DK176599B1 - Antifungalt middel, forbindelse til dette, fremgangsmåde til fremstilling af denne og metode til dets anvendelse - Google Patents

Antifungalt middel, forbindelse til dette, fremgangsmåde til fremstilling af denne og metode til dets anvendelse Download PDF

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Publication number
DK176599B1
DK176599B1 DK199800013A DK1398A DK176599B1 DK 176599 B1 DK176599 B1 DK 176599B1 DK 199800013 A DK199800013 A DK 199800013A DK 1398 A DK1398 A DK 1398A DK 176599 B1 DK176599 B1 DK 176599B1
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DK
Denmark
Prior art keywords
compound
preparation
parts
formula
dichlorophenyl
Prior art date
Application number
DK199800013A
Other languages
Danish (da)
English (en)
Other versions
DK1398A (da
Inventor
Hiroki Kodama
Yoshimi Niwano
Kazuo Kanai
Mananori Yoshida
Original Assignee
Nihon Nohyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Nohyaku Co Ltd filed Critical Nihon Nohyaku Co Ltd
Publication of DK1398A publication Critical patent/DK1398A/da
Application granted granted Critical
Publication of DK176599B1 publication Critical patent/DK176599B1/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK199800013A 1995-07-08 1998-01-07 Antifungalt middel, forbindelse til dette, fremgangsmåde til fremstilling af denne og metode til dets anvendelse DK176599B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP19617495 1995-07-08
JP19617495 1995-07-08
JP9601872 1996-07-05
PCT/JP1996/001872 WO1997002821A2 (en) 1995-07-08 1996-07-05 Antifungal agent, compound therefor, process for producing the same

Publications (2)

Publication Number Publication Date
DK1398A DK1398A (da) 1998-01-07
DK176599B1 true DK176599B1 (da) 2008-10-27

Family

ID=16353435

Family Applications (1)

Application Number Title Priority Date Filing Date
DK199800013A DK176599B1 (da) 1995-07-08 1998-01-07 Antifungalt middel, forbindelse til dette, fremgangsmåde til fremstilling af denne og metode til dets anvendelse

Country Status (22)

Country Link
US (1) US5900488A (de)
EP (1) EP0839035B1 (de)
KR (1) KR100386491B1 (de)
CN (1) CN1091596C (de)
AT (1) AT407832B (de)
CA (1) CA2226214C (de)
CH (1) CH692045A5 (de)
DE (1) DE19681478B4 (de)
DK (1) DK176599B1 (de)
ES (1) ES2137888B1 (de)
FI (1) FI119357B (de)
GB (1) GB2317615B (de)
HK (1) HK1009751A1 (de)
IL (1) IL122618A (de)
IN (1) IN185384B (de)
LU (1) LU90190B1 (de)
NO (1) NO980055L (de)
NZ (1) NZ311796A (de)
SE (1) SE9800016L (de)
TW (1) TW450969B (de)
WO (1) WO1997002821A2 (de)
ZA (1) ZA965745B (de)

Families Citing this family (33)

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US6127397A (en) * 1996-12-10 2000-10-03 Nihon Nohyaku Co., Ltd. Optically active (R)-(E)-(4-substituted-phenyl-1,3-dithiolan-2-ylidene)-1-imidazolylaceto nitrile derivative, antifungal composition comprising the same, and method for producing the same
ATE521349T1 (de) 2002-06-18 2011-09-15 Pola Pharma Inc Antimykotische medizinische zusammensetzungen
WO2003105903A1 (ja) * 2002-06-18 2003-12-24 ポーラ化成工業株式会社 抗真菌医薬組成物
PL2005958T3 (pl) 2006-03-08 2013-11-29 Nihon Nohyaku Co Ltd Kompozycja farmaceutyczna do stosowania zewnętrznego
CA2645110C (en) * 2006-03-08 2013-11-19 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
BRPI0621386B8 (pt) * 2006-03-08 2021-07-13 Nihon Nihyaku Co Ltd composição farmacêutica para o uso externo
ES2588188T3 (es) * 2007-08-27 2016-10-31 Nihon Nohyaku Co., Ltd. Agente para la dermatitis fúngica
JP5529539B2 (ja) * 2007-09-05 2014-06-25 株式会社ポーラファルマ 医薬組成物
JP5453093B2 (ja) 2007-09-05 2014-03-26 株式会社ポーラファルマ 抗真菌医薬組成物
EP2191827B1 (de) 2007-09-05 2013-10-30 Pola Pharma Inc. Antimykotische zusammensetzung
CN102395274B (zh) 2009-02-13 2014-03-12 托派卡医药股份有限公司 抗真菌制剂
KR101409792B1 (ko) 2009-04-09 2014-06-19 니혼노야쿠가부시키가이샤 항진균성 약제학적 조성물
JP5688405B2 (ja) 2009-04-09 2015-03-25 株式会社ポーラファルマ 抗真菌医薬組成物
CN102481286B (zh) * 2009-08-25 2014-02-26 宝丽制药股份有限公司 抗真菌药物组合物
JP5832451B2 (ja) 2010-06-11 2015-12-16 株式会社ポーラファルマ 抗真菌医薬組成物
CN103012385B (zh) * 2012-02-17 2015-07-08 山东威智医药工业有限公司 卢立康唑的晶型及其制备方法
EP2895479A1 (de) * 2012-09-14 2015-07-22 Pola Pharma Inc. Kristall mit kristallverhalten und durch die verarbeitung des kristalls gewonnene pharmazeutische zusammensetzung
RU2622644C2 (ru) * 2012-09-14 2017-06-19 Пола Фарма Инк. Кристаллическое вещество и содержащий его фармацевтический препарат
JP5460797B1 (ja) 2012-09-14 2014-04-02 株式会社ポーラファルマ アミド誘導体及び安定性指標としてのその使用
US9068958B1 (en) 2012-09-14 2015-06-30 Pola Pharma Inc. Use of surface free energy for differential evaluation of crystal, crystal evaluated on basis of surface free energy as index, and pharmaceutical composition prepared by containing the crystal
CN104955455A (zh) * 2013-01-28 2015-09-30 宝丽制药股份有限公司 针对由病原微生物诸如曲霉引起的疾病的药物组合物
US20150352078A1 (en) * 2013-01-28 2015-12-10 Pola Pharma Inc. Pharmaceutical composition for diseases caused by pathogenic microorganisms such as candida
JP5589110B1 (ja) 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
JP5680161B1 (ja) 2013-09-06 2015-03-04 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
JP5587488B1 (ja) 2013-12-12 2014-09-10 株式会社ポーラファルマ ルリコナゾールを含有する製剤の評価方法及び指標物質
AR100180A1 (es) * 2014-04-25 2016-09-14 Syngenta Participations Ag Derivados de imidazol microbiocidas
EP3230280A4 (de) * 2014-12-12 2018-05-09 Glenmark Pharmaceuticals Limited Verfahren zur herstellung von luliconazol
WO2017108972A1 (en) 2015-12-21 2017-06-29 Laboratorios Lesvi, S.L. Compounds of r-(-)-(e)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1 -imidazolylacetonitrile-ha (luliconazole-ha) as antifungals
CN106008166B (zh) * 2016-05-17 2018-09-25 上海福乐医药科技有限公司 一种手性2-氯-1-(2,4-二氯苯基)乙醇的工业化生产方法
US11185548B2 (en) 2016-12-23 2021-11-30 Helmholtz Zentrum Munchen—Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Inhibitors of cytochrome P450 family 7 subfamily B member 1 (CYP7B1) for use in treating diseases
TR201714882A2 (tr) 2017-10-03 2019-04-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Luli̇konazolün topi̇kal farmasöti̇k kompozi̇syonlari
US10898470B1 (en) 2019-08-13 2021-01-26 Sato Pharmaceutical Co., Ltd. Pharmaceutical composition containing antifungal agent as active ingredient
WO2023131969A1 (en) * 2022-01-09 2023-07-13 Kimia Biosciences Limited Improved process for the preparation of luliconazole

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0218736B1 (de) * 1985-10-10 1993-04-07 Nihon Nohyaku Co., Ltd. Keten-S,S,-acetalderivate, Verfahren zu ihrer Herstellung und Methode zur Heilung von Mykose unter Verwendung dieser Derivate
DE3587252T2 (de) * 1985-10-09 1993-07-15 Nihon Nohyaku Co Ltd Keten-s,s,-acetalderivate, verfahren zu ihrer herstellung und methode zur heilung von mykose unter verwendung dieser derivate.
JP3030780B2 (ja) * 1988-12-29 2000-04-10 日本農薬株式会社 光学活性なケテンジチオアセタール誘導体及びその製造方法
JPH0386337A (ja) * 1989-08-28 1991-04-11 Maeda Seisakusho:Kk エクスパンディングチャックを用いた多重巻締め機および多重巻締め方法
CN1038247C (zh) * 1990-05-16 1998-05-06 云南省建筑材料科学研究设计院 一种新型磷石膏胶结料
JP3038519B2 (ja) * 1992-01-28 2000-05-08 日本農薬株式会社 創傷治癒促進剤

Also Published As

Publication number Publication date
US5900488A (en) 1999-05-04
NO980055L (no) 1998-03-06
FI980023A (fi) 1998-01-07
IN185384B (de) 2001-01-13
CH692045A5 (de) 2002-01-15
FI980023A0 (fi) 1998-01-07
MX9710401A (es) 1998-07-31
EP0839035A2 (de) 1998-05-06
KR19990028772A (ko) 1999-04-15
AT407832B (de) 2001-06-25
NZ311796A (en) 1999-06-29
ES2137888B1 (es) 2001-01-01
CN1194582A (zh) 1998-09-30
NO980055D0 (no) 1998-01-06
IL122618A0 (en) 1998-08-16
CA2226214A1 (en) 1997-01-30
AU6319296A (en) 1997-02-10
CA2226214C (en) 2007-04-17
ATA906196A (de) 2000-11-15
FI119357B (fi) 2008-10-31
EP0839035B1 (de) 2002-10-02
HK1009751A1 (en) 1999-06-11
TW450969B (en) 2001-08-21
SE9800016D0 (sv) 1998-01-07
DE19681478B4 (de) 2006-09-21
ZA965745B (en) 1997-01-27
WO1997002821A3 (en) 1997-02-20
DE19681478T1 (de) 1998-07-02
ES2137888A1 (es) 1999-12-16
CN1091596C (zh) 2002-10-02
LU90190B1 (de) 1998-03-02
GB2317615A (en) 1998-04-01
AU697571B2 (en) 1998-10-08
KR100386491B1 (ko) 2003-08-21
GB9726766D0 (en) 1998-02-18
SE9800016L (sv) 1998-01-07
DK1398A (da) 1998-01-07
WO1997002821A2 (en) 1997-01-30
GB2317615B (en) 1998-09-02
IL122618A (en) 2002-07-25

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PUP Patent expired

Expiry date: 20180107