ES2116630T3 - Difluorprostaciclinas; productos intermediarios y procedimientos para su preparacion. - Google Patents

Difluorprostaciclinas; productos intermediarios y procedimientos para su preparacion.

Info

Publication number
ES2116630T3
ES2116630T3 ES95102195T ES95102195T ES2116630T3 ES 2116630 T3 ES2116630 T3 ES 2116630T3 ES 95102195 T ES95102195 T ES 95102195T ES 95102195 T ES95102195 T ES 95102195T ES 2116630 T3 ES2116630 T3 ES 2116630T3
Authority
ES
Spain
Prior art keywords
substituted
group
alkylyl
difluorprostaciclinas
procedures
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95102195T
Other languages
English (en)
Inventor
Yasushi Matsumura
Takashi Nakano
Mayumi Makino
Yoshitomi Morizawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AGC Inc
Original Assignee
Asahi Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP6020450A external-priority patent/JPH07228581A/ja
Priority claimed from JP08064194A external-priority patent/JP3719524B2/ja
Priority claimed from JP28385794A external-priority patent/JP3692553B2/ja
Application filed by Asahi Glass Co Ltd filed Critical Asahi Glass Co Ltd
Application granted granted Critical
Publication of ES2116630T3 publication Critical patent/ES2116630T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/1892—Preparation; Treatments not provided for in C07F7/20 by reactions not provided for in C07F7/1876 - C07F7/1888
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UNA DIFLUORPROSTACICLINA DE LA SIGUIENTE (V) FORMULA, SU ESTER ALCANOL INFERIOR O SU SAL FARMACEUTICAMENTE ACEPTABLE: EN DONDE A ES UN GRUPO ETILENO, UN GRUPO VINILENO O UN GRUPO ETINILENO, R ES UN GRUPO ALQUILO C1-10 SUSTITUIDO O INSUSTITUIDO, UN GRUPO ALQUENILO C1-10 SUSTITUIDO O INSUSTITUIDO, UN GRUPO ALQUINILO C1-10 SUSTITUIDO O INSUSTITUIDO, UN GRUPO CICLOALQUILO C3-8 SUSTITUIDO O INSUSTITUIDO, UN GRUPO ARALQUILO SUSTITUIDO O INSUSTITUIDO, O UN GRUPO ARILOXI SUSTITUIDO O INSUSTITUIDO, Q ES UN GRUPO ALQUILO C1-10 SUSTITUIDO O INSUSTITUIDO, UN GRUPO ALQUENILO C1-10 SUSTITUIDO O INSUSTITUIDO, UN GRUPO ALQUINILO C1-10 SUSTITUIDO O INSUSTITUIDO, UN GRUPO CICLOALQUILO SUSTITUIDO O INSUSTITUIDO, UN GRUPO ARALQUILO SUSTITUIDO O INSUSTITUIDO, O UN GRUPO ARILO SUSTITUIDO O INSUSTITUIDO.
ES95102195T 1994-02-17 1995-02-16 Difluorprostaciclinas; productos intermediarios y procedimientos para su preparacion. Expired - Lifetime ES2116630T3 (es)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP6020450A JPH07228581A (ja) 1994-02-17 1994-02-17 ジハロゲン化プロスタサイクリン類中間体およびその製造方法
JP4685394 1994-03-17
JP7109794 1994-04-08
JP7198994 1994-04-11
JP08064194A JP3719524B2 (ja) 1994-03-17 1994-04-19 ジハロゲン化プロスタサイクリン類の製造方法
JP28385794A JP3692553B2 (ja) 1994-11-17 1994-11-17 ジフルオロラクトン類の製造方法

Publications (1)

Publication Number Publication Date
ES2116630T3 true ES2116630T3 (es) 1998-07-16

Family

ID=27548920

Family Applications (2)

Application Number Title Priority Date Filing Date
ES95102195T Expired - Lifetime ES2116630T3 (es) 1994-02-17 1995-02-16 Difluorprostaciclinas; productos intermediarios y procedimientos para su preparacion.
ES97103129T Expired - Lifetime ES2201214T3 (es) 1994-02-17 1995-02-16 Difluoroprostaciclinas, intermediarios para la produccion y procedimietos de su produccion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES97103129T Expired - Lifetime ES2201214T3 (es) 1994-02-17 1995-02-16 Difluoroprostaciclinas, intermediarios para la produccion y procedimietos de su produccion.

Country Status (4)

Country Link
US (3) US5538995A (es)
EP (2) EP0669329B1 (es)
DE (2) DE69531110T2 (es)
ES (2) ES2116630T3 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1412347B1 (en) * 2001-08-01 2006-01-11 Basell Polyolefine GmbH Process for the preparation of heterocyclic pentalene derivatives
EP2343292B1 (en) * 2008-09-10 2014-08-06 Asahi Glass Company, Limited Novel prostaglandin i2 derivative
BR112012022632B1 (pt) * 2010-03-08 2020-03-31 Kaken Pharmaceutical Co., Ltd. Medicamento compreendendo Agonista de ep4
JPWO2019098254A1 (ja) * 2017-11-14 2020-12-03 千寿製薬株式会社 Ｐａｃａｐの安定化ペプチド

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1981001002A1 (en) * 1979-10-10 1981-04-16 Univ Chicago Fluoro-substituted prostaglandins and prostacyclins
US4324730A (en) * 1979-10-10 1982-04-13 The University Of Chicago Certain fluorine substituted PGI2 compounds
GB2088856B (en) * 1980-10-27 1984-06-27 Chinoin Gyogyszer Es Vegyeszet 7-substituted pg12-derivatives their preparation and pharmaceutical compositions containing them
JPS57165382A (en) * 1981-04-06 1982-10-12 Teijin Ltd Fluoro-pgi2 compound and its preparation
US4317906A (en) * 1980-12-15 1982-03-02 E. R. Squibb & Sons, Inc. Method for preparing 10,10-difluoro prostacyclins
ZA821449B (en) * 1981-03-11 1983-01-26 Hoffmann La Roche Novel fluoro prostacyclins
JPS6191136A (ja) * 1984-10-09 1986-05-09 Teijin Ltd プロスタグランジン類製剤用組成物
US4634782A (en) * 1985-06-24 1987-01-06 Hoffmann-La Roche Inc. 7-fluoro-dihydro PGI compounds
JPS6424147A (en) * 1987-07-15 1989-01-26 Mazda Motor Cylinder block structure for engine
JPH0314030A (ja) * 1989-06-12 1991-01-22 Nec Eng Ltd リクエスト制御装置
JPH0347272A (ja) * 1989-07-14 1991-02-28 Kuraray Co Ltd 中空繊維型液体処理装置
JP3195002B2 (ja) * 1990-09-07 2001-08-06 旭硝子株式会社 新規なプロスタグランジン誘導体

Also Published As

Publication number Publication date
US5538995A (en) 1996-07-23
ES2201214T3 (es) 2004-03-16
EP0789022B1 (en) 2003-06-18
DE69502517D1 (de) 1998-06-25
EP0789022A1 (en) 1997-08-13
EP0669329B1 (en) 1998-05-20
DE69531110T2 (de) 2004-05-19
EP0669329A1 (en) 1995-08-30
DE69531110D1 (de) 2003-07-24
US5747531A (en) 1998-05-05
DE69502517T2 (de) 1998-10-01
US5616732A (en) 1997-04-01

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