for delivering aerosolized medication |
| US6089911A (en) | 1997-12-05 | 2000-07-18 | The Whitaker Corporation | Apparatus and method for mounting a plurality of surface mount contacts |
| GB9804379D0 (en) | 1998-03-02 | 1998-04-22 | Bradford Particle Design Ltd | Method of particle formation |
| US6120613A (en) | 1998-04-30 | 2000-09-19 | Micell Technologies, Inc. | Carbon dioxide cleaning and separation systems |
| SE9801288D0 (sv) | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
| SE9801287D0 (sv) | 1998-04-14 | 1998-04-14 | Astra Ab | Incorporation of active substances in carrier matrixes |
| GB9808802D0 (en) * | 1998-04-24 | 1998-06-24 | Glaxo Group Ltd | Pharmaceutical formulations |
| GB9810126D0 (da) | 1998-05-13 | 1998-07-08 | Glaxo Group Ltd | |
| GB9810559D0 (en) * | 1998-05-15 | 1998-07-15 | Bradford Particle Design Ltd | Method and apparatus for particle formation |
| SE9802073D0 (sv) | 1998-06-11 | 1998-06-11 | Astra Ab | New use |
| ES2198922T3 (es) | 1998-06-24 | 2004-02-01 | Advanced Inhalation Research, Inc. | Particulas porosas grandes emitadas por un inhalador. |
| ES2234266T3 (es) | 1998-07-24 | 2005-06-16 | Jago Research Ag | Formulaciones medicas para aerosoles. |
| SE513162C2 (sv) | 1998-07-24 | 2000-07-17 | Allgon Ab | Antennanordning |
| US6387410B1 (en) * | 1998-09-10 | 2002-05-14 | Norton Healthcare Ltd | Anti-inflammatory pharmaceutical formulations |
| EP0989357B1 (en) | 1998-09-25 | 2003-04-02 | Stanley Electric Co., Ltd. | Headlamp with beam distribution switch mechanism |
| US5992306A (en) | 1998-10-15 | 1999-11-30 | Century Machinery Corp. | Structure of a hand holding net basket for frying |
| SE9804003D0 (sv) | 1998-11-23 | 1998-11-23 | Astra Ab | A method of producing drug particles |
| SE9804001D0 (sv) | 1998-11-23 | 1998-11-23 | Astra Ab | New process |
| ES2601855T3 (es) | 1998-11-25 | 2017-02-16 | Cima Labs Inc. | Comprimido de liberación rápida con núcleo recubierto que contiene el fármaco y capa circundante de enmascaramiento del sabor |
| GB9825883D0 (en) | 1998-11-27 | 1999-01-20 | Aea Technology Plc | Formation of monodisperse particles |
| US6119853A (en) | 1998-12-18 | 2000-09-19 | Glaxo Wellcome Inc. | Method and package for storing a pressurized container containing a drug |
| US6390291B1 (en) | 1998-12-18 | 2002-05-21 | Smithkline Beecham Corporation | Method and package for storing a pressurized container containing a drug |
| CN1204935C (zh) | 1999-01-14 | 2005-06-08 | 帝人株式会社 | 粉末药物多剂量给药器 |
| IL138990A0 (en) | 1999-02-12 | 2001-11-25 | Biostream Inc | Matrices for drug delivery and methods for making and using the same |
| HUP0200641A3 (en) | 1999-03-26 | 2002-09-30 | Pozen Inc | High potency dihydroergotamine compositions |
| SE9901667D0 (sv) | 1999-05-07 | 1999-05-07 | Astra Ab | Method and device for forming particles |
| US6395300B1 (en) * | 1999-05-27 | 2002-05-28 | Acusphere, Inc. | Porous drug matrices and methods of manufacture thereof |
| US6858199B1 (en) | 2000-06-09 | 2005-02-22 | Advanced Inhalation Research, Inc. | High efficient delivery of a large therapeutic mass aerosol |
| GB9915975D0 (en) | 1999-07-07 | 1999-09-08 | Bradford Particle Design Ltd | Method for the formation of particles |
| US20020081266A1 (en) * | 1999-08-20 | 2002-06-27 | Norton Healthcare Ltd. | Spray dried powders for pulmonary or nasal administration |
| US7678364B2 (en) | 1999-08-25 | 2010-03-16 | Alkermes, Inc. | Particles for inhalation having sustained release properties |
| GB9920558D0 (en) | 1999-08-31 | 1999-11-03 | Bradford Particle Design Ltd | Methods for particle formation and their products |
| MXPA02002714A (es) * | 1999-09-13 | 2003-10-14 | Sheffield Pharmaceuticals Inc | Sistema y metodo de control de flujo de aire en aerosol. |
| US6346323B1 (en) | 1999-10-07 | 2002-02-12 | Sig Pack Systems Ag | Multi-layer synthetic film |
| US6264981B1 (en) | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
| US6367471B1 (en) * | 1999-11-01 | 2002-04-09 | Sheffield Pharmaceuticals, Inc. | Internal vortex mechanism for inhaler device |
| US6514481B1 (en) * | 1999-11-22 | 2003-02-04 | The Research Foundation Of State University Of New York | Magnetic nanoparticles for selective therapy |
| KR100311975B1 (ko) * | 1999-12-16 | 2001-10-17 | 윤종용 | 반도체소자 및 그 제조방법 |
| KR20010088139A (ko) | 2000-03-10 | 2001-09-26 | 백승헌 | 텍스트 데이터 입력에 대응한 입모양 출력장치 및 그 방법 |
| PE20011227A1 (es) * | 2000-04-17 | 2002-01-07 | Chiesi Farma Spa | Formulaciones farmaceuticas para inhaladores de polvo seco en la forma de aglomerados duros |
| GB0011807D0 (en) | 2000-05-16 | 2000-07-05 | Quadrant Holdings Cambridge | Formulation for inhalation |
| US6316029B1 (en) | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
| US6620351B2 (en) * | 2000-05-24 | 2003-09-16 | Auburn University | Method of forming nanoparticles and microparticles of controllable size using supercritical fluids with enhanced mass transfer |
| US6451287B1 (en) | 2000-05-26 | 2002-09-17 | Smithkline Beecham Corporation | Fluorinated copolymer surfactants and use thereof in aerosol compositions |
| US6656492B2 (en) | 2000-06-30 | 2003-12-02 | Yamanouchi Pharmaceutical Co., Ltd. | Quick disintegrating tablet in buccal cavity and manufacturing method thereof |
| FR2812040B1 (fr) | 2000-07-18 | 2003-02-07 | Cit Alcatel | Carter monobloc pour pompe a vide |
| EP1373576A4 (en) | 2000-07-24 | 2005-06-15 | Inst Of Molecul & Cell Biology | NUCLEIC ACIDS AND METHODS FOR DETECTING VIRAL INFECTION, DISCOVERING CANDIDATE ANTI-VIRAL DRUGS AND DETERMINING DRUG RESISTANCE OF VIRAL ISOLATES |
| US6941569B2 (en) | 2000-08-18 | 2005-09-06 | Hewlett-Packard Development Company, L.P. | System and method utilizing a conductive brush for providing power signals to a cartridge access device |
| US6406681B1 (en) * | 2000-08-21 | 2002-06-18 | Aeropharm Technology, Inc. | Method of treating a systemic disease |
| WO2002019213A2 (en) | 2000-08-30 | 2002-03-07 | Lilly Icos Llc | Method for treatment of migraine using pde5 inhibitors |
| US6514482B1 (en) | 2000-09-19 | 2003-02-04 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| US6613308B2 (en) | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
| FR2815540B1 (fr) | 2000-10-19 | 2005-06-10 | Separex Sa | Procede de fabrication de tres fines particules constituees d'un principe insere dans une molecule hote |
| GB0027357D0 (en) | 2000-11-09 | 2000-12-27 | Bradford Particle Design Plc | Particle formation methods and their products |
| US6932861B2 (en) | 2000-11-28 | 2005-08-23 | Fmc Corporation | Edible PGA coating composition |
| GB0102075D0 (en) | 2001-01-26 | 2001-03-14 | Astrazeneca Ab | Process |
| EP1392262A1 (en) | 2001-05-24 | 2004-03-03 | Alexza Molecular Delivery Corporation | Delivery of drug esters through an inhalation route |
| US20030022910A1 (en) | 2001-07-05 | 2003-01-30 | R.T. Alamo Ventures I, Inc. | Compositions and methods for sublingual formulations of dihydroergotamine for the treatment of migraine |
| US6685951B2 (en) | 2001-07-05 | 2004-02-03 | R. T. Alamo Ventures I, Inc. | Administration of dihydroergotamine as a sublingual spray or aerosol for the treatment of migraine |
| US20030198669A1 (en) * | 2001-07-05 | 2003-10-23 | R.T. Alamo Ventures I, Llc | Compositions and methods for rapid dissolving formulations of dihydroergotamine and caffeine for the treatment of migraine |
| US20030008005A1 (en) * | 2001-07-05 | 2003-01-09 | R.T. Alamo Ventures, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
| US20030017175A1 (en) * | 2001-07-05 | 2003-01-23 | R.T. Alamo Ventures I, Inc. | Sublingual administration of dihydroergotamine for the treatment of migraine |
| TW586963B (en) | 2001-07-20 | 2004-05-11 | Nektar Therapeutics Uk Ltd | Method and apparatus for preparing target substance in particulate form and fluid inlet assembly for said apparatus |
| GB0208742D0 (en) | 2002-04-17 | 2002-05-29 | Bradford Particle Design Ltd | Particulate materials |
| GB0117696D0 (en) * | 2001-07-20 | 2001-09-12 | Bradford Particle Design Plc | Particle information |
| US20030181462A1 (en) | 2001-08-17 | 2003-09-25 | Boehringer Ingelheim Pharma Kg | Use of BIBN4096 in combination with other antimigraine drugs for the treatment of migraine |
| US20030091513A1 (en) * | 2001-10-03 | 2003-05-15 | Mohsen Nahed M. | Method to generate water soluble or nonwater soluble in nanoparticulates directly in suspension or dispersion media |
| AU2003208761A1 (en) | 2002-02-21 | 2003-09-09 | Amarin Development Ab | A method for releasing nanosized particles of an active substance from a diffusion-controlled pharmaceutical composition for oral use |
| US6941948B2 (en) | 2002-03-07 | 2005-09-13 | Vectura Drug Delivery | Medicament storage and delivery devices |
| WO2003075829A2 (en) * | 2002-03-08 | 2003-09-18 | M/S. Ind-Swift Limited | Tasteless directly compressible fast-dissolving complexes and pharmaceutical formulations thereof |
| DE10212564B4 (de) * | 2002-03-12 | 2007-04-19 | Neurobiotec Gmbh | 1-Allyl-ergotalkaloid-Derivate und ihre Verwendung zur Prophylaxe und Therapie von Migräne |
| US7582284B2 (en) * | 2002-04-17 | 2009-09-01 | Nektar Therapeutics | Particulate materials |
| JP2004184809A (ja) | 2002-12-05 | 2004-07-02 | Nitto Denko Corp | 偏光板の製造方法、偏光板およびそれを用いた画像表示装置 |
| AU2003900081A0 (en) | 2003-01-08 | 2003-01-23 | George Moore | Drilling jig |
| GB0300339D0 (en) | 2003-01-08 | 2003-02-05 | Bradford Particle Design Ltd | Particle formation |
| GB0300338D0 (en) | 2003-01-08 | 2003-02-05 | Bradford Particle Design Ltd | Particle formation |
| GB0304636D0 (en) | 2003-02-28 | 2003-04-02 | Britannia Pharmaceuticals Ltd | Pharmaceutical composition for nasal delivery |
| US20060147389A1 (en) * | 2004-04-14 | 2006-07-06 | Vectura Ltd. | Devices and pharmaceutical compositions for enhancing dosing efficiency |
| JP2006525303A (ja) | 2003-05-08 | 2006-11-09 | ネクター セラピューティクス ユーケー リミティド | 微粒子物質 |
| CA2538237A1 (en) * | 2003-09-10 | 2005-03-24 | Map Pharmaceuticals, Inc. | Aerosol formulations for delivery of dihydroergotamine to the systemic circulation via pulmonary inhalation |
| CA2548281C (en) | 2003-12-09 | 2013-11-12 | Medcrystalforms, Llc | Method of preparation of mixed phase co-crystals with active agents |
| US20070020299A1 (en) | 2003-12-31 | 2007-01-25 | Pipkin James D | Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid |
| US20060246070A1 (en) | 2004-09-30 | 2006-11-02 | Heavner George A | Methods and compositions for treating renal cell carcinoma related pathologies |
| EP1799264A2 (en) | 2004-10-08 | 2007-06-27 | Neuromolecular Pharmaceuticals Inc | Methods and compositions for treating migraine pain |
| US20090232898A1 (en) | 2005-03-28 | 2009-09-17 | Anders Pettersson | Pharmaceutical Compositions Useful in the Treatment of Migraine |
| US7219664B2 (en) * | 2005-04-28 | 2007-05-22 | Kos Life Sciences, Inc. | Breath actuated inhaler |
| CA2615378C (en) | 2005-07-15 | 2015-02-17 | Map Pharmaceuticals, Inc. | Multiple active pharmaceutical ingredients combined in discrete inhalation particles and formulations thereof |
| SE530445C2 (sv) | 2006-10-23 | 2008-06-10 | Volvo Lastvagnar Ab | Hyttupphängningssystem |
| EP2117506A2 (en) | 2006-12-13 | 2009-11-18 | Stephen M. Tuel | Methods of making pharmaceutical components for customized drug products |
| EP2425820B1 (en) * | 2007-02-11 | 2015-04-08 | MAP Pharmaceuticals Inc | Method of therapeutic administration of dhe to enable rapid relief of migraine while minimizing side effect profile |
| GB2448183A (en) | 2007-04-05 | 2008-10-08 | Optinose As | Nasal powder delivery device |
| US20110119657A1 (en) | 2007-12-07 | 2011-05-19 | Martin Vorbach | Using function calls as compiler directives |
| TW200938236A (en) | 2008-03-13 | 2009-09-16 | Fei-Peng Lin | Deodorization material composition, manufacturing method thereof, and deodorization method |
| EP2105189A1 (de) | 2008-03-27 | 2009-09-30 | Siemens Aktiengesellschaft | Verfahren und Vorrichtung zum Abtrennen von Kohlendioxid aus Rauchgas einer fossilbefeuerten Kraftwerksanlage |
| ES2563061T3 (es) | 2008-04-28 | 2016-03-10 | Zogenix, Inc. | Nuevas formulaciones para el tratamiento de la migraña |
| US20100236547A1 (en) * | 2008-07-11 | 2010-09-23 | Robert Owen Cook | Container for aerosol drug delivery |
| WO2010148519A1 (en) * | 2009-06-25 | 2010-12-29 | Queen's University At Kingston | Methods and therapies for alleviating pain comprising an ultra low dose of an alpha 2 receptor antagonist |
| EP2322326A1 (en) | 2009-11-13 | 2011-05-18 | Frederik Daniël Nossbaum | Multifunctional tool |
-
2008
- 2008-02-11 EP EP11191794.4A patent/EP2425820B1/en active Active
- 2008-02-11 CN CN200880011629A patent/CN101677954A/zh active Pending
- 2008-02-11 HU HUE11191794A patent/HUE026884T2/en unknown
- 2008-02-11 EP EP08725456.1A patent/EP2120875B1/en active Active
- 2008-02-11 DK DK08725456.1T patent/DK2120875T3/da active
- 2008-02-11 US US12/069,667 patent/US8148377B2/en active Active
- 2008-02-11 KR KR1020157007681A patent/KR20150041804A/ko not_active Application Discontinuation
- 2008-02-11 DK DK11191794.4T patent/DK2425820T3/da active
- 2008-02-11 KR KR1020167023885A patent/KR20160106200A/ko not_active Application Discontinuation
- 2008-02-11 SI SI200831425T patent/SI2425820T1/sl unknown
- 2008-02-11 ES ES11191794.4T patent/ES2538082T3/es active Active
- 2008-02-11 CN CN201410379903.5A patent/CN104188907A/zh active Pending
- 2008-02-11 JP JP2009549138A patent/JP5825757B2/ja active Active
- 2008-02-11 MX MX2009008582A patent/MX2009008582A/es active IP Right Grant
- 2008-02-11 CA CA2677838A patent/CA2677838C/en active Active
- 2008-02-11 PL PL11191794T patent/PL2425820T3/pl unknown
- 2008-02-11 PT PT111917944T patent/PT2425820E/pt unknown
- 2008-02-11 KR KR1020097019032A patent/KR20090129998A/ko not_active Application Discontinuation
- 2008-02-11 AU AU2008214205A patent/AU2008214205B2/en active Active
- 2008-02-11 EP EP20110191793 patent/EP2425819A1/en not_active Withdrawn
- 2008-02-11 ES ES08725456.1T patent/ES2691033T3/es active Active
- 2008-02-11 WO PCT/US2008/001829 patent/WO2008097664A1/en active Application Filing
-
2009
- 2009-08-11 IL IL200333A patent/IL200333A/en active IP Right Grant
- 2009-08-13 ZA ZA2009/05628A patent/ZA200905628B/en unknown
- 2009-08-26 US US12/548,304 patent/US20100081664A1/en not_active Abandoned
- 2009-08-26 US US12/548,292 patent/US7994197B2/en active Active
-
2010
- 2010-07-19 US US12/839,190 patent/US8119639B2/en active Active
-
2012
- 2012-02-27 US US13/406,391 patent/US20120245179A1/en not_active Abandoned
-
2013
- 2013-08-05 JP JP2013162032A patent/JP5908439B2/ja active Active
-
2014
- 2014-06-23 AU AU2014203389A patent/AU2014203389B2/en active Active
- 2014-10-14 US US14/514,322 patent/US20150057287A1/en not_active Abandoned
-
2015
- 2015-06-08 HK HK15105429.3A patent/HK1204918A1/xx unknown
- 2015-06-26 CY CY20151100551T patent/CY1116546T1/el unknown
- 2015-10-23 US US14/921,860 patent/US9833451B2/en active Active
- 2015-12-03 JP JP2015236885A patent/JP6209198B2/ja active Active
- 2015-12-03 JP JP2015236886A patent/JP2016040317A/ja active Pending
-
2016
- 2016-11-04 AU AU2016253689A patent/AU2016253689B2/en active Active
-
2017
- 2017-03-28 US US15/471,334 patent/US10172853B2/en active Active
-
2018
- 2018-09-11 US US16/127,734 patent/US20190247393A1/en not_active Abandoned
-
2019
- 2019-12-05 US US16/704,867 patent/US20200352939A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10172853B2 (en) | Method of therapeutic administration of DHE to enable rapid relief of migraine while minimizing side effect profile | |
| ZA200207420B (en) | The treatment of respiratory diseases. |