ES2137549T3 - Derivados antifungicos de sordaridina. - Google Patents
Derivados antifungicos de sordaridina.Info
- Publication number
- ES2137549T3 ES2137549T3 ES95938406T ES95938406T ES2137549T3 ES 2137549 T3 ES2137549 T3 ES 2137549T3 ES 95938406 T ES95938406 T ES 95938406T ES 95938406 T ES95938406 T ES 95938406T ES 2137549 T3 ES2137549 T3 ES 2137549T3
- Authority
- ES
- Spain
- Prior art keywords
- sordaridine
- antifungal
- derivatives
- antifungal derivatives
- medicine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/24—Condensed ring systems having three or more rings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
Abstract
UN COMPUESTO REPRESENTADO POR LA FORMULA (I), EN DONDE Z ES UN GRUPO TETRAHIDROPIRANO SELECCIONADO ENTRE (A) Y (B), QUE TIENE ACTIVIDAD ANTIFUNGICA, PROCESOS PARA SU PREPARACION Y SU USO EN MEDICINA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP94500175A EP0711784A1 (en) | 1994-11-08 | 1994-11-08 | Antifungal Sordarin derivatives |
EP94500173A EP0712859A1 (en) | 1994-11-08 | 1994-11-08 | Antifungal Sordarin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2137549T3 true ES2137549T3 (es) | 1999-12-16 |
Family
ID=26137608
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES95938406T Expired - Lifetime ES2137549T3 (es) | 1994-11-08 | 1995-11-06 | Derivados antifungicos de sordaridina. |
Country Status (35)
Country | Link |
---|---|
US (2) | US5854280A (es) |
EP (1) | EP0753001B1 (es) |
JP (1) | JPH09508144A (es) |
KR (1) | KR100391401B1 (es) |
CN (1) | CN1056849C (es) |
AP (1) | AP614A (es) |
AR (1) | AR013815A1 (es) |
AT (1) | ATE184284T1 (es) |
AU (1) | AU704405B2 (es) |
BG (1) | BG62620B1 (es) |
BR (1) | BR9506473A (es) |
CA (1) | CA2179403A1 (es) |
CO (1) | CO4520226A1 (es) |
CZ (1) | CZ202796A3 (es) |
DE (1) | DE69512041T2 (es) |
DK (1) | DK0753001T3 (es) |
EE (1) | EE9600117A (es) |
ES (1) | ES2137549T3 (es) |
FI (1) | FI962773A (es) |
GR (1) | GR3031677T3 (es) |
HK (1) | HK1004222A1 (es) |
HU (1) | HU218611B (es) |
IL (1) | IL115905A0 (es) |
IS (1) | IS4352A (es) |
MX (1) | MX9602563A (es) |
NO (1) | NO307092B1 (es) |
NZ (1) | NZ296091A (es) |
OA (1) | OA10303A (es) |
PE (1) | PE49696A1 (es) |
RU (1) | RU2152398C1 (es) |
SI (1) | SI0753001T1 (es) |
SK (1) | SK88496A3 (es) |
TW (1) | TW321644B (es) |
WO (1) | WO1996014326A1 (es) |
ZA (1) | ZA959362B (es) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6177457B1 (en) * | 1996-05-08 | 2001-01-23 | Glaxo Wellcome S.A. | Process for the preparation of indacene compound |
US6436395B1 (en) | 1996-09-18 | 2002-08-20 | Merck & Co., Inc. | Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control |
US6040463A (en) * | 1996-10-07 | 2000-03-21 | Merck & Co., Inc. | Sordarin derivatives |
US6096511A (en) * | 1997-06-10 | 2000-08-01 | Merck & Co., Inc. | Protein elongation factor 2 as a target for antifungal and antiparasitic agents |
US5972996A (en) * | 1997-08-22 | 1999-10-26 | Merck & Co., Inc. | 4-cyano-4-deformylsordarin derivatives |
US5965612A (en) * | 1997-08-22 | 1999-10-12 | Merck & Co., Inc. | 4-cyano-4-deformylsordaricin derivatives |
JP4339505B2 (ja) * | 1997-08-22 | 2009-10-07 | メルク エンド カムパニー インコーポレーテッド | 4−シアノ−4−デホルミルソルダリン誘導体 |
US6136853A (en) * | 1997-10-03 | 2000-10-24 | Merck & Co., Inc. | Sordarin derivatives |
FI974385A0 (fi) | 1997-12-01 | 1997-12-01 | Xyrofin Oy | Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning |
US7070965B1 (en) * | 1998-04-14 | 2006-07-04 | Zhenhua Yang | Small molecule anticancer compounds and related production process |
MA26628A1 (fr) * | 1998-05-11 | 2004-12-20 | Glaxo Wellcome Sa | Morpholino ethers |
WO2000024728A1 (en) | 1998-10-26 | 2000-05-04 | Merck & Co., Inc. | Microbial transformation product |
CA2371728C (en) | 1999-06-11 | 2009-06-02 | Neorx Corporation | High dose radionuclide complexes for bone marrow suppression |
US7094885B2 (en) | 1999-07-11 | 2006-08-22 | Neorx Corporation | Skeletal-targeted radiation to treat bone-associated pathologies |
US6645960B1 (en) | 1999-11-11 | 2003-11-11 | Glaxo Wellcome S.A. | Antifungal sordaricin derivatives |
AU2001289063A1 (en) * | 2000-09-15 | 2002-03-26 | Bristol-Myers Squibb Company | Novel thio derivatives of sordarin as antifungal agents |
CA2434302A1 (en) | 2001-01-08 | 2002-08-15 | Neorx Corporation | Therapeutic and diagnostic compounds, compositions, and methods |
WO2003007878A2 (en) | 2001-07-18 | 2003-01-30 | Merck & Co., Inc. | Antifungal agents of sordarin derivatives |
US7045116B2 (en) | 2001-12-13 | 2006-05-16 | Dow Global Technologies Inc. | Treatment of osteomyelitis with radiopharmaceuticals |
WO2003051889A1 (en) * | 2001-12-14 | 2003-06-26 | Merck & Co., Inc. | A novel sordarin derivative isolated from culture fermentations and functions as an antifungal agent |
WO2004060903A2 (en) * | 2002-12-31 | 2004-07-22 | Nektar Therapeutics | Aerosolizable pharmaceutical formulation for fungal infection therapy |
US9314524B2 (en) | 2007-12-31 | 2016-04-19 | Calla Therapeutics Llc | Topical formulations of Flucytosine |
US8419948B2 (en) * | 2009-11-22 | 2013-04-16 | United Laboratories International, Llc | Wastewater treatment |
WO2012033427A1 (ru) * | 2010-09-08 | 2012-03-15 | Dalin Mikhail Viktorovich | Способ лечения микотических инфекций и препарат для его осуществления |
RU2630403C2 (ru) * | 2016-02-25 | 2017-09-07 | Жанна Владимировна Вараткова | Абразивная масса для изготовления инструмента с высокими номерами структуры |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH465771A (de) * | 1965-12-06 | 1968-11-30 | Sandoz Ag | Verfahren zur Herstellung eines neuen Antibioticums |
JPH0615555B2 (ja) * | 1985-08-14 | 1994-03-02 | 三共株式会社 | 抗生物質ゾフイマリン |
JP3189443B2 (ja) * | 1992-11-20 | 2001-07-16 | 萬有製薬株式会社 | 抗真菌性物質be−31405 |
CZ88499A3 (cs) * | 1996-09-12 | 1999-10-13 | Merck And Co., Inc. | Kombinace látek s antifungálním účinkem |
-
1995
- 1995-11-06 EP EP95938406A patent/EP0753001B1/en not_active Expired - Lifetime
- 1995-11-06 AT AT95938406T patent/ATE184284T1/de not_active IP Right Cessation
- 1995-11-06 HU HU9701865A patent/HU218611B/hu not_active IP Right Cessation
- 1995-11-06 AP APAP/P/1996/000824A patent/AP614A/en active
- 1995-11-06 NZ NZ296091A patent/NZ296091A/en unknown
- 1995-11-06 MX MX9602563A patent/MX9602563A/es not_active IP Right Cessation
- 1995-11-06 PE PE1995283875A patent/PE49696A1/es not_active Application Discontinuation
- 1995-11-06 SK SK884-96A patent/SK88496A3/sk unknown
- 1995-11-06 JP JP8515051A patent/JPH09508144A/ja not_active Ceased
- 1995-11-06 DK DK95938406T patent/DK0753001T3/da active
- 1995-11-06 ES ES95938406T patent/ES2137549T3/es not_active Expired - Lifetime
- 1995-11-06 CN CN95192028A patent/CN1056849C/zh not_active Expired - Fee Related
- 1995-11-06 AU AU39809/95A patent/AU704405B2/en not_active Ceased
- 1995-11-06 CZ CZ962027A patent/CZ202796A3/cs unknown
- 1995-11-06 SI SI9530311T patent/SI0753001T1/xx not_active IP Right Cessation
- 1995-11-06 EE EE9600117A patent/EE9600117A/xx unknown
- 1995-11-06 ZA ZA959362A patent/ZA959362B/xx unknown
- 1995-11-06 US US08/669,441 patent/US5854280A/en not_active Expired - Fee Related
- 1995-11-06 KR KR1019960703661A patent/KR100391401B1/ko not_active IP Right Cessation
- 1995-11-06 CA CA002179403A patent/CA2179403A1/en not_active Abandoned
- 1995-11-06 WO PCT/EP1995/004331 patent/WO1996014326A1/en not_active Application Discontinuation
- 1995-11-06 BR BR9506473A patent/BR9506473A/pt not_active IP Right Cessation
- 1995-11-06 DE DE69512041T patent/DE69512041T2/de not_active Expired - Fee Related
- 1995-11-06 RU RU96115273/04A patent/RU2152398C1/ru active
- 1995-11-07 AR ARP950100073A patent/AR013815A1/es unknown
- 1995-11-07 IL IL11590595A patent/IL115905A0/xx unknown
- 1995-11-07 CO CO95052481A patent/CO4520226A1/es unknown
- 1995-11-18 TW TW084112259A patent/TW321644B/zh active
-
1996
- 1996-06-10 IS IS4352A patent/IS4352A/is unknown
- 1996-07-03 OA OA60855A patent/OA10303A/en unknown
- 1996-07-05 BG BG100699A patent/BG62620B1/xx unknown
- 1996-07-05 FI FI962773A patent/FI962773A/fi not_active IP Right Cessation
- 1996-07-05 NO NO962856A patent/NO307092B1/no not_active IP Right Cessation
-
1998
- 1998-04-21 HK HK98103335A patent/HK1004222A1/xx not_active IP Right Cessation
- 1998-05-19 US US09/081,090 patent/US5952334A/en not_active Expired - Fee Related
-
1999
- 1999-10-27 GR GR990402767T patent/GR3031677T3/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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