DK173954B1 - Alfa, alfa-diaryl-4-aryl-4-hydroxy-1-piperidinbutanamid, N-oxider, fremgangsmåde til fremstilling heraf og præparater indeholdende forbindelserne - Google Patents

Alfa, alfa-diaryl-4-aryl-4-hydroxy-1-piperidinbutanamid, N-oxider, fremgangsmåde til fremstilling heraf og præparater indeholdende forbindelserne Download PDF

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Publication number
DK173954B1
DK173954B1 DK198604868A DK486886A DK173954B1 DK 173954 B1 DK173954 B1 DK 173954B1 DK 198604868 A DK198604868 A DK 198604868A DK 486886 A DK486886 A DK 486886A DK 173954 B1 DK173954 B1 DK 173954B1
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DK
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Prior art keywords
hydroxy
compounds
compound
chlorophenyl
formula
Prior art date
Application number
DK198604868A
Other languages
Danish (da)
English (en)
Other versions
DK486886A (da
DK486886D0 (da
Inventor
Ludwig Paul Cooymans
Lourens Wals
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK486886D0 publication Critical patent/DK486886D0/da
Publication of DK486886A publication Critical patent/DK486886A/da
Application granted granted Critical
Publication of DK173954B1 publication Critical patent/DK173954B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Compositions Of Oxide Ceramics (AREA)
DK198604868A 1985-10-11 1986-10-10 Alfa, alfa-diaryl-4-aryl-4-hydroxy-1-piperidinbutanamid, N-oxider, fremgangsmåde til fremstilling heraf og præparater indeholdende forbindelserne DK173954B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78656685A 1985-10-11 1985-10-11
US78656685 1985-10-11

Publications (3)

Publication Number Publication Date
DK486886D0 DK486886D0 (da) 1986-10-10
DK486886A DK486886A (da) 1987-04-12
DK173954B1 true DK173954B1 (da) 2002-03-04

Family

ID=25138953

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198604868A DK173954B1 (da) 1985-10-11 1986-10-10 Alfa, alfa-diaryl-4-aryl-4-hydroxy-1-piperidinbutanamid, N-oxider, fremgangsmåde til fremstilling heraf og præparater indeholdende forbindelserne

Country Status (33)

Country Link
EP (1) EP0219898B1 (es)
JP (1) JPS6287569A (es)
KR (1) KR940001772B1 (es)
CN (1) CN1015453B (es)
AT (1) ATE53022T1 (es)
AU (1) AU583429B2 (es)
BG (1) BG61320B2 (es)
CA (1) CA1332236C (es)
CY (1) CY1603A (es)
DE (1) DE3671442D1 (es)
DK (1) DK173954B1 (es)
DZ (1) DZ997A1 (es)
EG (1) EG18126A (es)
ES (1) ES2002001A6 (es)
FI (1) FI83642C (es)
GR (1) GR862493B (es)
HK (1) HK52491A (es)
HU (1) HU196180B (es)
IE (1) IE59519B1 (es)
IL (1) IL80268A (es)
LT (1) LT2086B (es)
LV (2) LV5042A3 (es)
NL (1) NL950025I2 (es)
NO (2) NO168640C (es)
NZ (1) NZ217818A (es)
PH (1) PH22510A (es)
PT (1) PT83506B (es)
SG (1) SG46291G (es)
SU (1) SU1443798A3 (es)
TN (1) TNSN86138A1 (es)
ZA (1) ZA867713B (es)
ZM (1) ZM9486A1 (es)
ZW (1) ZW20386A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992002223A1 (en) * 1990-08-09 1992-02-20 The Procter & Gamble Company Process for formulating a solid oral dosage form of loperamide compounds
US5434158A (en) * 1994-04-26 1995-07-18 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin-3 antagonists
WO1997024325A1 (en) * 1995-12-28 1997-07-10 Takeda Chemical Industries, Ltd. DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS
CN1291984A (zh) * 1998-03-06 2001-04-18 詹森药业有限公司 甘氨酸传输抑制剂
KR101315751B1 (ko) * 2011-05-30 2013-10-10 주식회사 엔지켐생명과학 로페라미드 옥사이드 모노하이드레이트의 신규한 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714159A (en) * 1971-03-30 1973-01-30 Janssen Pharmaceutica Nv 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides
US4002618A (en) * 1976-02-23 1977-01-11 G. D. Searle & Co. 2,2-Diphenyl-5-(4-substituted-piperidino)-3-trans-pentenenitriles

Also Published As

Publication number Publication date
NL950025I1 (es) 1996-01-02
BG61320B2 (bg) 1997-05-30
FI83642B (fi) 1991-04-30
LV5042A3 (lv) 1993-06-10
CA1332236C (en) 1994-10-04
ATE53022T1 (de) 1990-06-15
KR870003986A (ko) 1987-05-06
EP0219898A1 (en) 1987-04-29
LV5767B4 (lv) 1997-06-20
IE862677L (en) 1987-04-11
NZ217818A (en) 1989-03-29
CN1015453B (zh) 1992-02-12
NO864045L (no) 1987-04-13
FI83642C (fi) 1991-08-12
NO168640C (no) 1992-03-18
TNSN86138A1 (fr) 1990-01-01
DE3671442D1 (de) 1990-06-28
HK52491A (en) 1991-07-19
SG46291G (en) 1991-07-26
CY1603A (en) 1992-04-03
PH22510A (en) 1988-09-12
NL950025I2 (nl) 1997-03-03
NO168640B (no) 1991-12-09
DK486886A (da) 1987-04-12
ES2002001A6 (es) 1988-07-01
JPS6287569A (ja) 1987-04-22
AU583429B2 (en) 1989-04-27
LV5767A4 (lv) 1996-12-20
PT83506B (pt) 1989-02-28
GR862493B (en) 1987-02-03
HU196180B (en) 1988-10-28
DZ997A1 (fr) 2004-09-13
AU6381586A (en) 1987-04-16
PT83506A (en) 1986-11-01
LT2086B (lt) 1993-07-15
FI864099A0 (fi) 1986-10-10
HUT42444A (en) 1987-07-28
NO1996010I1 (no) 1996-08-06
CN86106848A (zh) 1987-04-08
FI864099A (fi) 1987-04-12
IE59519B1 (en) 1994-03-09
ZA867713B (en) 1988-05-25
ZW20386A1 (en) 1988-05-11
JPH0517909B2 (es) 1993-03-10
EP0219898B1 (en) 1990-05-23
DK486886D0 (da) 1986-10-10
ZM9486A1 (en) 1988-04-29
IL80268A0 (en) 1987-01-30
IL80268A (en) 1991-03-10
SU1443798A3 (ru) 1988-12-07
NO864045D0 (no) 1986-10-10
KR940001772B1 (ko) 1994-03-05
EG18126A (en) 1992-08-30

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B1 Patent granted (law 1993)
PUP Patent expired