CY1113291T1 - Συνθεσεις και μεθοδοι για sirna αναστολη της αγγειογενεσης - Google Patents

Συνθεσεις και μεθοδοι για sirna αναστολη της αγγειογενεσης

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Publication number
CY1113291T1
CY1113291T1 CY20121100913T CY121100913T CY1113291T1 CY 1113291 T1 CY1113291 T1 CY 1113291T1 CY 20121100913 T CY20121100913 T CY 20121100913T CY 121100913 T CY121100913 T CY 121100913T CY 1113291 T1 CY1113291 T1 CY 1113291T1
Authority
CY
Cyprus
Prior art keywords
sirna
methods
treatment
anxiety
suspension
Prior art date
Application number
CY20121100913T
Other languages
English (en)
Inventor
Samuel Jotham Reich
Original Assignee
Exegenics, Inc., D/B/A Opko Health Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Exegenics, Inc., D/B/A Opko Health Inc. filed Critical Exegenics, Inc., D/B/A Opko Health Inc.
Publication of CY1113291T1 publication Critical patent/CY1113291T1/el

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C12N2310/111—Antisense spanning the whole gene, or a large part of it
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Αποκαλύπτονται εφαρμογές μεθόδων που χρησιμοποιούν siRNA για την στόχευση του VEGF, και οι οποίες περιλαμβάνουν κάποιο siRNA που καθορίζεται από τις SEQ ID NO: 77 και SEQ ID NO: 78 για τη σταθεροποίηση της οπτικής οξύτητας σε κάποιο άτομο, την αναστολή των βλαβών της χοριοειδικής νεοαγγείωσης, τη θεραπευτική αντιμετώπιση της ηλικιακής εκφύλισης της ωχράς κηλίδας, τη θεραπευτική αντιμετώπιση του διαβητικού οιδήματος της ωχράς κηλίδας και τη μείωση του πάχους του βοθρίου της ωχράς κηλίδας. Επιπλέον, περιγράφονται μέθοδοι για τη θεραπευτική αντιμετώπιση της ηλικιακής εκφύλισης της ωχράς κηλίδας και του διαβητικού οιδήματος της ωχράς κηλίδας με τη χορήγηση συνδυαστικής θεραπείας που περιλαμβάνει siRNA που στοχεύει τον VEGF και κάποιον ανταγωνιστή του VEGF διαφορετικό του siRNA.
CY20121100913T 2006-06-12 2012-10-02 Συνθεσεις και μεθοδοι για sirna αναστολη της αγγειογενεσης CY1113291T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US80450006P 2006-06-12 2006-06-12
US82497206P 2006-09-08 2006-09-08
US86444006P 2006-11-06 2006-11-06
EP07812121A EP2029746B1 (en) 2006-06-12 2007-06-12 Compositions and methods for sirna inhibition of angiogenesis

Publications (1)

Publication Number Publication Date
CY1113291T1 true CY1113291T1 (el) 2016-04-13

Family

ID=38832794

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20121100913T CY1113291T1 (el) 2006-06-12 2012-10-02 Συνθεσεις και μεθοδοι για sirna αναστολη της αγγειογενεσης

Country Status (9)

Country Link
US (1) US20080152654A1 (el)
EP (2) EP2029746B1 (el)
JP (1) JP2009540011A (el)
CY (1) CY1113291T1 (el)
DK (1) DK2029746T3 (el)
ES (1) ES2390499T3 (el)
IL (1) IL195803A0 (el)
PT (1) PT2029746E (el)
WO (1) WO2007146953A2 (el)

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WO2007146953A2 (en) 2007-12-21
WO2007146953A3 (en) 2008-03-06
IL195803A0 (en) 2011-08-01
JP2009540011A (ja) 2009-11-19
EP2029746A2 (en) 2009-03-04
EP2029746B1 (en) 2012-07-04
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WO2007146953A8 (en) 2009-11-19
US20080152654A1 (en) 2008-06-26

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