FI842614A - Halogenerade kefalosporinderivat. - Google Patents

Halogenerade kefalosporinderivat. Download PDF

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Publication number
FI842614A
FI842614A FI842614A FI842614A FI842614A FI 842614 A FI842614 A FI 842614A FI 842614 A FI842614 A FI 842614A FI 842614 A FI842614 A FI 842614A FI 842614 A FI842614 A FI 842614A
Authority
FI
Finland
Prior art keywords
salt
see diagramm
hydrate
salts
compounds
Prior art date
Application number
FI842614A
Other languages
English (en)
Other versions
FI71563B (fi
FI71563C (fi
FI842614A0 (fi
Inventor
Marc Montavon
Roland Reiner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of FI842614A publication Critical patent/FI842614A/fi
Publication of FI842614A0 publication Critical patent/FI842614A0/fi
Publication of FI71563B publication Critical patent/FI71563B/fi
Application granted granted Critical
Publication of FI71563C publication Critical patent/FI71563C/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Table Devices Or Equipment (AREA)
  • Laminated Bodies (AREA)
  • Suspension Of Electric Lines Or Cables (AREA)
  • Peptides Or Proteins (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
FI842614A 1979-11-21 1984-06-28 (6r,7r) 4-halogen-2-/(z)-metoxiimino/ acetamido -3- /subst.-as-triazin-3-yl)tio/metyl -8-oxo-5-tia-1 -azabicyklo/4.2.0/okt-2-en-2-karboxylsyror och deras estrar. FI71563C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH1038479 1979-11-21
CH1038479 1979-11-21
FI793768 1979-11-30
FI793768A FI67385C (fi) 1979-11-21 1979-11-30 Foerfarande foer framstaellning av (6r 7r)-7-(2-(2-amino-4-tiazolyl)-2-(z-metoxiimino)acetamido)-3-cefem-4-karboxylsyraderivat

Publications (4)

Publication Number Publication Date
FI842614A true FI842614A (fi) 1984-06-28
FI842614A0 FI842614A0 (fi) 1984-06-28
FI71563B FI71563B (fi) 1986-10-10
FI71563C FI71563C (fi) 1987-01-19

Family

ID=4362652

Family Applications (2)

Application Number Title Priority Date Filing Date
FI793768A FI67385C (fi) 1979-11-21 1979-11-30 Foerfarande foer framstaellning av (6r 7r)-7-(2-(2-amino-4-tiazolyl)-2-(z-metoxiimino)acetamido)-3-cefem-4-karboxylsyraderivat
FI842614A FI71563C (fi) 1979-11-21 1984-06-28 (6r,7r) 4-halogen-2-/(z)-metoxiimino/ acetamido -3- /subst.-as-triazin-3-yl)tio/metyl -8-oxo-5-tia-1 -azabicyklo/4.2.0/okt-2-en-2-karboxylsyror och deras estrar.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
FI793768A FI67385C (fi) 1979-11-21 1979-11-30 Foerfarande foer framstaellning av (6r 7r)-7-(2-(2-amino-4-tiazolyl)-2-(z-metoxiimino)acetamido)-3-cefem-4-karboxylsyraderivat

Country Status (21)

Country Link
EP (1) EP0030294B1 (fi)
JP (2) JPS5692894A (fi)
KR (1) KR860000852B1 (fi)
AT (1) ATE8896T1 (fi)
AU (1) AU533088B2 (fi)
CA (1) CA1146165A (fi)
DE (1) DE3068905D1 (fi)
DK (1) DK166728B1 (fi)
ES (2) ES496994A0 (fi)
FI (2) FI67385C (fi)
GR (1) GR71879B (fi)
HU (1) HU184941B (fi)
IE (1) IE50516B1 (fi)
IL (1) IL61486A (fi)
NO (2) NO166229C (fi)
NZ (1) NZ195547A (fi)
PH (2) PH17359A (fi)
PT (1) PT72084B (fi)
SI (1) SI8012952A8 (fi)
YU (1) YU42364B (fi)
ZA (1) ZA807099B (fi)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0830051B2 (ja) * 1986-05-21 1996-03-27 武田薬品工業株式会社 ４−ハロゲノ−２−置換オキシイミノ−３−オキソ酪酸のエステルまたはアミドの製造法
JP2595605B2 (ja) * 1988-01-18 1997-04-02 武田薬品工業株式会社 ２−置換オキシイミノ−３−オキソ酪酸の製造法
AT398764B (de) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat
AT399877B (de) * 1992-02-20 1995-08-25 Biochemie Gmbh Neues verfahren zur herstellung von ceftriaxon
AT411598B (de) * 1999-04-29 2004-03-25 Biochemie Gmbh Verfahren zur herstellung von cephalosporinen
AT408225B (de) * 1999-04-29 2001-09-25 Biochemie Gmbh Verfahren zur herstellung von cephalosporinen
WO2003004477A1 (en) * 2001-06-14 2003-01-16 Orchid Chemicals & Pharmaceuticals Limited 1,3,4-oxadiazol-2-yl thioesters and their use for acylating 7-aminocephalosporins
IN192139B (fi) 2001-11-26 2004-02-21 Lupin Ltd
US6919449B2 (en) 2002-04-19 2005-07-19 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds
AU2002337437A1 (en) * 2002-04-19 2003-11-03 Orchid Chemicals And Pharmaceuticals Limited A process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds
US6800756B2 (en) 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
WO2004083216A1 (en) * 2003-03-20 2004-09-30 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of cephalosporins
ATE473986T1 (de) 2003-04-16 2010-07-15 Sandoz Ag Verfahren zur herstellung von cefepim
US7847093B2 (en) 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
US7098329B2 (en) * 2003-06-19 2006-08-29 Orchid Chemicals & Pharmaceuticals Ltd. Process for the preparation of a cephalosporin antibiotic
WO2005019227A1 (en) 2003-08-22 2005-03-03 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cephalosporin antibiotic
US20050059820A1 (en) * 2003-09-17 2005-03-17 Debashish Datta Method for manufacture of ceftriaxone sodium
WO2005040175A2 (en) * 2003-10-22 2005-05-06 Ranbaxy Laboratories Limited Process for the preparation of cephem carboxylic acids
US20050119244A1 (en) 2003-12-02 2005-06-02 Acs Dobfar S.P.A. Process for preparing cephalosporins with salified intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles

Also Published As

Publication number Publication date
PH17359A (en) 1984-08-01
YU295280A (en) 1983-06-30
NO803516L (no) 1981-05-22
IE50516B1 (en) 1986-04-30
FI71563B (fi) 1986-10-10
ES8200694A1 (es) 1981-11-16
ES503583A0 (es) 1982-06-01
HU184941B (en) 1984-11-28
ZA807099B (en) 1981-11-25
NO166229B (no) 1991-03-11
AU6443880A (en) 1981-05-28
IL61486A0 (en) 1980-12-31
KR830004315A (ko) 1983-07-09
FI793768A (fi) 1981-05-22
PT72084A (en) 1980-12-01
JPS6145995B2 (fi) 1986-10-11
DK166728B1 (da) 1993-07-05
NO166228C (no) 1991-06-19
DE3068905D1 (en) 1984-09-13
NZ195547A (en) 1983-05-10
EP0030294B1 (de) 1984-08-08
YU42364B (en) 1988-08-31
JPS61143392A (ja) 1986-07-01
GR71879B (fi) 1983-08-03
IE802408L (en) 1981-05-21
PH18468A (en) 1985-07-18
FI71563C (fi) 1987-01-19
PT72084B (en) 1982-07-30
NO166229C (no) 1991-06-19
ATE8896T1 (de) 1984-08-15
IL61486A (en) 1984-04-30
EP0030294A2 (de) 1981-06-17
DK496380A (da) 1981-05-22
KR860000852B1 (ko) 1986-07-09
ES496994A0 (es) 1981-11-16
ES8204997A1 (es) 1982-06-01
EP0030294A3 (en) 1981-12-09
FI67385B (fi) 1984-11-30
CA1146165A (en) 1983-05-10
SI8012952A8 (en) 1997-06-30
JPS5692894A (en) 1981-07-27
JPH0248559B2 (fi) 1990-10-25
AU533088B2 (en) 1983-10-27
NO812083L (no) 1981-12-22
FI67385C (fi) 1985-03-11
NO166228B (no) 1991-03-11
FI842614A0 (fi) 1984-06-28

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Legal Events

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MA Patent expired

Owner name: F. HOFFMANN-LA ROCHE AG