DK0753001T3 - Antifungale sordaridinderivater - Google Patents

Antifungale sordaridinderivater

Info

Publication number
DK0753001T3
DK0753001T3 DK95938406T DK95938406T DK0753001T3 DK 0753001 T3 DK0753001 T3 DK 0753001T3 DK 95938406 T DK95938406 T DK 95938406T DK 95938406 T DK95938406 T DK 95938406T DK 0753001 T3 DK0753001 T3 DK 0753001T3
Authority
DK
Denmark
Prior art keywords
sordaridine
antifungal
derivatives
sordaridine derivatives
antifungal sordaridine
Prior art date
Application number
DK95938406T
Other languages
English (en)
Inventor
Jose Ramon Ruiz Gomez
Jose Maria Bueno Calderon
Dorado Silvestre Garcia-Ochoa
Gabaldon Maria Teresa Fraile
Julia Castro Pichel
Roman Jose Fiandor
Viola Domingo Garsallo
Zurita Juan Carlos Cueva
Diaz Jose Luis Lavandera
Sophie Huss
Original Assignee
Glaxo Wellcome Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94500175A external-priority patent/EP0711784A1/en
Priority claimed from EP94500173A external-priority patent/EP0712859A1/en
Application filed by Glaxo Wellcome Sa filed Critical Glaxo Wellcome Sa
Application granted granted Critical
Publication of DK0753001T3 publication Critical patent/DK0753001T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK95938406T 1994-11-08 1995-11-06 Antifungale sordaridinderivater DK0753001T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP94500175A EP0711784A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
EP94500173A EP0712859A1 (en) 1994-11-08 1994-11-08 Antifungal Sordarin derivatives
PCT/EP1995/004331 WO1996014326A1 (en) 1994-11-08 1995-11-06 Antifungal sordaridin derivatives

Publications (1)

Publication Number Publication Date
DK0753001T3 true DK0753001T3 (da) 2000-05-08

Family

ID=26137608

Family Applications (1)

Application Number Title Priority Date Filing Date
DK95938406T DK0753001T3 (da) 1994-11-08 1995-11-06 Antifungale sordaridinderivater

Country Status (35)

Country Link
US (2) US5854280A (da)
EP (1) EP0753001B1 (da)
JP (1) JPH09508144A (da)
KR (1) KR100391401B1 (da)
CN (1) CN1056849C (da)
AP (1) AP614A (da)
AR (1) AR013815A1 (da)
AT (1) ATE184284T1 (da)
AU (1) AU704405B2 (da)
BG (1) BG62620B1 (da)
BR (1) BR9506473A (da)
CA (1) CA2179403A1 (da)
CO (1) CO4520226A1 (da)
CZ (1) CZ202796A3 (da)
DE (1) DE69512041T2 (da)
DK (1) DK0753001T3 (da)
EE (1) EE9600117A (da)
ES (1) ES2137549T3 (da)
FI (1) FI962773A (da)
GR (1) GR3031677T3 (da)
HK (1) HK1004222A1 (da)
HU (1) HU218611B (da)
IL (1) IL115905A0 (da)
IS (1) IS4352A (da)
MX (1) MX9602563A (da)
NO (1) NO307092B1 (da)
NZ (1) NZ296091A (da)
OA (1) OA10303A (da)
PE (1) PE49696A1 (da)
RU (1) RU2152398C1 (da)
SI (1) SI0753001T1 (da)
SK (1) SK88496A3 (da)
TW (1) TW321644B (da)
WO (1) WO1996014326A1 (da)
ZA (1) ZA959362B (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177457B1 (en) * 1996-05-08 2001-01-23 Glaxo Wellcome S.A. Process for the preparation of indacene compound
US6436395B1 (en) 1996-09-18 2002-08-20 Merck & Co., Inc. Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) * 1996-10-07 2000-03-21 Merck & Co., Inc. Sordarin derivatives
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
AU740477B2 (en) * 1997-08-22 2001-11-08 Merck Sharp & Dohme Corp. 4-cyano-4-deformylsordarin derivatives
US6136853A (en) * 1997-10-03 2000-10-24 Merck & Co., Inc. Sordarin derivatives
FI974385A0 (fi) 1997-12-01 1997-12-01 Xyrofin Oy Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) * 1998-04-14 2006-07-04 Zhenhua Yang Small molecule anticancer compounds and related production process
MA26628A1 (fr) * 1998-05-11 2004-12-20 Glaxo Wellcome Sa Morpholino ethers
JP2002528444A (ja) 1998-10-26 2002-09-03 メルク エンド カムパニー インコーポレーテッド 微生物変換産物
WO2000076556A2 (en) 1999-06-11 2000-12-21 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
JP2003513964A (ja) * 1999-11-11 2003-04-15 グラクソ、ウェルカム、ソシエダッド、アノニマ 抗真菌性ソルダリシン誘導体
US6436930B1 (en) * 2000-09-15 2002-08-20 Bristol-Myers Squibb Company Thio derivatives of sordarin as antifungal agents
WO2002062398A2 (en) 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
WO2003007878A2 (en) 2001-07-18 2003-01-30 Merck & Co., Inc. Antifungal agents of sordarin derivatives
JP2005516933A (ja) 2001-12-13 2005-06-09 ダウ グローバル テクノロジーズ インコーポレイティド 放射性医薬による骨髄炎の治療
JP2005519039A (ja) * 2001-12-14 2005-06-30 メルク　エンド　カムパニー　インコーポレーテッド 培養株の発酵産物から単離された新規ソルダリン誘導体及び抗真菌剤としての機能
MXPA05007156A (es) * 2002-12-31 2005-09-21 Nektar Therapeutics Formulacion farmaceuticas aerosolizable para terapia para infecciones fungicas.
US9314524B2 (en) 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US8419948B2 (en) * 2009-11-22 2013-04-16 United Laboratories International, Llc Wastewater treatment
WO2012033427A1 (ru) * 2010-09-08 2012-03-15 Dalin Mikhail Viktorovich Способ лечения микотических инфекций и препарат для его осуществления
RU2630403C2 (ru) * 2016-02-25 2017-09-07 Жанна Владимировна Вараткова Абразивная масса для изготовления инструмента с высокими номерами структуры

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH465771A (de) * 1965-12-06 1968-11-30 Sandoz Ag Verfahren zur Herstellung eines neuen Antibioticums
JPH0615555B2 (ja) * 1985-08-14 1994-03-02 三共株式会社 抗生物質ゾフイマリン
JP3189443B2 (ja) * 1992-11-20 2001-07-16 萬有製薬株式会社 抗真菌性物質ｂｅ−３１４０５
ES2203819T3 (es) * 1996-09-12 2004-04-16 MERCK & CO., INC. Terapia antifungica combinada.

Also Published As

Publication number Publication date
NO307092B1 (no) 2000-02-07
BR9506473A (pt) 1997-10-07
HUT76292A (en) 1997-07-28
CZ202796A3 (en) 1997-02-12
BG62620B1 (en) 2000-03-31
MX9602563A (es) 1997-05-31
HU9601865D0 (en) 1996-11-28
ZA959362B (en) 1996-05-08
OA10303A (en) 1997-10-07
IS4352A (is) 1996-06-10
CN1056849C (zh) 2000-09-27
AP9600824A0 (en) 1996-07-31
FI962773A0 (fi) 1996-07-05
WO1996014326A1 (en) 1996-05-17
ES2137549T3 (es) 1999-12-16
GR3031677T3 (en) 2000-02-29
HU218611B (hu) 2000-10-28
CA2179403A1 (en) 1996-05-17
NO962856L (no) 1996-09-05
DE69512041D1 (de) 1999-10-14
CN1143965A (zh) 1997-02-26
FI962773A (fi) 1996-08-26
HK1004222A1 (en) 1998-11-20
SI0753001T1 (en) 1999-12-31
IL115905A0 (en) 1996-01-31
AP614A (en) 1997-09-05
KR100391401B1 (ko) 2003-12-31
NZ296091A (en) 1998-06-26
EE9600117A (et) 1997-04-15
ATE184284T1 (de) 1999-09-15
US5854280A (en) 1998-12-29
RU2152398C1 (ru) 2000-07-10
CO4520226A1 (es) 1997-10-15
AU704405B2 (en) 1999-04-22
EP0753001B1 (en) 1999-09-08
SK88496A3 (en) 1997-04-09
AR013815A1 (es) 2001-01-31
TW321644B (da) 1997-12-01
NO962856D0 (no) 1996-07-05
US5952334A (en) 1999-09-14
JPH09508144A (ja) 1997-08-19
EP0753001A1 (en) 1997-01-15
DE69512041T2 (de) 2000-02-03
PE49696A1 (es) 1996-12-05
BG100699A (bg) 1997-02-28
AU3980995A (en) 1996-05-31

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