ES8204997A1 - Un procedimiento para la preparacion de derivados de cefa- losporina - Google Patents

Un procedimiento para la preparacion de derivados de cefa- losporina

Info

Publication number
ES8204997A1
ES8204997A1 ES503583A ES503583A ES8204997A1 ES 8204997 A1 ES8204997 A1 ES 8204997A1 ES 503583 A ES503583 A ES 503583A ES 503583 A ES503583 A ES 503583A ES 8204997 A1 ES8204997 A1 ES 8204997A1
Authority
ES
Spain
Prior art keywords
salt
see diagramm
hydrate
salts
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503583A
Other languages
English (en)
Other versions
ES503583A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of ES503583A0 publication Critical patent/ES503583A0/es
Publication of ES8204997A1 publication Critical patent/ES8204997A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

PROCEDIMIENTO PARA LA OBTRENCION DE DERIVADOS DE CEFALOSPORINA. CONSISTE EN HACER REACCIONAR UNA AMINA PRIMARIA CON UN ACIDO CARBOXILICO HALOGENADO O CON UN DERIVADO REACTIVO RESPECTIVO. SE OBTIENE EL COMPUESTO DE FORMULA GENERAL (I), SIENDO X LOS COMPUESTOS (II) O (III); R, UN ATOMO DE HIDROGENO O UN GRUPO ESTER O ETER FACILMENTE HIDROLIZABLE, E Y, UN ATOMO DE HALOGENO, LOS COMPUESTOS OBTENIDOS PUEDEN HIDRATARSE EN EL PROCESO DE FABRICACION O GRADUALMENTE COMO RESULTADO DE LAS PROPIEDADES DE UN PRODUCTO INICIALMENTE ANHIDRO.
ES503583A 1979-11-21 1981-07-01 Un procedimiento para la preparacion de derivados de cefa- losporina Expired ES8204997A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1038479 1979-11-21

Publications (2)

Publication Number Publication Date
ES503583A0 ES503583A0 (es) 1982-06-01
ES8204997A1 true ES8204997A1 (es) 1982-06-01

Family

ID=4362652

Family Applications (2)

Application Number Title Priority Date Filing Date
ES496994A Granted ES496994A0 (es) 1979-11-21 1980-11-20 Un procedimiento para la preparacion de derivados de cefalosporina.
ES503583A Expired ES8204997A1 (es) 1979-11-21 1981-07-01 Un procedimiento para la preparacion de derivados de cefa- losporina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES496994A Granted ES496994A0 (es) 1979-11-21 1980-11-20 Un procedimiento para la preparacion de derivados de cefalosporina.

Country Status (21)

Country Link
EP (1) EP0030294B1 (es)
JP (2) JPS5692894A (es)
KR (1) KR860000852B1 (es)
AT (1) ATE8896T1 (es)
AU (1) AU533088B2 (es)
CA (1) CA1146165A (es)
DE (1) DE3068905D1 (es)
DK (1) DK166728B1 (es)
ES (2) ES496994A0 (es)
FI (2) FI67385C (es)
GR (1) GR71879B (es)
HU (1) HU184941B (es)
IE (1) IE50516B1 (es)
IL (1) IL61486A (es)
NO (2) NO166229C (es)
NZ (1) NZ195547A (es)
PH (2) PH17359A (es)
PT (1) PT72084B (es)
SI (1) SI8012952A8 (es)
YU (1) YU42364B (es)
ZA (1) ZA807099B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0830051B2 (ja) * 1986-05-21 1996-03-27 武田薬品工業株式会社 ４−ハロゲノ−２−置換オキシイミノ−３−オキソ酪酸のエステルまたはアミドの製造法
JP2595605B2 (ja) * 1988-01-18 1997-04-02 武田薬品工業株式会社 ２−置換オキシイミノ−３−オキソ酪酸の製造法
AT398764B (de) * 1992-01-28 1995-01-25 Lek Tovarna Farmacevtskih Verfahren zur herstellung von ceftriaxondinatrium-salzhemiheptahydrat
AT399877B (de) * 1992-02-20 1995-08-25 Biochemie Gmbh Neues verfahren zur herstellung von ceftriaxon
AT411598B (de) * 1999-04-29 2004-03-25 Biochemie Gmbh Verfahren zur herstellung von cephalosporinen
AT408225B (de) * 1999-04-29 2001-09-25 Biochemie Gmbh Verfahren zur herstellung von cephalosporinen
EP1399429A1 (en) * 2001-06-14 2004-03-24 Orchid Chemicals and Pharmaceuticals Ltd 1,3,4-oxadiazol-2-yl thioesters and their use for acylating 7-aminocephalosporins
IN192139B (es) 2001-11-26 2004-02-21 Lupin Ltd
US6919449B2 (en) 2002-04-19 2005-07-19 Orchid Chemicals And Pharmaceuticals Limited Process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds
WO2003089406A1 (en) * 2002-04-19 2003-10-30 Orchid Chemicals And Pharmaceuticals Limited A process for the preparation of cephalosporin intermediate and its use for the manufacture of cephalosporin compounds
US6800756B2 (en) 2002-05-03 2004-10-05 Orchid Chemicals And Pharmaceuticals, Ltd. Method for the preparation of ceftiofur sodium and its intermediates
WO2004083216A1 (en) * 2003-03-20 2004-09-30 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of cephalosporins
DE602004028111D1 (de) 2003-04-16 2010-08-26 Sandoz Ag Verfahren zur herstellung von cefepim
US7847093B2 (en) 2003-04-16 2010-12-07 Sandoz Ag Processes for the preparations of cefepime
WO2004111059A1 (en) * 2003-06-19 2004-12-23 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of a cephalosporin antibiotic
WO2005019227A1 (en) 2003-08-22 2005-03-03 Orchid Chemicals & Pharmaceuticals Ltd Process for the preparation of cephalosporin antibiotic
US20050059820A1 (en) * 2003-09-17 2005-03-17 Debashish Datta Method for manufacture of ceftriaxone sodium
WO2005040175A2 (en) * 2003-10-22 2005-05-06 Ranbaxy Laboratories Limited Process for the preparation of cephem carboxylic acids
US20050119244A1 (en) 2003-12-02 2005-06-02 Acs Dobfar S.P.A. Process for preparing cephalosporins with salified intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4200745A (en) * 1977-12-20 1980-04-29 Eli Lilly And Company 7[2-(2-Aminothiazol-4-yl)-2-alkoxyimino]acetamido 3[4-alkyl-5-oxo-6-hydroxy-3,4 dihydro 1,2,4-triazin 3-yl]thio methyl cephalosporins
JPS5498795A (en) * 1978-01-13 1979-08-03 Takeda Chem Ind Ltd Cephalosporin derivative and its preparation
MC1259A1 (fr) * 1978-05-30 1980-01-14 Hoffmann La Roche Derives acyles

Also Published As

Publication number Publication date
JPH0248559B2 (es) 1990-10-25
NO803516L (no) 1981-05-22
NO166229C (no) 1991-06-19
ATE8896T1 (de) 1984-08-15
IL61486A0 (en) 1980-12-31
CA1146165A (en) 1983-05-10
HU184941B (en) 1984-11-28
SI8012952A8 (en) 1997-06-30
DK166728B1 (da) 1993-07-05
NZ195547A (en) 1983-05-10
ES503583A0 (es) 1982-06-01
JPS61143392A (ja) 1986-07-01
JPS5692894A (en) 1981-07-27
AU6443880A (en) 1981-05-28
NO166228C (no) 1991-06-19
FI71563C (fi) 1987-01-19
EP0030294A3 (en) 1981-12-09
KR860000852B1 (ko) 1986-07-09
IE50516B1 (en) 1986-04-30
FI842614A0 (fi) 1984-06-28
EP0030294A2 (de) 1981-06-17
FI71563B (fi) 1986-10-10
FI793768A (fi) 1981-05-22
IE802408L (en) 1981-05-21
ES8200694A1 (es) 1981-11-16
NO812083L (no) 1981-12-22
NO166229B (no) 1991-03-11
FI67385B (fi) 1984-11-30
NO166228B (no) 1991-03-11
DE3068905D1 (en) 1984-09-13
JPS6145995B2 (es) 1986-10-11
DK496380A (da) 1981-05-22
GR71879B (es) 1983-08-03
YU42364B (en) 1988-08-31
IL61486A (en) 1984-04-30
AU533088B2 (en) 1983-10-27
PH18468A (en) 1985-07-18
FI67385C (fi) 1985-03-11
PT72084B (en) 1982-07-30
KR830004315A (ko) 1983-07-09
PH17359A (en) 1984-08-01
ZA807099B (en) 1981-11-25
EP0030294B1 (de) 1984-08-08
FI842614A (fi) 1984-06-28
PT72084A (en) 1980-12-01
ES496994A0 (es) 1981-11-16
YU295280A (en) 1983-06-30

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20020211