DK175366B1 - Fremgangsmåde til fremstilling af biologisk aktiv human vævstype-plasminogenaktivator - Google Patents

Fremgangsmåde til fremstilling af biologisk aktiv human vævstype-plasminogenaktivator Download PDF

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Publication number
DK175366B1
DK175366B1 DK198702881A DK288187A DK175366B1 DK 175366 B1 DK175366 B1 DK 175366B1 DK 198702881 A DK198702881 A DK 198702881A DK 288187 A DK288187 A DK 288187A DK 175366 B1 DK175366 B1 DK 175366B1
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DK
Denmark
Prior art keywords
medium
plasminogen activator
human tissue
type plasminogen
cell
Prior art date
Application number
DK198702881A
Other languages
Danish (da)
English (en)
Other versions
DK288187D0 (da
DK288187A (da
Inventor
William R Arathoon
Stuart E Builder
Anthony S Lubiniecki
Robert D Van Reis
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK288187D0 publication Critical patent/DK288187D0/da
Publication of DK288187A publication Critical patent/DK288187A/da
Application granted granted Critical
Publication of DK175366B1 publication Critical patent/DK175366B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6456—Plasminogen activators
    • C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21069—Protein C activated (3.4.21.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK198702881A 1986-06-06 1987-06-04 Fremgangsmåde til fremstilling af biologisk aktiv human vævstype-plasminogenaktivator DK175366B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87164286A 1986-06-06 1986-06-06
US87164286 1986-06-06

Publications (3)

Publication Number Publication Date
DK288187D0 DK288187D0 (da) 1987-06-04
DK288187A DK288187A (da) 1987-12-07
DK175366B1 true DK175366B1 (da) 2004-09-13

Family

ID=25357832

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198702881A DK175366B1 (da) 1986-06-06 1987-06-04 Fremgangsmåde til fremstilling af biologisk aktiv human vævstype-plasminogenaktivator

Country Status (21)

Country Link
US (1) US5053334A (ja)
EP (1) EP0248675B1 (ja)
JP (1) JPS6332484A (ja)
KR (1) KR930002888B1 (ja)
AT (1) ATE75775T1 (ja)
AU (1) AU601984B2 (ja)
DD (1) DD257087A5 (ja)
DE (2) DE3718939C2 (ja)
DK (1) DK175366B1 (ja)
ES (1) ES2032444T3 (ja)
FI (1) FI91886C (ja)
FR (1) FR2599625B1 (ja)
GB (1) GB2191493B (ja)
GR (1) GR3005245T3 (ja)
HU (1) HU205171B (ja)
IE (1) IE60485B1 (ja)
IL (1) IL82746A (ja)
NO (1) NO170595C (ja)
NZ (1) NZ220547A (ja)
PT (1) PT84991B (ja)
ZA (1) ZA874054B (ja)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT84991B (pt) * 1986-06-06 1990-03-08 Genentech Inc Processo para a producao de actividador do plasminogenio biologicamente activo
JP2576200B2 (ja) * 1988-03-09 1997-01-29 味の素株式会社 生理活性タンパク質の製造法
EP0338716A3 (en) * 1988-04-21 1990-04-11 Berlex Laboratories, Inc. Method and system for the production of non-degraded proteins from mammalian cells
DE3829244A1 (de) * 1988-08-29 1990-03-01 Boehringer Mannheim Gmbh Verfahren zur herstellung von einkettigem t-pa
CA2011548A1 (en) * 1989-03-07 1990-09-07 Hubertus Stockinger Process for the production of two-chain t-pa
GB2249099B (en) * 1990-09-26 1995-05-03 Squibb & Sons Inc Squalene synthetase
US5677184A (en) * 1994-04-19 1997-10-14 Takeda Chemical Industries, Ltd. CHO cells that express human LH-RH receptor
US6077940A (en) * 1997-12-24 2000-06-20 Genentech, Inc. Free solution ligand interaction molecular separation method
EP1495108A2 (en) * 2002-04-08 2005-01-12 Millenium Biologix Inc. Automated tissue engineering system
DK2343362T4 (da) * 2006-07-14 2024-07-08 Patheon Holdings I B V Forbedret fremgangsmåde til dyrkning af celler
US20090042253A1 (en) * 2007-08-09 2009-02-12 Wyeth Use of perfusion to enhance production of fed-batch cell culture in bioreactors
CA2787656A1 (en) * 2010-01-22 2011-07-28 Lonza Walkersville, Inc. High yield method and apparatus for volume reduction and washing of therapeutic cells using tangential flow filtration
US10934519B2 (en) * 2011-07-29 2021-03-02 Global Life Sciences Solutions Usa Llc Systems, methods and control laws for cell harvesting
CN104583386A (zh) * 2012-08-20 2015-04-29 泰尔茂比司特公司 浓缩穿过细胞生长腔室循环的流体的组分
KR20230092033A (ko) 2017-09-01 2023-06-23 론차 콜로그네 게엠베하 엔드-투-엔드 세포 요법의 자동화
CN113366099A (zh) 2018-12-21 2021-09-07 奥克泰生物科技股份有限公司 用于模块化生物生产单元的转盘
CA3123449A1 (en) 2018-12-21 2020-06-25 Lonza Walkersville, Inc. Automated production of viral vectors
KR20210110322A (ko) 2018-12-28 2021-09-07 옥테인 바이오테크 인코포레이티드 제어된 환경 존을 포함하는 세포 배양 및 조직 공학 시스템
WO2020163454A1 (en) 2019-02-08 2020-08-13 Lonza Walkersville, Inc. Cell concentration methods and devices for use in automated bioreactors
EP4363442A1 (en) 2021-07-02 2024-05-08 Combangio, Inc. Processes for making and using a cellular fibronectin composition

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3904480A (en) * 1972-10-24 1975-09-09 Lilly Co Eli Enhanced production of plasminogen activator
JPS5329985A (en) * 1976-08-27 1978-03-20 Kanegafuchi Chem Ind Co Ltd High concentration culturing of yeast
JPS5571496A (en) * 1978-11-24 1980-05-29 Asahi Chem Ind Co Ltd Preparation of living substance
US4409331A (en) * 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4232124A (en) * 1979-04-23 1980-11-04 Mann George F Method of producing plasminogen activator
DE3015699C2 (de) * 1979-04-26 1982-07-15 Asahi Kasei Kogyo K.K., Osaka Herstellung eines Plasminogen-Aktivators
JPS5642584A (en) * 1979-09-18 1981-04-20 Asahi Chem Ind Co Ltd Cell cultivation method
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
IL68561A (en) * 1982-05-05 1991-01-31 Genentech Inc Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof
JPS5951220A (ja) * 1982-08-02 1984-03-24 Asahi Chem Ind Co Ltd 新規なプラスミノ−ゲン・アクチベ−タ−およびその製法ならびにこれを含有する薬剤
US4537860A (en) * 1982-12-08 1985-08-27 Monsanto Company Static cell culture maintenance system
NZ206699A (en) * 1982-12-30 1989-08-29 Bio Response Inc Process for the production of serum independent cell lines
AU572108B2 (en) * 1983-01-19 1988-05-05 Genentech Inc. Human tpa production using vectors coding for dhfr protein
JPS59121172U (ja) * 1983-02-04 1984-08-15 ミネソタ・マイニング・アンド・マニユフアクチユアリング・コンパニ− ケーブル電線被覆の剥離部分のカバー装置
US4546083A (en) * 1983-04-22 1985-10-08 Stolle Research & Development Corporation Method and device for cell culture growth
EP0143081B1 (en) * 1983-11-21 1989-08-23 Ciba-Geigy Ag Synthesis of tissue plasminogen activator(tpa) by yeast
US4740461A (en) * 1983-12-27 1988-04-26 Genetics Institute, Inc. Vectors and methods for transformation of eucaryotic cells
US4888115A (en) * 1983-12-29 1989-12-19 Cuno, Incorporated Cross-flow filtration
US4757005A (en) * 1984-04-19 1988-07-12 Miles Inc. Method and cell line for obtaining plasminogen activators
JPH0740942B2 (ja) * 1985-03-22 1995-05-10 カイロン コ−ポレイシヨン 哺乳動物細胞におけるｔＰＡの発現
AU593264B2 (en) * 1985-07-10 1990-02-08 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Chromosomal DNA sequence, expression vector for human tissue plasminogen activating factor, cultured cells transfected with same and method of producing said activating factor
AU606582B2 (en) * 1985-09-06 1991-02-14 Codon Methods for the recovery of tissue plasminogen activator
JPH07110232B2 (ja) * 1985-10-14 1995-11-29 株式会社日立製作所 遺伝子組換え大腸菌の遺伝子生産物を採取する方法および装置
PT84991B (pt) * 1986-06-06 1990-03-08 Genentech Inc Processo para a producao de actividador do plasminogenio biologicamente activo

Also Published As

Publication number Publication date
GB8713267D0 (en) 1987-07-08
EP0248675B1 (en) 1992-05-06
HU205171B (en) 1992-03-30
DE3778758D1 (de) 1992-06-11
ZA874054B (en) 1989-02-22
NO170595B (no) 1992-07-27
KR930002888B1 (ko) 1993-04-12
FI91886B (fi) 1994-05-13
IE871504L (en) 1987-12-06
PT84991A (en) 1987-07-01
ES2032444T3 (es) 1993-02-16
ATE75775T1 (de) 1992-05-15
IE60485B1 (en) 1994-07-27
DK288187D0 (da) 1987-06-04
GB2191493B (en) 1991-02-27
GR3005245T3 (ja) 1993-05-24
NO170595C (no) 1992-11-04
FR2599625B1 (fr) 1992-03-13
KR880000590A (ko) 1988-03-28
US5053334A (en) 1991-10-01
FR2599625A1 (fr) 1987-12-11
AU7387287A (en) 1987-12-10
GB2191493A (en) 1987-12-16
FI872526A0 (fi) 1987-06-05
PT84991B (pt) 1990-03-08
FI872526A (fi) 1987-12-07
DE3718939A1 (de) 1987-12-17
FI91886C (fi) 1994-08-25
JPS6332484A (ja) 1988-02-12
DE3718939C2 (de) 1998-09-17
DK288187A (da) 1987-12-07
DD257087A5 (de) 1988-06-01
HUT43875A (en) 1987-12-28
NZ220547A (en) 1990-01-29
AU601984B2 (en) 1990-09-27
JPH0574346B2 (ja) 1993-10-18
IL82746A0 (en) 1987-12-20
NO872395L (no) 1987-12-07
IL82746A (en) 1994-10-07
NO872395D0 (no) 1987-06-05
EP0248675A1 (en) 1987-12-09

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