DK602488A - Disvovlanaloge af ll-e33288 2-i og deres anvendelse som middel mod tumorer - Google Patents

Disvovlanaloge af ll-e33288 2-i og deres anvendelse som middel mod tumorer

Info

Publication number
DK602488A
DK602488A DK602488A DK602488A DK602488A DK 602488 A DK602488 A DK 602488A DK 602488 A DK602488 A DK 602488A DK 602488 A DK602488 A DK 602488A DK 602488 A DK602488 A DK 602488A
Authority
DK
Denmark
Prior art keywords
disvovlanalogue
tumors
agent
Prior art date
Application number
DK602488A
Other languages
Danish (da)
English (en)
Other versions
DK602488D0 (da
Inventor
William James Mcgahren
Martin Leon Sassiver
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of DK602488D0 publication Critical patent/DK602488D0/da
Publication of DK602488A publication Critical patent/DK602488A/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DK602488A 1987-10-30 1988-10-28 Disvovlanaloge af ll-e33288 2-i og deres anvendelse som middel mod tumorer DK602488A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US11494087A 1987-10-30 1987-10-30

Publications (2)

Publication Number Publication Date
DK602488D0 DK602488D0 (da) 1988-10-28
DK602488A true DK602488A (da) 1989-05-01

Family

ID=22358378

Family Applications (2)

Application Number Title Priority Date Filing Date
DK602488A DK602488A (da) 1987-10-30 1988-10-28 Disvovlanaloge af ll-e33288 2-i og deres anvendelse som middel mod tumorer
DK198806025A DK174739B1 (da) 1987-10-30 1988-10-28 Bærer-lægemiddelkonjugater og deres fremstiling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK198806025A DK174739B1 (da) 1987-10-30 1988-10-28 Bærer-lægemiddelkonjugater og deres fremstiling

Country Status (19)

Country Link
EP (2) EP0313873B1 (fr)
JP (2) JP2720933B2 (fr)
KR (2) KR970011385B1 (fr)
AR (1) AR246083A1 (fr)
AT (2) ATE112172T1 (fr)
AU (2) AU618763B2 (fr)
BR (1) BR1100939A (fr)
CA (1) CA1321582C (fr)
DE (2) DE3851682T2 (fr)
DK (2) DK602488A (fr)
ES (2) ES2061586T3 (fr)
FI (2) FI91262C (fr)
HK (2) HK131897A (fr)
IE (2) IE65053B1 (fr)
IL (2) IL87946A (fr)
NO (2) NO173506C (fr)
NZ (2) NZ226727A (fr)
PT (2) PT88882B (fr)
ZA (2) ZA888123B (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5079233A (en) * 1987-01-30 1992-01-07 American Cyanamid Company N-acyl derivatives of the LL-E33288 antitumor antibiotics, composition and methods for using the same
US5606040A (en) * 1987-10-30 1997-02-25 American Cyanamid Company Antitumor and antibacterial substituted disulfide derivatives prepared from compounds possessing a methyl-trithio group
IL115770A (en) * 1989-04-14 1999-03-12 American Cyanamid Co Substituted disulfides of formula q-sp-ss-w their preparation and use for inhibiting the growth of tumours and for treating bacterial infections
GB9007384D0 (en) * 1990-04-02 1990-05-30 Duncan Ruth Coupling between polymers and other organic molecular entities utilising thiol-specific reactive groups
US5712374A (en) * 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
US5714586A (en) * 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
ES2350454T3 (es) 1998-11-27 2011-01-24 Ucb Pharma S.A. Composiciones y métodos para incrementar la mineralización de la sustancia ósea.
NZ511705A (en) * 2001-05-14 2004-03-26 Horticulture & Food Res Inst Methods and rapid immunoassay device for detecting progesterone and other steroids
ES2586401T3 (es) 2003-06-16 2016-10-14 Ucb Pharma S.A. Anticuerpos específicos para la esclerostina y métodos para aumentar la mineralización ósea
WO2008028050A2 (fr) * 2006-08-30 2008-03-06 Wisconsin Alumni Research Foundation Réactions catalysées par glycosyltransférase à base de produit naturel réversible, composés et procédés en rapport
KR100979928B1 (ko) * 2008-07-16 2010-09-03 한주학 수직축형 부력풍차
JP6494240B2 (ja) * 2013-11-04 2019-04-03 ファイザー・インク カリケアマイシン誘導体を合成するための中間体および方法
KR20190111086A (ko) * 2017-01-24 2019-10-01 화이자 인코포레이티드 칼리키아마이신 유도체 및 이의 항체 약물 접합체
SG11202108655TA (en) * 2019-02-15 2021-09-29 Univ Southern California Lym-1 and lym-2 antibody compositions and improved car constructs
WO2022085762A1 (fr) * 2020-10-22 2022-04-28 富士フイルム株式会社 Réactif pour la mesure d'une sensibilisation de la peau, composé et procédé pour la mesure d'une sensibilisation de la peau

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2430943A1 (fr) * 1978-07-13 1980-02-08 Toyo Jozo Kk Nouveaux derives disulfures
EP0040506B1 (fr) * 1980-05-21 1986-08-20 Teijin Limited Polymère réactif et procédé pour sa préparation
US4530835A (en) * 1983-07-08 1985-07-23 Warner-Lambert Company CL-1577 Antibiotic compounds and their production
CA1314245C (fr) * 1984-05-23 1993-03-09 Franz Jansen Methode de preparation de conjugues formes d'un ionophore carboxylique monovalent associe par une liaison de covalence a une macromolecule et utiles comme agents de potentialisation d'immunotoxines
EP0182152B1 (fr) * 1984-11-16 1999-05-26 American Cyanamid Company Antibiotiques antitumoraux (complexe LL-E33288)
EP0330874A3 (fr) * 1988-02-29 1989-10-18 American Cyanamid Company Agents antibactériens et antitumoraux LL-E33288 epsilon-I et LL-E33288-epsilon-Br, avec les procédés et intermédiaires pour obtention desdits agents
EP0342341A3 (fr) * 1988-05-17 1991-07-24 American Cyanamid Company Méthode pour la fabrication de l'antibiotique antitumoral LL-E33288 Gamma 2

Also Published As

Publication number Publication date
IE65053B1 (en) 1995-10-04
FI95204B (fi) 1995-09-29
KR890006245A (ko) 1989-06-12
ATE112172T1 (de) 1994-10-15
HK131897A (en) 1997-10-03
PT88882B (pt) 1993-01-29
ES2061586T3 (es) 1994-12-16
FI884984A0 (fi) 1988-10-28
CA1321582C (fr) 1993-08-24
JP2820256B2 (ja) 1998-11-05
FI91262C (fi) 1994-06-10
ATE104309T1 (de) 1994-04-15
NO173506C (no) 1993-12-22
KR890006244A (ko) 1989-06-12
NZ226726A (en) 1991-08-27
IE883262L (en) 1989-04-30
IL87947A (en) 1995-05-26
EP0313874B1 (fr) 1994-04-13
DE3889063D1 (de) 1994-05-19
ZA888127B (en) 1989-07-26
BR1100939A (pt) 1999-08-31
DK602488D0 (da) 1988-10-28
IL87946A (en) 1995-06-29
EP0313873A1 (fr) 1989-05-03
IE883261L (en) 1989-04-30
ZA888123B (en) 1989-07-26
DK174739B1 (da) 2003-10-13
DK602588D0 (da) 1988-10-28
NZ226727A (en) 1991-12-23
JPH01193282A (ja) 1989-08-03
NO884834D0 (no) 1988-10-28
AU612714B2 (en) 1991-07-18
DE3851682D1 (de) 1994-11-03
AR246083A1 (es) 1994-03-30
FI884984A (fi) 1989-05-01
NO176480C (no) 1995-04-12
IE65989B1 (en) 1995-11-29
DE3851682T2 (de) 1995-05-04
EP0313873B1 (fr) 1994-09-28
DE3889063T2 (de) 1994-12-01
HK131997A (en) 1997-10-03
JPH0296599A (ja) 1990-04-09
KR970011385B1 (ko) 1997-07-10
PT88881B (pt) 1993-01-29
ES2059464T3 (es) 1994-11-16
FI884983A (fi) 1989-05-01
NO176480B (no) 1995-01-02
EP0313874A2 (fr) 1989-05-03
AU2448988A (en) 1989-05-04
KR0133130B1 (ko) 1998-04-17
AU618763B2 (en) 1992-01-09
NO884833L (no) 1989-05-02
JP2720933B2 (ja) 1998-03-04
IL87946A0 (en) 1989-03-31
DK602588A (da) 1989-05-01
FI884983A0 (fi) 1988-10-28
IL87947A0 (en) 1989-03-31
NO173506B (no) 1993-09-13
NO884834L (no) 1989-05-02
NO884833D0 (no) 1988-10-28
FI95204C (fi) 1996-01-10
EP0313874A3 (en) 1990-05-09
AU2449488A (en) 1989-05-04
FI91262B (fi) 1994-02-28

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Legal Events

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AHS Application shelved for other reasons than non-payment