DK1787980T3 - Krystallint og rent modafinil og fremgangsmåde til atfremstille dette - Google Patents

Krystallint og rent modafinil og fremgangsmåde til atfremstille dette

Info

Publication number
DK1787980T3
DK1787980T3 DK07000780.2T DK07000780T DK1787980T3 DK 1787980 T3 DK1787980 T3 DK 1787980T3 DK 07000780 T DK07000780 T DK 07000780T DK 1787980 T3 DK1787980 T3 DK 1787980T3
Authority
DK
Denmark
Prior art keywords
crystalline
making
pure modafinil
modafinil
pure
Prior art date
Application number
DK07000780.2T
Other languages
Danish (da)
English (en)
Inventor
Claude Singer
Neomi Gershon
Arina Ceausu
Judith Aronhime
Anita Lieberman
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Application granted granted Critical
Publication of DK1787980T3 publication Critical patent/DK1787980T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/06—Separation; Purification; Stabilisation; Use of additives
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Metallurgy (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Laminated Bodies (AREA)
  • Glass Compositions (AREA)
DK07000780.2T 2000-07-27 2001-07-27 Krystallint og rent modafinil og fremgangsmåde til atfremstille dette DK1787980T3 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22111000P 2000-07-27 2000-07-27
US22649100P 2000-08-18 2000-08-18
US22916000P 2000-08-30 2000-08-30
US23008800P 2000-09-05 2000-09-05
US25933201P 2001-01-02 2001-01-02
EP01961766A EP1309547B1 (en) 2000-07-27 2001-07-27 Crystalline and pure modafinil, and process of preparing the same

Publications (1)

Publication Number Publication Date
DK1787980T3 true DK1787980T3 (da) 2010-04-26

Family

ID=27539819

Family Applications (2)

Application Number Title Priority Date Filing Date
DK07000780.2T DK1787980T3 (da) 2000-07-27 2001-07-27 Krystallint og rent modafinil og fremgangsmåde til atfremstille dette
DK01961766T DK1309547T3 (da) 2000-07-27 2001-07-27 Krystallinsk og ren modafinil og fremgangsmåde til fremstilling af samme

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK01961766T DK1309547T3 (da) 2000-07-27 2001-07-27 Krystallinsk og ren modafinil og fremgangsmåde til fremstilling af samme

Country Status (24)

Country Link
US (3) US6849120B2 (enExample)
EP (3) EP1309547B1 (enExample)
JP (2) JP4302977B2 (enExample)
KR (8) KR100729298B1 (enExample)
CN (2) CN100500651C (enExample)
AT (1) ATE453618T1 (enExample)
AU (1) AU2001283008A1 (enExample)
CA (3) CA2416792C (enExample)
CY (1) CY1110234T1 (enExample)
CZ (1) CZ2003529A3 (enExample)
DE (3) DE60140973D1 (enExample)
DK (2) DK1787980T3 (enExample)
ES (2) ES2277937T3 (enExample)
HR (2) HRP20030131B1 (enExample)
HU (1) HUP0400927A3 (enExample)
IL (2) IL154122A0 (enExample)
IS (1) IS6699A (enExample)
MX (1) MXPA03000747A (enExample)
NZ (1) NZ524359A (enExample)
PL (1) PL206371B1 (enExample)
PT (2) PT1309547E (enExample)
SK (1) SK2242003A3 (enExample)
WO (1) WO2002010125A1 (enExample)
ZA (1) ZA200300672B (enExample)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP20030131B1 (en) * 2000-07-27 2011-03-31 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same
HU229409B1 (en) 2000-10-11 2013-12-30 Cephalon Compositions comprising modafinil compounds
EP1330244B1 (en) * 2000-10-11 2008-12-17 Cephalon, Inc. Compositions comprising modafinil compounds
WO2003074474A2 (en) 2002-03-01 2003-09-12 University Of South Florida Multiple-component solid phases containing at least one active pharmaceutical ingredient
ITMI20020991A1 (it) 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
US6875893B2 (en) 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
EP1515703A1 (en) 2002-06-21 2005-03-23 Transform Pharmaceuticals, Inc. Pharmaceutical compositions with improved dissolution
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
TW200413296A (en) * 2002-08-09 2004-08-01 Cephalon France Modafinil polymorphic forms
US6992219B2 (en) * 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
FR2849029B1 (fr) * 2002-12-20 2005-03-18 Lafon Labor Procede de preparation et formes cristallines des enantiomeres optiques du modafinil.
MXPA05008088A (es) * 2003-02-24 2005-09-21 Mallinckrodt Inc Proceso mejorado para preparar benzhidril tioacetamida.
US20040253308A1 (en) * 2003-04-29 2004-12-16 Barr Laboratories, Inc. Surface-treated modafinil particles
ES2330321T3 (es) * 2003-05-16 2009-12-09 Cephalon France Procedimiento de sintesis de modafinilo.
ITMI20031298A1 (it) * 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).
JP4842819B2 (ja) * 2003-09-04 2011-12-21 セフアロン・インコーポレーテツド モダフィニル組成物
EP1516869A1 (en) * 2003-09-19 2005-03-23 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
JP4917441B2 (ja) * 2004-02-06 2012-04-18 セフアロン・インコーポレーテツド モダフィニル組成物
EP2292213A1 (en) * 2004-02-06 2011-03-09 Cephalon, Inc. Compositions comprising a polymorphic form of armodafinil
CN1980888B (zh) * 2004-02-06 2011-04-13 赛福伦公司 莫达芬尼组合物
US20090018202A1 (en) 2004-02-06 2009-01-15 Cephalon, Inc. Modafinil compositions
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7314875B2 (en) 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
EP1586560A1 (en) 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
US20060086667A1 (en) * 2004-09-13 2006-04-27 Cephalon, Inc., U.S. Corporation Methods for the separation of enantiomeric sulfinylacetamides
BRPI0500520A (pt) * 2005-02-16 2006-09-26 Henry Jun Suzuki uso de agentes flavorizantes aromáticos de alto ponto de fusão como agentes solubilizantes ou inibidores de cristalização em composições farmacêuticas
BRPI0501120A (pt) * 2005-02-18 2006-10-03 Henry Jun Suzuki composições farmacêuticas orais e parenterais contendo altas concentrações de agentes solubilizantes aromáticos
CN100393699C (zh) * 2005-03-10 2008-06-11 浙江工业大学 2-（二苯基甲基亚硫酰基）乙酰胺的合成方法
WO2007070238A2 (en) * 2005-12-09 2007-06-21 Mallinckrodt Inc. Processes for the preparation of modafinil and analogs thereof
EP1986994A2 (en) * 2006-02-21 2008-11-05 Teva Pharmaceutical Industries Ltd Novel crystalline forms of armodafinil and preparation thereof
EP2043623A4 (en) * 2006-07-12 2013-03-20 Elan Pharma Int Ltd NANOPARTICLE FORMULATIONS OF MODAFINIL
US20080181966A1 (en) * 2006-10-18 2008-07-31 Cephalon, Inc. Modafinil pharmaceutical compositions
CA2688430A1 (en) * 2007-06-04 2008-12-11 Generics [Uk] Limited Novel process
WO2009025791A2 (en) * 2007-08-16 2009-02-26 Teva Pharmaceutical Industries Ltd. Purification of armodafinil
FR2923482B1 (fr) * 2007-11-09 2010-01-29 Servier Lab Nouvelle forme cristalline vi de l'agomelatine, son procede de preparation et les compositions pharmaceutiques qui la contiennent
WO2009045488A2 (en) * 2007-10-02 2009-04-09 Teva Pharmaceutical Industries Ltd. Novel crystalline forms of armodafinil and preparation thereof
US20100036164A1 (en) * 2008-08-06 2010-02-11 Srinivas Areveli Preparation of armodafinil form i
US8551887B2 (en) 2009-12-22 2013-10-08 Air Products And Chemicals, Inc. Method for chemical mechanical planarization of a copper-containing substrate
CN102070498A (zh) * 2011-01-12 2011-05-25 华东师范大学 一种亚砜的制备方法
CN102746202B (zh) * 2012-07-04 2013-12-18 广州市博兴化工科技有限公司 一种含有甲基亚砜结构的丙烯酸酯化合物及其制备方法和应用
CR20160222U (es) 2013-11-15 2016-08-26 Akebia Therapeutics Inc Formas solidas de acido { [ -(3- clorofenil) -3- hidroxipiridin -2-carbonil] amino} acetico, composiciones, y usos de las mismas
CN104045588A (zh) * 2014-06-11 2014-09-17 江苏斯威森生物医药工程研究中心有限公司 一种2-(4,4’-二卤-二苯基甲基亚磺酰)乙酰胺的合成方法
US9616068B2 (en) 2014-10-27 2017-04-11 Pohela LLC Animal training using cognitive enhancement
KR102369302B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 압축 타입 힌지 스프링
KR102369295B1 (ko) 2020-11-12 2022-03-02 주식회사 에스코넥 벤딩 타입 힌지 스프링
KR102393940B1 (ko) 2020-11-12 2022-05-09 주식회사 에스코넥 토션 타입 힌지 스프링

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4127722A (en) 1975-10-02 1978-11-28 Laboratoire L. Lafon Benzhydrylsulphinyl derivatives
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them
FR2593809B1 (fr) * 1986-01-31 1988-07-22 Lafon Labor Benzhydrylsulfinylacetamide, procede de preparation et utilisation en therapeutique
FR2606015B1 (fr) 1986-08-13 1989-05-19 Lafon Labor Derives du benzhydrylthiomethane, leurs procedes de preparation et leurs applications en therapeutique
FR2611709B1 (fr) 1987-02-26 1989-06-09 Lafon Labor 2-(benzhydrylsulfonyl)acetamide, son procede de preparation et son application en therapeutique
US5843347A (en) * 1993-03-23 1998-12-01 Laboratoire L. Lafon Extrusion and freeze-drying method for preparing particles containing an active ingredient
FR2707637B1 (fr) 1993-06-30 1995-10-06 Lafon Labor Nouveaux dérivés d'acétamide, leur procédé de préparation et leur utilisation en thérapeutique.
US5618845A (en) * 1994-10-06 1997-04-08 Cephalon, Inc. Acetamide derivative having defined particle size
FR2771004B1 (fr) * 1997-11-19 2000-02-18 Inst Curie Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse
US6346548B1 (en) * 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6455588B1 (en) * 1999-08-20 2002-09-24 Cephalon, Inc. Compositions including modafinil for treatment of eating disorders and for appetite stimulation
CN1249932A (zh) * 1999-09-29 2000-04-12 付俊昌 一种莫达芬尼及其光学对映体l及d异构体的新用途
FR2804322B1 (fr) * 2000-01-31 2002-04-19 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies
HRP20030131B1 (en) * 2000-07-27 2011-03-31 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same
US6919378B2 (en) 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
IL143106A (en) * 2001-05-13 2005-11-20 Chemagis Ltd Process for the preparation of diphenylmethylthioacetamide
US7297346B2 (en) 2001-05-25 2007-11-20 Cephalon Inc. Pharmaceutical formulations of modafinil
ITMI20020991A1 (it) 2002-05-10 2003-11-10 Dinamite Dipharma S P A In For Procedimento per la sintesi del modafinil
US7229644B2 (en) 2002-05-23 2007-06-12 Cephalon, Inc. Pharmaceutical formulations of modafinil
US6875893B2 (en) * 2002-05-23 2005-04-05 Cephalon, Inc. Preparations of a sulfinyl acetamide
AU2003249105A1 (en) 2002-07-08 2004-01-23 Ranbaxy Laboratories Limited Processes for the preparation of oral dosage formulations of modafinil
US20040048931A1 (en) 2002-07-12 2004-03-11 Craig Heacock Modafinil pharmaceutical compositions
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
US20040116532A1 (en) 2002-09-13 2004-06-17 Craig Heacock Pharmaceutical formulations of modafinil
CA2409429A1 (en) * 2002-10-17 2004-04-17 Bayer Inc. Hydrogenated nitrile rubber composites with improved proccesability
IL153098A0 (en) * 2002-11-26 2003-06-24 Chemagis Ltd Pharmaceutical compositions containing modafinil
CA2514900A1 (en) 2003-01-31 2004-09-10 Alembic Limited Process for the preparation of 2-[(diphenylmethyl) thio] acetamide
MXPA05008088A (es) 2003-02-24 2005-09-21 Mallinckrodt Inc Proceso mejorado para preparar benzhidril tioacetamida.
CA2420180A1 (en) * 2003-02-28 2004-08-28 Bernard Charles Sherman Tablets comprising modafinil
AR045314A1 (es) * 2003-05-13 2005-10-26 Cephalon Inc Composiciones farmaceuticas de analepticos y antidepresivos
AR045423A1 (es) * 2003-05-13 2005-10-26 Cephalon Inc Combinaciones de analiticos y antidepresivos
US20040229941A1 (en) * 2003-05-13 2004-11-18 Cephalon, Inc. Analeptic and antidepressant combinations
US20040229943A1 (en) * 2003-05-16 2004-11-18 Cephalon Inc Analeptic and drug combinations
ITMI20031298A1 (it) 2003-06-26 2004-12-27 Erregierre Spa Processo di preparazione di modafinil forma polimorfa(i).

Also Published As

Publication number Publication date
KR100729298B1 (ko) 2007-06-18
PT1309547E (pt) 2007-03-30
KR20030029636A (ko) 2003-04-14
KR100729292B1 (ko) 2007-06-18
SK2242003A3 (en) 2003-10-07
EP1787980A2 (en) 2007-05-23
EP1309547A1 (en) 2003-05-14
EP1309547A4 (en) 2005-03-02
JP4980309B2 (ja) 2012-07-18
CN100500651C (zh) 2009-06-17
NZ524359A (en) 2005-06-24
HUP0400927A3 (en) 2007-11-28
JP4302977B2 (ja) 2009-07-29
KR101098749B1 (ko) 2011-12-23
CN101186590A (zh) 2008-05-28
PT1787980E (pt) 2010-03-18
DE20122504U1 (de) 2005-12-29
EP2168946A1 (en) 2010-03-31
KR20070097131A (ko) 2007-10-02
US6849120B2 (en) 2005-02-01
KR20070007970A (ko) 2007-01-16
KR101081212B1 (ko) 2011-11-07
KR20060097771A (ko) 2006-09-15
ES2277937T3 (es) 2007-08-01
CZ2003529A3 (cs) 2003-09-17
CY1110234T1 (el) 2015-01-14
DK1309547T3 (da) 2007-05-21
US7235691B2 (en) 2007-06-26
WO2002010125A1 (en) 2002-02-07
CA2634702C (en) 2011-07-19
JP2004509080A (ja) 2004-03-25
ATE453618T1 (de) 2010-01-15
CA2416792A1 (en) 2002-02-07
KR20090106661A (ko) 2009-10-09
CA2634702A1 (en) 2002-02-07
HUP0400927A2 (hu) 2004-07-28
PL365613A1 (en) 2005-01-10
KR20090103962A (ko) 2009-10-01
CA2685310A1 (en) 2002-02-07
US20050034652A1 (en) 2005-02-17
HRP20030131A2 (en) 2005-04-30
HRP20080373A2 (hr) 2008-12-31
KR20100098462A (ko) 2010-09-06
DE60140973D1 (de) 2010-02-11
US8048222B2 (en) 2011-11-01
AU2001283008A1 (en) 2002-02-13
DE60126099D1 (de) 2007-03-08
ZA200300672B (en) 2004-02-18
EP1787980B1 (en) 2009-12-30
MXPA03000747A (es) 2003-06-04
US20020043207A1 (en) 2002-04-18
PL206371B1 (pl) 2010-07-30
US20050038124A1 (en) 2005-02-17
IL154122A0 (en) 2003-07-31
EP1309547B1 (en) 2007-01-17
KR20060024028A (ko) 2006-03-15
IL154122A (en) 2009-07-20
EP1787980A3 (en) 2007-08-08
CN1466570A (zh) 2004-01-07
CA2685310C (en) 2012-10-16
HRP20030131B1 (en) 2011-03-31
CA2416792C (en) 2010-02-09
KR101019448B1 (ko) 2011-03-07
JP2009024006A (ja) 2009-02-05
DE60126099T2 (de) 2007-11-15
IS6699A (is) 2003-01-24
ES2337838T3 (es) 2010-04-29

Similar Documents

Publication Publication Date Title
DK1787980T3 (da) Krystallint og rent modafinil og fremgangsmåde til atfremstille dette
DK2380568T3 (da) Fremgangsmåde til fremstilling og krystallisation af reduceret coenzyme Q 10
AP1830A (en) Polymorphous form of rimonabant, preparation method and pharmaceutical compositions containing same.
SI1562941T1 (sl) Trans dehidroepotilon c in d njihovi analogi in postopek za izdelavo le teh
NO20035738L (no) Kontrollert frigivelsessammensetning og metode for a produsere det samme
NO20021559D0 (no) Fremgangsmåte til gjenvinning av ammoniakk
DK1383733T3 (da) Fremgangsmåde til fremstilling af 1,3-substituerede indener og aryl-sammenföjede azapolycykliske forbindelser
YU61103A (sh) Postupci za produkciju supstituisanih 2-(2-piridilmetil) sulfinil-1h-benzimidazola
DK1680430T3 (da) Fremgangsmåder til fremstilling af form I af (S)-(+)-Clopidogrel-bisulfat
DK1383742T3 (da) Syntese og fremgangsmåder til anvendelse af tetrahydroindolonanaloge og derivater
DE60326604D1 (de) Verfahren zur umwandlung von polysulfanen
DK1325022T3 (da) Fremgangsmåde til fremstilling af 21-hydroxy-6,19-oxidoprogesteron (21OH-6OP)
DK0785949T3 (da) Fremgangsmåde til oprensning af keratinocytvækstfaktorer
AU2003240634A8 (en) Method for producing bicalutamide
DK0749969T3 (da) Fremgangsmåde til fremstilling af polymorf form I af d4T
DK1373232T3 (da) Fremgangsmåde til fremstilling af N-substituerede 2,6-dialkylmorpholiner
DK0968997T3 (da) Fremgangsmåde til fremstilling af S-aryl-L-cystein og derivater
DK1262451T3 (da) Fremgangsmåde til at fremstille svovldioxid
DK1358179T3 (da) Syntesefremgangsmåde og mellemprodukter af pyridin-2-yl-methylamin
DK1309583T3 (da) Fremgangsmåde til fremstilling af discodermolid og analoge deraf
DK1408035T3 (da) Fremgangsmåde til fremstilling af derivater af 1,5-diaryl-3-trifluormethyl-delta2-pyrazoliner, der er racemiske og enantiomert rene
DE60200402D1 (de) Verfahren und Geräte zur Herstellung von Geschmackszusammensetzungen
DK1192308T3 (da) Fremgangsmåde til fremstilling af elastiske bånd til beklædningsindustrien
GB2382539B (en) Improved method of manufacture for hollow components
DK1385806T3 (da) Ettrinsfremgangsmåde til fremstilling af trimethoxytoluen