ATE184284T1 - Antifungale sordaridin-derivate - Google Patents

Antifungale sordaridin-derivate

Info

Publication number
ATE184284T1
ATE184284T1 AT95938406T AT95938406T ATE184284T1 AT E184284 T1 ATE184284 T1 AT E184284T1 AT 95938406 T AT95938406 T AT 95938406T AT 95938406 T AT95938406 T AT 95938406T AT E184284 T1 ATE184284 T1 AT E184284T1
Authority
AT
Austria
Prior art keywords
sordaridine
antifungal
derivatives
sordaridine derivatives
antifungal sordaridine
Prior art date
Application number
AT95938406T
Other languages
English (en)
Inventor
Jose Ramon Ruiz Gomez
Jose Maria Bueno Calderon
Dorado Silvestre Garcia-Ochoa
Gabaldon Maria Teresa G Fraile
Julia Castro Pichel
Roman Jose Fiandor
Viola Domingo Garsallo
Zurita Juan Carlos Cueva
Diaz Jose Luis Lavandera
Sophie Huss
Original Assignee
Glaxo Wellcome Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP94500175A external-priority patent/EP0711784A1/de
Priority claimed from EP94500173A external-priority patent/EP0712859A1/de
Application filed by Glaxo Wellcome Sa filed Critical Glaxo Wellcome Sa
Application granted granted Critical
Publication of ATE184284T1 publication Critical patent/ATE184284T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT95938406T 1994-11-08 1995-11-06 Antifungale sordaridin-derivate ATE184284T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP94500175A EP0711784A1 (de) 1994-11-08 1994-11-08 Antifungale Sordarinderivate
EP94500173A EP0712859A1 (de) 1994-11-08 1994-11-08 Antifungale Sordarinderivate

Publications (1)

Publication Number Publication Date
ATE184284T1 true ATE184284T1 (de) 1999-09-15

Family

ID=26137608

Family Applications (1)

Application Number Title Priority Date Filing Date
AT95938406T ATE184284T1 (de) 1994-11-08 1995-11-06 Antifungale sordaridin-derivate

Country Status (35)

Country Link
US (2) US5854280A (de)
EP (1) EP0753001B1 (de)
JP (1) JPH09508144A (de)
KR (1) KR100391401B1 (de)
CN (1) CN1056849C (de)
AP (1) AP614A (de)
AR (1) AR013815A1 (de)
AT (1) ATE184284T1 (de)
AU (1) AU704405B2 (de)
BG (1) BG62620B1 (de)
BR (1) BR9506473A (de)
CA (1) CA2179403A1 (de)
CO (1) CO4520226A1 (de)
CZ (1) CZ202796A3 (de)
DE (1) DE69512041T2 (de)
DK (1) DK0753001T3 (de)
EE (1) EE9600117A (de)
ES (1) ES2137549T3 (de)
FI (1) FI962773A (de)
GR (1) GR3031677T3 (de)
HK (1) HK1004222A1 (de)
HU (1) HU218611B (de)
IL (1) IL115905A0 (de)
IS (1) IS4352A (de)
MX (1) MX9602563A (de)
NO (1) NO307092B1 (de)
NZ (1) NZ296091A (de)
OA (1) OA10303A (de)
PE (1) PE49696A1 (de)
RU (1) RU2152398C1 (de)
SI (1) SI0753001T1 (de)
SK (1) SK88496A3 (de)
TW (1) TW321644B (de)
WO (1) WO1996014326A1 (de)
ZA (1) ZA959362B (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6177457B1 (en) * 1996-05-08 2001-01-23 Glaxo Wellcome S.A. Process for the preparation of indacene compound
US6436395B1 (en) 1996-09-18 2002-08-20 Merck & Co., Inc. Rosellinia subiculata ATCC 74386 and fungus ATCC 74387 for producing sordarin compounds for fungi control
US6040463A (en) * 1996-10-07 2000-03-21 Merck & Co., Inc. Sordarin derivatives
US6096511A (en) * 1997-06-10 2000-08-01 Merck & Co., Inc. Protein elongation factor 2 as a target for antifungal and antiparasitic agents
US5972996A (en) * 1997-08-22 1999-10-26 Merck & Co., Inc. 4-cyano-4-deformylsordarin derivatives
US5965612A (en) * 1997-08-22 1999-10-12 Merck & Co., Inc. 4-cyano-4-deformylsordaricin derivatives
JP4339505B2 (ja) * 1997-08-22 2009-10-07 メルク エンド カムパニー インコーポレーテッド ４−シアノ−４−デホルミルソルダリン誘導体
US6136853A (en) * 1997-10-03 2000-10-24 Merck & Co., Inc. Sordarin derivatives
FI974385A0 (fi) * 1997-12-01 1997-12-01 Xyrofin Oy Anvaendning av xylitol foer bekaempning av jaestinfektion och xylitolpreparat foer denna anvaendning
US7070965B1 (en) * 1998-04-14 2006-07-04 Zhenhua Yang Small molecule anticancer compounds and related production process
MA26628A1 (fr) * 1998-05-11 2004-12-20 Glaxo Wellcome Sa Morpholino ethers
AU760975B2 (en) 1998-10-26 2003-05-22 Merck & Co., Inc. Microbial transformation product
EP1191948A2 (de) 1999-06-11 2002-04-03 Neorx Corporation Hochdosierte radionuklide komplexe zur knochenmark-unterdrückung
US7094885B2 (en) 1999-07-11 2006-08-22 Neorx Corporation Skeletal-targeted radiation to treat bone-associated pathologies
AU1520601A (en) * 1999-11-11 2001-06-06 Glaxo Wellcome S.A. Antifungal sordaricin derivatives
AU2001289063A1 (en) * 2000-09-15 2002-03-26 Bristol-Myers Squibb Company Novel thio derivatives of sordarin as antifungal agents
WO2002062398A2 (en) 2001-01-08 2002-08-15 Neorx Corporation Radioactively labelled conjugates of phosphonates
WO2003007878A2 (en) 2001-07-18 2003-01-30 Merck & Co., Inc. Antifungal agents of sordarin derivatives
EP1458416A1 (de) 2001-12-13 2004-09-22 Dow Global Technologies Inc. Behandlung von osteomyelitis mit einer radiopharmazeutischen zusammensetzung
ATE354576T1 (de) * 2001-12-14 2007-03-15 Merck & Co Inc Neues, aus kulturfermentierungen isoliertes sordarinderivat und wirkungen als antipilzmittel
AU2003302274A1 (en) * 2002-12-31 2004-07-29 Novartis Ag Aerosolizable pharmaceutical formulation for fungal infection therapy
US9314524B2 (en) 2007-12-31 2016-04-19 Calla Therapeutics Llc Topical formulations of Flucytosine
US8419948B2 (en) * 2009-11-22 2013-04-16 United Laboratories International, Llc Wastewater treatment
WO2012033427A1 (ru) * 2010-09-08 2012-03-15 Dalin Mikhail Viktorovich Способ лечения микотических инфекций и препарат для его осуществления
RU2630403C2 (ru) * 2016-02-25 2017-09-07 Жанна Владимировна Вараткова Абразивная масса для изготовления инструмента с высокими номерами структуры

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH465771A (de) * 1965-12-06 1968-11-30 Sandoz Ag Verfahren zur Herstellung eines neuen Antibioticums
JPH0615555B2 (ja) * 1985-08-14 1994-03-02 三共株式会社 抗生物質ゾフイマリン
JP3189443B2 (ja) * 1992-11-20 2001-07-16 萬有製薬株式会社 抗真菌性物質ｂｅ−３１４０５
EA002469B1 (ru) * 1996-09-12 2002-06-27 Мерк Энд Ко., Инк. Способ лечения грибковой инфекции

Also Published As

Publication number Publication date
DE69512041D1 (de) 1999-10-14
AU3980995A (en) 1996-05-31
NO962856L (no) 1996-09-05
RU2152398C1 (ru) 2000-07-10
SK88496A3 (en) 1997-04-09
ES2137549T3 (es) 1999-12-16
HK1004222A1 (en) 1998-11-20
DE69512041T2 (de) 2000-02-03
KR100391401B1 (ko) 2003-12-31
CN1056849C (zh) 2000-09-27
GR3031677T3 (en) 2000-02-29
OA10303A (en) 1997-10-07
AP9600824A0 (en) 1996-07-31
ZA959362B (en) 1996-05-08
AR013815A1 (es) 2001-01-31
WO1996014326A1 (en) 1996-05-17
CA2179403A1 (en) 1996-05-17
NO962856D0 (no) 1996-07-05
FI962773A0 (fi) 1996-07-05
US5952334A (en) 1999-09-14
CO4520226A1 (es) 1997-10-15
NO307092B1 (no) 2000-02-07
HU218611B (hu) 2000-10-28
NZ296091A (en) 1998-06-26
TW321644B (de) 1997-12-01
DK0753001T3 (da) 2000-05-08
AP614A (en) 1997-09-05
CZ202796A3 (en) 1997-02-12
EP0753001A1 (de) 1997-01-15
BG100699A (bg) 1997-02-28
CN1143965A (zh) 1997-02-26
FI962773A (fi) 1996-08-26
PE49696A1 (es) 1996-12-05
EP0753001B1 (de) 1999-09-08
BR9506473A (pt) 1997-10-07
IS4352A (is) 1996-06-10
HU9601865D0 (en) 1996-11-28
SI0753001T1 (en) 1999-12-31
IL115905A0 (en) 1996-01-31
BG62620B1 (en) 2000-03-31
AU704405B2 (en) 1999-04-22
US5854280A (en) 1998-12-29
MX9602563A (es) 1997-05-31
HUT76292A (en) 1997-07-28
EE9600117A (et) 1997-04-15
JPH09508144A (ja) 1997-08-19

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee