DE19681478T1 - Fungizides Mittel, eine Verbindung hierfür, Verfahren zu ihrer Herstellung und Verfahren zu ihrer Verwendung - Google Patents

Fungizides Mittel, eine Verbindung hierfür, Verfahren zu ihrer Herstellung und Verfahren zu ihrer Verwendung

Info

Publication number
DE19681478T1
DE19681478T1 DE19681478T DE19681478T DE19681478T1 DE 19681478 T1 DE19681478 T1 DE 19681478T1 DE 19681478 T DE19681478 T DE 19681478T DE 19681478 T DE19681478 T DE 19681478T DE 19681478 T1 DE19681478 T1 DE 19681478T1
Authority
DE
Germany
Prior art keywords
processes
preparation
fungicidal agent
compound therefor
therefor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE19681478T
Other languages
English (en)
Other versions
DE19681478B4 (de
Inventor
Hiroki Kodama
Yoshimi Niwano
Kazuo Kanai
Masanori Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Nohyaku Co Ltd
Original Assignee
Nihon Nohyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Nohyaku Co Ltd filed Critical Nihon Nohyaku Co Ltd
Publication of DE19681478T1 publication Critical patent/DE19681478T1/de
Application granted granted Critical
Publication of DE19681478B4 publication Critical patent/DE19681478B4/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19681478T 1995-07-08 1996-07-05 R-(-)-(E)-[4-(2,4-Dichlorphenyl)-1,3-dithiolan-2-yliden]-1-imidazolylacetonitril,Verfahren zu seiner Herstellung und seine Verwendung Expired - Lifetime DE19681478B4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP07/196174 1995-07-08
JP19617495 1995-07-08
PCT/JP1996/001872 WO1997002821A2 (en) 1995-07-08 1996-07-05 Antifungal agent, compound therefor, process for producing the same

Publications (2)

Publication Number Publication Date
DE19681478T1 true DE19681478T1 (de) 1998-07-02
DE19681478B4 DE19681478B4 (de) 2006-09-21

Family

ID=16353435

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19681478T Expired - Lifetime DE19681478B4 (de) 1995-07-08 1996-07-05 R-(-)-(E)-[4-(2,4-Dichlorphenyl)-1,3-dithiolan-2-yliden]-1-imidazolylacetonitril,Verfahren zu seiner Herstellung und seine Verwendung

Country Status (22)

Country Link
US (1) US5900488A (de)
EP (1) EP0839035B1 (de)
KR (1) KR100386491B1 (de)
CN (1) CN1091596C (de)
AT (1) AT407832B (de)
CA (1) CA2226214C (de)
CH (1) CH692045A5 (de)
DE (1) DE19681478B4 (de)
DK (1) DK176599B1 (de)
ES (1) ES2137888B1 (de)
FI (1) FI119357B (de)
GB (1) GB2317615B (de)
HK (1) HK1009751A1 (de)
IL (1) IL122618A (de)
IN (1) IN185384B (de)
LU (1) LU90190B1 (de)
NO (1) NO980055L (de)
NZ (1) NZ311796A (de)
SE (1) SE9800016L (de)
TW (1) TW450969B (de)
WO (1) WO1997002821A2 (de)
ZA (1) ZA965745B (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6127397A (en) * 1996-12-10 2000-10-03 Nihon Nohyaku Co., Ltd. Optically active (R)-(E)-(4-substituted-phenyl-1,3-dithiolan-2-ylidene)-1-imidazolylaceto nitrile derivative, antifungal composition comprising the same, and method for producing the same
JPWO2003105903A1 (ja) * 2002-06-18 2005-10-13 ポーラ化成工業株式会社 抗真菌医薬組成物
CA2489854A1 (en) 2002-06-18 2003-12-24 Pola Chemical Industries Inc. Antifungal medicinal compositions
EP2005958B1 (de) * 2006-03-08 2013-04-17 Nihon Nohyaku Co., Ltd. Topische pharmazeutische zusammensetzung
CA2645058C (en) * 2006-03-08 2013-07-30 Nihon Nohyaku Co., Ltd. Pharmaceutical composition for external use
JP5184342B2 (ja) * 2006-03-08 2013-04-17 日本農薬株式会社 外用の医薬組成物
US8492421B2 (en) * 2007-08-27 2013-07-23 Nihon Nohyaku Co., Ltd. Agent for fungal dermatitis
US20100173965A1 (en) 2007-09-05 2010-07-08 Pola Pharma Inc. Antifungal composition
JP5529539B2 (ja) * 2007-09-05 2014-06-25 株式会社ポーラファルマ 医薬組成物
CN101808639B (zh) 2007-09-05 2012-12-05 宝丽制药股份有限公司 抗真菌医药组合物
JP5654497B2 (ja) * 2009-02-13 2015-01-14 トピカ ファーマシューティカルズ，インコーポレイテッド 抗真菌製剤
US10130610B2 (en) 2009-04-09 2018-11-20 Pola Pharma Inc. Antimycotic pharmaceutical composition
US9050271B2 (en) 2009-04-09 2015-06-09 Pola Pharma Inc. Antimycotic pharmaceutical composition
JP5635075B2 (ja) 2009-08-25 2014-12-03 株式会社ポーラファルマ 抗真菌医薬組成物
US8962669B2 (en) 2010-06-11 2015-02-24 Pola Pharma Inc. Antimycotic pharmaceutical composition
CN103012385B (zh) * 2012-02-17 2015-07-08 山东威智医药工业有限公司 卢立康唑的晶型及其制备方法
JP5460797B1 (ja) 2012-09-14 2014-04-02 株式会社ポーラファルマ アミド誘導体及び安定性指標としてのその使用
CN104619704B (zh) * 2012-09-14 2017-12-05 宝丽制药股份有限公司 表面自由能用于分化评价晶体的用途，基于表面自由能作为指标评价的晶体，以及通过包含所述晶体制备的药物组合物
IN2015DN02376A (de) * 2012-09-14 2015-09-04 Pola Pharma Inc
RU2622644C2 (ru) * 2012-09-14 2017-06-19 Пола Фарма Инк. Кристаллическое вещество и содержащий его фармацевтический препарат
JP6254597B2 (ja) * 2013-01-28 2017-12-27 株式会社ポーラファルマ カンジダ等の病原微生物による疾患用の医薬組成物
WO2014115487A1 (en) * 2013-01-28 2014-07-31 Pola Pharma Inc. Pharmaceutical composition for diseases caused by pathogenic microorganisms such as aspergillus
JP5589110B1 (ja) 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
JP5680161B1 (ja) * 2013-09-06 2015-03-04 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
JP5587488B1 (ja) 2013-12-12 2014-09-10 株式会社ポーラファルマ ルリコナゾールを含有する製剤の評価方法及び指標物質
WO2015162271A1 (en) * 2014-04-25 2015-10-29 Syngenta Participations Ag Microbiocidal imidazole derivatives
WO2016092478A1 (en) 2014-12-12 2016-06-16 Glenmark Pharmaceuticals Limited Process for preparation of luliconazole
WO2017108972A1 (en) 2015-12-21 2017-06-29 Laboratorios Lesvi, S.L. Compounds of r-(-)-(e)-[4-(2,4-dichlorophenyl)-1,3-dithiolan-2-ylidene]-1 -imidazolylacetonitrile-ha (luliconazole-ha) as antifungals
CN106008166B (zh) * 2016-05-17 2018-09-25 上海福乐医药科技有限公司 一种手性2-氯-1-(2,4-二氯苯基)乙醇的工业化生产方法
EP3558304A2 (de) 2016-12-23 2019-10-30 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibitoren des mitglieds 1 der unterfamilie b der cytochrom-p450-familie 7 (cyp7b1) zur verwendung in der behandlung von krankheiten
TR201714882A2 (tr) 2017-10-03 2019-04-22 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Luli̇konazolün topi̇kal farmasöti̇k kompozi̇syonlari
US10898470B1 (en) 2019-08-13 2021-01-26 Sato Pharmaceutical Co., Ltd. Pharmaceutical composition containing antifungal agent as active ingredient
WO2023131969A1 (en) * 2022-01-09 2023-07-13 Kimia Biosciences Limited Improved process for the preparation of luliconazole

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0218736B1 (de) * 1985-10-10 1993-04-07 Nihon Nohyaku Co., Ltd. Keten-S,S,-acetalderivate, Verfahren zu ihrer Herstellung und Methode zur Heilung von Mykose unter Verwendung dieser Derivate
DE3587252T2 (de) * 1985-10-09 1993-07-15 Nihon Nohyaku Co Ltd Keten-s,s,-acetalderivate, verfahren zu ihrer herstellung und methode zur heilung von mykose unter verwendung dieser derivate.
JP3030780B2 (ja) * 1988-12-29 2000-04-10 日本農薬株式会社 光学活性なケテンジチオアセタール誘導体及びその製造方法
JPH0386337A (ja) * 1989-08-28 1991-04-11 Maeda Seisakusho:Kk エクスパンディングチャックを用いた多重巻締め機および多重巻締め方法
CN1038247C (zh) * 1990-05-16 1998-05-06 云南省建筑材料科学研究设计院 一种新型磷石膏胶结料
JP3038519B2 (ja) * 1992-01-28 2000-05-08 日本農薬株式会社 創傷治癒促進剤

Also Published As

Publication number Publication date
ZA965745B (en) 1997-01-27
EP0839035B1 (de) 2002-10-02
GB2317615A (en) 1998-04-01
CA2226214C (en) 2007-04-17
NO980055D0 (no) 1998-01-06
ES2137888A1 (es) 1999-12-16
FI119357B (fi) 2008-10-31
AU697571B2 (en) 1998-10-08
CN1194582A (zh) 1998-09-30
NO980055L (no) 1998-03-06
EP0839035A2 (de) 1998-05-06
GB2317615B (en) 1998-09-02
KR100386491B1 (ko) 2003-08-21
NZ311796A (en) 1999-06-29
LU90190B1 (de) 1998-03-02
US5900488A (en) 1999-05-04
DK176599B1 (da) 2008-10-27
AU6319296A (en) 1997-02-10
CN1091596C (zh) 2002-10-02
IN185384B (de) 2001-01-13
IL122618A0 (en) 1998-08-16
AT407832B (de) 2001-06-25
DE19681478B4 (de) 2006-09-21
GB9726766D0 (en) 1998-02-18
HK1009751A1 (en) 1999-06-11
KR19990028772A (ko) 1999-04-15
DK1398A (da) 1998-01-07
ATA906196A (de) 2000-11-15
SE9800016D0 (sv) 1998-01-07
ES2137888B1 (es) 2001-01-01
IL122618A (en) 2002-07-25
FI980023A0 (fi) 1998-01-07
CA2226214A1 (en) 1997-01-30
FI980023A (fi) 1998-01-07
TW450969B (en) 2001-08-21
MX9710401A (es) 1998-07-31
WO1997002821A3 (en) 1997-02-20
SE9800016L (sv) 1998-01-07
CH692045A5 (de) 2002-01-15
WO1997002821A2 (en) 1997-01-30

Similar Documents

Publication Publication Date Title
DE19681478T1 (de) Fungizides Mittel, eine Verbindung hierfür, Verfahren zu ihrer Herstellung und Verfahren zu ihrer Verwendung
DE59810127D1 (de) Bispyrazolazaverbindungen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Haarfärbemittel
DE69700350D1 (de) 4,5-Diiminopyrazoline, Verfahren zu ihrer Herstellung und diese enthaltende Färbemittel
DE69615668T2 (de) O-carbamoyl-(d)-phenylalanilolverbindungen und verfahren zu ihrer herstellung.
ATE242762T1 (de) Acrylonitril-derivate, verfahren zu ihrer herstellung und diese enthaltende schädlingsbekämpfungsmittel
DE59108699D1 (de) Naphthylalkylaminopyrimidin-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende Schädlingsbekämpfungsmittel
DE69326569T2 (de) Sterinderivate, Verfahren zu ihrer Herstellung und dermatologische Präparate
DE59802412D1 (de) Biphenylsulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
ATE200075T1 (de) Hydroximsäurederivate, verfahren zu ihrer herstellung und ihre verwendung als schädlingsbekämpfungsmittel und fungizide
DE59609207D1 (de) Farbstoffmischungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DE69428029D1 (de) Chinizarin-Verbindungen, Verfahren zu ihrer Herstellung und ihre Anwendung
DE69603377T2 (de) Ammoxidationskatalysatoren und Verfahren zu ihrer Herstellung
DE69827939D1 (de) Oxim-verbindungen, ihre anwendung und zwischenprodukte zu ihrer herstellung
DE59506861D1 (de) Schwefelorganische Goldverbindungen, Verfahren zu ihrer Herstellung und Verwendung derselben
DE69531054D1 (de) Landwirtschaftliche chemische präparate und verfahren zu ihrer herstellung
ATE244246T1 (de) Pyridothienodiazepine, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
DE69500978D1 (de) Verzweigte Polyenen und Verfahren zu ihrer Herstellung
DE69803776D1 (de) Fungizide verbindungen, die einen fluorvinyloxyphenyl-rest enthalten und verfahren zu ihrer herstellung
DE69628580D1 (de) Pestizide verbindungen, verfahren zu ihrer herstellung und zusammensetzungen
DE69021602D1 (de) N-substituierte-3-Hydrazino-benzenesulfonamid-Derivate, Verfahren zu ihrer Herstellung und herbizide Mittel.
DE59800568D1 (de) Benzoxazindionderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19980787D2 (de) Substituierte Sulfonylcyanamide, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikament
DE69502517D1 (de) Difluorprostacycline, Zwischenprodukte und Verfahren zu deren Herstellung
DE69519713D1 (de) Diaminoverbindungen und Verfahren zu ihrer Herstellung
DE69300253T2 (de) Sulfonamidderivate, Verfahren zu ihrer Herstellung und diese enthaltende Herbizide.

Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8125 Change of the main classification

Ipc: C07D339/06

8364 No opposition during term of opposition
R071 Expiry of right