DK170165B1 - Analogifremgangsmåde til fremstilling af piperidinon- og pyrrolidinonchromanolforbindelser og forbindelse til anvendelse som udgangsmateriale hertil - Google Patents

Analogifremgangsmåde til fremstilling af piperidinon- og pyrrolidinonchromanolforbindelser og forbindelse til anvendelse som udgangsmateriale hertil Download PDF

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Publication number
DK170165B1
DK170165B1 DK424582A DK424582A DK170165B1 DK 170165 B1 DK170165 B1 DK 170165B1 DK 424582 A DK424582 A DK 424582A DK 424582 A DK424582 A DK 424582A DK 170165 B1 DK170165 B1 DK 170165B1
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DK
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Prior art keywords
compound
group
alkyl
hydrogen
carbon atoms
Prior art date
Application number
DK424582A
Other languages
Danish (da)
English (en)
Other versions
DK424582A (da
Inventor
John Morris Evans
Robin Edwin Buckingham
Kenneth Willcocks
Original Assignee
Beecham Group Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Plc filed Critical Beecham Group Plc
Publication of DK424582A publication Critical patent/DK424582A/da
Application granted granted Critical
Publication of DK170165B1 publication Critical patent/DK170165B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicinal Preparation (AREA)
  • Glass Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK424582A 1981-09-25 1982-09-23 Analogifremgangsmåde til fremstilling af piperidinon- og pyrrolidinonchromanolforbindelser og forbindelse til anvendelse som udgangsmateriale hertil DK170165B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
GB8129064 1981-09-25
GB8129064 1981-09-25
GB8206400 1982-03-04
GB8206400 1982-03-04
GB8210490 1982-04-08
GB8210490 1982-04-08

Publications (2)

Publication Number Publication Date
DK424582A DK424582A (da) 1983-03-26
DK170165B1 true DK170165B1 (da) 1995-06-06

Family

ID=27261315

Family Applications (1)

Application Number Title Priority Date Filing Date
DK424582A DK170165B1 (da) 1981-09-25 1982-09-23 Analogifremgangsmåde til fremstilling af piperidinon- og pyrrolidinonchromanolforbindelser og forbindelse til anvendelse som udgangsmateriale hertil

Country Status (24)

Country Link
US (1) US4446113A (fi)
EP (1) EP0076075B1 (fi)
JP (4) JPH0314573A (fi)
KR (1) KR880001943B1 (fi)
AT (1) ATE23718T1 (fi)
AU (1) AU561536B2 (fi)
CA (1) CA1174682A (fi)
DE (1) DE3274350D1 (fi)
DK (1) DK170165B1 (fi)
ES (4) ES515921A0 (fi)
FI (1) FI73675C (fi)
GB (1) GB2107706A (fi)
GR (1) GR76732B (fi)
HK (1) HK17588A (fi)
IE (1) IE53875B1 (fi)
MX (3) MX174532B (fi)
MY (1) MY102061A (fi)
NO (4) NO159597C (fi)
NZ (1) NZ201984A (fi)
PH (1) PH18691A (fi)
PL (4) PL141099B1 (fi)
PT (1) PT75598B (fi)
SG (1) SG98587G (fi)
YU (4) YU43279B (fi)

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EP0107423B1 (en) * 1982-10-19 1986-07-23 Beecham Group Plc Novel chromans and chromenes
GB8308064D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
GB8308063D0 (en) * 1983-03-24 1983-05-05 Beecham Group Plc Active compounds
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EP0126367B1 (en) * 1983-05-18 1994-10-12 Beecham Group Plc Chroman and chromene derivatives
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GB8409745D0 (en) * 1984-04-14 1984-05-23 Beecham Group Plc Active compounds
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EP0218373B1 (en) * 1985-09-11 1990-03-07 Beecham Group Plc Chroman derivatives and analogues having antihypertensive activity
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FR2628424B1 (fr) * 1988-03-09 1990-12-28 Sanofi Sa Derives du dimethyl-2,2 chromannol-3 procede d'obtention et compositions pharmaceutiques en contenant
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AU3693789A (en) * 1988-05-10 1989-11-29 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) New ophthalmic preparation for treating glaucoma
DE3818245A1 (de) * 1988-05-28 1989-12-07 Hoechst Ag Kombination von angiotensin-converting-enzyme-hemmern mit kaliumkanal-modulatoren sowie deren verwendung in arzneimitteln
US4988723A (en) * 1988-06-02 1991-01-29 Fujisawa Pharmaceutical Co., Ltd. Benzopyran derivatives and their use as anti-hypertensives
EP0346724A1 (de) * 1988-06-16 1989-12-20 MERCK PATENT GmbH Chromanderivate
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DE3827532A1 (de) * 1988-08-13 1990-03-01 Hoechst Ag 6-aroyl-substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
US5194442A (en) * 1988-09-17 1993-03-16 Hoechst Aktiengesellschaft 2,3,4,5-tetrahydro-1-benzoxepins, the use thereof and pharmaceutical products based on these compounds
US4992465A (en) * 1988-09-27 1991-02-12 Ciba-Geigy Corporation 3-amino-dihydro-(1)-benzopyrans
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
FR2639227A1 (fr) * 1988-11-23 1990-05-25 Sanofi Sa Utilisation de derives du chromane pour le traitement des etats depressifs
ATE120459T1 (de) * 1988-12-13 1995-04-15 Beecham Group Plc Benzopyran und verwandte verbindungen.
DE3901720A1 (de) * 1989-01-21 1990-07-26 Hoechst Ag Substituierte benzo(b)pyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
GB8902118D0 (en) * 1989-02-01 1989-03-22 Beecham Group Plc Chemical process
US5239090A (en) * 1989-02-01 1993-08-24 Beecham Group P.L.C. Certain optically active 3,4-dihydrobenzopyran-4-ols which are intermediates
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DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
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GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
GB1548221A (en) * 1976-01-27 1979-07-04 Beecham Group Ltd Trans-4-heterocycyl-3,4-dihydro-2h-benzo pyran-3-ol esters
NZ183551A (en) * 1976-04-02 1978-09-20 Beecham Group Ltd Aminochromanols and pharmaceutical compositions containingthem
GB1511187A (en) * 1976-04-02 1978-05-17 Beecham Group Ltd Chromans
GB1548222A (en) * 1976-12-17 1979-07-04 Beecham Group Ltd Trans-4-heterocyclyl-3,4-dihydro-2h-benzo pyarn-3-ol derivatives
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EP0093534A1 (en) * 1982-04-28 1983-11-09 Beecham Group Plc Novel chromanols

Also Published As

Publication number Publication date
MX174531B (es) 1994-05-24
ES8407490A1 (es) 1984-09-16
ES8401061A1 (es) 1983-11-16
MY102061A (en) 1992-03-31
ES515921A0 (es) 1983-11-16
YU43279B (en) 1989-06-30
PL247747A1 (en) 1985-04-24
IE822313L (en) 1983-03-25
GB2107706A (en) 1983-05-05
MX174533B (es) 1994-05-24
PL247748A1 (en) 1985-04-24
NO834135L (no) 1983-03-28
PL141134B1 (en) 1987-06-30
KR880001943B1 (ko) 1988-10-04
CA1174682A (en) 1984-09-18
JPH05310729A (ja) 1993-11-22
NO159597B (no) 1988-10-10
JPH05202034A (ja) 1993-08-10
NZ201984A (en) 1986-04-11
ES8407491A1 (es) 1984-09-16
PL141135B1 (en) 1987-06-30
FI823272A0 (fi) 1982-09-23
JPH05394B2 (fi) 1993-01-05
FI73675B (fi) 1987-07-31
YU145484A (en) 1986-06-30
DE3274350D1 (en) 1987-01-08
HK17588A (en) 1988-03-11
JPH0780875B2 (ja) 1995-08-30
EP0076075A1 (en) 1983-04-06
US4446113B1 (fi) 1985-12-10
ATE23718T1 (de) 1986-12-15
ES522937A0 (es) 1984-09-16
AU8867582A (en) 1983-03-31
US4446113A (en) 1984-05-01
ES522938A0 (es) 1984-09-16
JP2504708B2 (ja) 1996-06-05
FI73675C (fi) 1987-11-09
YU210182A (en) 1984-12-31
PH18691A (en) 1985-09-05
FI823272L (fi) 1983-03-26
JP2504707B2 (ja) 1996-06-05
ES8500268A1 (es) 1984-10-01
YU44766B (en) 1991-02-28
NO834133L (no) 1983-03-28
PT75598A (en) 1982-10-01
YU44768B (en) 1991-02-28
NO834134L (no) 1983-03-28
PL238342A1 (en) 1985-01-16
AU561536B2 (en) 1987-05-14
KR840001572A (ko) 1984-05-07
PL141099B1 (en) 1987-06-30
JPH0314573A (ja) 1991-01-23
NO159597C (no) 1989-01-18
YU44767B (en) 1991-02-28
GR76732B (fi) 1984-08-30
YU145284A (en) 1986-06-30
NO823247L (no) 1983-03-28
SG98587G (en) 1988-07-15
PT75598B (en) 1984-12-10
IE53875B1 (en) 1989-03-29
ES522939A0 (es) 1984-10-01
JPH05301866A (ja) 1993-11-16
MX174532B (es) 1994-05-24
DK424582A (da) 1983-03-26
PL141133B1 (en) 1987-06-30
YU145384A (en) 1986-06-30
PL247746A1 (en) 1985-01-30
EP0076075B1 (en) 1986-11-20

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B1 Patent granted (law 1993)
PUP Patent expired