DE3671442D1 - Alpha,alpha-diaryl-4-aryl-4-hydroxy-1-piperidin-butanamid-n-oxide. - Google Patents

Alpha,alpha-diaryl-4-aryl-4-hydroxy-1-piperidin-butanamid-n-oxide.

Info

Publication number
DE3671442D1
DE3671442D1 DE8686201676T DE3671442T DE3671442D1 DE 3671442 D1 DE3671442 D1 DE 3671442D1 DE 8686201676 T DE8686201676 T DE 8686201676T DE 3671442 T DE3671442 T DE 3671442T DE 3671442 D1 DE3671442 D1 DE 3671442D1
Authority
DE
Germany
Prior art keywords
alpha
6alkyl
compounds
diaryl
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686201676T
Other languages
English (en)
Inventor
Lourens Wals
Ludwig Paul Cooymans
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of DE3671442D1 publication Critical patent/DE3671442D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/94—Oxygen atom, e.g. piperidine N-oxide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Oxide Ceramics (AREA)
  • Electric Double-Layer Capacitors Or The Like (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
DE8686201676T 1985-10-11 1986-09-30 Alpha,alpha-diaryl-4-aryl-4-hydroxy-1-piperidin-butanamid-n-oxide. Expired - Lifetime DE3671442D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US78656685A 1985-10-11 1985-10-11

Publications (1)

Publication Number Publication Date
DE3671442D1 true DE3671442D1 (de) 1990-06-28

Family

ID=25138953

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686201676T Expired - Lifetime DE3671442D1 (de) 1985-10-11 1986-09-30 Alpha,alpha-diaryl-4-aryl-4-hydroxy-1-piperidin-butanamid-n-oxide.

Country Status (33)

Country Link
EP (1) EP0219898B1 (de)
JP (1) JPS6287569A (de)
KR (1) KR940001772B1 (de)
CN (1) CN1015453B (de)
AT (1) ATE53022T1 (de)
AU (1) AU583429B2 (de)
BG (1) BG61320B2 (de)
CA (1) CA1332236C (de)
CY (1) CY1603A (de)
DE (1) DE3671442D1 (de)
DK (1) DK173954B1 (de)
DZ (1) DZ997A1 (de)
EG (1) EG18126A (de)
ES (1) ES2002001A6 (de)
FI (1) FI83642C (de)
GR (1) GR862493B (de)
HK (1) HK52491A (de)
HU (1) HU196180B (de)
IE (1) IE59519B1 (de)
IL (1) IL80268A (de)
LT (1) LT2086B (de)
LV (2) LV5042A3 (de)
NL (1) NL950025I2 (de)
NO (2) NO168640C (de)
NZ (1) NZ217818A (de)
PH (1) PH22510A (de)
PT (1) PT83506B (de)
SG (1) SG46291G (de)
SU (1) SU1443798A3 (de)
TN (1) TNSN86138A1 (de)
ZA (1) ZA867713B (de)
ZM (1) ZM9486A1 (de)
ZW (1) ZW20386A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2088273C (en) * 1990-08-09 1996-05-14 Daniel Louis Barone Processes for formulating a solid oral dosage form of loperamide compounds
US5434158A (en) * 1994-04-26 1995-07-18 Merck & Co., Inc. Spiro-substituted azacycles as neurokinin-3 antagonists
WO1997024325A1 (en) * 1995-12-28 1997-07-10 Takeda Chemical Industries, Ltd. DIPHENYLMETHANE DERIVATIVES AS MIP-1α/RANTES RECEPTOR ANTAGONISTS
AU3254499A (en) * 1998-03-06 1999-09-20 Janssen Pharmaceutica N.V. Glycine transport inhibitors
KR101315751B1 (ko) * 2011-05-30 2013-10-10 주식회사 엔지켐생명과학 로페라미드 옥사이드 모노하이드레이트의 신규한 제조방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3714159A (en) * 1971-03-30 1973-01-30 Janssen Pharmaceutica Nv 2,2-diaryl-4-(4'-aryl-4'-hydroxy-piper-idino)-butyramides
US4002618A (en) * 1976-02-23 1977-01-11 G. D. Searle & Co. 2,2-Diphenyl-5-(4-substituted-piperidino)-3-trans-pentenenitriles

Also Published As

Publication number Publication date
SG46291G (en) 1991-07-26
FI864099A (fi) 1987-04-12
EP0219898B1 (de) 1990-05-23
KR940001772B1 (ko) 1994-03-05
FI864099A0 (fi) 1986-10-10
IE862677L (en) 1987-04-11
HU196180B (en) 1988-10-28
IE59519B1 (en) 1994-03-09
ZA867713B (en) 1988-05-25
NO1996010I1 (no) 1996-08-06
ZM9486A1 (en) 1988-04-29
ZW20386A1 (en) 1988-05-11
KR870003986A (ko) 1987-05-06
PT83506A (en) 1986-11-01
FI83642C (fi) 1991-08-12
EG18126A (en) 1992-08-30
LV5042A3 (lv) 1993-06-10
LT2086B (lt) 1993-07-15
JPS6287569A (ja) 1987-04-22
DK173954B1 (da) 2002-03-04
NZ217818A (en) 1989-03-29
IL80268A0 (en) 1987-01-30
DZ997A1 (fr) 2004-09-13
CA1332236C (en) 1994-10-04
CY1603A (en) 1992-04-03
SU1443798A3 (ru) 1988-12-07
NO168640C (no) 1992-03-18
DK486886A (da) 1987-04-12
ATE53022T1 (de) 1990-06-15
PH22510A (en) 1988-09-12
HUT42444A (en) 1987-07-28
DK486886D0 (da) 1986-10-10
GR862493B (en) 1987-02-03
NL950025I2 (nl) 1997-03-03
ES2002001A6 (es) 1988-07-01
PT83506B (pt) 1989-02-28
AU6381586A (en) 1987-04-16
LV5767B4 (lv) 1997-06-20
HK52491A (en) 1991-07-19
AU583429B2 (en) 1989-04-27
FI83642B (fi) 1991-04-30
EP0219898A1 (de) 1987-04-29
TNSN86138A1 (fr) 1990-01-01
NO168640B (no) 1991-12-09
JPH0517909B2 (de) 1993-03-10
NO864045D0 (no) 1986-10-10
BG61320B2 (bg) 1997-05-30
NL950025I1 (de) 1996-01-02
CN86106848A (zh) 1987-04-08
IL80268A (en) 1991-03-10
CN1015453B (zh) 1992-02-12
LV5767A4 (lv) 1996-12-20
NO864045L (no) 1987-04-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: LOPERAMIDOXID; REGISTRATION NO/DATE: 30537.00.00, 19960308

Spc suppl protection certif: 196 75 021

Filing date: 19960711

V448 Application of spc

Free format text: PRODUCT NAME: LOPERAMIDOXID, WASSERFREI; REGISTRATION NO/DATE: 30537.00.00, 19960308

Spc suppl protection certif: 196 75 026

Filing date: 19960809

V454 Spc application withdrawn or to be regarded as withdrawn

Free format text: PRODUCT NAME: LOPERAMIDOXID; REGISTRATION NO/DATE: 30537.00.00, 19960308

Spc suppl protection certif: 196 75 021

Filing date: 19960711

V457 Spc granted

Free format text: PRODUCT NAME: LOPERAMIDOXID, WASSERFREI; REGISTRATION NO/DATE: 30537.00.00, 19960308

Spc suppl protection certif: 196 75 026

Filing date: 19960809

V464 Spc expired

Free format text: PRODUCT NAME: LOPERAMIDOXID, WASSERFREI; REGISTRATION NO/DATE: 30537.00.00, 19960308

Spc suppl protection certif: 196 75 026

Filing date: 19960809