DE69502517D1 - Difluorprostacycline, Zwischenprodukte und Verfahren zu deren Herstellung - Google Patents

Difluorprostacycline, Zwischenprodukte und Verfahren zu deren Herstellung

Info

Publication number
DE69502517D1
DE69502517D1 DE69502517T DE69502517T DE69502517D1 DE 69502517 D1 DE69502517 D1 DE 69502517D1 DE 69502517 T DE69502517 T DE 69502517T DE 69502517 T DE69502517 T DE 69502517T DE 69502517 D1 DE69502517 D1 DE 69502517D1
Authority
DE
Germany
Prior art keywords
difluoroprostacyclins
intermediates
processes
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69502517T
Other languages
English (en)
Other versions
DE69502517T2 (de
Inventor
Yasushi Matsumura
Takashi Nakano
Mayumi Makino
Yoshitomi Morizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AGC Inc
Original Assignee
Asahi Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6020450A external-priority patent/JPH07228581A/ja
Priority claimed from JP08064194A external-priority patent/JP3719524B2/ja
Priority claimed from JP28385794A external-priority patent/JP3692553B2/ja
Application filed by Asahi Glass Co Ltd filed Critical Asahi Glass Co Ltd
Publication of DE69502517D1 publication Critical patent/DE69502517D1/de
Application granted granted Critical
Publication of DE69502517T2 publication Critical patent/DE69502517T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69502517T 1994-02-17 1995-02-16 Difluorprostacycline, Zwischenprodukte und Verfahren zu deren Herstellung Expired - Lifetime DE69502517T2 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP6020450A JPH07228581A (ja) 1994-02-17 1994-02-17 ジハロゲン化プロスタサイクリン類中間体およびその製造方法
JP4685394 1994-03-17
JP7109794 1994-04-08
JP7198994 1994-04-11
JP08064194A JP3719524B2 (ja) 1994-03-17 1994-04-19 ジハロゲン化プロスタサイクリン類の製造方法
JP28385794A JP3692553B2 (ja) 1994-11-17 1994-11-17 ジフルオロラクトン類の製造方法

Publications (2)

Publication Number Publication Date
DE69502517D1 true DE69502517D1 (de) 1998-06-25
DE69502517T2 DE69502517T2 (de) 1998-10-01

Family

ID=27548920

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69502517T Expired - Lifetime DE69502517T2 (de) 1994-02-17 1995-02-16 Difluorprostacycline, Zwischenprodukte und Verfahren zu deren Herstellung
DE69531110T Expired - Lifetime DE69531110T2 (de) 1994-02-17 1995-02-16 Difluoroprostacycline, Zwischenprodukte zu deren Herstellung und Herstellungsverfahren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69531110T Expired - Lifetime DE69531110T2 (de) 1994-02-17 1995-02-16 Difluoroprostacycline, Zwischenprodukte zu deren Herstellung und Herstellungsverfahren

Country Status (4)

Country Link
US (3) US5538995A (de)
EP (2) EP0789022B1 (de)
DE (2) DE69502517T2 (de)
ES (2) ES2116630T3 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60208683T2 (de) * 2001-08-01 2006-11-02 Basell Polyolefine Gmbh Verfahren zur herstellung von heterocyclischen pentalen derivaten
BRPI0918134B1 (pt) * 2008-09-10 2019-02-12 Kaken Pharmaceutical Co., Ltd Derivado de prostaglandina i2
CN102917703B (zh) * 2010-03-08 2015-08-19 科研制药株式会社 新型ep4激动剂
CN111344300B (zh) * 2017-11-14 2024-08-30 千寿制药株式会社 Pacap的稳定化肽

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS56501319A (de) * 1979-10-10 1981-09-17
US4324730A (en) * 1979-10-10 1982-04-13 The University Of Chicago Certain fluorine substituted PGI2 compounds
US4565827A (en) * 1980-10-27 1986-01-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara R.T. 7-Substituted PGI2 -derivatives and pharmaceutical compositions containing them
JPS57165382A (en) * 1981-04-06 1982-10-12 Teijin Ltd Fluoro-pgi2 compound and its preparation
US4317906A (en) * 1980-12-15 1982-03-02 E. R. Squibb & Sons, Inc. Method for preparing 10,10-difluoro prostacyclins
ZA821449B (en) * 1981-03-11 1983-01-26 Hoffmann La Roche Novel fluoro prostacyclins
JPS6191136A (ja) * 1984-10-09 1986-05-09 Teijin Ltd プロスタグランジン類製剤用組成物
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds
JPS6424147A (en) * 1987-07-15 1989-01-26 Mazda Motor Cylinder block structure for engine
JPH0314030A (ja) * 1989-06-12 1991-01-22 Nec Eng Ltd リクエスト制御装置
JPH0347272A (ja) * 1989-07-14 1991-02-28 Kuraray Co Ltd 中空繊維型液体処理装置
JP3195002B2 (ja) * 1990-09-07 2001-08-06 旭硝子株式会社 新規なプロスタグランジン誘導体

Also Published As

Publication number Publication date
US5538995A (en) 1996-07-23
ES2116630T3 (es) 1998-07-16
EP0669329B1 (de) 1998-05-20
US5747531A (en) 1998-05-05
ES2201214T3 (es) 2004-03-16
EP0789022B1 (de) 2003-06-18
US5616732A (en) 1997-04-01
DE69531110T2 (de) 2004-05-19
DE69531110D1 (de) 2003-07-24
EP0669329A1 (de) 1995-08-30
EP0789022A1 (de) 1997-08-13
DE69502517T2 (de) 1998-10-01

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DE69502517D1 (de) Difluorprostacycline, Zwischenprodukte und Verfahren zu deren Herstellung

Legal Events

Date Code Title Description
8364 No opposition during term of opposition