DK166728B1 - Analogifremgangsmaade til fremstilling af cephalosporinderivater samt udgangsmateriale til anvendelse ved fremgangsmaaden - Google Patents

Analogifremgangsmaade til fremstilling af cephalosporinderivater samt udgangsmateriale til anvendelse ved fremgangsmaaden Download PDF

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Publication number
DK166728B1
DK166728B1 DK496380A DK496380A DK166728B1 DK 166728 B1 DK166728 B1 DK 166728B1 DK 496380 A DK496380 A DK 496380A DK 496380 A DK496380 A DK 496380A DK 166728 B1 DK166728 B1 DK 166728B1
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Prior art keywords
process according
formula
compound
salts
general formula
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DK496380A
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Danish (da)
English (en)
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DK496380A (da
Inventor
Marc Montavon
Roland Reiner
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Hoffmann La Roche
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Publication of DK496380A publication Critical patent/DK496380A/da
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Publication of DK166728B1 publication Critical patent/DK166728B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Table Devices Or Equipment (AREA)
  • Laminated Bodies (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • Peptides Or Proteins (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
DK496380A 1979-11-21 1980-11-20 Analogifremgangsmaade til fremstilling af cephalosporinderivater samt udgangsmateriale til anvendelse ved fremgangsmaaden DK166728B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH1038479 1979-11-21
CH1038479 1979-11-21

Publications (2)

Publication Number Publication Date
DK496380A DK496380A (da) 1981-05-22
DK166728B1 true DK166728B1 (da) 1993-07-05

Family

ID=4362652

Family Applications (1)

Application Number Title Priority Date Filing Date
DK496380A DK166728B1 (da) 1979-11-21 1980-11-20 Analogifremgangsmaade til fremstilling af cephalosporinderivater samt udgangsmateriale til anvendelse ved fremgangsmaaden

Country Status (21)

Country Link
EP (1) EP0030294B1 (ja)
JP (2) JPS5692894A (ja)
KR (1) KR860000852B1 (ja)
AT (1) ATE8896T1 (ja)
AU (1) AU533088B2 (ja)
CA (1) CA1146165A (ja)
DE (1) DE3068905D1 (ja)
DK (1) DK166728B1 (ja)
ES (2) ES8200694A1 (ja)
FI (2) FI67385C (ja)
GR (1) GR71879B (ja)
HU (1) HU184941B (ja)
IE (1) IE50516B1 (ja)
IL (1) IL61486A (ja)
NO (2) NO166229C (ja)
NZ (1) NZ195547A (ja)
PH (2) PH17359A (ja)
PT (1) PT72084B (ja)
SI (1) SI8012952A8 (ja)
YU (1) YU42364B (ja)
ZA (1) ZA807099B (ja)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0830051B2 (ja) * 1986-05-21 1996-03-27 武田薬品工業株式会社 ４−ハロゲノ−２−置換オキシイミノ−３−オキソ酪酸のエステルまたはアミドの製造法
JP2595605B2 (ja) * 1988-01-18 1997-04-02 武田薬品工業株式会社 ２−置換オキシイミノ−３−オキソ酪酸の製造法
AT398764B (de) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat
AT399877B (de) * 1992-02-20 1995-08-25 Biochemie Gmbh Neues verfahren zur herstellung von ceftriaxon
AT411598B (de) * 1999-04-29 2004-03-25 Biochemie Gmbh Verfahren zur herstellung von cephalosporinen
AT408225B (de) * 1999-04-29 2001-09-25 Biochemie Gmbh Verfahren zur herstellung von cephalosporinen
WO2003004477A1 (en) * 2001-06-14 2003-01-16 Orchid Chemicals & Pharmaceuticals Limited 1,3,4-oxadiazol-2-yl thioesters and their use for acylating 7-aminocephalosporins
IN192139B (ja) 2001-11-26 2004-02-21 Lupin Ltd
US6919449B2 (en) 2002-04-19 2005-07-19 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds
AU2002337437A1 (en) * 2002-04-19 2003-11-03 Orchid Chemicals And Pharmaceuticals Limited A process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds
US6800756B2 (en) * 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
WO2004083216A1 (en) * 2003-03-20 2004-09-30 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of cephalosporins
ATE473986T1 (de) 2003-04-16 2010-07-15 Sandoz Ag Verfahren zur herstellung von cefepim
US7847093B2 (en) 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
US7098329B2 (en) * 2003-06-19 2006-08-29 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of a cephalosporin antibiotic
WO2005019227A1 (en) 2003-08-22 2005-03-03 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cephalosporin antibiotic
US20050059820A1 (en) * 2003-09-17 2005-03-17 Debashish Datta Method for manufacture of ceftriaxone sodium
WO2005040175A2 (en) * 2003-10-22 2005-05-06 Ranbaxy Laboratories Limited Process for the preparation of cephem carboxylic acids
US20050119244A1 (en) 2003-12-02 2005-06-02 Acs Dobfar S.P.A. Process for preparing cephalosporins with salified intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles

Also Published As

Publication number Publication date
JPH0248559B2 (ja) 1990-10-25
NO166229C (no) 1991-06-19
NO803516L (no) 1981-05-22
ES503583A0 (es) 1982-06-01
PT72084B (en) 1982-07-30
ZA807099B (en) 1981-11-25
DE3068905D1 (en) 1984-09-13
DK496380A (da) 1981-05-22
ES496994A0 (es) 1981-11-16
NO166228B (no) 1991-03-11
GR71879B (ja) 1983-08-03
KR860000852B1 (ko) 1986-07-09
FI793768A (fi) 1981-05-22
NO812083L (no) 1981-12-22
YU295280A (en) 1983-06-30
JPS6145995B2 (ja) 1986-10-11
IE50516B1 (en) 1986-04-30
IL61486A (en) 1984-04-30
HU184941B (en) 1984-11-28
IL61486A0 (en) 1980-12-31
JPS61143392A (ja) 1986-07-01
JPS5692894A (en) 1981-07-27
CA1146165A (en) 1983-05-10
SI8012952A8 (en) 1997-06-30
EP0030294B1 (de) 1984-08-08
FI842614A (fi) 1984-06-28
PH18468A (en) 1985-07-18
FI842614A0 (fi) 1984-06-28
IE802408L (en) 1981-05-21
FI67385C (fi) 1985-03-11
ATE8896T1 (de) 1984-08-15
ES8200694A1 (es) 1981-11-16
EP0030294A2 (de) 1981-06-17
FI67385B (fi) 1984-11-30
FI71563B (fi) 1986-10-10
AU6443880A (en) 1981-05-28
NZ195547A (en) 1983-05-10
EP0030294A3 (en) 1981-12-09
NO166228C (no) 1991-06-19
YU42364B (en) 1988-08-31
AU533088B2 (en) 1983-10-27
PT72084A (en) 1980-12-01
PH17359A (en) 1984-08-01
NO166229B (no) 1991-03-11
ES8204997A1 (es) 1982-06-01
KR830004315A (ko) 1983-07-09
FI71563C (fi) 1987-01-19

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Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired