DK1601776T3 - Ekspressionsvektorer omfattende mCmV-IE2-promotoren - Google Patents
Ekspressionsvektorer omfattende mCmV-IE2-promotorenInfo
- Publication number
- DK1601776T3 DK1601776T3 DK04718972T DK04718972T DK1601776T3 DK 1601776 T3 DK1601776 T3 DK 1601776T3 DK 04718972 T DK04718972 T DK 04718972T DK 04718972 T DK04718972 T DK 04718972T DK 1601776 T3 DK1601776 T3 DK 1601776T3
- Authority
- DK
- Denmark
- Prior art keywords
- mcmv
- promoter
- expression vectors
- gene
- expression
- Prior art date
Links
- 239000013604 expression vector Substances 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/03—Herpetoviridae, e.g. pseudorabies virus
- C07K14/04—Varicella-zoster virus
- C07K14/045—Cytomegalovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16141—Use of virus, viral particle or viral elements as a vector
- C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
- C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Tropical Medicine & Parasitology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03100617 | 2003-03-11 | ||
| PCT/EP2004/050280 WO2004081167A2 (en) | 2003-03-11 | 2004-03-10 | Expression vectors comprising the mcmv ie2 promoter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1601776T3 true DK1601776T3 (da) | 2008-10-13 |
Family
ID=32981915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK04718972T DK1601776T3 (da) | 2003-03-11 | 2004-03-10 | Ekspressionsvektorer omfattende mCmV-IE2-promotoren |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US7824907B2 (no) |
| EP (1) | EP1601776B1 (no) |
| JP (3) | JP5171033B2 (no) |
| KR (1) | KR101180139B1 (no) |
| CN (1) | CN100429315C (no) |
| AT (1) | ATE399872T1 (no) |
| AU (1) | AU2004219917B2 (no) |
| BR (1) | BRPI0408246A (no) |
| CA (1) | CA2516157C (no) |
| CY (1) | CY1108344T1 (no) |
| DE (1) | DE602004014738D1 (no) |
| DK (1) | DK1601776T3 (no) |
| EA (1) | EA010096B1 (no) |
| ES (1) | ES2309508T3 (no) |
| HK (1) | HK1085766A1 (no) |
| HR (1) | HRP20050705B1 (no) |
| IL (1) | IL170754A (no) |
| MX (1) | MXPA05009608A (no) |
| NO (1) | NO333818B1 (no) |
| PL (1) | PL1601776T4 (no) |
| PT (1) | PT1601776E (no) |
| RS (1) | RS50488B (no) |
| SI (1) | SI1601776T1 (no) |
| UA (1) | UA88138C2 (no) |
| WO (1) | WO2004081167A2 (no) |
| ZA (1) | ZA200506400B (no) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| JP5171033B2 (ja) * | 2003-03-11 | 2013-03-27 | メルク セローノ ソシエテ アノニム | ｍＣＭＶＩＥ２プロモーターを含んで成る発現ベクター |
| ES2384241T3 (es) * | 2003-05-13 | 2012-07-02 | Merck Serono Sa | Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas |
| PT1675956E (pt) * | 2003-10-21 | 2010-11-04 | Merck Serono Sa | Sequência mínima de adn que actua como um isolador de cromatina e sua utilização na expressão de proteína |
| RS50516B (sr) | 2003-11-05 | 2010-05-07 | Ares Trading S.A. | Prečišćavanje il-18 vezujućeg proteina |
| PT1720979E (pt) | 2004-03-01 | 2007-10-25 | Ares Trading Sa | Utilização de um meio de cultura de células sem soro para a produção de il-18bp em células de mamífero |
| US7439336B2 (en) * | 2004-06-29 | 2008-10-21 | Ares Trading S.A. | Process for the purification of IL-18 binding protein |
| CA2593429A1 (en) * | 2004-12-02 | 2006-06-08 | Laboratoires Serono S.A. | The lupac bifunctional marker and its use in protein production |
| JP2008536506A (ja) | 2005-04-22 | 2008-09-11 | ロンザ・バイオロジクス・ピーエルシー | ｍＣＭＶプロモーターおよびｈＣＭＶ主要最初期遺伝子を含む哺乳類発現ベクター |
| CA2608656A1 (en) * | 2005-05-16 | 2006-11-23 | Morphotek, Inc. | Regulated vectors for selection of cells exhibiting desired phenotypes |
| PL1885753T3 (pl) * | 2005-06-03 | 2011-12-30 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| PT1891088E (pt) | 2005-06-10 | 2011-12-19 | Ares Trading Sa | Processo para a purificação da proteína de ligação il-18 |
| EP1760092A1 (en) * | 2005-08-26 | 2007-03-07 | Applied Research Systems ARS Holding N.V. | System for screening cells for high expression of a protein of interest |
| CN101903526B (zh) * | 2007-12-21 | 2014-02-12 | 诺华股份有限公司 | 有机化合物 |
| JP2009276724A (ja) * | 2008-05-19 | 2009-11-26 | Nitto Denko Corp | 光導波路装置の製造方法 |
| SG173456A1 (en) | 2009-02-27 | 2011-09-29 | Novartis Ag | Expression vector system comprising two selection markers |
| JP5502406B2 (ja) * | 2009-09-14 | 2014-05-28 | ロンザ・バイオロジクス・ピーエルシー | Ｃｈｏ細胞において組換えタンパク質を発現する方法 |
| KR101038126B1 (ko) * | 2010-11-30 | 2011-05-31 | 주식회사 엘지생명과학 | 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터 |
| US9249785B2 (en) * | 2012-01-31 | 2016-02-02 | Brightsource Industries (Isreal) Ltd. | Method and system for operating a solar steam system during reduced-insolation events |
| ES2540753T3 (es) | 2012-09-24 | 2015-07-13 | Lonza Biologics Plc. | Vectores de expresión que comprenden secuencias quiméricas de promotor y amplificador de citomegalovirus |
| ITFI20120221A1 (it) * | 2012-10-22 | 2014-04-23 | Nuovo Pignone Srl | "exhaust gas collector and gas turbine" |
| WO2014133468A1 (en) * | 2013-02-28 | 2014-09-04 | Agency For Science, Technology And Research | Chimeric promoters for high gene expression level and stability in mammalian cells |
| CN103173481A (zh) * | 2013-03-01 | 2013-06-26 | 上海中医药大学附属普陀医院 | 一种含有abcb1基因3′utr序列和报告基因的质粒载体及其构建方法和用途 |
| CN103173480B (zh) * | 2013-03-01 | 2015-06-24 | 上海中医药大学附属曙光医院 | 一种利用双荧光素酶报告基因筛选多药耐药相关microRNA的方法 |
| EP2970956A1 (en) | 2013-03-11 | 2016-01-20 | Novartis AG | Method of screening cell clones |
| EP3412684B1 (en) | 2013-07-31 | 2022-04-06 | Novartis AG | Novel selection vectors and methods of selecting eukaryotic host cells |
| CN106029692A (zh) | 2013-12-20 | 2016-10-12 | 诺华股份有限公司 | 用于重组表达感兴趣产物的新型真核细胞和方法 |
| RU2712507C2 (ru) | 2013-12-20 | 2020-01-29 | Новартис Аг | Новые эукариотические клетки и способы их получения для рекомбинантной экспрессии представляющего интерес продукта |
| JP6265020B2 (ja) * | 2014-04-16 | 2018-01-24 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| PL3536776T3 (pl) | 2014-04-29 | 2024-03-25 | Novartis Ag | Nowe komórki kręgowców i sposoby ekspresji rekombinowanej polipeptydu będącego przedmiotem zainteresowania |
| RU2699715C2 (ru) * | 2014-05-19 | 2019-09-09 | Ф. Хоффманн-Ля Рош Аг | Способ получения полипептидов |
| KR20160068558A (ko) | 2014-12-05 | 2016-06-15 | 삼성바이오에피스 주식회사 | 마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법 |
| CN107660150B (zh) | 2015-03-05 | 2023-10-24 | Ab2生物股份有限公司 | Il-18结合蛋白(il-18bp)和抗体在炎性疾病中 |
| EP3283634B1 (en) | 2015-04-14 | 2019-05-22 | Janssen Vaccines & Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
| ES2823173T3 (es) | 2016-01-27 | 2021-05-06 | Just Biotherapeutics Inc | Promotor híbrido y usos del mismo |
| EP3455358B1 (en) * | 2016-05-12 | 2020-08-26 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| US11001858B2 (en) | 2016-06-20 | 2021-05-11 | Janssen Vaccines & Prevention B.V. | Potent and balanced bidirectional promoter |
| KR101864581B1 (ko) * | 2016-11-04 | 2018-07-13 | 국립암센터 | 양방향 프로모터를 포함하는 렌티바이러스 발현 벡터 및 이의 용도 |
| CN110268061B (zh) | 2017-02-09 | 2024-07-16 | 扬森疫苗与预防公司 | 用于表达异源基因的有效的短启动子 |
| US20200370056A1 (en) | 2017-10-02 | 2020-11-26 | Astrazeneca Ab | Cell lines and methods for increased protein production |
| CA3119799A1 (en) * | 2018-12-04 | 2020-06-11 | Catalent Pharma Solutions, Llc | Vectors for protein manufacture |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2007A (en) * | 1841-03-16 | Improvement in the mode of harvesting grain | ||
| US4968615A (en) | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| JPS63502719A (ja) * | 1985-12-18 | 1988-10-13 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | プロモ−タ−系 |
| US4963481A (en) * | 1985-12-18 | 1990-10-16 | Genetics Institute Inc | Promoter system |
| WO1999036514A1 (en) * | 1998-01-16 | 1999-07-22 | California Pacific Medical Center Research Institute | Methods and compositions for gene delivery |
| AU2001245427A1 (en) * | 2000-03-03 | 2001-09-17 | Valentis, Inc. | Nucleic acid formulations for gene delivery and methods of use |
| EA007014B1 (ru) * | 2000-05-05 | 2006-06-30 | Апплайд Резеч Системз Арс Холдинг Н.В. | Применение il-18 в качестве диагностического маркера |
| US7812148B2 (en) * | 2001-04-05 | 2010-10-12 | Millipore Corporation | Vectors comprising CpG islands without position effect varigation and having increased expression |
| US20040161817A1 (en) * | 2001-06-04 | 2004-08-19 | Corixa Corporation | Compositions and methods for high-level, large-scale production of recombinant proteins |
| JP5171033B2 (ja) * | 2003-03-11 | 2013-03-27 | メルク セローノ ソシエテ アノニム | ｍＣＭＶＩＥ２プロモーターを含んで成る発現ベクター |
| ES2384241T3 (es) * | 2003-05-13 | 2012-07-02 | Merck Serono Sa | Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas |
| PT1675956E (pt) | 2003-10-21 | 2010-11-04 | Merck Serono Sa | Sequência mínima de adn que actua como um isolador de cromatina e sua utilização na expressão de proteína |
| RS50516B (sr) | 2003-11-05 | 2010-05-07 | Ares Trading S.A. | Prečišćavanje il-18 vezujućeg proteina |
| PT1720979E (pt) | 2004-03-01 | 2007-10-25 | Ares Trading Sa | Utilização de um meio de cultura de células sem soro para a produção de il-18bp em células de mamífero |
| US7439336B2 (en) | 2004-06-29 | 2008-10-21 | Ares Trading S.A. | Process for the purification of IL-18 binding protein |
| CA2593429A1 (en) * | 2004-12-02 | 2006-06-08 | Laboratoires Serono S.A. | The lupac bifunctional marker and its use in protein production |
| PL1885753T3 (pl) * | 2005-06-03 | 2011-12-30 | Ares Trading Sa | Wytwarzanie rekombinowanego białka wiążącego IL-18 |
| PT1891088E (pt) | 2005-06-10 | 2011-12-19 | Ares Trading Sa | Processo para a purificação da proteína de ligação il-18 |
| JP6182066B2 (ja) * | 2011-04-01 | 2017-08-16 | 中外製薬株式会社 | 組換えポリペプチドの製造方法 |
-
2004
- 2004-03-10 JP JP2006505456A patent/JP5171033B2/ja not_active Expired - Lifetime
- 2004-03-10 WO PCT/EP2004/050280 patent/WO2004081167A2/en active IP Right Grant
- 2004-03-10 DE DE602004014738T patent/DE602004014738D1/de not_active Expired - Lifetime
- 2004-03-10 CN CNB2004800067294A patent/CN100429315C/zh not_active Expired - Lifetime
- 2004-03-10 EA EA200501444A patent/EA010096B1/ru not_active IP Right Cessation
- 2004-03-10 RS YUP-2005/0687A patent/RS50488B/sr unknown
- 2004-03-10 DK DK04718972T patent/DK1601776T3/da active
- 2004-03-10 PL PL04718972T patent/PL1601776T4/pl unknown
- 2004-03-10 PT PT04718972T patent/PT1601776E/pt unknown
- 2004-03-10 ES ES04718972T patent/ES2309508T3/es not_active Expired - Lifetime
- 2004-03-10 AT AT04718972T patent/ATE399872T1/de active
- 2004-03-10 BR BRPI0408246-0A patent/BRPI0408246A/pt not_active Application Discontinuation
- 2004-03-10 CA CA2516157A patent/CA2516157C/en not_active Expired - Lifetime
- 2004-03-10 US US10/548,364 patent/US7824907B2/en active Active
- 2004-03-10 AU AU2004219917A patent/AU2004219917B2/en not_active Expired
- 2004-03-10 EP EP04718972A patent/EP1601776B1/en not_active Expired - Lifetime
- 2004-03-10 KR KR1020057015746A patent/KR101180139B1/ko active IP Right Grant
- 2004-03-10 SI SI200430835T patent/SI1601776T1/sl unknown
- 2004-03-10 MX MXPA05009608A patent/MXPA05009608A/es active IP Right Grant
- 2004-10-03 UA UAA200509529A patent/UA88138C2/ru unknown
-
2005
- 2005-08-09 HR HRP20050705AA patent/HRP20050705B1/hr not_active IP Right Cessation
- 2005-08-11 ZA ZA200506400A patent/ZA200506400B/en unknown
- 2005-09-08 IL IL170754A patent/IL170754A/en unknown
- 2005-10-10 NO NO20054642A patent/NO333818B1/no unknown
-
2006
- 2006-07-14 HK HK06107903A patent/HK1085766A1/xx not_active IP Right Cessation
-
2008
- 2008-09-16 CY CY20081100997T patent/CY1108344T1/el unknown
-
2010
- 2010-08-31 US US12/872,151 patent/US9051582B2/en active Active
-
2012
- 2012-07-13 JP JP2012157563A patent/JP5848202B2/ja not_active Expired - Lifetime
-
2015
- 2015-05-20 US US14/716,937 patent/US20150252383A1/en not_active Abandoned
- 2015-06-10 JP JP2015117538A patent/JP2015180222A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1601776T3 (da) | Ekspressionsvektorer omfattende mCmV-IE2-promotoren | |
| YU9404A (sh) | Multimerna, usmerena kontrastna sredstva na bazi peptida | |
| DE602004024107D1 (de) | Vektoren zur gerichteten klonierung | |
| EP1344827A3 (en) | Antifreeze proteins from basidiomycetes | |
| WO2004087874A3 (en) | Novel nucleic acids and polypeptides | |
| WO2003074546A8 (de) | Streptavidin-bindungspeptid | |
| WO2002068465A3 (en) | Novel p53-inducible protein | |
| ATE532861T1 (de) | Expressionsvektor | |
| WO2002100895A3 (de) | Antimikrobiell wirkendes peptid | |
| SG146640A1 (en) | Isolated photoprotein mtclytin, and use thereof | |
| WO2005035719A3 (en) | Modified luciferase | |
| WO2004056964A3 (en) | Vectors for inducible rna interference | |
| DK1339853T3 (da) | Isolerede luciferaser og deres anvendelse | |
| ATE500338T1 (de) | Verwendung des adenoviralen e2-late-promotors | |
| ZA200308303B (en) | Condensates for the retanning of fe-tanned leather. | |
| HK1082510A1 (en) | Promoter to il-18bp, its preparation and use | |
| WO2003093300A3 (en) | Anti-microbial peptides and compositions | |
| DE60330140D1 (de) | Gen-silencing-vektor und diesen verwendendes gen-silencing-verfahren | |
| SE0101519D0 (sv) | Nucleic ACID | |
| TW200617021A (en) | Isolated photoprotein aequorin y89f, and its use | |
| TW200716177A (en) | Isolated photoprotein aqdecay, and its use | |
| TW200716666A (en) | Isolated photoprotein gr-bolinopsin, and its use | |
| ITVR20030001A1 (it) | Chiodo ad elica. | |
| TH60455B (th) | โมโนเนกาไวเรลส์ไวรัสเวคเตอร์ชนิดรีคอมบิแนนท์ | |
| TH90012A (th) | โมโนเนกาไวเรลส์ไวรัสเวคเตอร์ชนิดรีคอมบิแนนท์ |