DK174739B1 - Bærer-lægemiddelkonjugater og deres fremstiling - Google Patents

Bærer-lægemiddelkonjugater og deres fremstiling Download PDF

Info

Publication number
DK174739B1
DK174739B1 DK198806025A DK602588A DK174739B1 DK 174739 B1 DK174739 B1 DK 174739B1 DK 198806025 A DK198806025 A DK 198806025A DK 602588 A DK602588 A DK 602588A DK 174739 B1 DK174739 B1 DK 174739B1
Authority
DK
Denmark
Prior art keywords
formula
compound
defined above
divalent
group
Prior art date
Application number
DK198806025A
Other languages
Danish (da)
English (en)
Other versions
DK602588A (da
DK602588D0 (da
Inventor
William James Mcgahren
Martin Leon Sassiver
George A Ellestad
Philip R Hamann
Lois M Hinman
Janis Upeslacis
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK602588D0 publication Critical patent/DK602588D0/da
Publication of DK602588A publication Critical patent/DK602588A/da
Application granted granted Critical
Publication of DK174739B1 publication Critical patent/DK174739B1/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK198806025A 1987-10-30 1988-10-28 Bærer-lægemiddelkonjugater og deres fremstiling DK174739B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11494087A 1987-10-30 1987-10-30
US11494087 1987-10-30

Publications (3)

Publication Number Publication Date
DK602588D0 DK602588D0 (da) 1988-10-28
DK602588A DK602588A (da) 1989-05-01
DK174739B1 true DK174739B1 (da) 2003-10-13

Family

ID=22358378

Family Applications (2)

Application Number Title Priority Date Filing Date
DK602488A DK602488A (da) 1987-10-30 1988-10-28 Disvovlanaloge af ll-e33288 2-i og deres anvendelse som middel mod tumorer
DK198806025A DK174739B1 (da) 1987-10-30 1988-10-28 Bærer-lægemiddelkonjugater og deres fremstiling

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK602488A DK602488A (da) 1987-10-30 1988-10-28 Disvovlanaloge af ll-e33288 2-i og deres anvendelse som middel mod tumorer

Country Status (19)

Country Link
EP (2) EP0313873B1 (fr)
JP (2) JP2720933B2 (fr)
KR (2) KR0133130B1 (fr)
AR (1) AR246083A1 (fr)
AT (2) ATE112172T1 (fr)
AU (2) AU612714B2 (fr)
BR (1) BR1100939A (fr)
CA (1) CA1321582C (fr)
DE (2) DE3889063T2 (fr)
DK (2) DK602488A (fr)
ES (2) ES2059464T3 (fr)
FI (2) FI91262C (fr)
HK (2) HK131997A (fr)
IE (2) IE65989B1 (fr)
IL (2) IL87946A (fr)
NO (2) NO176480C (fr)
NZ (2) NZ226726A (fr)
PT (2) PT88882B (fr)
ZA (2) ZA888127B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL93733A (en) * 1989-04-14 1996-01-19 American Cyanamid Co History of Dissolved Drug Sulphides Antibacterial and Antibacterial, Prepared from Compounds Containing Methyl-Thriteo Groups and Their Target Form
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
BRPI9915679B8 (pt) 1998-11-27 2021-05-25 Darwin Discovery Ltd composições e métodos para aumentar a mineralização óssea
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
RS20050934A (en) 2003-06-16 2008-04-04 Celltech R. & D. Inc., Antibodies specific for sclerostin and methods fo r increasing bone mineralization
WO2008028050A2 (fr) * 2006-08-30 2008-03-06 Wisconsin Alumni Research Foundation Réactions catalysées par glycosyltransférase à base de produit naturel réversible, composés et procédés en rapport
KR100979928B1 (ko) * 2008-07-16 2010-09-03 한주학 수직축형 부력풍차
AU2014343268B2 (en) * 2013-11-04 2018-11-15 Pfizer Inc. Intermediates and methods for synthesizing calicheamicin derivatives
BR112019015069A2 (pt) * 2017-01-24 2020-03-03 Pfizer Inc. Derivados de caliqueamicina e conjugados de anticorpo-fármaco dos mesmos
CA3129501A1 (fr) * 2019-02-15 2020-08-20 University Of Southern California Compositions d'anticorps lym-1 et lym-2 et constructions car ameliorees
EP4234537A4 (fr) * 2020-10-22 2024-05-29 FUJIFILM Corporation Réactif pour la mesure d'une sensibilisation de la peau, composé et procédé pour la mesure d'une sensibilisation de la peau

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
DE3175151D1 (en) * 1980-05-21 1986-09-25 Teijin Ltd Reactive polymer and process for the preparation thereof
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
CA1314245C (fr) * 1984-05-23 1993-03-09 Franz Jansen Methode de preparation de conjugues formes d'un ionophore carboxylique monovalent associe par une liaison de covalence a une macromolecule et utiles comme agents de potentialisation d'immunotoxines
IL76878A (en) * 1984-11-16 1991-12-15 American Cyanamid Co Antitumor antibiotic ll-33288alpha-br complex and process for its preparation
EP0330874A3 (fr) * 1988-02-29 1989-10-18 American Cyanamid Company Agents antibactériens et antitumoraux LL-E33288 epsilon-I et LL-E33288-epsilon-Br, avec les procédés et intermédiaires pour obtention desdits agents
EP0342341A3 (fr) * 1988-05-17 1991-07-24 American Cyanamid Company Méthode pour la fabrication de l'antibiotique antitumoral LL-E33288 Gamma 2

Also Published As

Publication number Publication date
FI884984A0 (fi) 1988-10-28
FI95204B (fi) 1995-09-29
ES2061586T3 (es) 1994-12-16
FI91262B (fi) 1994-02-28
FI884984A (fi) 1989-05-01
EP0313873A1 (fr) 1989-05-03
ATE112172T1 (de) 1994-10-15
IL87946A0 (en) 1989-03-31
NO884834D0 (no) 1988-10-28
AU612714B2 (en) 1991-07-18
DE3851682D1 (de) 1994-11-03
JPH0296599A (ja) 1990-04-09
ES2059464T3 (es) 1994-11-16
NO173506B (no) 1993-09-13
JP2720933B2 (ja) 1998-03-04
DE3889063T2 (de) 1994-12-01
HK131997A (en) 1997-10-03
AU2449488A (en) 1989-05-04
NO173506C (no) 1993-12-22
DE3889063D1 (de) 1994-05-19
IL87947A0 (en) 1989-03-31
AU618763B2 (en) 1992-01-09
JP2820256B2 (ja) 1998-11-05
NZ226726A (en) 1991-08-27
NZ226727A (en) 1991-12-23
FI91262C (fi) 1994-06-10
NO176480C (no) 1995-04-12
PT88882B (pt) 1993-01-29
FI884983A0 (fi) 1988-10-28
CA1321582C (fr) 1993-08-24
PT88881B (pt) 1993-01-29
NO884833D0 (no) 1988-10-28
DE3851682T2 (de) 1995-05-04
EP0313874A2 (fr) 1989-05-03
KR890006244A (ko) 1989-06-12
EP0313874B1 (fr) 1994-04-13
AR246083A1 (es) 1994-03-30
HK131897A (en) 1997-10-03
KR970011385B1 (ko) 1997-07-10
IE883261L (en) 1989-04-30
AU2448988A (en) 1989-05-04
IL87947A (en) 1995-05-26
DK602488A (da) 1989-05-01
NO176480B (no) 1995-01-02
JPH01193282A (ja) 1989-08-03
IE65989B1 (en) 1995-11-29
NO884834L (no) 1989-05-02
DK602588A (da) 1989-05-01
NO884833L (no) 1989-05-02
ZA888127B (en) 1989-07-26
ZA888123B (en) 1989-07-26
DK602488D0 (da) 1988-10-28
EP0313874A3 (en) 1990-05-09
FI884983A (fi) 1989-05-01
FI95204C (fi) 1996-01-10
KR890006245A (ko) 1989-06-12
IE883262L (en) 1989-04-30
IL87946A (en) 1995-06-29
KR0133130B1 (ko) 1998-04-17
EP0313873B1 (fr) 1994-09-28
ATE104309T1 (de) 1994-04-15
BR1100939A (pt) 1999-08-31
IE65053B1 (en) 1995-10-04
DK602588D0 (da) 1988-10-28

Similar Documents

Publication Publication Date Title
US5053394A (en) Targeted forms of methyltrithio antitumor agents
DK174739B1 (da) Bærer-lægemiddelkonjugater og deres fremstiling
US5770701A (en) Process for preparing targeted forms of methyltrithio antitumor agents
JP3234980B2 (ja) 新規な二官能性化合物を含むコンジュゲートの製法
CA2076465C (fr) Conjugues agents de liaison cellulaire d'analogues et de derives de cc-1065
CZ393997A3 (cs) Způsoby přípravy monomerních konjugátů nosiče a derivátu calicheamicinu
HU208161B (en) Process for producing cytotoxic active ingredient - antibody conjugates and pharmaceutical compositions
KR20140035393A (ko) 단백질-활성제 접합체 및 이의 제조 방법
JPS63166897A (ja) 免疫グロブリンコンジュゲート
HU206377B (en) Process for producing cytotoxic vinc-dimer conjugates and pharmaceutical compositions comprising same
JP2022552757A (ja) カンプトテシン類医薬品及びその抗体複合体
CS235525B2 (en) Method of conjugate preparation containing immunoglobulin or immunoglobulin's fragment
TW201905000A (zh) 含有抗globo h抗體之抗體－藥物共軛物及其用途
EP0392384B1 (fr) Formes ciblés d'agents méthyltrithio antitumoraux
CN110759940A (zh) 连接子、含连接子的抗体偶联药物及连接子的用途
Goerlach et al. In vitro antitumor activity of 2'-deoxy-5-fluorouridine-monoclonal antibody conjugates
NZ212118A (en) Conjugate of macromolecule and ionophore; use as immunotoxin potentiator
KR0159767B1 (ko) 메틸-트리티오기를 갖는 화합물로 부터 제조된 항종양항균 물질인 치환 디설파이드, 그의 목적 형태및 그의 제조 방법
CA2014459C (fr) Formes ciblees d'agents antitumoraux methyltrithio
CA1341315C (fr) Formes ciblees d'agents antitumoraux methyltrithio

Legal Events

Date Code Title Description
PUP Patent expired