JP5529539B2 - 医薬組成物 - Google Patents
医薬組成物 Download PDFInfo
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- JP5529539B2 JP5529539B2 JP2009531290A JP2009531290A JP5529539B2 JP 5529539 B2 JP5529539 B2 JP 5529539B2 JP 2009531290 A JP2009531290 A JP 2009531290A JP 2009531290 A JP2009531290 A JP 2009531290A JP 5529539 B2 JP5529539 B2 JP 5529539B2
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- antifungal
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- alcohol
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- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- BWMISRWJRUSYEX-SZKNIZGXSA-N terbinafine hydrochloride Chemical compound Cl.C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 BWMISRWJRUSYEX-SZKNIZGXSA-N 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 201000003875 tinea corporis Diseases 0.000 description 1
- 229910052719 titanium Inorganic materials 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 229960000984 tocofersolan Drugs 0.000 description 1
- AOBORMOPSGHCAX-DGHZZKTQSA-N tocofersolan Chemical compound OCCOC(=O)CCC(=O)OC1=C(C)C(C)=C2O[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C AOBORMOPSGHCAX-DGHZZKTQSA-N 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 239000003860 topical agent Substances 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 150000003698 vitamin B derivatives Chemical class 0.000 description 1
- 235000011912 vitamin B7 Nutrition 0.000 description 1
- 239000011735 vitamin B7 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 235000007680 β-tocopherol Nutrition 0.000 description 1
- 239000011590 β-tocopherol Substances 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
かかる知見により、本発明者らは、発明を完成させるに至った。即ち、本発明は以下に示す通りである。
一般式(1)で示される化合物のXがハロゲンである場合には、ハロゲンとして塩素原子、臭素原子、ヨウ素原子及びフッ素原子が好ましく例示でき、塩素であることが特に好ましい。
また、一般式(1)で示される化合物の抗真菌外用剤組成物全量に対する含有量は0.01〜20質量%であることが好ましく、0.1〜10質量%であることが特に好ましい。
この製剤の刺激感は認められなかった。
この製剤の刺激感は認められなかった。
この製剤の刺激感は認められなかった。
この製剤の刺激感は認められなかった。
Claims (5)
- 一般式(1)で示される化合物がルリコナゾールであることを特徴とする、請求項1に記載の抗真菌用外用剤。
- 一相の溶液形態であることを特徴とする、請求項1または2に記載の抗真菌用外用剤。
- 適用される疾患が足白癬、体部白癬もしくは股部白癬、間擦疹を伴うカンジタ症もしくは指間びらんを伴うカンジタ症、癜風または脂漏性皮膚炎であることを特徴とする、請求項1〜3のいずれか一項に記載の抗真菌用外用剤。
- 適用される疾患が脂漏性皮膚炎であることを特徴とする、請求項4に記載の抗真菌用外用剤。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009531290A JP5529539B2 (ja) | 2007-09-05 | 2008-09-05 | 医薬組成物 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007229619 | 2007-09-05 | ||
JP2007229619 | 2007-09-05 | ||
PCT/JP2008/066056 WO2009031642A1 (ja) | 2007-09-05 | 2008-09-05 | 医薬組成物 |
JP2009531290A JP5529539B2 (ja) | 2007-09-05 | 2008-09-05 | 医薬組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2009031642A1 JPWO2009031642A1 (ja) | 2010-12-16 |
JP5529539B2 true JP5529539B2 (ja) | 2014-06-25 |
Family
ID=40428954
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009531290A Active JP5529539B2 (ja) | 2007-09-05 | 2008-09-05 | 医薬組成物 |
Country Status (6)
Country | Link |
---|---|
US (2) | US20100204293A1 (ja) |
EP (1) | EP2191826B1 (ja) |
JP (1) | JP5529539B2 (ja) |
KR (1) | KR20100075475A (ja) |
CN (1) | CN101808637B (ja) |
WO (1) | WO2009031642A1 (ja) |
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US10898470B1 (en) | 2019-08-13 | 2021-01-26 | Sato Pharmaceutical Co., Ltd. | Pharmaceutical composition containing antifungal agent as active ingredient |
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MX2008011433A (es) * | 2006-03-08 | 2008-09-18 | Nihon Nohyaku Co Ltd | Composicion farmaceutica para uso externo. |
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US10130610B2 (en) | 2009-04-09 | 2018-11-20 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
WO2010117091A2 (en) | 2009-04-09 | 2010-10-14 | Pola Pharma Inc. | Antimycotic pharmaceutical composition |
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2008
- 2008-09-05 CN CN2008801059132A patent/CN101808637B/zh active Active
- 2008-09-05 KR KR1020107007255A patent/KR20100075475A/ko active IP Right Grant
- 2008-09-05 JP JP2009531290A patent/JP5529539B2/ja active Active
- 2008-09-05 EP EP08829061.4A patent/EP2191826B1/en active Active
- 2008-09-05 WO PCT/JP2008/066056 patent/WO2009031642A1/ja active Application Filing
- 2008-09-05 US US12/676,346 patent/US20100204293A1/en not_active Abandoned
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2012
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10898470B1 (en) | 2019-08-13 | 2021-01-26 | Sato Pharmaceutical Co., Ltd. | Pharmaceutical composition containing antifungal agent as active ingredient |
KR20220035954A (ko) | 2019-08-13 | 2022-03-22 | 사토 세이야쿠 가부시키가이샤 | 항진균약을 유효성분으로 하는 의약 조성물 |
US11738006B2 (en) | 2019-08-13 | 2023-08-29 | Sato Pharmaceutical Co., Ltd. | Pharmaceutical composition containing antifungal agent as active ingredient |
Also Published As
Publication number | Publication date |
---|---|
KR20100075475A (ko) | 2010-07-02 |
WO2009031642A1 (ja) | 2009-03-12 |
CN101808637B (zh) | 2013-07-24 |
US20120329845A1 (en) | 2012-12-27 |
EP2191826B1 (en) | 2017-03-08 |
EP2191826A1 (en) | 2010-06-02 |
JPWO2009031642A1 (ja) | 2010-12-16 |
EP2191826A4 (en) | 2010-09-15 |
US8513296B2 (en) | 2013-08-20 |
US20100204293A1 (en) | 2010-08-12 |
CN101808637A (zh) | 2010-08-18 |
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