DK1578933T3 - Sammensætninger og fremgangsmåder til SI-RNA-hæmning af angiogenese - Google Patents

Sammensætninger og fremgangsmåder til SI-RNA-hæmning af angiogenese

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Publication number
DK1578933T3
DK1578933T3 DK03765708T DK03765708T DK1578933T3 DK 1578933 T3 DK1578933 T3 DK 1578933T3 DK 03765708 T DK03765708 T DK 03765708T DK 03765708 T DK03765708 T DK 03765708T DK 1578933 T3 DK1578933 T3 DK 1578933T3
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Prior art keywords
vegf
angiogenesis
compositions
methods
small interfering
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DK03765708T
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English (en)
Inventor
Michael J Tolentino
Samuel Jotham Reich
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Univ Pennsylvania
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Publication of DK1578933T3 publication Critical patent/DK1578933T3/da

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/531—Stem-loop; Hairpin
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance

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DK03765708T 2002-07-24 2003-07-18 Sammensætninger og fremgangsmåder til SI-RNA-hæmning af angiogenese DK1578933T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39841702P 2002-07-24 2002-07-24
US10/294,228 US7148342B2 (en) 2002-07-24 2002-11-14 Compositions and methods for sirna inhibition of angiogenesis
PCT/US2003/022444 WO2004009769A2 (en) 2002-07-24 2003-07-18 COMPOSITIONS AND METHODS FOR siRNA INHIBITION OF ANGIOGENESIS

Publications (1)

Publication Number Publication Date
DK1578933T3 true DK1578933T3 (da) 2010-07-12

Family

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DK03765708T DK1578933T3 (da) 2002-07-24 2003-07-18 Sammensætninger og fremgangsmåder til SI-RNA-hæmning af angiogenese

Country Status (16)

Country Link
US (13) US7148342B2 (da)
EP (3) EP2345718A3 (da)
JP (1) JP5337337B2 (da)
KR (2) KR101280269B1 (da)
AT (1) ATE460500T1 (da)
AU (1) AU2003253995B2 (da)
CA (1) CA2493499C (da)
CY (1) CY1110141T1 (da)
DE (1) DE60331683D1 (da)
DK (1) DK1578933T3 (da)
ES (1) ES2340843T3 (da)
IL (3) IL166274A0 (da)
MX (1) MXPA05001000A (da)
NZ (1) NZ537833A (da)
PT (1) PT1578933E (da)
WO (1) WO2004009769A2 (da)

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